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LPL cDNA ORF clone, Homo sapiens (human)

Gene Symbol LPL
Entrez Gene ID 4023
Full Name lipoprotein lipase
Synonyms HDLCQ11, LIPD
General protein information
Preferred Names
lipoprotein lipase
Names
lipoprotein lipase
NP_000228.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p22

Summary LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

609708

Disorder Html: Lipoprotein lipase deficiency, 238600 (3); Combined hyperlipidemia,

mRNA and Protein(s)

mRNA Protein Name
NM_000237 NP_000228 lipoprotein lipase precursor



Homo sapiens (human) LPL NP_000228.1
Pan troglodytes (chimpanzee) LPL XP_001149804.1
Canis lupus familiaris (dog) LPL XP_005635791.1
Bos taurus (cattle) LPL NP_001068588.1
Mus musculus (house mouse) Lpl NP_032535.2
Rattus norvegicus (Norway rat) Lpl NP_036730.1
Gallus gallus (chicken) LPL NP_990613.1
Danio rerio (zebrafish) lpl NP_571202.1
Danio rerio (zebrafish) LOC101884800 XP_005174466.1
Xenopus (Silurana) tropicalis (western clawed frog) lpl XP_002934038.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LPL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LPL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25014
NM_000237 Homo sapiens lipoprotein lipase (LPL), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25014
Clone ID Related Accession (Same CDS sequence) NM_000237
Accession Version NM_000237.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1428bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product lipoprotein lipase precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA485210.1, M15856.1 and AC100802.2. This sequence is a reference standard in the RefSeqGene project. On Apr 13, 2007 this sequence version replaced gi:4557726. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M15856.1, BC011353.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGAGCA AAGCCCTGCT CGTGCTGACT CTGGCCGTGT GGCTCCAGAG TCTGACCGCC 
TCCCGCGGAG GGGTGGCCGC CGCCGACCAA AGAAGAGATT TTATCGACAT CGAAAGTAAA
TTTGCCCTAA GGACCCCTGA AGACACAGCT GAGGACACTT GCCACCTCAT TCCCGGAGTA
GCAGAGTCCG TGGCTACCTG TCATTTCAAT CACAGCAGCA AAACCTTCAT GGTGATCCAT
GGCTGGACGG TAACAGGAAT GTATGAGAGT TGGGTGCCAA AACTTGTGGC CGCCCTGTAC
AAGAGAGAAC CAGACTCCAA TGTCATTGTG GTGGACTGGC TGTCACGGGC TCAGGAGCAT
TACCCAGTGT CCGCGGGCTA CACCAAACTG GTGGGACAGG ATGTGGCCCG GTTTATCAAC
TGGATGGAGG AGGAGTTTAA CTACCCTCTG GACAATGTCC ATCTCTTGGG ATACAGCCTT
GGAGCCCATG CTGCTGGCAT TGCAGGAAGT CTGACCAATA AGAAAGTCAA CAGAATTACT
GGCCTCGATC CAGCTGGACC TAACTTTGAG TATGCAGAAG CCCCGAGTCG TCTTTCTCCT
GATGATGCAG ATTTTGTAGA CGTCTTACAC ACATTCACCA GAGGGTCCCC TGGTCGAAGC
ATTGGAATCC AGAAACCAGT TGGGCATGTT GACATTTACC CGAATGGAGG TACTTTTCAG
CCAGGATGTA ACATTGGAGA AGCTATCCGC GTGATTGCAG AGAGAGGACT TGGAGATGTG
GACCAGCTAG TGAAGTGCTC CCACGAGCGC TCCATTCATC TCTTCATCGA CTCTCTGTTG
AATGAAGAAA ATCCAAGTAA GGCCTACAGG TGCAGTTCCA AGGAAGCCTT TGAGAAAGGG
CTCTGCTTGA GTTGTAGAAA GAACCGCTGC AACAATCTGG GCTATGAGAT CAATAAAGTC
AGAGCCAAAA GAAGCAGCAA AATGTACCTG AAGACTCGTT CTCAGATGCC CTACAAAGTC
TTCCATTACC AAGTAAAGAT TCATTTTTCT GGGACTGAGA GTGAAACCCA TACCAATCAG
GCCTTTGAGA TTTCTCTGTA TGGCACCGTG GCCGAGAGTG AGAACATCCC ATTCACTCTG
CCTGAAGTTT CCACAAATAA GACCTACTCC TTCCTAATTT ACACAGAGGT AGATATTGGA
GAACTACTCA TGTTGAAGCT CAAATGGAAG AGTGATTCAT ACTTTAGCTG GTCAGACTGG
TGGAGCAGTC CCGGCTTCGC CATTCAGAAG ATCAGAGTAA AAGCAGGAGA GACTCAGAAA
AAGGTGATCT TCTGTTCTAG GGAGAAAGTG TCTCATTTGC AGAAAGGAAA GGCACCTGCG
GTATTTGTGA AATGCCATGA CAAGTCTCTG AATAAGAAGT CAGGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000228.1
CDS371..1798
Misc Feature(1)173..175(+)
Misc Feature(2)467..1789(+)
Misc Feature(3)479..1372(+)
Misc Feature(4)839..853(+)
Misc Feature(5)845..1174(+)
Misc Feature(6)1097..1168(+)
Misc Feature(7)1391..1765(+)
Misc Feature(8)1406..1693(+)
Exon (1)1..458
Gene:LPL
Gene Synonym:
Exon (2)459..619
Gene:LPL
Gene Synonym:
Exon (3)620..799
Gene:LPL
Gene Synonym:
Exon (4)800..911
Gene:LPL
Gene Synonym:
Exon (5)912..1145
Gene:LPL
Gene Synonym:
Exon (6)1146..1388
Gene:LPL
Gene Synonym:
Exon (7)1389..1509
Gene:LPL
Gene Synonym:
Exon (8)1510..1692
Gene:LPL
Gene Synonym:
Exon (9)1693..1797
Gene:LPL
Gene Synonym:
Exon (10)1798..3747
Gene:LPL
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000237
Organism Homo sapiens (human)
Definition Homo sapiens lipoprotein lipase (LPL), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000237

