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ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) [Homo sapiens (human)]

Gene Symbol ITPA
Entrez Gene ID 3704
Full Name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Synonyms C20orf37, HLC14-06-P, My049, dJ794I6.3
General protein information
Preferred Names
inosine triphosphate pyrophosphatase
Names
inosine triphosphate pyrophosphatase
ITPase
NTPase
inosine triphosphatase-A
putative oncogene protein HLC14-06-P
nucleoside-triphosphate diphosphatase
non-standard purine NTP pyrophosphatase
non-canonical purine NTP pyrophosphatase
inosine triphosphate pyrophosphohydrolase
NP_001254552.1
NP_258412.1
NP_852470.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20p

Summary This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. lac of sum
Disorder MIM:

147520

Disorder Html: [Inosine triphosphatase deficiency] (3)





The following ITPA gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITPA gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu52713 XM_006723564 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199
OHu52714 XM_006723565 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu58519 XM_011529234 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu58520 XM_011529235 PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu23700 NM_033453 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99
OHu23830 NM_181493 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu23901 NM_001267623 Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu52713
Accession Version XM_006723564.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011387.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578835408. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGAACGCTGT
CATAGTAGCC GGCATCTGGC TTGTCCACGG AGTTCAGGGG CCGGATCGTG GCACCCAGAG
GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG CAGACGTACG
CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC CTGCTGGAGC
TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GACTTCTGCA GCTGGAGGAG GCCCCTCAGG
CCGGGGATCT GGGGAGGGCT AGCCCAAAAC CTCCCGCATC GGGCAGGCAC CCCCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_006723627.1
CDS489..1205
Misc Feature(1)516..>896(+)
Misc Feature(2)534..830(+)
Misc Feature(3)618..758(+)
Translation
Position Chain Variation Link
26 26 c, g dbSNP:572125805
35 35 c, t dbSNP:559986593
71 71 a, t dbSNP:558593064
116 116 a, t dbSNP:373125609
117 117 g, t dbSNP:377348304
122 122 c, g dbSNP:531683963
142 142 a, g dbSNP:549749492
154 154 c, t dbSNP:759226937
168 168 -, c dbSNP:748389266
204 204 g, t dbSNP:74421967
245 245 c, t dbSNP:554291436
273 273 a, g dbSNP:6139031
279 279 a, g dbSNP:547201049
281 281 g, t dbSNP:191863069
290 290 a, g dbSNP:113832617
293 293 c, t dbSNP:144574212
307 307 a, c dbSNP:548805912
320 320 c, g dbSNP:570012331
330 330 c, g dbSNP:45620433
341 341 a, g dbSNP:368841354
342 342 c, t dbSNP:558483099
376 376 c, t dbSNP:148477247
382 382 a, c dbSNP:372802171
409 409 c, t dbSNP:553176721
440 440 c, g, t dbSNP:764863870
446 446 c, g dbSNP:758142239
447 447 c, t dbSNP:777576449
450 450 a, g dbSNP:751432726
460 460 g, t dbSNP:757203879
462 462 a, g dbSNP:780173810
464 464 c, g, t dbSNP:370491898
466 466 c, t dbSNP:779049825
467 467 a, t dbSNP:574915930
475 475 a, g dbSNP:772521949
477 477 c, g dbSNP:374429574
479 479 a, g dbSNP:773712912
481 481 c, g dbSNP:747460222
483 483 a, g dbSNP:771400282
489 489 a, g dbSNP:776199615
493 493 a, c, t dbSNP:150370229
494 494 g, t dbSNP:774967345
501 501 c, t dbSNP:762598981
509 509 a, g dbSNP:763819744
511 511 a, g dbSNP:751416592
512 512 g, t dbSNP:757185748
522 522 c, t dbSNP:767397739
531 531 c, g dbSNP:137954403
532 532 a, g dbSNP:753934298
537 537 g, t dbSNP:754960642
538 538 c, t dbSNP:779078806
545 545 a, g dbSNP:748310335
546 546 a, c dbSNP:758704128
557 557 c, t dbSNP:757523885
558 558 a, g dbSNP:777033296
574 574 a, g dbSNP:746302972
581 581 c, t dbSNP:555480105
582 582 a, c, g, t dbSNP:1127354
584 584 a, g dbSNP:144682597
588 588 a, g dbSNP:199769023
589 589 a, c dbSNP:773947334
591 591 c, t dbSNP:761555605
