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LRPAP1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol LRPAP1
Entrez Gene ID 4043
Full Name low density lipoprotein receptor-related protein associated protein 1
Synonyms A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP
General protein information
Preferred Names
alpha-2-macroglobulin receptor-associated protein
Names
alpha-2-macroglobulin receptor-associated protein
alpha-2-MRAP
lipoprotein receptor associated protein
alpha-2-macroglobulin receptor-associated protein 1
low density lipoprotein receptor-related protein-associated protein 1
low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4p16.3

Summary This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. lac of sum
Disorder MIM:

104225


mRNA and Protein(s)

mRNA Protein Name
NM_002337 NP_002328 alpha-2-macroglobulin receptor-associated protein precursor



Homo sapiens (human) LRPAP1 NP_002328.1
Pan troglodytes (chimpanzee) LRPAP1 NP_001233320.1
Macaca mulatta (Rhesus monkey) LRPAP1 XP_001085674.1
Canis lupus familiaris (dog) LRPAP1 XP_536218.3
Bos taurus (cattle) LRPAP1 NP_001073694.1
Mus musculus (house mouse) Lrpap1 NP_038615.2
Rattus norvegicus (Norway rat) Lrpap1 NP_001162584.1
Gallus gallus (chicken) LRPAP1 NP_990393.1
Danio rerio (zebrafish) lrpap1 NP_958463.1
Drosophila melanogaster (fruit fly) CG8507 NP_649950.1
Xenopus (Silurana) tropicalis (western clawed frog) lrpap1 NP_001090847.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following LRPAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRPAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25194
NM_002337 Homo sapiens low density lipoprotein receptor-related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25194
Clone ID Related Accession (Same CDS sequence) NM_002337
Accession Version NM_002337.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1074bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-2-macroglobulin receptor-associated protein precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB035408.1, BC112067.1, BX647984.1, AK222504.1 and AL590235.23. This sequence is a reference standard in the RefSeqGene project. On Jun 22, 2011 this sequence version replaced gi:194440683. Transcript Variant: This variant (1) represents the longer transcript and encodes the protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222504.1, BX647984.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337, SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002328.1
CDS86..1159
Misc Feature(1)50..52(+)
Misc Feature(2)245..457(+)
Misc Feature(3)257..286(+)
Misc Feature(4)308..373(+)
Misc Feature(5)374..376(+)
Misc Feature(6)404..445(+)
Misc Feature(7)515..1156(+)
Misc Feature(8)521..814(+)
Misc Feature(9)533..562(+)
Misc Feature(10)584..670(+)
Misc Feature(11)743..814(+)
Misc Feature(12)839..1156(+)
Misc Feature(13)860..883(+)
Misc Feature(14)902..1003(+)
Misc Feature(15)941..1087(+)
Misc Feature(16)1046..1135(+)
Exon (1)1..289
Gene:LRPAP1
Gene Synonym:
Exon (2)290..434
Gene:LRPAP1
Gene Synonym:
Exon (3)435..556
Gene:LRPAP1
Gene Synonym:
Exon (4)557..677
Gene:LRPAP1
Gene Synonym:
Exon (5)678..836
Gene:LRPAP1
Gene Synonym:
Exon (6)837..919
Gene:LRPAP1
Gene Synonym:
Exon (7)920..1096
Gene:LRPAP1
Gene Synonym:
Exon (8)1097..10536
Gene:LRPAP1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002337
Organism Homo sapiens (human)
Definition Homo sapiens low density lipoprotein receptor-related protein associated protein 1 (LRPAP1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002337

