×

PDX1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PDX1
Entrez Gene ID 3651
Full Name pancreatic and duodenal homeobox 1
Synonyms GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1
General protein information
Preferred Names
pancreas/duodenum homeobox protein 1
Names
pancreas/duodenum homeobox protein 1
IPF-1
IUF-1
glucose-sensitive factor
insulin upstream factor 1
islet/duodenum homeobox-1
somatostatin transcription factor 1
pancreatic-duodenal homeobox factor 1
somatostatin-transactivating factor 1
insulin promoter factor 1, homeodomain transcription factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12.1

Summary The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600733

Disorder Html: Pancreatic agenesis, 260370 (3); MODY, type IV, 606392 (3); {Diabetes





The following PDX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19441 NM_000209 Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.30
$309.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19441
Accession Version NM_000209.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 852bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pancreas/duodenum homeobox protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CA848737.1, U30329.1 and AL353195.14. This sequence is a reference standard in the RefSeqGene project. On May 28, 2008 this sequence version replaced gi:119392075. Summary: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA848737.1, X99894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAACGGCG AGGAGCAGTA CTACGCGGCC ACGCAGCTTT ACAAGGACCC ATGCGCGTTC 
CAGCGAGGCC CGGCGCCGGA GTTCAGCGCC AGCCCCCCTG CGTGCCTGTA CATGGGCCGC
CAGCCCCCGC CGCCGCCGCC GCACCCGTTC CCTGGCGCCC TGGGCGCGCT GGAGCAGGGC
AGCCCCCCGG ACATCTCCCC GTACGAGGTG CCCCCCCTCG CCGACGACCC CGCGGTGGCG
CACCTTCACC ACCACCTCCC GGCTCAGCTC GCGCTCCCCC ACCCGCCCGC CGGGCCCTTC
CCGGAGGGAG CCGAGCCGGG CGTCCTGGAG GAGCCCAACC GCGTCCAGCT GCCTTTCCCA
TGGATGAAGT CTACCAAAGC TCACGCGTGG AAAGGCCAGT GGGCAGGCGG CGCCTACGCT
GCGGAGCCGG AGGAGAACAA GCGGACGCGC ACGGCCTACA CGCGCGCACA GCTGCTAGAG
CTGGAGAAGG AGTTCCTATT CAACAAGTAC ATCTCACGGC CGCGCCGGGT GGAGCTGGCT
GTCATGTTGA ACTTGACCGA GAGACACATC AAGATCTGGT TCCAAAACCG CCGCATGAAG
TGGAAAAAGG AGGAGGACAA GAAGCGCGGC GGCGGGACAG CTGTCGGGGG TGGCGGGGTC
GCGGAGCCTG AGCAGGACTG CGCCGTGACC TCCGGCGAGG AGCTTCTGGC GCTGCCGCCG
CCGCCGCCCC CCGGAGGTGC TGTGCCGCCC GCTGCCCCCG TTGCCGCCCG AGAGGGCCGC
CTGCCGCCTG GCCTTAGCGC GTCGCCACAG CCCTCCAGCG TCGCGCCTCG GCGGCCGCAG
GAACCACGAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000200.1
CDS109..960
Misc Feature(1)145..327(+)
Misc Feature(2)460..477(+)
Misc Feature(3)547..723(+)
Misc Feature(4)547..717(+)
Misc Feature(5)553..705(+)
Misc Feature(6)697..717(+)
Misc Feature(7)910..912(+)
Exon (1)1..514
Gene:PDX1
Gene Synonym:
Exon (2)515..2573
Gene:PDX1
Gene Synonym:
Translation
Position Chain Variation Link
4 4 -, t dbSNP:201066590
23 23 g, t dbSNP:188482874
58 58 -, ctcccgg dbSNP:759395473
59 59 -, ctcccgg dbSNP:774060840
84 84 c, t dbSNP:557174897
85 85 a, g dbSNP:779510037
86 86 -, ctcccgg dbSNP:193922352
91 91 c, t dbSNP:193922351
114 114 c, t dbSNP:146936598
115 115 a, g dbSNP:773555653
153 153 g, t dbSNP:747304604
160 160 c, t dbSNP:137852785
168 168 c, g dbSNP:776516205
193 193 a, g dbSNP:759692004
205 205 a, c, g, t dbSNP:192902098
206 206 a, c dbSNP:767363575
209 209 c, t dbSNP:750219172
234 234 -, ccg dbSNP:755562714
235 235 -, ccg dbSNP:752633548
264 264 a, c dbSNP:541495521
265 265 a, g dbSNP:755703581
270 270 a, g dbSNP:28509441
