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MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) [Homo sapiens (human)]

Gene Symbol MAD2L1
Entrez Gene ID 4085
Full Name MAD2 mitotic arrest deficient-like 1 (yeast)
Synonyms HSMAD2, MAD2
General protein information
Preferred Names
mitotic spindle assembly checkpoint protein MAD2A
Names
mitotic spindle assembly checkpoint protein MAD2A
MAD2-like protein 1
mitotic arrest deficient 2-like protein 1
mitotic arrest deficient, yeast, homolog-like 1
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q27

Summary MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601467

Disorder Html:





The following MAD2L1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAD2L1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24019 NM_002358 Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

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**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu24019
Accession Version NM_002358.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 618bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product mitotic spindle assembly checkpoint protein MAD2A
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA443733.1, AK313827.1, AK223433.1 and BC000356.2. On Jul 30, 2008 this sequence version replaced gi:6466452. Summary: MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000356.2, BC005945.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGGCGCTGC AGCTCTCCCG GGAGCAGGGA ATCACCCTGC GCGGGAGCGC CGAAATCGTG 
GCCGAGTTCT TCTCATTCGG CATCAACAGC ATTTTATATC AGCGTGGCAT ATATCCATCT
GAAACCTTTA CTCGAGTGCA GAAATACGGA CTCACCTTGC TTGTAACTAC TGATCTTGAG
CTCATAAAAT ACCTAAATAA TGTGGTGGAA CAACTGAAAG ATTGGTTATA CAAGTGTTCA
GTTCAGAAAC TGGTTGTAGT TATCTCAAAT ATTGAAAGTG GTGAGGTCCT GGAAAGATGG
CAGTTTGATA TTGAGTGTGA CAAGACTGCA AAAGATGACA GTGCACCCAG AGAAAAGTCT
CAGAAAGCTA TCCAGGATGA AATCCGTTCA GTGATCAGAC AGATCACAGC TACGGTGACA
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCA TTTGATCTGC TGATTTATAC AGACAAAGAT
TTGGTTGTAC CTGAAAAATG GGAAGAGTCG GGACCACAGT TTATTACCAA TTCTGAGGAA
GTCCGCCTTC GTTCATTTAC TACTACAATC CACAAAGTAA ATAGCATGGT GGCCTACAAA
ATTCCTGTCA ATGACTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002349.1
CDS125..742
Misc Feature(1)128..130(+)
Misc Feature(2)158..697(+)
Misc Feature(3)632..634(+)
Misc Feature(4)632..634(+)
Misc Feature(5)656..658(+)
Misc Feature(6)656..658(+)
Misc Feature(7)707..739(+)
Misc Feature(8)707..709(+)
Misc Feature(9)707..709(+)
Exon (1)1..197
Gene:MAD2L1
Gene Synonym:
Exon (2)198..344
Gene:MAD2L1
Gene Synonym:
Exon (3)345..465
Gene:MAD2L1
Gene Synonym:
Exon (4)466..569
Gene:MAD2L1
Gene Synonym:
Exon (5)570..1438
Gene:MAD2L1
Gene Synonym:
Translation
Position Chain Variation Link
13 13 a, g dbSNP:541212332
16 16 c, g dbSNP:572197728
19 19 g, t dbSNP:142741206
34 34 a, t dbSNP:777122300
45 45 c, t dbSNP:186459665
65 65 c, g dbSNP:576351571
67 67 a, g dbSNP:538637470
80 80 -, gc dbSNP:538690213
85 85 a, c dbSNP:375432097
86 86 a, g dbSNP:763221187
95 95 a, g dbSNP:750202365
98 98 a, c, g dbSNP:761723829
104 104 c, g, t dbSNP:768206152
107 107 g, t dbSNP:536937745
113 113 g, t dbSNP:372801671
114 114 a, t dbSNP:771733311
121 121 a, g dbSNP:745467143
125 125 a, g dbSNP:778000548
129 129 c, t dbSNP:770186875
138 138 a, t dbSNP:748657577
139 139 c, g dbSNP:781707248
141 141 c, t dbSNP:755503995
143 143 c, g dbSNP:375700698
144 144 a, g dbSNP:144346584
145 145 a, g dbSNP:758702337
146 146 a, g dbSNP:750653937
155 155 a, g dbSNP:765001112
163 163 g, t dbSNP:757054374
164 164 c, t dbSNP:753762145
169 169 a, g dbSNP:764048695
190 190 a, g dbSNP:140487496
197 197 c, t dbSNP:773884131
203 203 a, g dbSNP:767071365
205 205 c, t dbSNP:759063752
220 220 a, g dbSNP:758541913
223 223 a, t dbSNP:766080399
228 228 a, g dbSNP:762457318
232 232 c, g dbSNP:777140652
235 235 a, g dbSNP:769138377
243 243 c, g dbSNP:747580882
244 244 a, t dbSNP:553500398
250 250 c, g dbSNP:368678145
255 255 c, t dbSNP:745994403
262 262 a, g dbSNP:778806579
271 271 c, t dbSNP:199627005
315 315 a, t dbSNP:749442266
317 317 a, c, t dbSNP:2193126
328 328 a, g dbSNP:755890062
335 335 c, t dbSNP:752678732
337 337 a, g dbSNP:781075650
338 338 a, c dbSNP:2859834
349 349 g, t dbSNP:769616080
357 357 a, g dbSNP:747966227
358 358 c, g dbSNP:149949223
359 359 a, t dbSNP:368386354
364 364 a, t dbSNP:577220356
369 369 a, c, g dbSNP:557538317
379 379 a, t dbSNP:139205919
388 388 c, t dbSNP:757962988
392 392 a, g dbSNP:750143980
395 395 a, g dbSNP:765016504
407 407 a, g dbSNP:761511460
410 410 a, g dbSNP:753122638
420 420 g, t dbSNP:767704519
469 469 a, g dbSNP:778506790
471 471 c, t dbSNP:756971877
480 480 a, t dbSNP:372366391
483 483 c, t dbSNP:150812263
486 486 a, c dbSNP:370388308
487 487 a, g dbSNP:752146697
488 488 a, t dbSNP:766825408
491 491 a, g dbSNP:763399814
509 509 c, t dbSNP:773286573
522 522 a, g dbSNP:78047690
538 538 a, g dbSNP:529786403
553 553 a, g dbSNP:61752609
570 570 a, g dbSNP:371009570
578 578 c, g dbSNP:776735919
580 580 a, t dbSNP:764247276
586 586 a, g dbSNP:376755613
602 602 c, g dbSNP:775149389
611 611 g, t dbSNP:138835443
613 613 a, g dbSNP:745854645
624 624 c, g dbSNP:774405611
631 631 a, g dbSNP:370042213
634 634 a, g dbSNP:748779990
635 635 a, g dbSNP:146087467
649 649 a, t dbSNP:769344064
667 667 a, c dbSNP:747834213
668 668 c, t dbSNP:780456520
669 669 a, g dbSNP:758740535
674 674 c, t dbSNP:750970089
675 675 a, g dbSNP:779431364
679 679 a, g dbSNP:757737153
689 689 a, g dbSNP:200592551
692 692 a, g dbSNP:61752608
700 700 a, g dbSNP:760870683
706 706 c, t dbSNP:752951123
710 710 a, g dbSNP:767464526
711 711 a, t dbSNP:201933811
722 722 a, g dbSNP:774246429
727 727 g, t dbSNP:770795554
735 735 a, g dbSNP:762888359
738 738 a, c dbSNP:772601160
751 751 g, t dbSNP:769335442
755 755 a, g dbSNP:747806570
759 759 a, g dbSNP:373089732
768 768 c, t dbSNP:187158111
781 781 a, g dbSNP:746259085
784 784 c, t dbSNP:779192940
785 785 a, g dbSNP:375995529
790 790 c, t dbSNP:754362286
801 801 a, g dbSNP:2908990
813 813 c, t dbSNP:569591328
824 824 g, t dbSNP:764147614
870 870 a, g dbSNP:556120384
877 877 g, t dbSNP:535968010
878 878 g, t dbSNP:567328380
887 887 c, t dbSNP:547628264
888 888 g, t dbSNP:182761177
897 897 -, t dbSNP:369801593
916 916 c, g dbSNP:756809162
924 924 a, g dbSNP:571442973
943 943 c, t dbSNP:551418862
951 951 a, g dbSNP:531634440
981 981 c, t dbSNP:190679989
1040 1040 a, g dbSNP:777973088
1053 1053 a, t dbSNP:530141070
1089 1089 c, t dbSNP:375160196
1098 1098 a, g dbSNP:763729075
1118 1118 c, g dbSNP:762890062
1161 1161 g, t dbSNP:543761963
1169 1169 c, t dbSNP:765364467
1216 1216 a, t dbSNP:759578406
1298 1298 c, t dbSNP:530151759
1347 1347 g, t dbSNP:567503861
1364 1364 -, ca dbSNP:199889773
1373 1373 g, t dbSNP:776769703
1381 1381 c, g dbSNP:771210860
1384 1384 c, g dbSNP:187940971