595 595 a, t dbSNP:771694985
598 598 c, g dbSNP:773069391
605 605 a, c dbSNP:538432614
612 612 c, t dbSNP:142574480
613 613 c, t dbSNP:780431801
616 616 c, t dbSNP:142979373
617 617 a, g, t dbSNP:146112146
626 626 a, g dbSNP:8362
634 634 c, t dbSNP:757955055
635 635 a, g dbSNP:777528511
639 639 a, g dbSNP:746662660
648 648 a, g dbSNP:770808787
649 649 c, t dbSNP:776582353
658 658 a, g dbSNP:138760860
662 662 a, g dbSNP:769920670
670 670 a, t dbSNP:774267237
672 672 c, t dbSNP:201119006
673 673 g, t dbSNP:767520628
678 678 g, t dbSNP:760868571
687 687 a, c dbSNP:766652238
690 690 a, g dbSNP:776945646
695 695 g, t dbSNP:759942180
697 697 c, t dbSNP:765540058
710 710 c, t dbSNP:144254646
721 721 a, g dbSNP:150904363
734 734 g, t dbSNP:763647607
737 737 -, c dbSNP:760003902
740 740 c, t dbSNP:751182646
746 746 c, t dbSNP:201971455
765 765 c, g dbSNP:746043760
766 766 a, g dbSNP:34982958
779 779 g, t dbSNP:145329644
782 782 a, c dbSNP:763279021
789 789 c, t dbSNP:781245748
797 797 a, c, t dbSNP:756210209
803 803 c, t dbSNP:114819623
804 804 c, g dbSNP:202194282
806 806 a, g dbSNP:769078931
815 815 c, g dbSNP:774873659
828 828 a, g dbSNP:748655979
831 831 c, t dbSNP:538462304
841 841 c, t dbSNP:772743575
845 845 -, ctcagcac dbSNP:763029259
849 849 a, g dbSNP:760148508
851 851 a, c dbSNP:765934653
857 857 a, g dbSNP:776106117
861 861 c, t dbSNP:759229958
869 869 g, t dbSNP:556565777
871 871 c, t dbSNP:780479868
873 873 a, c, g, t dbSNP:200558616
876 876 c, t dbSNP:578227905
877 877 a, g dbSNP:764069034
881 881 c, g dbSNP:751539410
884 884 c, t dbSNP:756108585
885 885 a, g dbSNP:140777194
891 891 c, t dbSNP:749416835
896 896 c, g dbSNP:755312961
897 897 g, t dbSNP:779412457
898 898 a, c, t dbSNP:370326110
903 903 c, t dbSNP:6139034
904 904 a, g dbSNP:755848189
918 918 c, t dbSNP:771909446
919 919 a, g dbSNP:536963293
922 922 a, g dbSNP:139853412
935 935 a, g dbSNP:779545134
949 949 c, g dbSNP:747414954
951 951 a, g dbSNP:771525761
955 955 c, t dbSNP:374366773
957 957 g, t dbSNP:745432420
960 960 c, t dbSNP:564801704
966 966 a, g dbSNP:201766921
975 975 a, g dbSNP:762600988
987 987 a, g dbSNP:200086262
991 991 -, c dbSNP:751797711
992 992 a, c dbSNP:774264132
996 996 c, g dbSNP:761656231
1004 1004 c, g, t dbSNP:144703520
1005 1005 c, g dbSNP:759636468
1018 1018 a, g dbSNP:765436989
1022 1022 a, c dbSNP:752897937
1023 1023 c, t dbSNP:758706191
1027 1027 c, t dbSNP:751753003
1028 1028 a, g dbSNP:371471145
1034 1034 a, c dbSNP:767875009
1043 1043 a, g dbSNP:199706843
1044 1044 c, t dbSNP:551976639
1045 1045 a, g dbSNP:374703513
1048 1048 c, g dbSNP:748840853
1051 1051 a, g dbSNP:754560867
1054 1054 -, c dbSNP:748042110
1054 1054 c, t dbSNP:145578636
1055 1055 a, g, t dbSNP:747784107
1056 1056 c, t dbSNP:148875609
1067 1067 c, t dbSNP:746930990
1073 1073 a, c, t dbSNP:771060121
1074 1074 a, g dbSNP:567048681
1075 1075 a, g dbSNP:202174987
1083 1083 c, t dbSNP:774564315
1092 1092 a, g dbSNP:761952728
1096 1096 a, g dbSNP:9101
1102 1102 c, t dbSNP:183325660
1106 1106 a, c dbSNP:756579000
1108 1108 -, ttggcagc dbSNP:757922816
1110 1110 c, t dbSNP:766916111
1114 1114 a, g dbSNP:754328088
1128 1128 a, g dbSNP:559255996
1133 1133 a, g dbSNP:373968062
1139 1139 c, g dbSNP:1043688
1142 1142 c, t dbSNP:537806030
1145 1145 c, t dbSNP:778293577
1151 1151 a, g dbSNP:371144538
1157 1157 c, t dbSNP:200804979
1160 1160 c, g dbSNP:116106310
1163 1163 a, t dbSNP:746841015
1164 1164 a, g dbSNP:770970214
1166 1166 g, t dbSNP:45446691
1167 1167 c, t dbSNP:745796492
1171 1171 -, c dbSNP:746651326
1171 1171 c, t dbSNP:768722341
1173 1173 c, t dbSNP:553880142
1183 1183 c, t dbSNP:188444210
1184 1184 a, g dbSNP:540465364
1188 1188 c, t dbSNP:75609817
1194 1194 a, g dbSNP:750760017
1195 1195 g, t dbSNP:371995344
1218 1218 a, g dbSNP:147032627
1243 1243 a, g dbSNP:13830
1298 1298 a, g dbSNP:562525055
1309 1309 a, g dbSNP:138324501
1315 1315 c, t dbSNP:551485592
1352 1352 a, g dbSNP:566613134
1401 1401 c, t dbSNP:527885928
1406 1406 c, g dbSNP:549558720
1414 1414 a, g dbSNP:764846340
1439 1439 c, t dbSNP:530649397
1472 1472 c, t dbSNP:1043959
1505 1505 a, g dbSNP:112815120

