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MAL mal, T-cell differentiation protein [Homo sapiens (human)]

Gene Symbol MAL
Entrez Gene ID 4118
Full Name mal, T-cell differentiation protein
Synonyms
General protein information
Preferred Names
myelin and lymphocyte protein
Names
myelin and lymphocyte protein
T-lymphocyte maturation-associated protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q11.1

Summary The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. lac of sum
Disorder MIM:

188860

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu15983 NM_002371 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu16029 NM_022438 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu15772 NM_022439 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu15962 NM_022440 Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu15983D
Sequence Information ORF Nucleotide Sequence (Length: 462bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76678.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408666. Summary: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. Transcript Variant: This variant (a) includes both alternatively spliced exons 2 and 3, resulting in the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000458.2, M15800.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCATT AA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_002362.1
CDS139..600
Misc Feature(1)94..96(+)
Misc Feature(2)193..573(+)
Misc Feature(3)211..276(+)
Misc Feature(4)298..363(+)
Misc Feature(5)415..480(+)
Misc Feature(6)514..579(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..399
Gene:MAL
Gene Synonym:
Exon (3)400..525
Gene:MAL
Gene Synonym:
Exon (4)526..1137
Gene:MAL
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:536693627
42 42 a, g dbSNP:553191134
69 69 a, g dbSNP:573317762
74 74 a, c dbSNP:545183243
89 89 a, g dbSNP:760450781
97 97 a, g dbSNP:558740167
105 105 c, t dbSNP:770786417
106 106 a, g dbSNP:775591411
108 108 a, c dbSNP:763188371
118 118 a, g dbSNP:200341801
124 124 a, c dbSNP:544504207
135 135 a, c dbSNP:761855577
140 140 a, t dbSNP:768067073
143 143 c, t dbSNP:377339355
145 145 c, g dbSNP:369944847
147 147 c, t dbSNP:199509227
152 152 c, t dbSNP:756474748
158 158 -, g dbSNP:750821753
159 159 a, g, t dbSNP:138435313
160 160 c, g dbSNP:764075737
161 161 g, t dbSNP:778409734
162 162 a, g dbSNP:373299589
163 163 a, g dbSNP:747719195
164 164 g, t dbSNP:757977215
171 171 a, c dbSNP:777861979
178 178 a, g dbSNP:763237159
180 180 a, t dbSNP:528873033
186 186 c, t dbSNP:770874447
189 189 g, t dbSNP:569573663
191 191 g, t dbSNP:776450028
197 197 c, t dbSNP:145146615
198 198 c, t dbSNP:768969496
201 201 c, t dbSNP:774420361
205 205 a, c dbSNP:143011599
215 215 -, tct dbSNP:758493164
234 234 c, t dbSNP:759806636
237 237 c, t dbSNP:765007780
238 238 a, c, g dbSNP:752335452
251 251 g, t dbSNP:777372192
252 252 g, t dbSNP:751581717
261 261 a, g dbSNP:561017528
268 268 g, t dbSNP:780966454
277 277 c, t dbSNP:745729561
280 280 c, t dbSNP:769467078
287 287 a, t dbSNP:141511881
298 298 c, t dbSNP:150858137
304 304 a, g dbSNP:772160362
309 309 c, t dbSNP:773233622
316 316 a, g dbSNP:760723204
321 321 c, g dbSNP:771527865
