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IDO1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol IDO1
Entrez Gene ID 3620
Full Name indoleamine 2,3-dioxygenase 1
Synonyms IDO, IDO-1, INDO
General protein information
Preferred Names
indoleamine 2,3-dioxygenase 1
Names
indoleamine 2,3-dioxygenase 1
indole 2,3-dioxygenase
indolamine 2,3 dioxygenase
indoleamine-pyrrole 2,3-dioxygenase
NP_002155.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12-p11

Summary This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]. lac of sum
Disorder MIM:

147435

Disorder Html:





The following IDO1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDO1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20074 NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$265.30
$379.00

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CloneID OHu20074
Accession Version NM_002164.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1212bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product indoleamine 2,3-dioxygenase 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU137351.1, BC027882.1, CD366252.1 and BF094375.1. This sequence is a reference standard in the RefSeqGene project. On Feb 18, 2011 this sequence version replaced gi:156071492. Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027882.1, X17668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA 
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_002155.1
CDS115..1326
Misc Feature(1)85..87(+)
Misc Feature(2)136..1314(+)
Exon (1)1..201
Gene:IDO1
Gene Synonym:
Exon (2)202..297
Gene:IDO1
Gene Synonym:
Exon (3)298..417
Gene:IDO1
Gene Synonym:
Exon (4)418..536
Gene:IDO1
Gene Synonym:
Exon (5)537..551
Gene:IDO1
Gene Synonym:
Exon (6)552..651
Gene:IDO1
Gene Synonym:
Exon (7)652..769
Gene:IDO1
Gene Synonym:
Exon (8)770..821
Gene:IDO1
Gene Synonym:
Exon (9)822..970
Gene:IDO1
Gene Synonym:
Exon (10)971..1931
Gene:IDO1
Gene Synonym:
Translation
Position Chain Variation Link
6 6 c, t dbSNP:750509314
8 8 c, t dbSNP:553206432
26 26 c, t dbSNP:114621275
40 40 -, gggg dbSNP:139463288
73 73 c, t dbSNP:773622191
74 74 c, t dbSNP:763279663
81 81 a, t dbSNP:377358744
83 83 a, g dbSNP:370408015
88 88 a, c, g dbSNP:541586371
90 90 g, t dbSNP:561548679
94 94 a, c dbSNP:759551618
96 96 a, g dbSNP:146125455
104 104 a, t dbSNP:752820091
107 107 a, c dbSNP:374566329
109 109 a, g dbSNP:377577519
123 123 c, t dbSNP:544291309
124 124 a, g dbSNP:35059413
128 128 -, g dbSNP:755786618
135 135 c, g dbSNP:758170169
137 137 c, t dbSNP:779594371
142 142 a, g dbSNP:746614436
143 143 a, c dbSNP:768056394
150 150 c, t dbSNP:780742846
175 175 a, g dbSNP:533336421
187 187 a, c dbSNP:770331245
196 196 c, t dbSNP:773675581
200 200 a, g dbSNP:749677651
207 207 c, t dbSNP:188033932
213 213 c, t dbSNP:751303113
216 216 c, t dbSNP:754713493
240 240 g, t dbSNP:780797736
241 241 g, t dbSNP:75896742
264 264 -, ag dbSNP:748707039
268 268 c, t dbSNP:747693827
269 269 a, c dbSNP:755574786
281 281 a, g dbSNP:778268528
290 290 g, t dbSNP:749740278
297 297 c, g dbSNP:753248170
303 303 c, t dbSNP:779260713
311 311 a, g dbSNP:746277432
315 315 c, t dbSNP:772518234
317 317 a, g dbSNP:780434457
318 318 c, t dbSNP:747157869
319 319 a, c, t dbSNP:763006663
322 322 c, t dbSNP:374076241
330 330 c, t dbSNP:568434333
343 343 c, t dbSNP:200980431