Target ORF information:

RefSeq Version XM_006723564
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006723564

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGAACGCTGT
CATAGTAGCC GGCATCTGGC TTGTCCACGG AGTTCAGGGG CCGGATCGTG GCACCCAGAG
GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG CAGACGTACG
CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC CTGCTGGAGC
TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GACTTCTGCA GCTGGAGGAG GCCCCTCAGG
CCGGGGATCT GGGGAGGGCT AGCCCAAAAC CTCCCGCATC GGGCAGGCAC CCCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu52714
Accession Version XM_006723565.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 594bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011387.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578835410. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGA ACGCTGTCAT
AGTAGCCGGC ATCTGGCTTG TCCACGGAGT TCAGGGGCCG GATCGTGGCA CCCAGAGGCT
GCCAGGACTT TGGCTGGGAC CCCTGCTTTC AGCCTGATGG ATATGAGCAG ACGTACGCAG
AGATGCCTAA GGCGGAGAAG AACGCTGTCT CCCATCGCTT CCGGGCCCTG CTGGAGCTGC
AGGAGTACTT TGGCAGTTTG GCAGCTTGAC TTCTGCAGCT GGAGGAGGCC CCTCAGGCCG
GGGATCTGGG GAGGGCTAGC CCAAAACCTC CCGCATCGGG CAGGCACCCC CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_006723628.1
CDS495..1088
Misc Feature(1)522..>779(+)
Misc Feature(2)534..587(+)
Translation
Position Chain Variation Link
32 32 c, g dbSNP:572125805
41 41 c, t dbSNP:559986593
77 77 a, t dbSNP:558593064
122 122 a, t dbSNP:373125609
123 123 g, t dbSNP:377348304
128 128 c, g dbSNP:531683963
148 148 a, g dbSNP:549749492
160 160 c, t dbSNP:759226937
174 174 -, c dbSNP:748389266
210 210 g, t dbSNP:74421967
251 251 c, t dbSNP:554291436
279 279 a, g dbSNP:6139031
285 285 a, g dbSNP:547201049
287 287 g, t dbSNP:191863069
296 296 a, g dbSNP:113832617
299 299 c, t dbSNP:144574212
313 313 a, c dbSNP:548805912
326 326 c, g dbSNP:570012331
336 336 c, g dbSNP:45620433
347 347 a, g dbSNP:368841354
348 348 c, t dbSNP:558483099
382 382 c, t dbSNP:148477247
388 388 a, c dbSNP:372802171
415 415 c, t dbSNP:553176721
446 446 c, g, t dbSNP:764863870
452 452 c, g dbSNP:758142239
453 453 c, t dbSNP:777576449
456 456 a, g dbSNP:751432726
466 466 g, t dbSNP:757203879
468 468 a, g dbSNP:780173810
470 470 c, g, t dbSNP:370491898
472 472 c, t dbSNP:779049825
473 473 a, t dbSNP:574915930
481 481 a, g dbSNP:772521949
483 483 c, g dbSNP:374429574
485 485 a, g dbSNP:773712912
487 487 c, g dbSNP:747460222
489 489 a, g dbSNP:771400282
495 495 a, g dbSNP:776199615
499 499 a, c, t dbSNP:150370229
500 500 g, t dbSNP:774967345
507 507 c, t dbSNP:762598981
515 515 a, g dbSNP:763819744
517 517 a, g dbSNP:751416592
518 518 g, t dbSNP:757185748
528 528 c, t dbSNP:767397739
537 537 c, g dbSNP:137954403
538 538 a, g dbSNP:753934298
543 543 g, t dbSNP:754960642
544 544 c, t dbSNP:779078806
551 551 a, g dbSNP:748310335
552 552 a, c dbSNP:758704128
561 561 g, t dbSNP:760868571
570 570 a, c dbSNP:766652238
573 573 a, g dbSNP:776945646
578 578 g, t dbSNP:759942180
580 580 c, t dbSNP:765540058
593 593 c, t dbSNP:144254646
604 604 a, g dbSNP:150904363
617 617 g, t dbSNP:763647607
620 620 -, c dbSNP:760003902
623 623 c, t dbSNP:751182646
629 629 c, t dbSNP:201971455
648 648 c, g dbSNP:746043760
649 649 a, g dbSNP:34982958
662 662 g, t dbSNP:145329644
665 665 a, c dbSNP:763279021
672 672 c, t dbSNP:781245748
680 680 a, c, t dbSNP:756210209
686 686 c, t dbSNP:114819623
687 687 c, g dbSNP:202194282
689 689 a, g dbSNP:769078931
698 698 c, g dbSNP:774873659
711 711 a, g dbSNP:748655979
714 714 c, t dbSNP:538462304
724 724 c, t dbSNP:772743575
728 728 -, ctcagcac dbSNP:763029259
732 732 a, g dbSNP:760148508
734 734 a, c dbSNP:765934653
740 740 a, g dbSNP:776106117
744 744 c, t dbSNP:759229958
752 752 g, t dbSNP:556565777
754 754 c, t dbSNP:780479868
756 756 a, c, g, t dbSNP:200558616
759 759 c, t dbSNP:578227905
760 760 a, g dbSNP:764069034
764 764 c, g dbSNP:751539410
767 767 c, t dbSNP:756108585
768 768 a, g dbSNP:140777194
774 774 c, t dbSNP:749416835
779 779 c, g dbSNP:755312961
780 780 g, t dbSNP:779412457
781 781 a, c, t dbSNP:370326110
786 786 c, t dbSNP:6139034
787 787 a, g dbSNP:755848189
801 801 c, t dbSNP:771909446
802 802 a, g dbSNP:536963293
805 805 a, g dbSNP:139853412
818 818 a, g dbSNP:779545134
832 832 c, g dbSNP:747414954
834 834 a, g dbSNP:771525761
838 838 c, t dbSNP:374366773
840 840 g, t dbSNP:745432420
843 843 c, t dbSNP:564801704
849 849 a, g dbSNP:201766921
858 858 a, g dbSNP:762600988
870 870 a, g dbSNP:200086262
874 874 -, c dbSNP:751797711
875 875 a, c dbSNP:774264132
879 879 c, g dbSNP:761656231
887 887 c, g, t dbSNP:144703520
888 888 c, g dbSNP:759636468
901 901 a, g dbSNP:765436989
905 905 a, c dbSNP:752897937
906 906 c, t dbSNP:758706191
910 910 c, t dbSNP:751753003
911 911 a, g dbSNP:371471145
917 917 a, c dbSNP:767875009
926 926 a, g dbSNP:199706843
927 927 c, t dbSNP:551976639
928 928 a, g dbSNP:374703513
931 931 c, g dbSNP:748840853
934 934 a, g dbSNP:754560867
937 937 -, c dbSNP:748042110
937 937 c, t dbSNP:145578636
938 938 a, g, t dbSNP:747784107
939 939 c, t dbSNP:148875609
950 950 c, t dbSNP:746930990
956 956 a, c, t dbSNP:771060121
957 957 a, g dbSNP:567048681
958 958 a, g dbSNP:202174987
966 966 c, t dbSNP:774564315
975 975 a, g dbSNP:761952728
979 979 a, g dbSNP:9101
985 985 c, t dbSNP:183325660
989 989 a, c dbSNP:756579000
991 991 -, ttggcagc dbSNP:757922816
993 993 c, t dbSNP:766916111
997 997 a, g dbSNP:754328088
1011 1011 a, g dbSNP:559255996
1016 1016 a, g dbSNP:373968062
1022 1022 c, g dbSNP:1043688
1025 1025 c, t dbSNP:537806030
1028 1028 c, t dbSNP:778293577
1034 1034 a, g dbSNP:371144538
1040 1040 c, t dbSNP:200804979
1043 1043 c, g dbSNP:116106310
1046 1046 a, t dbSNP:746841015
1047 1047 a, g dbSNP:770970214
1049 1049 g, t dbSNP:45446691
1050 1050 c, t dbSNP:745796492
1054 1054 -, c dbSNP:746651326
1054 1054 c, t dbSNP:768722341
1056 1056 c, t dbSNP:553880142
1066 1066 c, t dbSNP:188444210
1067 1067 a, g dbSNP:540465364
1071 1071 c, t dbSNP:75609817
1077 1077 a, g dbSNP:750760017
1078 1078 g, t dbSNP:371995344
1101 1101 a, g dbSNP:147032627
1126 1126 a, g dbSNP:13830
1181 1181 a, g dbSNP:562525055
1192 1192 a, g dbSNP:138324501
1198 1198 c, t dbSNP:551485592
1235 1235 a, g dbSNP:566613134
1284 1284 c, t dbSNP:527885928
1289 1289 c, g dbSNP:549558720
1297 1297 a, g dbSNP:764846340
1322 1322 c, t dbSNP:530649397
1355 1355 c, t dbSNP:1043959
1388 1388 a, g dbSNP:112815120

