||ORF Nucleotide Sequence (Length: 1488bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||potassium voltage-gated channel subfamily A member 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA236475.1 and AC006063.1.
This sequence is a reference standard in the RefSeqGene project.
On or before Dec 16, 2006 this sequence version replaced
Summary: This gene encodes a voltage-gated delayed potassium
channel that is phylogenetically related to the Drosophila Shaker
channel. The encoded protein has six putative transmembrane
segments (S1-S6), and the loop between S5 and S6 forms the pore and
contains the conserved selectivity filter motif (GYGD). The
functional channel is a homotetramer. The N-terminus of the channel
is associated with beta subunits that can modify the inactivation
properties of the channel as well as affect expression levels. The
C-terminus of the channel is complexed to a PDZ domain protein that
is responsible for channel targeting. Mutations in this gene have
been associated with myokymia with periodic ataxia (AEMK).
[provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created largely from genomic
sequence because transcripts were not available for the entire
length of the gene. This transcript is supported by sequences from
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: DA236475.1, DA244238.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.