324 324 c, t dbSNP:368992625
327 327 c, t dbSNP:759950832
328 328 a, g dbSNP:746387184
335 335 c, g dbSNP:201902217
342 342 c, t dbSNP:772207139
346 346 a, g dbSNP:147657459
351 351 c, g dbSNP:149950864
357 357 c, t dbSNP:751162202
362 362 a, c, t dbSNP:756706491
364 364 c, g dbSNP:370567810
368 368 c, t dbSNP:534758572
372 372 c, t dbSNP:755950135
373 373 a, g dbSNP:145008901
376 376 a, g dbSNP:146710044
380 380 a, g dbSNP:772319664
387 387 c, t dbSNP:202002524
395 395 a, c dbSNP:747181152
396 396 c, t dbSNP:770848870
402 402 c, t dbSNP:749735071
403 403 a, g dbSNP:552937397
409 409 c, t dbSNP:140265685
415 415 g, t dbSNP:77106368
420 420 c, t dbSNP:761322906
421 421 a, g, t dbSNP:11553832
428 428 c, t dbSNP:137867670
430 430 c, t dbSNP:367581116
436 436 c, t dbSNP:766371823
437 437 a, g, t dbSNP:753710631
438 438 c, t dbSNP:764966929
439 439 a, g dbSNP:113895068
441 441 c, t dbSNP:751842663
442 442 a, g dbSNP:577290749
459 459 c, g, t dbSNP:200135924
462 462 a, g dbSNP:756256436
463 463 a, g dbSNP:780706526
473 473 c, t dbSNP:749751444
474 474 a, g dbSNP:769164854
483 483 c, t dbSNP:779106964
489 489 c, t dbSNP:748513184
492 492 c, g dbSNP:138931615
498 498 c, g dbSNP:772914357
504 504 c, t dbSNP:760185446
515 515 c, t dbSNP:770370071
518 518 c, t dbSNP:776572875
519 519 c, t dbSNP:201691542
522 522 c, t dbSNP:149416032
526 526 a, c, g dbSNP:139989847
528 528 a, g dbSNP:147251990
530 530 c, t dbSNP:778160897
539 539 c, t dbSNP:747348029
542 542 a, c dbSNP:756956650
554 554 a, g dbSNP:61734216
555 555 c, t dbSNP:780812100
556 556 a, g dbSNP:745452422
562 562 a, c dbSNP:769278316
566 566 a, c, t dbSNP:775300945
567 567 a, c, g dbSNP:116607248
568 568 a, g dbSNP:761679063
570 570 a, g dbSNP:139621459
575 575 c, g dbSNP:776987437
577 577 c, t dbSNP:759549552
585 585 a, g dbSNP:765314357
587 587 g, t dbSNP:753178087
593 593 a, c dbSNP:758986088
602 602 c, g dbSNP:139187744
604 604 c, t dbSNP:751983118
605 605 a, g dbSNP:757617050
606 606 a, c dbSNP:557914281
636 636 -, gtta dbSNP:757245847
645 645 a, g dbSNP:200487878
647 647 a, c, t dbSNP:543658210
648 648 a, g dbSNP:141636399
658 658 c, g dbSNP:775612192
674 674 a, g dbSNP:147090133
681 681 a, g dbSNP:542967198
686 686 a, g dbSNP:531451060
715 715 -, c dbSNP:71382807
719 719 c, g dbSNP:559480799
721 721 a, c, g dbSNP:374545322
722 722 c, g dbSNP:565073649
731 731 a, c dbSNP:530978762
740 740 a, g dbSNP:75051637
741 741 a, g dbSNP:79066966
748 748 c, t dbSNP:768306808
774 774 c, t dbSNP:550895681
792 792 c, t dbSNP:776366175
795 795 c, t dbSNP:192956297
797 797 a, g dbSNP:535146147
826 826 a, g dbSNP:547317053
845 845 a, g dbSNP:750397935
847 847 a, g dbSNP:565517368
863 863 a, t dbSNP:534637718
903 903 c, t dbSNP:557853207
939 939 a, c dbSNP:184779179
946 946 a, g dbSNP:774566595
976 976 a, t dbSNP:759985617
982 982 a, g dbSNP:2033
991 991 a, g dbSNP:537197712
1005 1005 a, g dbSNP:547668149
1064 1064 a, g dbSNP:138440190
1071 1071 c, t dbSNP:573823349
1103 1103 a, c dbSNP:41310787
1135 1135 c, g dbSNP:753402592

Target ORF information:

RefSeq Version NM_002371
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant a, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_002371