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGAGAGCA AAGCCCTGCT CGTGCTGACT CTGGCCGTGT GGCTCCAGAG TCTGACCGCC 
TCCCGCGGAG GGGTGGCCGC CGCCGACCAA AGAAGAGATT TTATCGACAT CGAAAGTAAA
TTTGCCCTAA GGACCCCTGA AGACACAGCT GAGGACACTT GCCACCTCAT TCCCGGAGTA
GCAGAGTCCG TGGCTACCTG TCATTTCAAT CACAGCAGCA AAACCTTCAT GGTGATCCAT
GGCTGGACGG TAACAGGAAT GTATGAGAGT TGGGTGCCAA AACTTGTGGC CGCCCTGTAC
AAGAGAGAAC CAGACTCCAA TGTCATTGTG GTGGACTGGC TGTCACGGGC TCAGGAGCAT
TACCCAGTGT CCGCGGGCTA CACCAAACTG GTGGGACAGG ATGTGGCCCG GTTTATCAAC
TGGATGGAGG AGGAGTTTAA CTACCCTCTG GACAATGTCC ATCTCTTGGG ATACAGCCTT
GGAGCCCATG CTGCTGGCAT TGCAGGAAGT CTGACCAATA AGAAAGTCAA CAGAATTACT
GGCCTCGATC CAGCTGGACC TAACTTTGAG TATGCAGAAG CCCCGAGTCG TCTTTCTCCT
GATGATGCAG ATTTTGTAGA CGTCTTACAC ACATTCACCA GAGGGTCCCC TGGTCGAAGC
ATTGGAATCC AGAAACCAGT TGGGCATGTT GACATTTACC CGAATGGAGG TACTTTTCAG
CCAGGATGTA ACATTGGAGA AGCTATCCGC GTGATTGCAG AGAGAGGACT TGGAGATGTG
GACCAGCTAG TGAAGTGCTC CCACGAGCGC TCCATTCATC TCTTCATCGA CTCTCTGTTG
AATGAAGAAA ATCCAAGTAA GGCCTACAGG TGCAGTTCCA AGGAAGCCTT TGAGAAAGGG
CTCTGCTTGA GTTGTAGAAA GAACCGCTGC AACAATCTGG GCTATGAGAT CAATAAAGTC
AGAGCCAAAA GAAGCAGCAA AATGTACCTG AAGACTCGTT CTCAGATGCC CTACAAAGTC
TTCCATTACC AAGTAAAGAT TCATTTTTCT GGGACTGAGA GTGAAACCCA TACCAATCAG
GCCTTTGAGA TTTCTCTGTA TGGCACCGTG GCCGAGAGTG AGAACATCCC ATTCACTCTG
CCTGAAGTTT CCACAAATAA GACCTACTCC TTCCTAATTT ACACAGAGGT AGATATTGGA
GAACTACTCA TGTTGAAGCT CAAATGGAAG AGTGATTCAT ACTTTAGCTG GTCAGACTGG
TGGAGCAGTC CCGGCTTCGC CATTCAGAAG ATCAGAGTAA AAGCAGGAGA GACTCAGAAA
AAGGTGATCT TCTGTTCTAG GGAGAAAGTG TCTCATTTGC AGAAAGGAAA GGCACCTGCG
GTATTTGTGA AATGCCATGA CAAGTCTCTG AATAAGAAGT CAGGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity
Arterioscler. Thromb. Vasc. Biol. 34 (3), 669-675 (2014)
Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ and Berg G.