Target ORF information:

RefSeq Version XM_006723565
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006723565

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGA ACGCTGTCAT
AGTAGCCGGC ATCTGGCTTG TCCACGGAGT TCAGGGGCCG GATCGTGGCA CCCAGAGGCT
GCCAGGACTT TGGCTGGGAC CCCTGCTTTC AGCCTGATGG ATATGAGCAG ACGTACGCAG
AGATGCCTAA GGCGGAGAAG AACGCTGTCT CCCATCGCTT CCGGGCCCTG CTGGAGCTGC
AGGAGTACTT TGGCAGTTTG GCAGCTTGAC TTCTGCAGCT GGAGGAGGCC CCTCAGGCCG
GGGATCTGGG GAGGGCTAGC CCAAAACCTC CCGCATCGGG CAGGCACCCC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58519
Accession Version XM_011529234.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011387.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGAAACAGT
TGGCTAACAG CTCCTGAGGC CTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011527536.1
CDS488..931
Misc Feature(1)515..>901(+)
Misc Feature(2)533..829(+)
Misc Feature(3)617..757(+)
Translation
Position Chain Variation Link
25 25 c, g dbSNP:572125805
34 34 c, t dbSNP:559986593
70 70 a, t dbSNP:558593064
115 115 a, t dbSNP:373125609
116 116 g, t dbSNP:377348304
121 121 c, g dbSNP:531683963
141 141 a, g dbSNP:549749492
153 153 c, t dbSNP:759226937
167 167 -, c dbSNP:748389266
203 203 g, t dbSNP:74421967
244 244 c, t dbSNP:554291436
272 272 a, g dbSNP:6139031
278 278 a, g dbSNP:547201049
280 280 g, t dbSNP:191863069
289 289 a, g dbSNP:113832617
292 292 c, t dbSNP:144574212
306 306 a, c dbSNP:548805912
319 319 c, g dbSNP:570012331
329 329 c, g dbSNP:45620433
340 340 a, g dbSNP:368841354
341 341 c, t dbSNP:558483099
375 375 c, t dbSNP:148477247
381 381 a, c dbSNP:372802171
408 408 c, t dbSNP:553176721
439 439 c, g, t dbSNP:764863870
445 445 c, g dbSNP:758142239
446 446 c, t dbSNP:777576449
449 449 a, g dbSNP:751432726
459 459 g, t dbSNP:757203879
461 461 a, g dbSNP:780173810
463 463 c, g, t dbSNP:370491898
465 465 c, t dbSNP:779049825
466 466 a, t dbSNP:574915930
474 474 a, g dbSNP:772521949
476 476 c, g dbSNP:374429574
478 478 a, g dbSNP:773712912
480 480 c, g dbSNP:747460222
482 482 a, g dbSNP:771400282
488 488 a, g dbSNP:776199615
492 492 a, c, t dbSNP:150370229
493 493 g, t dbSNP:774967345
500 500 c, t dbSNP:762598981
508 508 a, g dbSNP:763819744
510 510 a, g dbSNP:751416592
511 511 g, t dbSNP:757185748
521 521 c, t dbSNP:767397739
530 530 c, g dbSNP:137954403
531 531 a, g dbSNP:753934298
536 536 g, t dbSNP:754960642
537 537 c, t dbSNP:779078806
544 544 a, g dbSNP:748310335
545 545 a, c dbSNP:758704128
556 556 c, t dbSNP:757523885
557 557 a, g dbSNP:777033296
573 573 a, g dbSNP:746302972
580 580 c, t dbSNP:555480105
581 581 a, c, g, t dbSNP:1127354
583 583 a, g dbSNP:144682597
587 587 a, g dbSNP:199769023
588 588 a, c dbSNP:773947334
590 590 c, t dbSNP:761555605
594 594 a, t dbSNP:771694985
597 597 c, g dbSNP:773069391
604 604 a, c dbSNP:538432614
611 611 c, t dbSNP:142574480
612 612 c, t dbSNP:780431801
615 615 c, t dbSNP:142979373
616 616 a, g, t dbSNP:146112146
625 625 a, g dbSNP:8362
633 633 c, t dbSNP:757955055
634 634 a, g dbSNP:777528511
638 638 a, g dbSNP:746662660
647 647 a, g dbSNP:770808787
648 648 c, t dbSNP:776582353
657 657 a, g dbSNP:138760860
661 661 a, g dbSNP:769920670
669 669 a, t dbSNP:774267237
671 671 c, t dbSNP:201119006
672 672 g, t dbSNP:767520628
677 677 g, t dbSNP:760868571
686 686 a, c dbSNP:766652238
689 689 a, g dbSNP:776945646
694 694 g, t dbSNP:759942180
696 696 c, t dbSNP:765540058
709 709 c, t dbSNP:144254646
720 720 a, g dbSNP:150904363
733 733 g, t dbSNP:763647607
736 736 -, c dbSNP:760003902
739 739 c, t dbSNP:751182646
745 745 c, t dbSNP:201971455
764 764 c, g dbSNP:746043760
765 765 a, g dbSNP:34982958
778 778 g, t dbSNP:145329644
781 781 a, c dbSNP:763279021
788 788 c, t dbSNP:781245748
796 796 a, c, t dbSNP:756210209
802 802 c, t dbSNP:114819623
803 803 c, g dbSNP:202194282
805 805 a, g dbSNP:769078931
814 814 c, g dbSNP:774873659
827 827 a, g dbSNP:748655979
830 830 c, t dbSNP:538462304
840 840 c, t dbSNP:772743575
844 844 -, ctcagcac dbSNP:763029259
848 848 a, g dbSNP:760148508
850 850 a, c dbSNP:765934653
856 856 a, g dbSNP:776106117
860 860 c, t dbSNP:759229958
868 868 g, t dbSNP:556565777
870 870 c, t dbSNP:780479868
872 872 a, c, g, t dbSNP:200558616
875 875 c, t dbSNP:578227905
876 876 a, g dbSNP:764069034
880 880 c, g dbSNP:751539410
883 883 c, t dbSNP:756108585
884 884 a, g dbSNP:140777194
890 890 c, t dbSNP:749416835
895 895 c, g dbSNP:755312961
896 896 g, t dbSNP:779412457
897 897 a, c, t dbSNP:370326110
900 900 c, g dbSNP:190894350
956 956 a, g dbSNP:370225799
974 974 -, t dbSNP:749675961
975 975 c, t dbSNP:540665984
976 976 c, t dbSNP:6037505
984 984 a, g dbSNP:78650559
994 994 -, tttat dbSNP:757639841