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGACGCAGCC TACCACTGCA CCGCTGCCCT CTTTTACCTC
AGCGCCTCAG TCCTGGAGGC CCTGGCCACC ATCACGATGC AAGACGGCTT CACCTACAGG
CACTACCATG AAAACATTGC TGCCGTGGTG TTCTCCTACA TAGCCACTCT GCTCTACGTG
GTCCATGCGG TGTTCTCTTT AATCAGATGG AAGTCTTCATT AA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu16029D
Sequence Information ORF Nucleotide Sequence (Length: 336bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76679.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408660. Summary: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. Transcript Variant: This variant (b) includes alternatively spliced exon 2 but is missing exon 3, resulting in isoform b which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76679.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670, SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_071883.1
CDS139..474
Misc Feature(1)94..96(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..399
Gene:MAL
Gene Synonym:
Exon (3)400..1011
Gene:MAL
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:536693627
42 42 a, g dbSNP:553191134
69 69 a, g dbSNP:573317762
74 74 a, c dbSNP:545183243
89 89 a, g dbSNP:760450781
97 97 a, g dbSNP:558740167
105 105 c, t dbSNP:770786417
106 106 a, g dbSNP:775591411
108 108 a, c dbSNP:763188371
118 118 a, g dbSNP:200341801
124 124 a, c dbSNP:544504207
135 135 a, c dbSNP:761855577
140 140 a, t dbSNP:768067073
143 143 c, t dbSNP:377339355
145 145 c, g dbSNP:369944847
147 147 c, t dbSNP:199509227
152 152 c, t dbSNP:756474748
158 158 -, g dbSNP:750821753
159 159 a, g, t dbSNP:138435313
160 160 c, g dbSNP:764075737
161 161 g, t dbSNP:778409734
162 162 a, g dbSNP:373299589
163 163 a, g dbSNP:747719195
164 164 g, t dbSNP:757977215
171 171 a, c dbSNP:777861979
178 178 a, g dbSNP:763237159
180 180 a, t dbSNP:528873033
186 186 c, t dbSNP:770874447
189 189 g, t dbSNP:569573663
191 191 g, t dbSNP:776450028
197 197 c, t dbSNP:145146615
198 198 c, t dbSNP:768969496
201 201 c, t dbSNP:774420361
205 205 a, c dbSNP:143011599
215 215 -, tct dbSNP:758493164
234 234 c, t dbSNP:759806636
237 237 c, t dbSNP:765007780
238 238 a, c, g dbSNP:752335452
251 251 g, t dbSNP:777372192
252 252 g, t dbSNP:751581717
261 261 a, g dbSNP:561017528
268 268 g, t dbSNP:780966454
277 277 c, t dbSNP:745729561
280 280 c, t dbSNP:769467078
287 287 a, t dbSNP:141511881
298 298 c, t dbSNP:150858137
304 304 a, g dbSNP:772160362
309 309 c, t dbSNP:773233622
316 316 a, g dbSNP:760723204
321 321 c, g dbSNP:771527865
324 324 c, t dbSNP:368992625
327 327 c, t dbSNP:759950832
328 328 a, g dbSNP:746387184
335 335 c, g dbSNP:201902217
342 342 c, t dbSNP:772207139
346 346 a, g dbSNP:147657459
351 351 c, g dbSNP:149950864
357 357 c, t dbSNP:751162202
362 362 a, c, t dbSNP:756706491
364 364 c, g dbSNP:370567810
368 368 c, t dbSNP:534758572
372 372 c, t dbSNP:755950135
373 373 a, g dbSNP:145008901
376 376 a, g dbSNP:146710044
380 380 a, g dbSNP:772319664
387 387 c, t dbSNP:202002524
395 395 a, c dbSNP:747181152
396 396 c, t dbSNP:770848870
400 400 a, c, g dbSNP:139989847
402 402 a, g dbSNP:147251990
404 404 c, t dbSNP:778160897
413 413 c, t dbSNP:747348029
416 416 a, c dbSNP:756956650
428 428 a, g dbSNP:61734216
429 429 c, t dbSNP:780812100
430 430 a, g dbSNP:745452422
436 436 a, c dbSNP:769278316
440 440 a, c, t dbSNP:775300945
441 441 a, c, g dbSNP:116607248
442 442 a, g dbSNP:761679063
444 444 a, g dbSNP:139621459
449 449 c, g dbSNP:776987437
451 451 c, t dbSNP:759549552
459 459 a, g dbSNP:765314357
461 461 g, t dbSNP:753178087
467 467 a, c dbSNP:758986088
476 476 c, g dbSNP:139187744
478 478 c, t dbSNP:751983118
479 479 a, g dbSNP:757617050
480 480 a, c dbSNP:557914281
510 510 -, gtta dbSNP:757245847
519 519 a, g dbSNP:200487878
521 521 a, c, t dbSNP:543658210
522 522 a, g dbSNP:141636399
532 532 c, g dbSNP:775612192
548 548 a, g dbSNP:147090133
555 555 a, g dbSNP:542967198
560 560 a, g dbSNP:531451060
589 589 -, c dbSNP:71382807
593 593 c, g dbSNP:559480799
595 595 a, c, g dbSNP:374545322
596 596 c, g dbSNP:565073649
605 605 a, c dbSNP:530978762
614 614 a, g dbSNP:75051637
615 615 a, g dbSNP:79066966
622 622 c, t dbSNP:768306808
648 648 c, t dbSNP:550895681
666 666 c, t dbSNP:776366175
669 669 c, t dbSNP:192956297
671 671 a, g dbSNP:535146147
700 700 a, g dbSNP:547317053
719 719 a, g dbSNP:750397935
721 721 a, g dbSNP:565517368
737 737 a, t dbSNP:534637718
777 777 c, t dbSNP:557853207
813 813 a, c dbSNP:184779179
820 820 a, g dbSNP:774566595
850 850 a, t dbSNP:759985617
856 856 a, g dbSNP:2033
865 865 a, g dbSNP:537197712
879 879 a, g dbSNP:547668149
938 938 a, g dbSNP:138440190
945 945 c, t dbSNP:573823349
977 977 a, c dbSNP:41310787
1009 1009 c, g dbSNP:753402592

