The following PDX1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDX1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 852bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||pancreas/duodenum homeobox protein 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CA848737.1, U30329.1 and
This sequence is a reference standard in the RefSeqGene project.
On May 28, 2008 this sequence version replaced gi:119392075.
Summary: The protein encoded by this gene is a transcriptional
activator of several genes, including insulin, somatostatin,
glucokinase, islet amyloid polypeptide, and glucose transporter
type 2. The encoded nuclear protein is involved in the early
development of the pancreas and plays a major role in
glucose-dependent regulation of insulin gene expression. Defects in
this gene are a cause of pancreatic agenesis, which can lead to
early-onset insulin-dependent diabetes mellitus (NIDDM), as well as
maturity onset diabetes of the young type 4 (MODY4). [provided by
RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: CA848737.1, X99894.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.