Target ORF information:

RefSeq Version XM_011529234
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011529234

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGAAACAGT
TGGCTAACAG CTCCTGAGGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu58520
Accession Version XM_011529235.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform X4
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_011387.9) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GTTTTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011527537.1
CDS485..901
Misc Feature(1)512..>892(+)
Misc Feature(2)530..826(+)
Misc Feature(3)614..754(+)
Translation
Position Chain Variation Link
22 22 c, g dbSNP:572125805
31 31 c, t dbSNP:559986593
67 67 a, t dbSNP:558593064
112 112 a, t dbSNP:373125609
113 113 g, t dbSNP:377348304
118 118 c, g dbSNP:531683963
138 138 a, g dbSNP:549749492
150 150 c, t dbSNP:759226937
164 164 -, c dbSNP:748389266
200 200 g, t dbSNP:74421967
241 241 c, t dbSNP:554291436
269 269 a, g dbSNP:6139031
275 275 a, g dbSNP:547201049
277 277 g, t dbSNP:191863069
286 286 a, g dbSNP:113832617
289 289 c, t dbSNP:144574212
303 303 a, c dbSNP:548805912
316 316 c, g dbSNP:570012331
326 326 c, g dbSNP:45620433
337 337 a, g dbSNP:368841354
338 338 c, t dbSNP:558483099
372 372 c, t dbSNP:148477247
378 378 a, c dbSNP:372802171
405 405 c, t dbSNP:553176721
436 436 c, g, t dbSNP:764863870
442 442 c, g dbSNP:758142239
443 443 c, t dbSNP:777576449
446 446 a, g dbSNP:751432726
456 456 g, t dbSNP:757203879
458 458 a, g dbSNP:780173810
460 460 c, g, t dbSNP:370491898
462 462 c, t dbSNP:779049825
463 463 a, t dbSNP:574915930
471 471 a, g dbSNP:772521949
473 473 c, g dbSNP:374429574
475 475 a, g dbSNP:773712912
477 477 c, g dbSNP:747460222
479 479 a, g dbSNP:771400282
485 485 a, g dbSNP:776199615
489 489 a, c, t dbSNP:150370229
490 490 g, t dbSNP:774967345
497 497 c, t dbSNP:762598981
505 505 a, g dbSNP:763819744
507 507 a, g dbSNP:751416592
508 508 g, t dbSNP:757185748
518 518 c, t dbSNP:767397739
527 527 c, g dbSNP:137954403
528 528 a, g dbSNP:753934298
533 533 g, t dbSNP:754960642
534 534 c, t dbSNP:779078806
541 541 a, g dbSNP:748310335
542 542 a, c dbSNP:758704128
553 553 c, t dbSNP:757523885
554 554 a, g dbSNP:777033296
570 570 a, g dbSNP:746302972
577 577 c, t dbSNP:555480105
578 578 a, c, g, t dbSNP:1127354
580 580 a, g dbSNP:144682597
584 584 a, g dbSNP:199769023
585 585 a, c dbSNP:773947334
587 587 c, t dbSNP:761555605
591 591 a, t dbSNP:771694985
594 594 c, g dbSNP:773069391
601 601 a, c dbSNP:538432614
608 608 c, t dbSNP:142574480
609 609 c, t dbSNP:780431801
612 612 c, t dbSNP:142979373
613 613 a, g, t dbSNP:146112146
622 622 a, g dbSNP:8362
630 630 c, t dbSNP:757955055
631 631 a, g dbSNP:777528511
635 635 a, g dbSNP:746662660
644 644 a, g dbSNP:770808787
645 645 c, t dbSNP:776582353
654 654 a, g dbSNP:138760860
658 658 a, g dbSNP:769920670
666 666 a, t dbSNP:774267237
668 668 c, t dbSNP:201119006
669 669 g, t dbSNP:767520628
674 674 g, t dbSNP:760868571
683 683 a, c dbSNP:766652238
686 686 a, g dbSNP:776945646
691 691 g, t dbSNP:759942180
693 693 c, t dbSNP:765540058
706 706 c, t dbSNP:144254646
717 717 a, g dbSNP:150904363
730 730 g, t dbSNP:763647607
733 733 -, c dbSNP:760003902
736 736 c, t dbSNP:751182646
742 742 c, t dbSNP:201971455
761 761 c, g dbSNP:746043760
762 762 a, g dbSNP:34982958
775 775 g, t dbSNP:145329644
778 778 a, c dbSNP:763279021
785 785 c, t dbSNP:781245748
793 793 a, c, t dbSNP:756210209
799 799 c, t dbSNP:114819623
800 800 c, g dbSNP:202194282
802 802 a, g dbSNP:769078931
811 811 c, g dbSNP:774873659
824 824 a, g dbSNP:748655979
827 827 c, t dbSNP:538462304
837 837 c, t dbSNP:772743575
841 841 -, ctcagcac dbSNP:763029259
845 845 a, g dbSNP:760148508
847 847 a, c dbSNP:765934653
853 853 a, g dbSNP:776106117
857 857 c, t dbSNP:759229958
865 865 g, t dbSNP:556565777
867 867 c, t dbSNP:780479868
869 869 a, c, g, t dbSNP:200558616
872 872 c, t dbSNP:578227905
873 873 a, g dbSNP:764069034
877 877 c, g dbSNP:751539410
880 880 c, t dbSNP:756108585
881 881 a, g dbSNP:140777194
887 887 c, t dbSNP:749416835
892 892 c, g dbSNP:755312961
893 893 g, t dbSNP:779412457
894 894 a, c, t dbSNP:370326110
923 923 a, g dbSNP:546219217
926 926 c, g dbSNP:758511400
1014 1014 a, g dbSNP:564529134
1047 1047 c, g dbSNP:777852495
1051 1051 c, t dbSNP:747070183
1053 1053 a, g dbSNP:147852348
1092 1092 a, c dbSNP:78671971
1113 1113 a, c dbSNP:142316045
1122 1122 c, t dbSNP:371792358
1129 1129 a, g dbSNP:565714596
1149 1149 c, t dbSNP:189994006
1150 1150 a, g dbSNP:529932662
1153 1153 a, g dbSNP:757804847
1178 1178 a, g dbSNP:548178589
1183 1183 c, g dbSNP:781664540
1190 1190 c, g dbSNP:552423798
1216 1216 c, t dbSNP:76378710
1234 1234 a, g dbSNP:536602054
1252 1252 c, t dbSNP:146456662
1261 1261 a, g dbSNP:541514230
1268 1268 c, t dbSNP:374749526
1288 1288 a, c dbSNP:551765967
1295 1295 c, t dbSNP:564907796
1304 1304 c, t dbSNP:570179829
1315 1315 c, t dbSNP:534442782
1316 1316 g, t dbSNP:3810559
1351 1351 c, t dbSNP:574921133
1356 1356 c, t dbSNP:775648283
1367 1367 c, t dbSNP:79728257
1383 1383 c, t dbSNP:557321661
1386 1386 c, t dbSNP:3810560
1394 1394 c, t dbSNP:772894166
1427 1427 a, g dbSNP:6115820
1449 1449 c, t dbSNP:760231413
1450 1450 a, g dbSNP:181257166
1453 1453 a, g dbSNP:6115821
1472 1472 c, g dbSNP:138796180
1504 1504 c, t dbSNP:573300297
1522 1522 a, c dbSNP:185458286
1562 1562 a, t dbSNP:562250463
1595 1595 a, g dbSNP:529846023
1647 1647 a, g dbSNP:548367489
1649 1649 a, g dbSNP:776616609