Target ORF information:

RefSeq Version NM_002358
Organism Homo sapiens (human)
Definition Homo sapiens MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002358

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCGCTGC AGCTCTCCCG GGAGCAGGGA ATCACCCTGC GCGGGAGCGC CGAAATCGTG 
GCCGAGTTCT TCTCATTCGG CATCAACAGC ATTTTATATC AGCGTGGCAT ATATCCATCT
GAAACCTTTA CTCGAGTGCA GAAATACGGA CTCACCTTGC TTGTAACTAC TGATCTTGAG
CTCATAAAAT ACCTAAATAA TGTGGTGGAA CAACTGAAAG ATTGGTTATA CAAGTGTTCA
GTTCAGAAAC TGGTTGTAGT TATCTCAAAT ATTGAAAGTG GTGAGGTCCT GGAAAGATGG
CAGTTTGATA TTGAGTGTGA CAAGACTGCA AAAGATGACA GTGCACCCAG AGAAAAGTCT
CAGAAAGCTA TCCAGGATGA AATCCGTTCA GTGATCAGAC AGATCACAGC TACGGTGACA
TTTCTGCCAC TGTTGGAAGT TTCTTGTTCA TTTGATCTGC TGATTTATAC AGACAAAGAT
TTGGTTGTAC CTGAAAAATG GGAAGAGTCG GGACCACAGT TTATTACCAA TTCTGAGGAA
GTCCGCCTTC GTTCATTTAC TACTACAATC CACAAAGTAA ATAGCATGGT GGCCTACAAA
ATTCCTGTCA ATGACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.