344 344 a, g dbSNP:35099072
346 346 c, g dbSNP:759391476
352 352 c, t dbSNP:767234834
353 353 a, g dbSNP:752486286
355 355 a, c dbSNP:760377982
361 361 c, g dbSNP:763717877
365 365 a, g dbSNP:753432194
379 379 a, g dbSNP:756686054
381 381 a, c dbSNP:774456014
383 383 a, g dbSNP:375715414
389 389 a, g dbSNP:750836111
406 406 c, g dbSNP:758835146
407 407 a, g dbSNP:780628699
408 408 c, t dbSNP:747360195
412 412 c, t dbSNP:769048421
413 413 a, g dbSNP:200244502
419 419 a, t dbSNP:748254602
420 420 c, t dbSNP:756356983
428 428 a, g dbSNP:12545877
433 433 a, g dbSNP:749348250
439 439 a, g dbSNP:772041863
442 442 c, t dbSNP:775369606
445 445 g, t dbSNP:746831661
462 462 a, g, t dbSNP:12545878
463 463 a, c dbSNP:776348512
465 465 -, c dbSNP:775610754
499 499 g, t dbSNP:761435727
500 500 a, g dbSNP:540988047
507 507 a, g dbSNP:772894000
511 511 a, g dbSNP:554606280
525 525 g, t dbSNP:767023043
526 526 c, g, t dbSNP:752063551
527 527 a, t dbSNP:767839645
531 531 g, t dbSNP:753094747
533 533 a, g dbSNP:756341315
536 536 a, g dbSNP:574530240
539 539 c, t dbSNP:61753677
546 546 -, t dbSNP:766317554
549 549 c, t dbSNP:749071072
553 553 a, g dbSNP:757069658
555 555 c, t dbSNP:778446814
561 561 c, g, t dbSNP:745461399
562 562 a, g dbSNP:559841492
567 567 a, g dbSNP:746476355
569 569 -, g dbSNP:34155785
570 570 a, c, g dbSNP:115833371
577 577 a, c, t dbSNP:370075063
578 578 a, c, g dbSNP:200635255
582 582 a, c, t dbSNP:185712428
598 598 c, g dbSNP:201170433
602 602 c, t dbSNP:764150078
607 607 c, t dbSNP:753774898
612 612 a, c dbSNP:757126776
614 614 c, g dbSNP:189439950
616 616 c, t dbSNP:377288389
622 622 c, g dbSNP:758115203
628 628 a, t dbSNP:779539216
630 630 a, c dbSNP:746549488
644 644 a, c dbSNP:754431478
646 646 a, g dbSNP:781672740
648 648 c, t dbSNP:748587460
655 655 a, c dbSNP:771143153
663 663 g, t dbSNP:372561405
669 669 c, g dbSNP:376724401
690 690 -, acgggac dbSNP:757943387
690 690 a, g dbSNP:201671570
691 691 c, t dbSNP:372512518
692 692 a, c, g, t dbSNP:371014998
692 692 -, g dbSNP:763466410
699 699 -, cccgttc dbSNP:752144501
699 699 g, t dbSNP:772970602
705 705 a, t dbSNP:185947694
709 709 a, g dbSNP:375907817
710 710 cg, tt dbSNP:267606590
710 710 c, t dbSNP:751350971
711 711 -, gctgttgga dbSNP:553639551
711 711 a, g dbSNP:759243166
724 724 a, c, g dbSNP:369075008
735 735 a, g dbSNP:772198770
736 736 a, g dbSNP:755531208
739 739 a, t dbSNP:373871520
752 752 c, g, t dbSNP:376530940
759 759 c, t dbSNP:144836646
768 768 c, t dbSNP:773520481
769 769 a, g dbSNP:373557196
770 770 a, t dbSNP:781185642
771 771 a, t dbSNP:148682026
774 774 c, t dbSNP:770895038
805 805 c, t dbSNP:774225205
806 806 a, g, t dbSNP:745677091
808 808 a, g dbSNP:775351762
810 810 a, g dbSNP:760305717
812 812 a, g dbSNP:763782527
814 814 c, g, t dbSNP:776049118
818 818 c, g dbSNP:746221832
820 820 g, t dbSNP:765858179
834 834 c, t dbSNP:778828448
836 836 a, c dbSNP:745873650
838 838 c, t dbSNP:771986770
849 849 c, t dbSNP:775200359
850 850 a, g dbSNP:766025154
851 851 a, g dbSNP:768228145
852 852 c, t dbSNP:776294123
853 853 c, g dbSNP:761417963
868 868 c, t dbSNP:769359330
869 869 c, t dbSNP:376097320
874 874 a, g dbSNP:763611687
876 876 a, g dbSNP:531108370
883 883 a, g dbSNP:751360195
884 884 a, g dbSNP:759904076
890 890 c, t dbSNP:767647296
892 892 g, t dbSNP:752898584