Target ORF information:

RefSeq Version XM_011529235
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant X4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011529235

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GTTTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23700
Accession Version NM_033453.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu23700D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, AF026816.2 and CA425905.1. This sequence is a reference standard in the RefSeqGene project. On Jun 9, 2012 this sequence version replaced gi:31657145. Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM560812.1, AF219116.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGCCGGATC
GTGGCACCCA GAGGCTGCCA GGACTTTGGC TGGGACCCCT GCTTTCAGCC TGATGGATAT
GAGCAGACGT ACGCAGAGAT GCCTAAGGCG GAGAAGAACG CTGTCTCCCA TCGCTTCCGG
GCCCTGCTGG AGCTGCAGGA GTACTTTGGC AGTTTGGCAG CTTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_258412.1
CDS193..777
Misc Feature(1)178..180(+)
Misc Feature(2)196..198(+)
Misc Feature(3)220..756(+)
Misc Feature(4)232..249(+)
Misc Feature(5)238..726(+)
Misc Feature(6)322..462(+)
Misc Feature(7)406..411(+)
Misc Feature(8)637..648(+)
Misc Feature(9)721..726(+)
Exon (1)1..258
Gene:ITPA
Gene Synonym:
Exon (2)259..316
Gene:ITPA
Gene Synonym:
Exon (3)317..381
Gene:ITPA
Gene Synonym:
Exon (4)382..455
Gene:ITPA
Gene Synonym:
Exon (5)456..487
Gene:ITPA
Gene Synonym:
Exon (6)488..603
Gene:ITPA
Gene Synonym:
Exon (7)604..680
Gene:ITPA
Gene Synonym:
Exon (8)681..1185
Gene:ITPA
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, c dbSNP:548805912
24 24 c, g dbSNP:570012331
34 34 c, g dbSNP:45620433
45 45 a, g dbSNP:368841354
46 46 c, t dbSNP:558483099
80 80 c, t dbSNP:148477247
86 86 a, c dbSNP:372802171
113 113 c, t dbSNP:553176721
144 144 c, g, t dbSNP:764863870
150 150 c, g dbSNP:758142239
151 151 c, t dbSNP:777576449
154 154 a, g dbSNP:751432726
164 164 g, t dbSNP:757203879
166 166 a, g dbSNP:780173810
168 168 c, g, t dbSNP:370491898
170 170 c, t dbSNP:779049825
171 171 a, t dbSNP:574915930
179 179 a, g dbSNP:772521949
181 181 c, g dbSNP:374429574
183 183 a, g dbSNP:773712912
185 185 c, g dbSNP:747460222
187 187 a, g dbSNP:771400282
193 193 a, g dbSNP:776199615
197 197 a, c, t dbSNP:150370229
198 198 g, t dbSNP:774967345
205 205 c, t dbSNP:762598981
213 213 a, g dbSNP:763819744
215 215 a, g dbSNP:751416592
216 216 g, t dbSNP:757185748
226 226 c, t dbSNP:767397739
235 235 c, g dbSNP:137954403
236 236 a, g dbSNP:753934298
241 241 g, t dbSNP:754960642
242 242 c, t dbSNP:779078806
249 249 a, g dbSNP:748310335
250 250 a, c dbSNP:758704128
261 261 c, t dbSNP:757523885
262 262 a, g dbSNP:777033296
278 278 a, g dbSNP:746302972
285 285 c, t dbSNP:555480105
286 286 a, c, g, t dbSNP:1127354
288 288 a, g dbSNP:144682597
292 292 a, g dbSNP:199769023
293 293 a, c dbSNP:773947334
295 295 c, t dbSNP:761555605
299 299 a, t dbSNP:771694985
302 302 c, g dbSNP:773069391
309 309 a, c dbSNP:538432614
316 316 c, t dbSNP:142574480
317 317 c, t dbSNP:780431801
320 320 c, t dbSNP:142979373
321 321 a, g, t dbSNP:146112146
330 330 a, g dbSNP:8362
338 338 c, t dbSNP:757955055
339 339 a, g dbSNP:777528511
343 343 a, g dbSNP:746662660
352 352 a, g dbSNP:770808787
353 353 c, t dbSNP:776582353
362 362 a, g dbSNP:138760860
366 366 a, g dbSNP:769920670
374 374 a, t dbSNP:774267237
376 376 c, t dbSNP:201119006
377 377 g, t dbSNP:767520628
382 382 g, t dbSNP:760868571
391 391 a, c dbSNP:766652238
394 394 a, g dbSNP:776945646
399 399 g, t dbSNP:759942180
401 401 c, t dbSNP:765540058
414 414 c, t dbSNP:144254646
425 425 a, g dbSNP:150904363
438 438 g, t dbSNP:763647607
441 441 -, c dbSNP:760003902
444 444 c, t dbSNP:751182646
450 450 c, t dbSNP:201971455
469 469 c, g dbSNP:746043760
470 470 a, g dbSNP:34982958
483 483 g, t dbSNP:145329644
486 486 a, c dbSNP:763279021
493 493 c, t dbSNP:781245748
501 501 a, c, t dbSNP:756210209
507 507 c, t dbSNP:114819623
508 508 c, g dbSNP:202194282
510 510 a, g dbSNP:769078931
519 519 c, g dbSNP:774873659
532 532 a, g dbSNP:748655979
535 535 c, t dbSNP:538462304
545 545 c, t dbSNP:772743575
549 549 -, ctcagcac dbSNP:763029259
553 553 a, g dbSNP:760148508
555 555 a, c dbSNP:765934653
561 561 a, g dbSNP:776106117
565 565 c, t dbSNP:759229958
573 573 g, t dbSNP:556565777
575 575 c, t dbSNP:780479868
577 577 a, c, g, t dbSNP:200558616
580 580 c, t dbSNP:578227905
581 581 a, g dbSNP:764069034
585 585 c, g dbSNP:751539410
588 588 c, t dbSNP:756108585
589 589 a, g dbSNP:140777194
595 595 c, t dbSNP:749416835
600 600 c, g dbSNP:755312961
601 601 g, t dbSNP:779412457
602 602 a, c, t dbSNP:370326110
606 606 c, g dbSNP:747414954
608 608 a, g dbSNP:771525761
612 612 c, t dbSNP:374366773
614 614 g, t dbSNP:745432420
617 617 c, t dbSNP:564801704
623 623 a, g dbSNP:201766921
632 632 a, g dbSNP:762600988
644 644 a, g dbSNP:200086262
648 648 -, c dbSNP:751797711
649 649 a, c dbSNP:774264132
653 653 c, g dbSNP:761656231
661 661 c, g, t dbSNP:144703520
662 662 c, g dbSNP:759636468
675 675 a, g dbSNP:765436989
679 679 a, c dbSNP:752897937
680 680 c, t dbSNP:758706191
684 684 c, t dbSNP:751753003
685 685 a, g dbSNP:371471145
691 691 a, c dbSNP:767875009
700 700 a, g dbSNP:199706843
701 701 c, t dbSNP:551976639
702 702 a, g dbSNP:374703513
705 705 c, g dbSNP:748840853
708 708 a, g dbSNP:754560867
711 711 -, c dbSNP:748042110
711 711 c, t dbSNP:145578636
712 712 a, g, t dbSNP:747784107
713 713 c, t dbSNP:148875609
724 724 c, t dbSNP:746930990
730 730 a, c, t dbSNP:771060121
731 731 a, g dbSNP:567048681
732 732 a, g dbSNP:202174987
740 740 c, t dbSNP:774564315
749 749 a, g dbSNP:761952728
753 753 a, g dbSNP:9101
759 759 c, t dbSNP:183325660
763 763 a, c dbSNP:756579000
765 765 -, ttggcagc dbSNP:757922816
767 767 c, t dbSNP:766916111
771 771 a, g dbSNP:754328088
785 785 a, g dbSNP:559255996
790 790 a, g dbSNP:373968062
796 796 c, g dbSNP:1043688
799 799 c, t dbSNP:537806030
802 802 c, t dbSNP:778293577
808 808 a, g dbSNP:371144538
814 814 c, t dbSNP:200804979
817 817 c, g dbSNP:116106310
820 820 a, t dbSNP:746841015
821 821 a, g dbSNP:770970214
823 823 g, t dbSNP:45446691
824 824 c, t dbSNP:745796492
828 828 -, c dbSNP:746651326
828 828 c, t dbSNP:768722341
830 830 c, t dbSNP:553880142
840 840 c, t dbSNP:188444210
841 841 a, g dbSNP:540465364
845 845 c, t dbSNP:75609817
851 851 a, g dbSNP:750760017
852 852 g, t dbSNP:371995344
875 875 a, g dbSNP:147032627
900 900 a, g dbSNP:13830
955 955 a, g dbSNP:562525055
966 966 a, g dbSNP:138324501
972 972 c, t dbSNP:551485592
1009 1009 a, g dbSNP:566613134
1058 1058 c, t dbSNP:527885928
1063 1063 c, g dbSNP:549558720
1071 1071 a, g dbSNP:764846340
1096 1096 c, t dbSNP:530649397
1129 1129 c, t dbSNP:1043959
1162 1162 a, g dbSNP:112815120