Target ORF information:

RefSeq Version NM_022438
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant b, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022438

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTATCTTCG GGGGCCTGGT GTGGATCCTG
GTGGCCTCCT CCCTGGTGCC CTGGCCCCTG GTCCAGGGCT GGGTGATGTT CGTGTCTGTG
TTCTGCTTCG TGGCCACCAC CACCTTGATC ATCCTGTACA TAATTGGAGC CCACGGTGGA
GAGACTTCCT GGGTCACCTT GGTGTTCTCC TACATAGCCA CTCTGCTCTA CGTGGTCCAT
GCGGTGTTCT CTTTAATCAG ATGGAAGTCT TCATAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu15772D
Sequence Information ORF Nucleotide Sequence (Length: 294bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76680.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408662. Summary: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. Transcript Variant: This variant (c) is missing alternatively spliced exon 2 but includes exon 3, resulting in isoform c which is shorter than the predominant isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX457478.2, X76680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_071884.1
CDS139..432
Misc Feature(1)94..96(+)
Misc Feature(2)229..405(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..357
Gene:MAL
Gene Synonym:
Exon (3)358..969
Gene:MAL
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:536693627
42 42 a, g dbSNP:553191134
69 69 a, g dbSNP:573317762
74 74 a, c dbSNP:545183243
89 89 a, g dbSNP:760450781
97 97 a, g dbSNP:558740167
105 105 c, t dbSNP:770786417
106 106 a, g dbSNP:775591411
108 108 a, c dbSNP:763188371
118 118 a, g dbSNP:200341801
124 124 a, c dbSNP:544504207
135 135 a, c dbSNP:761855577
140 140 a, t dbSNP:768067073
143 143 c, t dbSNP:377339355
145 145 c, g dbSNP:369944847
147 147 c, t dbSNP:199509227
152 152 c, t dbSNP:756474748
158 158 -, g dbSNP:750821753
159 159 a, g, t dbSNP:138435313
160 160 c, g dbSNP:764075737
161 161 g, t dbSNP:778409734
162 162 a, g dbSNP:373299589
163 163 a, g dbSNP:747719195
164 164 g, t dbSNP:757977215
171 171 a, c dbSNP:777861979
178 178 a, g dbSNP:763237159
180 180 a, t dbSNP:528873033
186 186 c, t dbSNP:770874447
189 189 g, t dbSNP:569573663
191 191 g, t dbSNP:776450028
197 197 c, t dbSNP:145146615
198 198 c, t dbSNP:768969496
201 201 c, t dbSNP:774420361
205 205 a, c dbSNP:143011599
215 215 -, tct dbSNP:758493164
234 234 c, t dbSNP:749735071
235 235 a, g dbSNP:552937397
241 241 c, t dbSNP:140265685
