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KRT81 cDNA ORF clone, Homo sapiens (human)

Gene Symbol KRT81
Entrez Gene ID 3887
Full Name keratin 81, type II
Synonyms HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1
General protein information
Preferred Names
keratin, type II cuticular Hb1
Names
keratin, type II cuticular Hb1
K81
ghHb1
MLN 137
keratin-81
hair keratin K2.9
type-II keratin Kb21
keratin, hair, basic, 1
hard keratin, type II, 1
type II hair keratin Hb1
metastatic lymph node 137 gene protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13

Summary The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602153

Disorder Html: Monilethrix, 158000 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011538334 XP_011536636 keratin, type II cuticular Hb1 isoform X1
NM_002281 NP_002272 keratin, type II cuticular Hb1


Homo sapiens (human) KRT81 NP_002272.2
Pan troglodytes (chimpanzee) KRT81 XP_003313755.1
Macaca mulatta (Rhesus monkey) KRT81 XP_001093214.1
Canis lupus familiaris (dog) KRT81 XP_543657.2
Canis lupus familiaris (dog) LOC486529 XP_850166.2
Bos taurus (cattle) KRT81 NP_001069674.1
Mus musculus (house mouse) Krt81 NP_001159629.1
Rattus norvegicus (Norway rat) Krt81 NP_001008814.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRT81 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT81 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24118 XM_011538334 PREDICTED: Homo sapiens keratin 81, type II (KRT81), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu24118 NM_002281 Homo sapiens keratin 81, type II (KRT81), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24118
Clone ID Related Accession (Same CDS sequence) NM_002281 , XM_011538334
Accession Version XM_011538334.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1518bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product keratin, type II cuticular Hb1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_029419.13) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGACCTGCG GATCAGGATT TGGTGGGCGC GCCTTCAGCT GCATCTCGGC CTGCGGGCCG 
CGGCCCGGCC GCTGCTGCAT CACCGCCGCC CCCTACCGTG GCATCTCCTG CTACCGCGGC
CTCACCGGGG GCTTCGGCAG CCACAGCGTG TGCGGAGGCT TTCGGGCCGG CTCCTGCGGA
CGCAGCTTCG GCTACCGCTC CGGGGGCGTG TGCGGGCCCA GTCCCCCATG CATCACCACC
GTGTCGGTCA ACGAGAGCCT CCTCACGCCC CTCAACCTGG AGATCGACCC CAACGCGCAG
TGCGTGAAGC AGGAGGAGAA GGAGCAGATC AAGTCCCTCA ACAGCAGGTT CGCGGCCTTC
ATCGACAAGG TGCGCTTCCT GGAGCAGCAG AACAAACTGC TGGAGACAAA GCTGCAGTTC
TACCAGAACC GCGAGTGTTG CCAGAGCAAC CTGGAGCCCC TGTTTGAGGG CTACATCGAG
ACTCTGCGGC GGGAGGCCGA GTGCGTGGAG GCCGACAGCG GGAGGCTGGC CTCAGAGCTT
AACCACGTGC AGGAGGTGCT GGAGGGCTAC AAGAAGAAGT ATGAGGAGGA GGTTTCTCTG
AGAGCAACAG CTGAGAACGA GTTTGTGGCT CTGAAGAAGG ATGTGGACTG CGCCTACCTC
CGCAAGTCAG ACCTGGAGGC CAACGTGGAG GCCCTGATCC AGGAGATCGA CTTCCTGAGG
CGGCTGTATG AGGAGGAGAT CCTCATTCTC CAGTCGCACA TCTCAGACAC CTCCGTGGTT
GTCAAGCTGG ACAACAGCCG GGACCTGAAC ATGGACTGCA TCATTGCCGA GATTAAGGCA
CAGTATGACG ACATTGTCAC CCGCAGCCGG GCCGAGGCCG AGTCCTGGTA CCGCAGCAAG
TGTGAGGAGA TGAAGGCCAC GGTGATCAGG CACGGGGAGA CCCTGCGCCG CACCAAGGAG
GAGATCAATG AGCTGAACCG CATGATCCAA AGGCTGACGG CCGAGGTGGA GAATGCCAAG
TGCCAGAACT CCAAGCTGGA GGCCGCGGTG GCCCAGTCTG AGCAGCAGGG TGAGGCGGCC
CTCAGTGATG CCCGCTGCAA GCTGGCCGAG CTGGAGGGCG CCCTGCAGAA GGCCAAGCAG
GACATGGCCT GCCTGATCAG GGAGTACCAG GAGGTGATGA ACTCCAAGCT GGGCCTGGAC
ATCGAGATCG CCACCTACAG GCGCCTGCTG GAGGGCGAGG AGCAGAGGCT ATGTGAAGGC
ATTGGGGCTG TGAATGTCTG TGTCAGCAGC TCCCGGGGCG GGGTCGTGTG CGGGGACCTC
TGCGTGTCAG GCTCCCGGCC AGTGACTGGC AGTGTCTGCA GCGCTCCGTG CAACGGGAAC
GTGGCGGTGA GCACCGGCCT GTGTGCGCCC TGCGGCCAAT TGAACACCAC CTGCGGAGGG
GGTTCCTGCG GCGTGGGCTC CTGTGGTATC AGCTCCCTGG GTGTGGGGTC TTGCGGCAGC
AGCTGCCGGA AATGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011536636.1
CDS412..1929
Misc Feature(1)724..1659(+)
Misc Feature(2)1084..1431(+)
Misc Feature(3)1330..1674(+)
Translation