Target ORF information:

RefSeq Version NM_033453
Organism Homo sapiens (human)
Definition Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_033453

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTCG TTCAGATTCT AGGAGATAAG TTTCCATGCA CTTTGGTGGC ACAGAAAATT
GACCTGCCGG AGTACCAGGG GGAGCCGGAT GAGATTTCCA TACAGAAATG TCAGGAGGCA
GTTCGCCAGG TACAGGGGCC CGTGCTGGTT GAGGACACTT GTCTGTGCTT CAATGCCCTT
GGAGGGCTCC CCGGCCCCTA CATAAAGTGG TTTCTGGAGA AGTTAAAGCC TGAAGGTCTC
CACCAGCTCC TGGCCGGGTT CGAGGACAAG TCAGCCTATG CGCTCTGCAC GTTTGCACTC
AGCACCGGGG ACCCAAGCCA GCCCGTGCGC CTGTTCAGGG GCCGGACCTC GGGCCGGATC
GTGGCACCCA GAGGCTGCCA GGACTTTGGC TGGGACCCCT GCTTTCAGCC TGATGGATAT
GAGCAGACGT ACGCAGAGAT GCCTAAGGCG GAGAAGAACG CTGTCTCCCA TCGCTTCCGG
GCCCTGCTGG AGCTGCAGGA GTACTTTGGC AGTTTGGCAG CTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23830
Accession Version NM_181493.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 534bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV694278.1, EF213026.1, AF026816.2 and CA425905.1. On Jun 9, 2012 this sequence version replaced gi:31657143. Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM910626.1, BG332818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_852470.1
CDS65..598
Misc Feature(1)50..52(+)
Misc Feature(2)86..577(+)
Misc Feature(3)143..283(+)
Misc Feature(4)230..547(+)
Exon (1)1..79
Gene:ITPA
Gene Synonym:
Exon (2)80..137
Gene:ITPA
Gene Synonym:
Exon (3)138..202
Gene:ITPA
Gene Synonym:
Exon (4)203..276
Gene:ITPA
Gene Synonym:
Exon (5)277..308
Gene:ITPA
Gene Synonym:
Exon (6)309..424
Gene:ITPA
Gene Synonym:
Exon (7)425..501
Gene:ITPA
Gene Synonym:
Exon (8)502..1006
Gene:ITPA
Gene Synonym:
Translation
Position Chain Variation Link
16 16 c, g, t dbSNP:764863870
22 22 c, g dbSNP:758142239
23 23 c, t dbSNP:777576449
26 26 a, g dbSNP:751432726
36 36 g, t dbSNP:757203879
38 38 a, g dbSNP:780173810
40 40 c, g, t dbSNP:370491898
42 42 c, t dbSNP:779049825
43 43 a, t dbSNP:574915930
51 51 a, g dbSNP:772521949
53 53 c, g dbSNP:374429574
55 55 a, g dbSNP:773712912
57 57 c, g dbSNP:747460222
59 59 a, g dbSNP:771400282
65 65 a, g dbSNP:776199615
69 69 a, c, t dbSNP:150370229
70 70 g, t dbSNP:774967345
77 77 c, t dbSNP:762598981
82 82 c, t dbSNP:757523885
83 83 a, g dbSNP:777033296
99 99 a, g dbSNP:746302972
106 106 c, t dbSNP:555480105
107 107 a, c, g, t dbSNP:1127354
109 109 a, g dbSNP:144682597
113 113 a, g dbSNP:199769023
114 114 a, c dbSNP:773947334
116 116 c, t dbSNP:761555605
120 120 a, t dbSNP:771694985
123 123 c, g dbSNP:773069391
130 130 a, c dbSNP:538432614
137 137 c, t dbSNP:142574480
138 138 c, t dbSNP:780431801
141 141 c, t dbSNP:142979373
142 142 a, g, t dbSNP:146112146
151 151 a, g dbSNP:8362
159 159 c, t dbSNP:757955055
160 160 a, g dbSNP:777528511
164 164 a, g dbSNP:746662660
173 173 a, g dbSNP:770808787
174 174 c, t dbSNP:776582353
183 183 a, g dbSNP:138760860
187 187 a, g dbSNP:769920670
195 195 a, t dbSNP:774267237
197 197 c, t dbSNP:201119006
198 198 g, t dbSNP:767520628
203 203 g, t dbSNP:760868571
212 212 a, c dbSNP:766652238
215 215 a, g dbSNP:776945646
220 220 g, t dbSNP:759942180
222 222 c, t dbSNP:765540058
235 235 c, t dbSNP:144254646
246 246 a, g dbSNP:150904363
259 259 g, t dbSNP:763647607
262 262 -, c dbSNP:760003902
265 265 c, t dbSNP:751182646
271 271 c, t dbSNP:201971455
290 290 c, g dbSNP:746043760
291 291 a, g dbSNP:34982958
304 304 g, t dbSNP:145329644
307 307 a, c dbSNP:763279021
314 314 c, t dbSNP:781245748
322 322 a, c, t dbSNP:756210209
328 328 c, t dbSNP:114819623
329 329 c, g dbSNP:202194282
331 331 a, g dbSNP:769078931
340 340 c, g dbSNP:774873659
353 353 a, g dbSNP:748655979
356 356 c, t dbSNP:538462304
366 366 c, t dbSNP:772743575
370 370 -, ctcagcac dbSNP:763029259
374 374 a, g dbSNP:760148508
376 376 a, c dbSNP:765934653
382 382 a, g dbSNP:776106117
386 386 c, t dbSNP:759229958
394 394 g, t dbSNP:556565777
396 396 c, t dbSNP:780479868
398 398 a, c, g, t dbSNP:200558616
401 401 c, t dbSNP:578227905
402 402 a, g dbSNP:764069034
406 406 c, g dbSNP:751539410
409 409 c, t dbSNP:756108585
410 410 a, g dbSNP:140777194
416 416 c, t dbSNP:749416835
421 421 c, g dbSNP:755312961
422 422 g, t dbSNP:779412457
423 423 a, c, t dbSNP:370326110
427 427 c, g dbSNP:747414954
429 429 a, g dbSNP:771525761
433 433 c, t dbSNP:374366773
435 435 g, t dbSNP:745432420
438 438 c, t dbSNP:564801704
444 444 a, g dbSNP:201766921
453 453 a, g dbSNP:762600988
465 465 a, g dbSNP:200086262
469 469 -, c dbSNP:751797711
470 470 a, c dbSNP:774264132
474 474 c, g dbSNP:761656231
482 482 c, g, t dbSNP:144703520
483 483 c, g dbSNP:759636468
496 496 a, g dbSNP:765436989
500 500 a, c dbSNP:752897937
501 501 c, t dbSNP:758706191
505 505 c, t dbSNP:751753003
506 506 a, g dbSNP:371471145
512 512 a, c dbSNP:767875009
521 521 a, g dbSNP:199706843
522 522 c, t dbSNP:551976639
523 523 a, g dbSNP:374703513
526 526 c, g dbSNP:748840853
529 529 a, g dbSNP:754560867
532 532 -, c dbSNP:748042110
532 532 c, t dbSNP:145578636
533 533 a, g, t dbSNP:747784107
534 534 c, t dbSNP:148875609
545 545 c, t dbSNP:746930990
551 551 a, c, t dbSNP:771060121
552 552 a, g dbSNP:567048681
553 553 a, g dbSNP:202174987
561 561 c, t dbSNP:774564315
570 570 a, g dbSNP:761952728
574 574 a, g dbSNP:9101
580 580 c, t dbSNP:183325660
584 584 a, c dbSNP:756579000
586 586 -, ttggcagc dbSNP:757922816
588 588 c, t dbSNP:766916111
592 592 a, g dbSNP:754328088
606 606 a, g dbSNP:559255996
611 611 a, g dbSNP:373968062
617 617 c, g dbSNP:1043688
620 620 c, t dbSNP:537806030
623 623 c, t dbSNP:778293577
629 629 a, g dbSNP:371144538
635 635 c, t dbSNP:200804979
638 638 c, g dbSNP:116106310
641 641 a, t dbSNP:746841015
642 642 a, g dbSNP:770970214
644 644 g, t dbSNP:45446691
645 645 c, t dbSNP:745796492
649 649 -, c dbSNP:746651326
649 649 c, t dbSNP:768722341
651 651 c, t dbSNP:553880142
661 661 c, t dbSNP:188444210
662 662 a, g dbSNP:540465364
666 666 c, t dbSNP:75609817
672 672 a, g dbSNP:750760017
673 673 g, t dbSNP:371995344
696 696 a, g dbSNP:147032627
721 721 a, g dbSNP:13830
776 776 a, g dbSNP:562525055
787 787 a, g dbSNP:138324501
793 793 c, t dbSNP:551485592
830 830 a, g dbSNP:566613134
879 879 c, t dbSNP:527885928
884 884 c, g dbSNP:549558720
892 892 a, g dbSNP:764846340
917 917 c, t dbSNP:530649397
950 950 c, t dbSNP:1043959
983 983 a, g dbSNP:112815120

Target ORF information:

RefSeq Version NM_181493
Organism Homo sapiens (human)
Definition Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_181493

