The following KRT6A gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT6A gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1695bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||keratin, type II cytoskeletal 6A
||REVIEWED REFSEQ: This record has been curated by NCBI staff in
collaboration with Michael Rogers. The reference sequence was
derived from DA451441.1, BC008807.2 and BG059253.1.
This sequence is a reference standard in the RefSeqGene project.
On or before Feb 27, 2007 this sequence version replaced
Summary: The protein encoded by this gene is a member of the
keratin gene family. The type II cytokeratins consist of basic or
neutral proteins which are arranged in pairs of heterotypic keratin
chains coexpressed during differentiation of simple and stratified
epithelial tissues. As many as six of this type II cytokeratin
(KRT6) have been identified; the multiplicity of the genes is
attributed to successive gene duplication events. The genes are
expressed with family members KRT16 and/or KRT17 in the filiform
papillae of the tongue, the stratified epithelial lining of oral
mucosa and esophagus, the outer root sheath of hair follicles, and
the glandular epithelia. This KRT6 gene in particular encodes the
most abundant isoform. Mutations in these genes have been
associated with pachyonychia congenita. In addition, peptides from
the C-terminal region of the protein have antimicrobial activity
against bacterial pathogens. The type II cytokeratins are clustered
in a region of chromosome 12q12-q13. [provided by RefSeq, Oct
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Protein has antimicrobial activity :: PMID: 23006328
Transcript exon combination :: BC014152.2, BC008807.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.