Target ORF information:

RefSeq Version XM_011538334
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens keratin 81, type II (KRT81), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011538334

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGACCTGCG GATCAGGATT TGGTGGGCGC GCCTTCAGCT GCATCTCGGC CTGCGGGCCG 
CGGCCCGGCC GCTGCTGCAT CACCGCCGCC CCCTACCGTG GCATCTCCTG CTACCGCGGC
CTCACCGGGG GCTTCGGCAG CCACAGCGTG TGCGGAGGCT TTCGGGCCGG CTCCTGCGGA
CGCAGCTTCG GCTACCGCTC CGGGGGCGTG TGCGGGCCCA GTCCCCCATG CATCACCACC
GTGTCGGTCA ACGAGAGCCT CCTCACGCCC CTCAACCTGG AGATCGACCC CAACGCGCAG
TGCGTGAAGC AGGAGGAGAA GGAGCAGATC AAGTCCCTCA ACAGCAGGTT CGCGGCCTTC
ATCGACAAGG TGCGCTTCCT GGAGCAGCAG AACAAACTGC TGGAGACAAA GCTGCAGTTC
TACCAGAACC GCGAGTGTTG CCAGAGCAAC CTGGAGCCCC TGTTTGAGGG CTACATCGAG
ACTCTGCGGC GGGAGGCCGA GTGCGTGGAG GCCGACAGCG GGAGGCTGGC CTCAGAGCTT
AACCACGTGC AGGAGGTGCT GGAGGGCTAC AAGAAGAAGT ATGAGGAGGA GGTTTCTCTG
AGAGCAACAG CTGAGAACGA GTTTGTGGCT CTGAAGAAGG ATGTGGACTG CGCCTACCTC
CGCAAGTCAG ACCTGGAGGC CAACGTGGAG GCCCTGATCC AGGAGATCGA CTTCCTGAGG
CGGCTGTATG AGGAGGAGAT CCTCATTCTC CAGTCGCACA TCTCAGACAC CTCCGTGGTT
GTCAAGCTGG ACAACAGCCG GGACCTGAAC ATGGACTGCA TCATTGCCGA GATTAAGGCA
CAGTATGACG ACATTGTCAC CCGCAGCCGG GCCGAGGCCG AGTCCTGGTA CCGCAGCAAG
TGTGAGGAGA TGAAGGCCAC GGTGATCAGG CACGGGGAGA CCCTGCGCCG CACCAAGGAG
GAGATCAATG AGCTGAACCG CATGATCCAA AGGCTGACGG CCGAGGTGGA GAATGCCAAG
TGCCAGAACT CCAAGCTGGA GGCCGCGGTG GCCCAGTCTG AGCAGCAGGG TGAGGCGGCC
CTCAGTGATG CCCGCTGCAA GCTGGCCGAG CTGGAGGGCG CCCTGCAGAA GGCCAAGCAG
GACATGGCCT GCCTGATCAG GGAGTACCAG GAGGTGATGA ACTCCAAGCT GGGCCTGGAC
ATCGAGATCG CCACCTACAG GCGCCTGCTG GAGGGCGAGG AGCAGAGGCT ATGTGAAGGC
ATTGGGGCTG TGAATGTCTG TGTCAGCAGC TCCCGGGGCG GGGTCGTGTG CGGGGACCTC
TGCGTGTCAG GCTCCCGGCC AGTGACTGGC AGTGTCTGCA GCGCTCCGTG CAACGGGAAC
GTGGCGGTGA GCACCGGCCT GTGTGCGCCC TGCGGCCAAT TGAACACCAC CTGCGGAGGG
GGTTCCTGCG GCGTGGGCTC CTGTGGTATC AGCTCCCTGG GTGTGGGGTC TTGCGGCAGC
AGCTGCCGGA AATGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24118
Clone ID Related Accession (Same CDS sequence) NM_002281 , XM_011538334
Accession Version NM_002281.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1518bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product keratin, type II cuticular Hb1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from AC121757.8 and X81420.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced gi:15431319. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the bull length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81420.1, BC117467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159931, SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGACCTGCG GATCAGGATT TGGTGGGCGC GCCTTCAGCT GCATCTCGGC CTGCGGGCCG 