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCGGCCT CATTGGTCGT TCAGATTCTA GGAGATAAGT TTCCATGCAC TTTGGTGGCA 
CAGAAAATTG ACCTGCCGGA GTACCAGGGG GAGCCGGATG AGATTTCCAT ACAGAAATGT
CAGGAGGCAG TTCGCCAGGT ACAGGGGCCC GTGCTGGTTG AGGACACTTG TCTGTGCTTC
AATGCCCTTG GAGGGCTCCC CGGCCCCTAC ATAAAGTGGT TTCTGGAGAA GTTAAAGCCT
GAAGGTCTCC ACCAGCTCCT GGCCGGGTTC GAGGACAAGT CAGCCTATGC GCTCTGCACG
TTTGCACTCA GCACCGGGGA CCCAAGCCAG CCCGTGCGCC TGTTCAGGGG CCGGACCTCG
GGCCGGATCG TGGCACCCAG AGGCTGCCAG GACTTTGGCT GGGACCCCTG CTTTCAGCCT
GATGGATATG AGCAGACGTA CGCAGAGATG CCTAAGGCGG AGAAGAACGC TGTCTCCCAT
CGCTTCCGGG CCCTGCTGGA GCTGCAGGAG TACTTTGGCA GTTTGGCAGC TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23901
Accession Version NM_001267623.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 462bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product inosine triphosphate pyrophosphatase isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM560812.1, BI115811.1, AF026816.2 and CA425905.1. Summary: This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]. Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI115811.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGG CCGGATCGTG
GCACCCAGAG GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG
CAGACGTACG CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC
CTGCTGGAGC TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001254552.1
CDS193..654
Misc Feature(1)178..180(+)
Misc Feature(2)220..633(+)
Misc Feature(3)238..603(+)
Misc Feature(4)307..339(+)
Exon (1)1..258
Gene:ITPA
Gene Synonym:
Exon (2)259..332
Gene:ITPA
Gene Synonym:
Exon (3)333..364
Gene:ITPA
Gene Synonym:
Exon (4)365..480
Gene:ITPA
Gene Synonym:
Exon (5)481..557
Gene:ITPA
Gene Synonym:
Exon (6)558..1062
Gene:ITPA
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, c dbSNP:548805912
24 24 c, g dbSNP:570012331
34 34 c, g dbSNP:45620433
45 45 a, g dbSNP:368841354
46 46 c, t dbSNP:558483099
80 80 c, t dbSNP:148477247
86 86 a, c dbSNP:372802171
113 113 c, t dbSNP:553176721
144 144 c, g, t dbSNP:764863870
150 150 c, g dbSNP:758142239
151 151 c, t dbSNP:777576449
154 154 a, g dbSNP:751432726
164 164 g, t dbSNP:757203879
166 166 a, g dbSNP:780173810
168 168 c, g, t dbSNP:370491898
170 170 c, t dbSNP:779049825
171 171 a, t dbSNP:574915930
179 179 a, g dbSNP:772521949
181 181 c, g dbSNP:374429574
183 183 a, g dbSNP:773712912
185 185 c, g dbSNP:747460222
187 187 a, g dbSNP:771400282
193 193 a, g dbSNP:776199615
197 197 a, c, t dbSNP:150370229
198 198 g, t dbSNP:774967345
205 205 c, t dbSNP:762598981
213 213 a, g dbSNP:763819744
215 215 a, g dbSNP:751416592
216 216 g, t dbSNP:757185748
226 226 c, t dbSNP:767397739
235 235 c, g dbSNP:137954403
236 236 a, g dbSNP:753934298
241 241 g, t dbSNP:754960642
242 242 c, t dbSNP:779078806
249 249 a, g dbSNP:748310335
250 250 a, c dbSNP:758704128
259 259 g, t dbSNP:760868571
268 268 a, c dbSNP:766652238
271 271 a, g dbSNP:776945646
276 276 g, t dbSNP:759942180
278 278 c, t dbSNP:765540058
291 291 c, t dbSNP:144254646
302 302 a, g dbSNP:150904363
315 315 g, t dbSNP:763647607
318 318 -, c dbSNP:760003902
321 321 c, t dbSNP:751182646
327 327 c, t dbSNP:201971455
346 346 c, g dbSNP:746043760
347 347 a, g dbSNP:34982958
360 360 g, t dbSNP:145329644
363 363 a, c dbSNP:763279021
370 370 c, t dbSNP:781245748
378 378 a, c, t dbSNP:756210209
384 384 c, t dbSNP:114819623
385 385 c, g dbSNP:202194282
387 387 a, g dbSNP:769078931
396 396 c, g dbSNP:774873659
409 409 a, g dbSNP:748655979
412 412 c, t dbSNP:538462304
422 422 c, t dbSNP:772743575
426 426 -, ctcagcac dbSNP:763029259
430 430 a, g dbSNP:760148508
432 432 a, c dbSNP:765934653
438 438 a, g dbSNP:776106117
442 442 c, t dbSNP:759229958
450 450 g, t dbSNP:556565777
452 452 c, t dbSNP:780479868
454 454 a, c, g, t dbSNP:200558616
457 457 c, t dbSNP:578227905
458 458 a, g dbSNP:764069034
462 462 c, g dbSNP:751539410
465 465 c, t dbSNP:756108585
466 466 a, g dbSNP:140777194
472 472 c, t dbSNP:749416835
477 477 c, g dbSNP:755312961
478 478 g, t dbSNP:779412457
479 479 a, c, t dbSNP:370326110
483 483 c, g dbSNP:747414954
485 485 a, g dbSNP:771525761
489 489 c, t dbSNP:374366773
491 491 g, t dbSNP:745432420
494 494 c, t dbSNP:564801704
500 500 a, g dbSNP:201766921
509 509 a, g dbSNP:762600988
521 521 a, g dbSNP:200086262
525 525 -, c dbSNP:751797711
526 526 a, c dbSNP:774264132
530 530 c, g dbSNP:761656231
538 538 c, g, t dbSNP:144703520
539 539 c, g dbSNP:759636468
552 552 a, g dbSNP:765436989
556 556 a, c dbSNP:752897937
557 557 c, t dbSNP:758706191
561 561 c, t dbSNP:751753003
562 562 a, g dbSNP:371471145
568 568 a, c dbSNP:767875009
577 577 a, g dbSNP:199706843
578 578 c, t dbSNP:551976639
579 579 a, g dbSNP:374703513
582 582 c, g dbSNP:748840853
585 585 a, g dbSNP:754560867
588 588 -, c dbSNP:748042110
588 588 c, t dbSNP:145578636
589 589 a, g, t dbSNP:747784107
590 590 c, t dbSNP:148875609
601 601 c, t dbSNP:746930990
607 607 a, c, t dbSNP:771060121
608 608 a, g dbSNP:567048681
609 609 a, g dbSNP:202174987
617 617 c, t dbSNP:774564315
626 626 a, g dbSNP:761952728
630 630 a, g dbSNP:9101
636 636 c, t dbSNP:183325660
640 640 a, c dbSNP:756579000
642 642 -, ttggcagc dbSNP:757922816
644 644 c, t dbSNP:766916111
648 648 a, g dbSNP:754328088
662 662 a, g dbSNP:559255996
667 667 a, g dbSNP:373968062
673 673 c, g dbSNP:1043688
676 676 c, t dbSNP:537806030
679 679 c, t dbSNP:778293577
685 685 a, g dbSNP:371144538
691 691 c, t dbSNP:200804979
694 694 c, g dbSNP:116106310
697 697 a, t dbSNP:746841015
698 698 a, g dbSNP:770970214
700 700 g, t dbSNP:45446691
701 701 c, t dbSNP:745796492
705 705 -, c dbSNP:746651326
705 705 c, t dbSNP:768722341
707 707 c, t dbSNP:553880142
717 717 c, t dbSNP:188444210
718 718 a, g dbSNP:540465364
722 722 c, t dbSNP:75609817
728 728 a, g dbSNP:750760017
729 729 g, t dbSNP:371995344
752 752 a, g dbSNP:147032627
777 777 a, g dbSNP:13830
832 832 a, g dbSNP:562525055
843 843 a, g dbSNP:138324501
849 849 c, t dbSNP:551485592
886 886 a, g dbSNP:566613134
935 935 c, t dbSNP:527885928
940 940 c, g dbSNP:549558720
948 948 a, g dbSNP:764846340
973 973 c, t dbSNP:530649397
1006 1006 c, t dbSNP:1043959
1039 1039 a, g dbSNP:112815120

Target ORF information:

RefSeq Version NM_001267623
Organism Homo sapiens (human)
Definition Homo sapiens inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (ITPA), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001267623

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCGGCCT CATTGGTGGG GAAGAAGATC GTGTTTGTAA CGGGGAACGC CAAGAAGCTG 
GAGGAGGTAC AGGGGCCCGT GCTGGTTGAG GACACTTGTC TGTGCTTCAA TGCCCTTGGA
GGGCTCCCCG GCCCCTACAT AAAGTGGTTT CTGGAGAAGT TAAAGCCTGA AGGTCTCCAC
CAGCTCCTGG CCGGGTTCGA GGACAAGTCA GCCTATGCGC TCTGCACGTT TGCACTCAGC
ACCGGGGACC CAAGCCAGCC CGTGCGCCTG TTCAGGGGCC GGACCTCGGG CCGGATCGTG
GCACCCAGAG GCTGCCAGGA CTTTGGCTGG GACCCCTGCT TTCAGCCTGA TGGATATGAG
CAGACGTACG CAGAGATGCC TAAGGCGGAG AAGAACGCTG TCTCCCATCG CTTCCGGGCC
CTGCTGGAGC TGCAGGAGTA CTTTGGCAGT TTGGCAGCTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.