272 272 a, g dbSNP:753249965
273 273 a, c dbSNP:530567443
284 284 a, t dbSNP:137852784
291 291 -, c dbSNP:763650383
292 292 c, t dbSNP:779269166
294 294 a, c dbSNP:550685153
296 296 -, c dbSNP:193929377
318 318 g, t dbSNP:748725637
319 319 a, c dbSNP:564129447
322 322 a, c dbSNP:778216763
323 323 c, t dbSNP:572689574
324 324 c, t dbSNP:193922353
334 334 a, g dbSNP:137852783
339 339 c, t dbSNP:752236361
355 355 c, t dbSNP:781516081
366 366 c, t dbSNP:745911015
367 367 c, g dbSNP:769974289
369 369 a, c, g dbSNP:546786946
379 379 c, g dbSNP:772008981
380 380 -, g dbSNP:753499583
381 381 a, g dbSNP:772939313
383 383 c, t dbSNP:566665917
384 384 -, ccc dbSNP:756909200
386 386 c, g dbSNP:760498179
387 387 -, ag dbSNP:778651779
388 388 c, g, t dbSNP:765919889
392 392 -, ggaggga dbSNP:746180578
392 392 a, c dbSNP:375009107
396 396 -, ga dbSNP:758841244
404 404 a, c dbSNP:764870332
408 408 -, c dbSNP:780653054
408 408 c, t dbSNP:752260094
410 410 c, t dbSNP:758919455
411 411 a, g dbSNP:778447909
412 412 a, g dbSNP:751940952
415 415 a, g dbSNP:757687785
420 420 a, c, t dbSNP:535722487
426 426 g, t dbSNP:193922354
429 429 a, c dbSNP:201701313
441 441 a, g dbSNP:749389364
444 444 c, g dbSNP:149275902
446 446 a, g dbSNP:773176417
449 449 g, t dbSNP:760443155
457 457 a, c, g dbSNP:573752557
459 459 a, g dbSNP:759162149
472 472 a, t dbSNP:764810731
477 477 a, g dbSNP:752207066
486 486 a, g dbSNP:762584321
492 492 c, g dbSNP:764675125
502 502 a, g dbSNP:752168064
503 503 a, g dbSNP:757558416
504 504 c, t dbSNP:781552927
507 507 g, t dbSNP:750762696
509 509 g, t dbSNP:756308187
514 514 a, g dbSNP:780282811
517 517 g, t dbSNP:781025559
521 521 c, t dbSNP:745645852
526 526 a, g dbSNP:143517122
528 528 c, t dbSNP:775275110
529 529 g, t dbSNP:748882815
536 536 c, g dbSNP:771656169
537 537 -, gga dbSNP:768856218
537 537 a, c, g dbSNP:148001995
550 550 c, g dbSNP:193922355
560 560 a, c, t dbSNP:565726855
567 567 c, t dbSNP:768033680
571 571 a, c dbSNP:773643850
574 574 a, g dbSNP:761089644
576 576 a, g dbSNP:766799672
597 597 a, g dbSNP:754210302
600 600 g, t dbSNP:80356661
606 606 a, g dbSNP:780117858
616 616 c, t dbSNP:765466519
630 630 a, g dbSNP:752784234
636 636 g, t dbSNP:758448475
640 640 a, g dbSNP:80356662
641 641 a, g dbSNP:387906777
645 645 a, g dbSNP:200760158
650 650 a, t dbSNP:750392535
651 651 c, t dbSNP:75498935
653 653 c, t dbSNP:369507870
660 660 c, t dbSNP:574643007
662 662 g, t dbSNP:202159230
666 666 c, g, t dbSNP:768380374
676 676 a, g dbSNP:747669305
679 679 a, c dbSNP:193922356
695 695 a, c dbSNP:771543377
698 698 a, g dbSNP:137852786
700 700 a, c dbSNP:773768784
725 725 a, t dbSNP:761107416
734 734 a, g dbSNP:771445149
741 741 c, t dbSNP:776932903
742 742 a, g dbSNP:749996964
744 744 a, c, g dbSNP:765415673
750 750 a, t dbSNP:763082291
753 753 c, t dbSNP:764011596
757 757 g, t dbSNP:751672722
759 759 -, ggc dbSNP:748376235
759 759 -, t dbSNP:776610329
763 763 g, t dbSNP:756067225
767 767 a, t dbSNP:201343646
768 768 a, c dbSNP:753650635
769 769 a, g dbSNP:150559931
771 771 a, g dbSNP:754867917
772 772 a, g dbSNP:368507502
775 775 c, t dbSNP:747825143
777 777 c, t dbSNP:771764758
778 778 a, g dbSNP:137852787
783 783 a, g dbSNP:746545394
787 787 c, t dbSNP:372765489
789 789 c, t dbSNP:777164146
798 798 c, g dbSNP:759874752
801 801 c, g, t dbSNP:200411304
802 802 a, g dbSNP:367625089
805 805 g, t dbSNP:371525768
808 808 a, g dbSNP:751645380
821 821 -, gcc dbSNP:560348621
822 822 a, g dbSNP:762020686
824 824 a, c dbSNP:199644078
827 827 a, c dbSNP:753881947