247 247 g, t dbSNP:77106368
252 252 c, t dbSNP:761322906
253 253 a, g, t dbSNP:11553832
260 260 c, t dbSNP:137867670
262 262 c, t dbSNP:367581116
268 268 c, t dbSNP:766371823
269 269 a, g, t dbSNP:753710631
270 270 c, t dbSNP:764966929
271 271 a, g dbSNP:113895068
273 273 c, t dbSNP:751842663
274 274 a, g dbSNP:577290749
291 291 c, g, t dbSNP:200135924
294 294 a, g dbSNP:756256436
295 295 a, g dbSNP:780706526
305 305 c, t dbSNP:749751444
306 306 a, g dbSNP:769164854
315 315 c, t dbSNP:779106964
321 321 c, t dbSNP:748513184
324 324 c, g dbSNP:138931615
330 330 c, g dbSNP:772914357
336 336 c, t dbSNP:760185446
347 347 c, t dbSNP:770370071
350 350 c, t dbSNP:776572875
351 351 c, t dbSNP:201691542
354 354 c, t dbSNP:149416032
358 358 a, c, g dbSNP:139989847
360 360 a, g dbSNP:147251990
362 362 c, t dbSNP:778160897
371 371 c, t dbSNP:747348029
374 374 a, c dbSNP:756956650
386 386 a, g dbSNP:61734216
387 387 c, t dbSNP:780812100
388 388 a, g dbSNP:745452422
394 394 a, c dbSNP:769278316
398 398 a, c, t dbSNP:775300945
399 399 a, c, g dbSNP:116607248
400 400 a, g dbSNP:761679063
402 402 a, g dbSNP:139621459
407 407 c, g dbSNP:776987437
409 409 c, t dbSNP:759549552
417 417 a, g dbSNP:765314357
419 419 g, t dbSNP:753178087
425 425 a, c dbSNP:758986088
434 434 c, g dbSNP:139187744
436 436 c, t dbSNP:751983118
437 437 a, g dbSNP:757617050
438 438 a, c dbSNP:557914281
468 468 -, gtta dbSNP:757245847
477 477 a, g dbSNP:200487878
479 479 a, c, t dbSNP:543658210
480 480 a, g dbSNP:141636399
490 490 c, g dbSNP:775612192
506 506 a, g dbSNP:147090133
513 513 a, g dbSNP:542967198
518 518 a, g dbSNP:531451060
547 547 -, c dbSNP:71382807
551 551 c, g dbSNP:559480799
553 553 a, c, g dbSNP:374545322
554 554 c, g dbSNP:565073649
563 563 a, c dbSNP:530978762
572 572 a, g dbSNP:75051637
573 573 a, g dbSNP:79066966
580 580 c, t dbSNP:768306808
606 606 c, t dbSNP:550895681
624 624 c, t dbSNP:776366175
627 627 c, t dbSNP:192956297
629 629 a, g dbSNP:535146147
658 658 a, g dbSNP:547317053
677 677 a, g dbSNP:750397935
679 679 a, g dbSNP:565517368
695 695 a, t dbSNP:534637718
735 735 c, t dbSNP:557853207
771 771 a, c dbSNP:184779179
778 778 a, g dbSNP:774566595
808 808 a, t dbSNP:759985617
814 814 a, g dbSNP:2033
823 823 a, g dbSNP:537197712
837 837 a, g dbSNP:547668149
896 896 a, g dbSNP:138440190
903 903 c, t dbSNP:573823349
935 935 a, c dbSNP:41310787
967 967 c, g dbSNP:753402592