CGGCCCGGCC GCTGCTGCAT CACCGCCGCC CCCTACCGTG GCATCTCCTG CTACCGCGGC
CTCACCGGGG GCTTCGGCAG CCACAGCGTG TGCGGAGGCT TTCGGGCCGG CTCCTGCGGA
CGCAGCTTCG GCTACCGCTC CGGGGGCGTG TGCGGGCCCA GTCCCCCATG CATCACCACC
GTGTCGGTCA ACGAGAGCCT CCTCACGCCC CTCAACCTGG AGATCGACCC CAACGCGCAG
TGCGTGAAGC AGGAGGAGAA GGAGCAGATC AAGTCCCTCA ACAGCAGGTT CGCGGCCTTC
ATCGACAAGG TGCGCTTCCT GGAGCAGCAG AACAAACTGC TGGAGACAAA GCTGCAGTTC
TACCAGAACC GCGAGTGTTG CCAGAGCAAC CTGGAGCCCC TGTTTGAGGG CTACATCGAG
ACTCTGCGGC GGGAGGCCGA GTGCGTGGAG GCCGACAGCG GGAGGCTGGC CTCAGAGCTT
AACCACGTGC AGGAGGTGCT GGAGGGCTAC AAGAAGAAGT ATGAGGAGGA GGTTTCTCTG
AGAGCAACAG CTGAGAACGA GTTTGTGGCT CTGAAGAAGG ATGTGGACTG CGCCTACCTC
CGCAAGTCAG ACCTGGAGGC CAACGTGGAG GCCCTGATCC AGGAGATCGA CTTCCTGAGG
CGGCTGTATG AGGAGGAGAT CCTCATTCTC CAGTCGCACA TCTCAGACAC CTCCGTGGTT
GTCAAGCTGG ACAACAGCCG GGACCTGAAC ATGGACTGCA TCATTGCCGA GATTAAGGCA
CAGTATGACG ACATTGTCAC CCGCAGCCGG GCCGAGGCCG AGTCCTGGTA CCGCAGCAAG
TGTGAGGAGA TGAAGGCCAC GGTGATCAGG CACGGGGAGA CCCTGCGCCG CACCAAGGAG
GAGATCAATG AGCTGAACCG CATGATCCAA AGGCTGACGG CCGAGGTGGA GAATGCCAAG
TGCCAGAACT CCAAGCTGGA GGCCGCGGTG GCCCAGTCTG AGCAGCAGGG TGAGGCGGCC
CTCAGTGATG CCCGCTGCAA GCTGGCCGAG CTGGAGGGCG CCCTGCAGAA GGCCAAGCAG
GACATGGCCT GCCTGATCAG GGAGTACCAG GAGGTGATGA ACTCCAAGCT GGGCCTGGAC
ATCGAGATCG CCACCTACAG GCGCCTGCTG GAGGGCGAGG AGCAGAGGCT ATGTGAAGGC
ATTGGGGCTG TGAATGTCTG TGTCAGCAGC TCCCGGGGCG GGGTCGTGTG CGGGGACCTC
TGCGTGTCAG GCTCCCGGCC AGTGACTGGC AGTGTCTGCA GCGCTCCGTG CAACGGGAAC
GTGGCGGTGA GCACCGGCCT GTGTGCGCCC TGCGGCCAAT TGAACACCAC CTGCGGAGGG
GGTTCCTGCG GCGTGGGCTC CTGTGGTATC AGCTCCCTGG GTGTGGGGTC TTGCGGCAGC
AGCTGCCGGA AATGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002272.2
CDS51..1568
Misc Feature(1)51..368(+)
Misc Feature(2)363..1298(+)
Misc Feature(3)369..1289(+)
Misc Feature(4)369..473(+)
Misc Feature(5)474..503(+)
Misc Feature(6)504..806(+)
Misc Feature(7)723..1070(+)
Misc Feature(8)807..857(+)
Misc Feature(9)858..1289(+)
Misc Feature(10)969..1313(+)
Misc Feature(11)1290..1565(+)
Exon (1)1..419
Gene:KRT81
Gene Synonym:
Exon (2)420..628
Gene:KRT81
Gene Synonym:
Exon (3)629..689
Gene:KRT81
Gene Synonym:
Exon (4)690..785
Gene:KRT81
Gene Synonym:
Exon (5)786..950
Gene:KRT81
Gene Synonym:
Exon (6)951..1076
Gene:KRT81
Gene Synonym:
Exon (7)1077..1297
Gene:KRT81
Gene Synonym:
Exon (8)1298..1329
Gene:KRT81
Gene Synonym:
Exon (9)1330..1910
Gene:KRT81
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002281
Organism Homo sapiens (human)
Definition Homo sapiens keratin 81, type II (KRT81), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002281