894 894 a, c dbSNP:756327390
895 895 g, t dbSNP:368545447
896 896 a, g dbSNP:753896549
897 897 a, g dbSNP:758375035
906 906 a, g dbSNP:551298786
918 918 c, t dbSNP:746805754
919 919 -, gt dbSNP:768812233
919 919 a, g dbSNP:200544059
920 920 c, t dbSNP:780708858
921 921 c, t dbSNP:377110494
927 927 c, g dbSNP:769553865
928 928 a, t dbSNP:780851323
936 936 c, g, t dbSNP:374857714
937 937 a, g dbSNP:187334376
938 938 g, t dbSNP:759824915
939 939 c, g dbSNP:767992637
941 941 g, t dbSNP:753048386
946 946 c, g dbSNP:760939743
960 960 c, g, t dbSNP:764272112
968 968 g, t dbSNP:757315154
977 977 c, t dbSNP:761799363
980 980 c, t dbSNP:765420484
991 991 c, t dbSNP:750453634
993 993 a, g dbSNP:754990051
997 997 a, t dbSNP:144063606
1002 1002 a, g dbSNP:752570452
1004 1004 g, t dbSNP:755922529
1008 1008 c, t dbSNP:777581912
1010 1010 c, t dbSNP:749015694
1016 1016 c, t dbSNP:756847667
1019 1019 c, g dbSNP:369888099
1025 1025 g, t dbSNP:745341242
1026 1026 a, g, t dbSNP:772669654
1035 1035 g, t dbSNP:747391374
1063 1063 a, c dbSNP:768938457
1064 1064 a, g dbSNP:761098064
1068 1068 a, g dbSNP:75174100
1073 1073 a, t dbSNP:376170633
1079 1079 c, t dbSNP:773380478
1085 1085 c, g dbSNP:762900972
1091 1091 c, g dbSNP:561831334
1097 1097 g, t dbSNP:752623859
1100 1100 a, g dbSNP:756117395
1102 1102 a, g dbSNP:764039576
1107 1107 a, t dbSNP:753555345
1113 1113 a, c, t dbSNP:370900557
1114 1114 a, g dbSNP:749974684
1137 1137 a, c dbSNP:757849719
1145 1145 -, ctac dbSNP:774264973
1153 1153 c, g dbSNP:780546669
1161 1161 c, t dbSNP:373317694
1162 1162 a, g dbSNP:376621895
1168 1168 a, g dbSNP:781582282
1171 1171 a, t dbSNP:748428322
1186 1186 a, g dbSNP:370251807
1193 1193 a, g dbSNP:773257114
1194 1194 a, g dbSNP:763106555
1206 1206 c, g dbSNP:374895308
1208 1208 a, g dbSNP:542806301
1225 1225 c, t dbSNP:760744665
1251 1251 a, t dbSNP:563087970
1256 1256 c, g dbSNP:753700103
1287 1287 a, g dbSNP:761470075
1294 1294 a, g dbSNP:764960264
1295 1295 a, c dbSNP:749981788
1304 1304 a, c dbSNP:377702129
1305 1305 a, g, t dbSNP:576594773
1308 1308 c, t dbSNP:755517393
1328 1328 a, g dbSNP:781509240
1337 1337 a, c dbSNP:748566469
1347 1347 -, t dbSNP:747017540
1348 1348 a, t dbSNP:769993963
1351 1351 a, g dbSNP:778060773
1356 1356 a, g dbSNP:371336850
1366 1366 g, t dbSNP:771256577
1408 1408 a, c dbSNP:753352149
1441 1441 a, g dbSNP:112777448
1476 1476 c, g dbSNP:543884126
1477 1477 c, t dbSNP:146382455
1538 1538 -, atc dbSNP:547131449
1592 1592 c, t dbSNP:532734786
1593 1593 g, t dbSNP:558540924
1594 1594 a, g dbSNP:560144720
1600 1600 c, t dbSNP:529187886
1601 1601 a, g dbSNP:565717928
1645 1645 c, t dbSNP:539055517
1646 1646 a, g dbSNP:181854364
1649 1649 c, t dbSNP:552871147
1650 1650 a, g dbSNP:551876466
1657 1657 a, g dbSNP:570791065
1675 1675 c, t dbSNP:372492160
1680 1680 c, t dbSNP:538117842
1684 1684 c, t dbSNP:139027344
1701 1701 c, t dbSNP:201339184
1727 1727 a, t dbSNP:376997707
1737 1737 a, g dbSNP:187024006
1743 1743 a, g dbSNP:370645816
1766 1766 c, t dbSNP:191858087
1771 1771 g, t dbSNP:545214196
1791 1791 a, g dbSNP:557391783
1805 1805 c, t dbSNP:577324316
1813 1813 a, g dbSNP:539988422
1843 1843 c, t dbSNP:372424675
1857 1857 c, g dbSNP:375417495
1861 1861 a, g dbSNP:528913100
1873 1873 -, a, aaaaaaaaaaaaaaaaaaaaaaaa dbSNP:540012666
1890 1890 -, a dbSNP:34719328

