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MAGEA8 melanoma antigen family A8 [Homo sapiens (human)]

Gene Symbol MAGEA8
Entrez Gene ID 4107
Full Name melanoma antigen family A8
Synonyms CT1.8, MAGE8
General protein information
Preferred Names
melanoma-associated antigen 8
Names
melanoma-associated antigen 8
MAGE-8 antigen
cancer/testis antigen 1.8
cancer/testis antigen family 1, member 8
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xq28

Summary This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

300341

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu12673 NM_001166400 Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu12673 NM_005364 Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu12673 NM_001166401 Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu12673D
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 08-FEB-2015
Organism Homo sapiens (human)
Product melanoma-associated antigen 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313943.1, AC244099.2, BC002455.2 and AA045817.1. Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BE729897.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001159872.1
CDS550..1506
Misc Feature(1)541..543(+)
Misc Feature(2)556..843(+)
Misc Feature(3)904..1416(+)
Exon (1)1..145
Gene:MAGEA8
Gene Synonym:
Exon (2)146..424
Gene:MAGEA8
Gene Synonym:
Exon (3)425..486
Gene:MAGEA8
Gene Synonym:
Exon (4)487..2112
Gene:MAGEA8
Gene Synonym:
Translation
Position Chain Variation Link
736 736 c, t dbSNP:202095571
763 763 c, t dbSNP:200126191
1230 1230 a, g dbSNP:5983916

Target ORF information:

RefSeq Version NM_001166400
Organism Homo sapiens (human)
Definition Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001166400

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu12673D
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product melanoma-associated antigen 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313943.1, BC002455.2 and AA045817.1. This sequence is a reference standard in the RefSeqGene project. On Oct 23, 2009 this sequence version replaced gi:29029628. Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK313943.1, BC002455.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_005355.2
CDS271..1227
Misc Feature(1)262..264(+)
Misc Feature(2)277..564(+)
Misc Feature(3)625..1137(+)
Exon (1)1..145
Gene:MAGEA8
Gene Synonym:
Exon (2)146..207
Gene:MAGEA8
Gene Synonym:
Exon (3)208..1833
Gene:MAGEA8
Gene Synonym:
Translation
Position Chain Variation Link
457 457 c, t dbSNP:202095571
484 484 c, t dbSNP:200126191
951 951 a, g dbSNP:5983916

Target ORF information:

RefSeq Version NM_005364
Organism Homo sapiens (human)
Definition Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_005364

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu12673D
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product melanoma-associated antigen 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313943.1, BI092675.1, BC002455.2 and AA045817.1. Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BI092675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001159873.1
CDS522..1478
Misc Feature(1)513..515(+)
Misc Feature(2)528..815(+)
Misc Feature(3)876..1388(+)
Exon (1)1..145
Gene:MAGEA8
Gene Synonym:
Exon (2)146..458
Gene:MAGEA8
Gene Synonym:
Exon (3)459..2084
Gene:MAGEA8
Gene Synonym:
Translation
Position Chain Variation Link
350 350 c, t dbSNP:41304954
708 708 c, t dbSNP:202095571
735 735 c, t dbSNP:200126191
1202 1202 a, g dbSNP:5983916

Target ORF information:

RefSeq Version NM_001166401
Organism Homo sapiens (human)
Definition Homo sapiens melanoma antigen family A8 (MAGEA8), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001166401

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGCTTCTTG GGCAGAAGAG TCAGCGCTAC AAGGCTGAGG AAGGCCTTCA GGCCCAAGGA 
GAGGCACCAG GGCTTATGGA TGTGCAGATT CCCACAGCTG AGGAGCAGAA GGCTGCATCC
TCCTCCTCTA CTCTGATCAT GGGAACCCTT GAGGAGGTGA CTGATTCTGG GTCACCAAGT
CCTCCCCAGA GTCCTGAGGG TGCCTCCTCT TCCCTGACTG TCACCGACAG CACTCTGTGG
AGCCAATCCG ATGAGGGTTC CAGCAGCAAT GAAGAGGAGG GGCCAAGCAC CTCCCCGGAC
CCAGCTCACC TGGAGTCCCT GTTCCGGGAA GCACTTGATG AGAAAGTGGC TGAGTTAGTT
CGTTTCCTGC TCCGCAAATA TCAAATTAAG GAGCCGGTCA CAAAGGCAGA AATGCTTGAG
AGTGTCATCA AAAATTACAA GAACCACTTT CCTGATATCT TCAGCAAAGC CTCTGAGTGC
ATGCAGGTGA TCTTTGGCAT TGATGTGAAG GAAGTGGACC CTGCCGGCCA CTCCTACATC
CTTGTCACCT GCCTGGGCCT CTCCTATGAT GGCCTGCTGG GTGATGATCA GAGTACGCCC
AAGACCGGCC TCCTGATAAT CGTCCTGGGC ATGATCTTAA TGGAGGGCAG CCGCGCCCCG
GAGGAGGCAA TCTGGGAAGC GTTGAGTGTG ATGGGGCTGT ATGATGGGAG GGAGCACAGT
GTCTATTGGA AGCTCAGGAA GCTGCTCACC CAAGAGTGGG TGCAGGAGAA CTACCTGGAG
TACCGCCAGG CGCCCGGCAG TGATCCTGTG CGCTACGAGT TCCTGTGGGG TCCAAGGGCC
CTTGCTGAAA CCAGCTATGT GAAAGTCCTG GAGCATGTGG TCAGGGTCAA TGCAAGAGTT
CGCATTTCCT ACCCATCCCT GCATGAAGAG GCTTTGGGAG AGGAGAAAGG AGTTTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.