831 831 a, g, t dbSNP:754818945
832 832 a, c dbSNP:752553392
833 833 c, t dbSNP:193922358
834 834 -, ccg dbSNP:193922357
836 836 -, gcc dbSNP:193922359
840 840 c, g dbSNP:777512281
842 842 c, g dbSNP:746492280
843 843 a, g dbSNP:756811291
865 865 c, t dbSNP:370787126
867 867 a, c, g dbSNP:781657590
881 881 a, g dbSNP:193922360
894 894 g, t dbSNP:527882800
900 900 c, t dbSNP:770346335
919 919 c, g dbSNP:541584830
925 925 a, g dbSNP:775667083
956 956 a, g dbSNP:754817283
969 969 a, g dbSNP:561437933
979 979 g, t dbSNP:768725073
988 988 g, t dbSNP:774759417
998 998 c, t dbSNP:530404627
1028 1028 a, g dbSNP:374397203
1048 1048 c, t dbSNP:17847223
1065 1065 g, t dbSNP:569303756
1070 1070 g, t dbSNP:532113600
1116 1116 c, t dbSNP:778200349
1144 1144 c, g dbSNP:551863908
1177 1177 -, a dbSNP:55957037
1201 1201 a, g dbSNP:749402485
1227 1227 a, t dbSNP:565741807
1243 1243 -, ggggg, ggggggggg dbSNP:141044960
1290 1290 c, t dbSNP:534535620
1317 1317 a, g dbSNP:771071897
1330 1330 c, g dbSNP:554736447
1450 1450 a, g dbSNP:568295650
1491 1491 a, g dbSNP:537340336
1505 1505 c, t dbSNP:556636257
1506 1506 c, t dbSNP:576516071
1523 1523 -, tct dbSNP:200414219
1523 1523 c, t dbSNP:538988629
1532 1532 -, c dbSNP:372179991
1536 1536 c, t dbSNP:558803711
1537 1537 c, t dbSNP:551783385
1587 1587 c, t dbSNP:572467700
1602 1602 -, tct dbSNP:113506161
1608 1608 -, tcc dbSNP:201597488
1627 1627 a, t dbSNP:541297096
1634 1634 -, ctc dbSNP:567194464
1657 1657 -, ctc dbSNP:771050094
1675 1675 c, t dbSNP:561511065
1703 1703 -, tccccctcctctccctcctcctcttcttct dbSNP:373152010
1703 1703 a, t dbSNP:71433245
1704 1704 c, t dbSNP:574837616
1705 1705 -, ccctcctct dbSNP:749161312
1706 1706 -, ccctcctct dbSNP:139276646
1724 1724 -, tct dbSNP:201227980
1725 1725 c, t dbSNP:543696560
1741 1741 c, t dbSNP:11617235
1746 1746 c, g dbSNP:563597142
1747 1747 ctcctcttcttctc, tt dbSNP:386769404
1754 1754 c, t dbSNP:143062765
1796 1796 g, t dbSNP:11617238
1802 1802 c, t dbSNP:537515100
1804 1804 c, t dbSNP:190800391
1805 1805 a, g dbSNP:374204593
1811 1811 c, t dbSNP:11617239
1812 1812 -, tcc dbSNP:71993976
1817 1817 c, t dbSNP:11620272
1822 1822 -, ttcttctccctcctcttcctcctc dbSNP:371209265
1823 1823 -, ctc dbSNP:60008665
1823 1823 c, t dbSNP:74799049
1830 1830 -, tc dbSNP:764496076
1831 1831 c, t dbSNP:78382412
1833 1833 c, t dbSNP:11620280
1839 1839 a, t dbSNP:147791430
1841 1841 c, t dbSNP:12560601
1852 1852 c, g dbSNP:548132595
1863 1863 a, t dbSNP:9554205
1864 1864 a, c dbSNP:537204017
1866 1866 -, tctt dbSNP:560079500
1921 1921 c, t dbSNP:761083009
1965 1965 c, t dbSNP:541144902
1975 1975 c, t dbSNP:112637982
1982 1982 a, t dbSNP:112525679
1993 1993 a, t dbSNP:74905790
2000 2000 c, t dbSNP:75697516
2028 2028 a, g dbSNP:558894682
2050 2050 a, g dbSNP:572475449
2084 2084 a, g dbSNP:7981781
2085 2085 a, g dbSNP:554902597
2091 2091 a, g dbSNP:574699287
2095 2095 c, g dbSNP:776277133
2180 2180 c, t dbSNP:112431822
2198 2198 a, g dbSNP:113931775
2205 2205 c, g dbSNP:530321473
2262 2262 a, g dbSNP:545512348
2276 2276 c, t dbSNP:776354464
2302 2302 a, g, t dbSNP:9319402
2315 2315 c, g dbSNP:113776422
2358 2358 c, g dbSNP:555696245
2383 2383 c, t dbSNP:548276958
2390 2390 c, t dbSNP:764829593
2395 2395 a, g dbSNP:183052606
2417 2417 a, g dbSNP:112640306
2420 2420 c, t dbSNP:530749157
2448 2448 a, c dbSNP:187952798
2466 2466 c, t dbSNP:749955222
2469 2469 g, t dbSNP:75445448
2534 2534 c, g dbSNP:570793936
2560 2560 c, t dbSNP:112632160
2561 2561 -, tgttt dbSNP:764742419

