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IL13 cDNA ORF clone, Homo sapiens (human)

Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms IL-13, P600
General protein information
Preferred Names
interleukin-13
Names
interleukin-13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31

Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

147683

Disorder Html: {Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,

mRNA and Protein(s)

mRNA Protein Name
NM_002188 NP_002179 interleukin-13 precursor



Homo sapiens (human) IL13 NP_002179.2
Pan troglodytes (chimpanzee) IL13 NP_001008992.1
Macaca mulatta (Rhesus monkey) IL13 NP_001028101.1
Canis lupus familiaris (dog) IL13 NP_001003384.1
Bos taurus (cattle) IL13 NP_776514.1
Mus musculus (house mouse) Il13 NP_032381.1
Rattus norvegicus (Norway rat) Il13 NP_446280.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18161
NM_002188 Homo sapiens interleukin 13 (IL13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18161
Clone ID Related Accession (Same CDS sequence) NM_002188
Accession Version NM_002188.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 441bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product interleukin-13 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X69079.1. This sequence is a reference standard in the RefSeqGene project. On Dec 13, 2002 this sequence version replaced gi:4504644. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X69079.1, AF043334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002179.2
CDS15..455
Misc Feature(1)72..449(+)
Misc Feature(2)57..59(+)
Exon (1)1..188
Gene:IL13
Gene Synonym:
Exon (2)189..242
Gene:IL13
Gene Synonym:
Exon (3)243..347
Gene:IL13
Gene Synonym:
Exon (4)348..1282
Gene:IL13
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002188
Organism Homo sapiens (human)
Definition Homo sapiens interleukin 13 (IL13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002188

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCATCCGC TCCTCAATCC TCTCCTGTTG GCACTGGGCC TCATGGCGCT TTTGTTGACC 
ACGGTCATTG CTCTCACTTG CCTTGGCGGC TTTGCCTCCC CAGGCCCTGT GCCTCCCTCT
ACAGCCCTCA GGGAGCTCAT TGAGGAGCTG GTCAACATCA CCCAGAACCA GAAGGCTCCG
CTCTGCAATG GCAGCATGGT ATGGAGCATC AACCTGACAG CTGGCATGTA CTGTGCAGCC
CTGGAATCCC TGATCAACGT GTCAGGCTGC AGTGCCATCG AGAAGACCCA GAGGATGCTG
AGCGGATTCT GCCCGCACAA GGTCTCAGCT GGGCAGTTTT CCAGCTTGCA TGTCCGAGAC
ACCAAAATCG AGGTGGCCCA GTTTGTAAAG GACCTGCTCT TACATTTAAA GAAACTTTTT
CGCGAGGGAC AGTTCAACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7
Am. J. Physiol. Endocrinol. Metab. 305 (11), E1359-E1366 (2013)
Jiang LQ, Franck N, Egan B, Sjogren RJ, Katayama M, Duque-Guimaraes D, Arner P, Zierath JR and Krook A.


book

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis
Hum. Mol. Genet. 22 (23), 4841-4856 (2013)
Weidinger S, Willis-Owen SA, Kamatani Y, Baurecht H, Morar N, Liang L, Edser P, Street T, Rodriguez E, O'Regan GM, Beattie P, Folster-Holst R, Franke A, Novak N, Fahy CM, Winge MC, Kabesch M, Illig T, Heath S, Soderhall C, Melen E, Pershagen G, Kere J, Bradley M, Lieden A, Nordenskjold M, Harper JI, McLean WH, Brown SJ, Cookson WO, Lathrop GM, Irvine AD and Moffatt MF.


book

IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients
J Allergy Asthma Immunol 12 (4), 391-396 (2013)
Shazia M, Kanza M, Mehwish I, Irum S, Farida A and Asifa A.


book

IL-13/IL-22-coproducing T cells, a novel subset, are increased in atopic dermatitis
J. Allergy Clin. Immunol. 132 (4), 971-974 (2013)
Teraki Y, Sakurai A and Izaki S.


book

Interleukin-13 and RANTES polymorphisms in relation to asthma in children of Chinese Han nationality
Asian Pac. J. Allergy Immunol. 31 (3), 247-252 (2013)
Liu Q, Hua L, Fang D, Lin Q, Zhu Y, Gan X and Bao Y.


book

Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization
Gene 155 (2), 277-281 (1995)
Smirnov DV, Smirnova MG, Korobko VG and Frolova EI.


book

Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production
Blood 84 (6), 1913-1921 (1994)
Sironi M, Sciacca FL, Matteucci C, Conni M, Vecchi A, Bernasconi S, Minty A, Caput D, Ferrara P and Colotta F.


book

Predictive modelling of the 3-D structure of interleukin-13
Protein Eng. 7 (9), 1077-1082 (1994)
Bamborough P, Duncan D and Richards WG.


book

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses
Nature 362 (6417), 248-250 (1993)
Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P and Miloux B.


book

The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes
Nucleic Acids Res. 20 (19), 5173-5179 (1992)
Morgan JG, Dolganov GM, Robbins SE, Hinton LM and Lovett M.


 
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