Target ORF information:

RefSeq Version NM_002164
Organism Homo sapiens (human)
Definition Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002164

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGCACACG CTATGGAAAA CTCCTGGACA ATCAGTAAAG AGTACCATAT TGATGAAGAA 
GTGGGCTTTG CTCTGCCAAA TCCACAGGAA AATCTACCTG ATTTTTATAA TGACTGGATG
TTCATTGCTA AACATCTGCC TGATCTCATA GAGTCTGGCC AGCTTCGAGA AAGAGTTGAG
AAGTTAAACA TGCTCAGCAT TGATCATCTC ACAGACCACA AGTCACAGCG CCTTGCACGT
CTAGTTCTGG GATGCATCAC CATGGCATAT GTGTGGGGCA AAGGTCATGG AGATGTCCGT
AAGGTCTTGC CAAGAAATAT TGCTGTTCCT TACTGCCAAC TCTCCAAGAA ACTGGAACTG
CCTCCTATTT TGGTTTATGC AGACTGTGTC TTGGCAAACT GGAAGAAAAA GGATCCTAAT
AAGCCCCTGA CTTATGAGAA CATGGACGTT TTGTTCTCAT TTCGTGATGG AGACTGCAGT
AAAGGATTCT TCCTGGTCTC TCTATTGGTG GAAATAGCAG CTGCTTCTGC AATCAAAGTA
ATTCCTACTG TATTCAAGGC AATGCAAATG CAAGAACGGG ACACTTTGCT AAAGGCGCTG
TTGGAAATAG CTTCTTGCTT GGAGAAAGCC CTTCAAGTGT TTCACCAAAT CCACGATCAT
GTGAACCCAA AAGCATTTTT CAGTGTTCTT CGCATATATT TGTCTGGCTG GAAAGGCAAC
CCCCAGCTAT CAGACGGTCT GGTGTATGAA GGGTTCTGGG AAGACCCAAA GGAGTTTGCA
GGGGGCAGTG CAGGCCAAAG CAGCGTCTTT CAGTGCTTTG ACGTCCTGCT GGGCATCCAG
CAGACTGCTG GTGGAGGACA TGCTGCTCAG TTCCTCCAGG ACATGAGAAG ATATATGCCA
CCAGCTCACA GGAACTTCCT GTGCTCATTA GAGTCAAATC CCTCAGTCCG TGAGTTTGTC
CTTTCAAAAG GTGATGCTGG CCTGCGGGAA GCTTATGACG CCTGTGTGAA AGCTCTGGTC
TCCCTGAGGA GCTACCATCT GCAAATCGTG ACTAAGTACA TCCTGATTCC TGCAAGCCAG
CAGCCAAAGG AGAATAAGAC CTCTGAAGAC CCTTCAAAAC TGGAAGCCAA AGGAACTGGA
GGCACTGATT TAATGAATTT CCTGAAGACT GTAAGAAGTA CAACTGAGAA ATCCCTTTTG
AAGGAAGGTT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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