Target ORF information:

RefSeq Version NM_000209
Organism Homo sapiens (human)
Definition Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000209

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGAACGGCG AGGAGCAGTA CTACGCGGCC ACGCAGCTTT ACAAGGACCC ATGCGCGTTC 
CAGCGAGGCC CGGCGCCGGA GTTCAGCGCC AGCCCCCCTG CGTGCCTGTA CATGGGCCGC
CAGCCCCCGC CGCCGCCGCC GCACCCGTTC CCTGGCGCCC TGGGCGCGCT GGAGCAGGGC
AGCCCCCCGG ACATCTCCCC GTACGAGGTG CCCCCCCTCG CCGACGACCC CGCGGTGGCG
CACCTTCACC ACCACCTCCC GGCTCAGCTC GCGCTCCCCC ACCCGCCCGC CGGGCCCTTC
CCGGAGGGAG CCGAGCCGGG CGTCCTGGAG GAGCCCAACC GCGTCCAGCT GCCTTTCCCA
TGGATGAAGT CTACCAAAGC TCACGCGTGG AAAGGCCAGT GGGCAGGCGG CGCCTACGCT
GCGGAGCCGG AGGAGAACAA GCGGACGCGC ACGGCCTACA CGCGCGCACA GCTGCTAGAG
CTGGAGAAGG AGTTCCTATT CAACAAGTAC ATCTCACGGC CGCGCCGGGT GGAGCTGGCT
GTCATGTTGA ACTTGACCGA GAGACACATC AAGATCTGGT TCCAAAACCG CCGCATGAAG
TGGAAAAAGG AGGAGGACAA GAAGCGCGGC GGCGGGACAG CTGTCGGGGG TGGCGGGGTC
GCGGAGCCTG AGCAGGACTG CGCCGTGACC TCCGGCGAGG AGCTTCTGGC GCTGCCGCCG
CCGCCGCCCC CCGGAGGTGC TGTGCCGCCC GCTGCCCCCG TTGCCGCCCG AGAGGGCCGC
CTGCCGCCTG GCCTTAGCGC GTCGCCACAG CCCTCCAGCG TCGCGCCTCG GCGGCCGCAG
GAACCACGAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
*
*
*
*