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IL13 interleukin 13 [Homo sapiens (human)]

Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms IL-13, P600
General protein information
Preferred Names
interleukin-13
Names
interleukin-13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31

Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

147683

Disorder Html: {Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,





The following IL13 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL13 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18161 NM_002188 Homo sapiens interleukin 13 (IL13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18161
Accession Version NM_002188.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu18161D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-13 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X69079.1. This sequence is a reference standard in the RefSeqGene project. On Dec 13, 2002 this sequence version replaced gi:4504644. Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X69079.1, AF043334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002179.2
CDS15..455
Misc Feature(1)72..449(+)
Misc Feature(2)57..59(+)
Exon (1)1..188
Gene:IL13
Gene Synonym:
Exon (2)189..242
Gene:IL13
Gene Synonym:
Exon (3)243..347
Gene:IL13
Gene Synonym:
Exon (4)348..1282
Gene:IL13
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, g dbSNP:76471112
6 6 a, c dbSNP:202009492
19 19 a, t dbSNP:778963746
22 22 c, t dbSNP:200168712
33 33 c, t dbSNP:771833459
34 34 a, c dbSNP:201121980
41 41 a, g dbSNP:746947963
45 45 g, t dbSNP:770488630
48 48 c, t dbSNP:202050622
50 50 a, g dbSNP:758908496
52 52 a, c, g dbSNP:529456706
53 53 c, t dbSNP:762306581
57 57 a, c dbSNP:767987922
61 61 c, t dbSNP:376870298
62 62 a, g dbSNP:199924106
69 69 c, t dbSNP:201053365
74 74 c, t dbSNP:55733734
76 76 c, t dbSNP:78181870
79 79 c, t dbSNP:754964536
89 89 c, g dbSNP:200186367
101 101 c, t dbSNP:201424420
102 102 a, g dbSNP:758258492
107 107 g, t dbSNP:777533503
115 115 c, t dbSNP:746751863
116 116 a, g dbSNP:202220644
122 122 c, t dbSNP:200638839
136 136 c, t dbSNP:374069088
137 137 a, t dbSNP:769152159
139 139 a, c dbSNP:200571678
143 143 c, t dbSNP:202011628
149 149 c, g dbSNP:56035208
160 160 a, g dbSNP:768364050
162 162 a, c dbSNP:773714921
167 167 a, c dbSNP:34255686
190 190 c, t dbSNP:138680496
193 193 c, t dbSNP:146770163
194 194 a, g dbSNP:140369292
197 197 c, t dbSNP:371914367
204 204 a, g dbSNP:199869056
216 216 c, t dbSNP:143660447
226 226 a, c, g dbSNP:765719901
228 228 a, c dbSNP:762983915
229 229 c, t dbSNP:148077750
234 234 g, t dbSNP:200120288
237 237 a, g dbSNP:751745832
248 248 c, t dbSNP:192837804
250 250 a, c dbSNP:34654684
253 253 c, t dbSNP:553444004
254 254 c, t dbSNP:150226731
263 263 c, t dbSNP:756707941
266 266 c, g dbSNP:200913948
272 272 c, t dbSNP:201716976
273 273 c, g dbSNP:778560262
274 274 c, g, t dbSNP:199513811
286 286 c, g dbSNP:777431829
288 288 a, g dbSNP:746245700
293 293 c, g, t dbSNP:770108365
301 301 a, c dbSNP:374668631
302 302 c, t dbSNP:780855186
