The following IDO1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IDO1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1212bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||indoleamine 2,3-dioxygenase 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU137351.1, BC027882.1,
CD366252.1 and BF094375.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 18, 2011 this sequence version replaced gi:156071492.
Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a
heme enzyme that catalyzes the first and rate-limiting step in
tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on
multiple tryptophan substrates including D-tryptophan,
L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This
enzyme is thought to play a role in a variety of pathophysiological
processes such as antimicrobial and antitumor defense,
neuropathology, immunoregulation, and antioxidant activity. Through
its expression in dendritic cells, monocytes, and macrophages this
enzyme modulates T-cell behavior by its peri-cellular
catabolization of the essential amino acid tryptophan.[provided by
RefSeq, Feb 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC027882.1, X17668.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.