The following KCNA1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNA1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1488bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||potassium voltage-gated channel subfamily A member 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA236475.1 and AC006063.1.
This sequence is a reference standard in the RefSeqGene project.
On or before Dec 16, 2006 this sequence version replaced
Summary: This gene encodes a voltage-gated delayed potassium
channel that is phylogenetically related to the Drosophila Shaker
channel. The encoded protein has six putative transmembrane
segments (S1-S6), and the loop between S5 and S6 forms the pore and
contains the conserved selectivity filter motif (GYGD). The
functional channel is a homotetramer. The N-terminus of the channel
is associated with beta subunits that can modify the inactivation
properties of the channel as well as affect expression levels. The
C-terminus of the channel is complexed to a PDZ domain protein that
is responsible for channel targeting. Mutations in this gene have
been associated with myokymia with periodic ataxia (AEMK).
[provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created largely from genomic
sequence because transcripts were not available for the entire
length of the gene. This transcript is supported by sequences from
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: DA236475.1, DA244238.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.