311 311 a, g dbSNP:749795771
312 312 c, g dbSNP:200793410
317 317 c, t dbSNP:769087732
318 318 a, g dbSNP:774429439
328 328 c, t dbSNP:201804555
329 329 a, g dbSNP:200113399
342 342 -, c dbSNP:781754061
359 359 c, t dbSNP:762414781
364 364 a, g, t dbSNP:184944562
369 369 c, t dbSNP:756919832
370 370 a, g dbSNP:140828306
381 381 a, g dbSNP:376384925
383 383 c, g, t dbSNP:78628956
384 384 a, g dbSNP:375653129
387 387 a, g dbSNP:140196099
388 388 c, t dbSNP:777911950
401 401 a, g dbSNP:747026798
404 404 a, g dbSNP:201624646
407 407 a, c dbSNP:200380202
430 430 g, t dbSNP:771297548
435 435 c, t dbSNP:201475069
436 436 a, g dbSNP:745694958
437 437 c, t dbSNP:199797009
438 438 a, g dbSNP:775360450
440 440 c, g, t dbSNP:200247901
444 444 c, t dbSNP:763882844
445 445 a, g dbSNP:20541
450 450 a, g dbSNP:761274909
451 451 a, c dbSNP:56258826
461 461 a, c, t dbSNP:767198237
462 462 a, g dbSNP:755393562
467 467 c, t dbSNP:374535004
471 471 a, g dbSNP:558907104
472 472 c, t dbSNP:775363860
475 475 c, t dbSNP:758955797
491 491 a, c dbSNP:569385458
492 492 c, t dbSNP:2069749
498 498 c, t dbSNP:56318025
506 506 a, c, g dbSNP:75868517
510 510 a, g dbSNP:201863406
542 542 g, t dbSNP:199516826
551 551 a, g dbSNP:200797041
609 609 c, t dbSNP:201802470
610 610 a, g dbSNP:200196698
615 615 c, t dbSNP:200786939
625 625 a, g dbSNP:540617089
672 672 c, t dbSNP:375776378
675 675 c, t dbSNP:201490660
677 677 a, g dbSNP:199955551
690 690 c, t dbSNP:200895460
691 691 a, g dbSNP:554174789
696 696 a, g dbSNP:202233186
711 711 a, g dbSNP:190222211
717 717 a, g dbSNP:150177673
725 725 c, t dbSNP:529997471
750 750 a, t dbSNP:201185816
752 752 c, t dbSNP:202101165
755 755 a, g dbSNP:200632360
770 770 a, t dbSNP:115325936
778 778 -, at dbSNP:149809253
792 792 c, g dbSNP:199511991
793 793 c, g dbSNP:200265585
803 803 a, c dbSNP:201420607
822 822 a, c dbSNP:199804866
841 841 c, g dbSNP:200650844
844 844 c, t dbSNP:201965069
875 875 c, t dbSNP:766993780
893 893 c, t dbSNP:181825588
897 897 a, g dbSNP:184838848
898 898 c, t dbSNP:199713326
913 913 c, g dbSNP:368300404
919 919 a, g dbSNP:200586394
920 920 g, t dbSNP:527319875
926 926 a, g dbSNP:1295685
927 927 c, g dbSNP:765879797
942 942 g, t dbSNP:199903635
951 951 a, t dbSNP:570083916
952 952 c, t dbSNP:200557616
971 971 a, g dbSNP:753119382
981 981 a, c dbSNP:848
998 998 a, g dbSNP:200202231
1037 1037 c, t dbSNP:189329440
1048 1048 a, g dbSNP:202204367
1057 1057 c, t dbSNP:181985600
1059 1059 c, t dbSNP:201076793
1060 1060 c, g dbSNP:202147858
1067 1067 a, g dbSNP:200189368
1078 1078 c, g dbSNP:2069750
1091 1091 a, g dbSNP:370110665
1096 1096 g, t dbSNP:202102174
1103 1103 c, g dbSNP:200635007
1107 1107 c, t dbSNP:116240019
1150 1150 c, t dbSNP:847
1196 1196 a, g dbSNP:138637232
1233 1233 g, t dbSNP:143032763
1243 1243 a, g dbSNP:199848775
1267 1267 a, g dbSNP:546023282
1271 1271 c, t dbSNP:556618159

Target ORF information:

RefSeq Version NM_002188
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 13 (IL13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002188

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.