The following SMAD4 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SMAD4 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1659bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||mothers against decapentaplegic homolog 4
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU120224.1, BC002379.2,
AC091551.14 and BM701399.1.
This sequence is a reference standard in the RefSeqGene project.
On Aug 8, 2008 this sequence version replaced gi:164565433.
Summary: This gene encodes a member of the Smad family of signal
transduction proteins. Smad proteins are phosphorylated and
activated by transmembrane serine-threonine receptor kinases in
response to TGF-beta signaling. The product of this gene forms
homomeric complexes and heteromeric complexes with other activated
Smad proteins, which then accumulate in the nucleus and regulate
the transcription of target genes. This protein binds to DNA and
recognizes an 8-bp palindromic sequence (GTCTAGAC) called the
Smad-binding element (SBE). The Smad proteins are subject to
complex regulation by post-translational modifications. Mutations
or deletions in this gene have been shown to result in pancreatic
cancer, juvenile polyposis syndrome, and hereditary hemorrhagic
telangiectasia syndrome. [provided by RefSeq, Oct 2009].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
CDS exon combination :: BC002379.2, U44378.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682 [ECO:0000348]
COMPLETENESS: complete on the 3' end.