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGACCTGCG GATCAGGATT TGGTGGGCGC GCCTTCAGCT GCATCTCGGC CTGCGGGCCG 
CGGCCCGGCC GCTGCTGCAT CACCGCCGCC CCCTACCGTG GCATCTCCTG CTACCGCGGC
CTCACCGGGG GCTTCGGCAG CCACAGCGTG TGCGGAGGCT TTCGGGCCGG CTCCTGCGGA
CGCAGCTTCG GCTACCGCTC CGGGGGCGTG TGCGGGCCCA GTCCCCCATG CATCACCACC
GTGTCGGTCA ACGAGAGCCT CCTCACGCCC CTCAACCTGG AGATCGACCC CAACGCGCAG
TGCGTGAAGC AGGAGGAGAA GGAGCAGATC AAGTCCCTCA ACAGCAGGTT CGCGGCCTTC
ATCGACAAGG TGCGCTTCCT GGAGCAGCAG AACAAACTGC TGGAGACAAA GCTGCAGTTC
TACCAGAACC GCGAGTGTTG CCAGAGCAAC CTGGAGCCCC TGTTTGAGGG CTACATCGAG
ACTCTGCGGC GGGAGGCCGA GTGCGTGGAG GCCGACAGCG GGAGGCTGGC CTCAGAGCTT
AACCACGTGC AGGAGGTGCT GGAGGGCTAC AAGAAGAAGT ATGAGGAGGA GGTTTCTCTG
AGAGCAACAG CTGAGAACGA GTTTGTGGCT CTGAAGAAGG ATGTGGACTG CGCCTACCTC
CGCAAGTCAG ACCTGGAGGC CAACGTGGAG GCCCTGATCC AGGAGATCGA CTTCCTGAGG
CGGCTGTATG AGGAGGAGAT CCTCATTCTC CAGTCGCACA TCTCAGACAC CTCCGTGGTT
GTCAAGCTGG ACAACAGCCG GGACCTGAAC ATGGACTGCA TCATTGCCGA GATTAAGGCA
CAGTATGACG ACATTGTCAC CCGCAGCCGG GCCGAGGCCG AGTCCTGGTA CCGCAGCAAG
TGTGAGGAGA TGAAGGCCAC GGTGATCAGG CACGGGGAGA CCCTGCGCCG CACCAAGGAG
GAGATCAATG AGCTGAACCG CATGATCCAA AGGCTGACGG CCGAGGTGGA GAATGCCAAG
TGCCAGAACT CCAAGCTGGA GGCCGCGGTG GCCCAGTCTG AGCAGCAGGG TGAGGCGGCC
CTCAGTGATG CCCGCTGCAA GCTGGCCGAG CTGGAGGGCG CCCTGCAGAA GGCCAAGCAG
GACATGGCCT GCCTGATCAG GGAGTACCAG GAGGTGATGA ACTCCAAGCT GGGCCTGGAC
ATCGAGATCG CCACCTACAG GCGCCTGCTG GAGGGCGAGG AGCAGAGGCT ATGTGAAGGC
ATTGGGGCTG TGAATGTCTG TGTCAGCAGC TCCCGGGGCG GGGTCGTGTG CGGGGACCTC
TGCGTGTCAG GCTCCCGGCC AGTGACTGGC AGTGTCTGCA GCGCTCCGTG CAACGGGAAC
GTGGCGGTGA GCACCGGCCT GTGTGCGCCC TGCGGCCAAT TGAACACCAC CTGCGGAGGG
GGTTCCTGCG GCGTGGGCTC CTGTGGTATC AGCTCCCTGG GTGTGGGGTC TTGCGGCAGC
AGCTGCCGGA AATGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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