The following IL12B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL12B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 987bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||interleukin-12 subunit beta precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from M65272.1, M65290.1 and
On Nov 3, 2002 this sequence version replaced gi:4504640.
Summary: This gene encodes a subunit of interleukin 12, a cytokine
that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked
heterodimer composed of the 40 kD cytokine receptor like subunit
encoded by this gene, and a 35 kD subunit encoded by IL12A. This
cytokine is expressed by activated macrophages that serve as an
essential inducer of Th1 cells development. This cytokine has been
found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an
intracellular pathogen. Overexpression of this gene was observed in
the central nervous system of patients with multiple sclerosis
(MS), suggesting a role of this cytokine in the pathogenesis of the
disease. The promoter polymorphism of this gene has been reported
to be associated with the severity of atopic and non-atopic asthma
in children. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: M65290.1, BC074723.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns