||ORF Nucleotide Sequence (Length: 1212bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||indoleamine 2,3-dioxygenase 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU137351.1, BC027882.1,
CD366252.1 and BF094375.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 18, 2011 this sequence version replaced gi:156071492.
Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a
heme enzyme that catalyzes the first and rate-limiting step in
tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on
multiple tryptophan substrates including D-tryptophan,
L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This
enzyme is thought to play a role in a variety of pathophysiological
processes such as antimicrobial and antitumor defense,
neuropathology, immunoregulation, and antioxidant activity. Through
its expression in dendritic cells, monocytes, and macrophages this
enzyme modulates T-cell behavior by its peri-cellular
catabolization of the essential amino acid tryptophan.[provided by
RefSeq, Feb 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC027882.1, X17668.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.