||ORF Nucleotide Sequence (Length: 855bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||paired mesoderm homeobox protein 2A
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290645.1 and BC041564.1.
This sequence is a reference standard in the RefSeqGene project.
On May 20, 2008 this sequence version replaced gi:46249381.
Summary: The protein encoded by this gene contains a paired-like
homeodomain most similar to that of the Drosophila aristaless gene
product. The encoded protein plays a central role in development of
the autonomic nervous system. It regulates the expression of
tyrosine hydroxylase and dopamine beta-hydroxylase, two
catecholaminergic biosynthetic enzymes essential for the
differentiation and maintenance of the noradrenergic
neurotransmitter phenotype. The encoded protein has also been shown
to regulate transcription of the alpha3 nicotinic acetylcholine
receptor gene. Mutations in this gene have been associated with
autosomal recessive congenital fibrosis of the extraocular muscles.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC041564.1, BX376662.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.