book

Apolipoproteins C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets
J. Biol. Chem. 288 (47), 33997-34008 (2013)
Larsson M, Vorrsjo E, Talmud P, Lookene A and Olivecrona G.


book

Discovery and refinement of loci associated with lipid levels
Nat. Genet. 45 (11), 1274-1283 (2013)
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Doring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR.


book

Effects of lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene variants on metabolic syndrome traits
Coll Antropol 37 (3), 801-808 (2013)
Bozina T, Simic I, Lovric J, Pecin I, Jelakovic B, Sertic J and Reiner Z.


book

[Polymorphisms Ser447Ter of lipoprotein-lipase gene, Cys112Arg and Arg158Cys of apolipoprotein E gene in patients with obesity]
Vopr Pitan 82 (4), 4-9 (2013)
Kirillova,O.O., Vorozhko,I.V., Gapparova,K.M., Chekhonina,Iu.G., Sentsova,T.B. and Tutel'ian,V.A.


book

Familial Lipoprotein Lipase Deficiency
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Brunzell,J.D.


book

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase
J. Biol. Chem. 267 (36), 25764-25767 (1992)
Chappell DA, Fry GL, Waknitz MA, Iverius PH, Williams SE and Strickland DK.


book

Missense mutations in exon 5 of the human lipoprotein lipase gene. Inactivation correlates with loss of dimerization
J. Biol. Chem. 267 (28), 20132-20139 (1992)
Hata A, Ridinger DN, Sutherland SD, Emi M, Kwong LK, Shuhua J, Lubbers A, Guy-Grand B, Basdevant A and Iverius PH.


book

Human lipoprotein lipase. Analysis of the catalytic triad by site-directed mutagenesis of Ser-132, Asp-156, and His-241
J. Biol. Chem. 267 (6), 4161-4165 (1992)
Emmerich J, Beg OU, Peterson J, Previato L, Brunzell JD, Brewer HB Jr and Santamarina-Fojo S.


book

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase
FEBS Lett. 65 (3), 354-357 (1976)
Kinnunen,P.K. and Ehnolm,C.


 
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