||ORF Nucleotide Sequence (Length: 441bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from X69079.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 13, 2002 this sequence version replaced gi:4504644.
Summary: This gene encodes an immunoregulatory cytokine produced
primarily by activated Th2 cells. This cytokine is involved in
several stages of B-cell maturation and differentiation. It
up-regulates CD23 and MHC class II expression, and promotes IgE
isotype switching of B cells. This cytokine down-regulates
macrophage activity, thereby inhibits the production of
pro-inflammatory cytokines and chemokines. This cytokine is found
to be critical to the pathogenesis of allergen-induced asthma but
operates through mechanisms independent of IgE and eosinophils.
This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on
chromosome 5q, with this gene particularly close to IL4. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: X69079.1, AF043334.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.