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCGCCGC GGAGGGTCAG GTCGTTTCTG CGCGGGCTCC CGGCGCTGCT ACTGCTGCTG 
CTCTTCCTCG GGCCCTGGCC CGCTGCGAGC CACGGCGGCA AGTACTCGCG GGAGAAGAAC
CAGCCCAAGC CGTCCCCGAA ACGCGAGTCC GGAGAGGAGT TCCGCATGGA GAAGTTGAAC
CAGCTGTGGG AGAAGGCCCA GCGACTGCAT CTTCCTCCCG TGAGGCTGGC CGAGCTCCAC
GCTGATCTGA AGATACAGGA GAGGGACGAA CTCGCCTGGA AGAAACTAAA GCTTGACGGC
TTGGACGAAG ATGGGGAGAA GGAAGCGAGA CTCATACGCA ACCTCAATGT CATCTTGGCC
AAGTATGGTC TGGACGGAAA GAAGGACGCT CGGCAGGTGA CCAGCAACTC CCTCAGTGGC
ACCCAGGAAG ACGGGCTGGA TGACCCCAGG CTGGAAAAGC TGTGGCACAA GGCGAAGACC
TCTGGGAAAT TCTCCGGCGA AGAACTGGAC AAGCTCTGGC GGGAGTTCCT GCATCACAAA
GAGAAAGTTC ACGAGTACAA CGTCCTGCTG GAGACCCTGA GCAGGACCGA AGAAATCCAC
GAGAACGTCA TTAGCCCCTC GGACCTGAGC GACATCAAGG GCAGCGTCCT GCACAGCAGG
CACACGGAGC TGAAGGAGAA GCTGCGCAGC ATCAACCAGG GCCTGGACCG CCTGCGCAGG
GTCAGCCACC AGGGCTACAG CACTGAGGCT GAGTTCGAGG AGCCCAGGGT GATTGACCTG
TGGGACCTGG CGCAGTCCGC CAACCTCACG GACAAGGAGC TGGAGGCGTT CCGGGAGGAG
CTCAAGCACT TCGAAGCCAA AATCGAGAAG CACAACCACT ACCAGAAGCA GCTGGAGATT
GCGCACGAGA AGCTGAGGCA CGCAGAGAGC GTGGGCGACG GCGAGCGTGT GAGCCGCAGC
CGCGAGAAGC ACGCCCTGCT GGAGGGGCGG ACCAAGGAGC TGGGCTACAC GGTGAAGAAG
CATCTGCAGG ACCTGTCCGG CAGGATCTCC AGAGCTCGGC ACAACGAACT CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Discovery and refinement of loci associated with lipid levels
Nat. Genet. 45 (11), 1274-1283 (2013)
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Doring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR.


book

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease
Circulation 128 (12), 1310-1324 (2013)
Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Malarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Raikkonen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Volzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A and O'Donnell CJ.


book

Mutations in LRPAP1 are associated with severe myopia in humans
Am. J. Hum. Genet. 93 (2), 313-320 (2013)
Aldahmesh MA, Khan AO, Alkuraya H, Adly N, Anazi S, Al-Saleh AA, Mohamed JY, Hijazi H, Prabakaran S, Tacke M, Al-Khrashi A, Hashem M, Reinheckel T, Assiri A and Alkuraya FS.


book

Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells
PLoS ONE 8 (7), E70276 (2013)
Sengul S, Erturk S, Khan AM and Batuman V.


book

Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein
Genomics 25 (2), 492-500 (1995)
Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP and Van den Berghe H.


book

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330
J. Biol. Chem. 267 (29), 21162-21166 (1992)
Kounnas MZ, Argraves WS and Strickland DK.


book

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein
J. Biol. Chem. 267 (13), 9035-9040 (1992)
Williams SE, Ashcom JD, Argraves WS and Strickland DK.


book

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
J. Biol. Chem. 266 (31), 21232-21238 (1991)
Herz J, Goldstein JL, Strickland DK, Ho YK and Brown MS.


book

Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen
J. Biol. Chem. 266 (20), 13364-13369 (1991)
Strickland DK, Ashcom JD, Williams S, Battey F, Behre E, McTigue K, Battey JF and Argraves WS.


book

A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis
J. Biochem. 108 (2), 297-302 (1990)
Furukawa T, Ozawa M, Huang RP and Muramatsu T.


 
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