Target ORF information:

RefSeq Version NM_022439
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant c, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022439

ORF Insert Sequence:

1
61
121
181
241
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGACGCAG CCTACCACTG CACCGCTGCC
CTCTTTTACC TCAGCGCCTC AGTCCTGGAG GCCCTGGCCA CCATCACGAT GCAAGACGGC
TTCACCTACA GGCACTACCA TGAAAACATT GCTGCCGTGG TGTTCTCCTA CATAGCCACT
CTGCTCTACG TGGTCCATGC GGTGTTCTCT TTAATCAGAT GGAAGTCTTC ATAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu15962D
Sequence Information ORF Nucleotide Sequence (Length: 168bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myelin and lymphocyte protein isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DT215613.1, X76681.1 and BC000458.2. On May 9, 2012 this sequence version replaced gi:12408664. Summary: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]. Transcript Variant: This variant (d) is missing alternatively spliced exons 2 and 3, resulting in the shortest isoform (d). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X76681.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147975, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_071885.1
CDS139..306
Misc Feature(1)94..96(+)
Exon (1)1..231
Gene:MAL
Gene Synonym:
Exon (2)232..843
Gene:MAL
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:536693627
42 42 a, g dbSNP:553191134
69 69 a, g dbSNP:573317762
74 74 a, c dbSNP:545183243
89 89 a, g dbSNP:760450781
97 97 a, g dbSNP:558740167
105 105 c, t dbSNP:770786417
106 106 a, g dbSNP:775591411
108 108 a, c dbSNP:763188371
118 118 a, g dbSNP:200341801
124 124 a, c dbSNP:544504207
135 135 a, c dbSNP:761855577
140 140 a, t dbSNP:768067073
143 143 c, t dbSNP:377339355
145 145 c, g dbSNP:369944847
147 147 c, t dbSNP:199509227
152 152 c, t dbSNP:756474748
158 158 -, g dbSNP:750821753
159 159 a, g, t dbSNP:138435313
160 160 c, g dbSNP:764075737
161 161 g, t dbSNP:778409734
162 162 a, g dbSNP:373299589
163 163 a, g dbSNP:747719195
164 164 g, t dbSNP:757977215
171 171 a, c dbSNP:777861979
178 178 a, g dbSNP:763237159
180 180 a, t dbSNP:528873033
186 186 c, t dbSNP:770874447
189 189 g, t dbSNP:569573663
191 191 g, t dbSNP:776450028
197 197 c, t dbSNP:145146615
198 198 c, t dbSNP:768969496
201 201 c, t dbSNP:774420361
205 205 a, c dbSNP:143011599
215 215 -, tct dbSNP:758493164
232 232 a, c, g dbSNP:139989847
234 234 a, g dbSNP:147251990
236 236 c, t dbSNP:778160897
245 245 c, t dbSNP:747348029
248 248 a, c dbSNP:756956650
260 260 a, g dbSNP:61734216
261 261 c, t dbSNP:780812100
262 262 a, g dbSNP:745452422
268 268 a, c dbSNP:769278316
272 272 a, c, t dbSNP:775300945
273 273 a, c, g dbSNP:116607248
274 274 a, g dbSNP:761679063
276 276 a, g dbSNP:139621459
281 281 c, g dbSNP:776987437
283 283 c, t dbSNP:759549552
291 291 a, g dbSNP:765314357
293 293 g, t dbSNP:753178087
299 299 a, c dbSNP:758986088
308 308 c, g dbSNP:139187744
310 310 c, t dbSNP:751983118
311 311 a, g dbSNP:757617050
312 312 a, c dbSNP:557914281
342 342 -, gtta dbSNP:757245847
351 351 a, g dbSNP:200487878
353 353 a, c, t dbSNP:543658210
354 354 a, g dbSNP:141636399
364 364 c, g dbSNP:775612192
380 380 a, g dbSNP:147090133
387 387 a, g dbSNP:542967198
392 392 a, g dbSNP:531451060
421 421 -, c dbSNP:71382807
425 425 c, g dbSNP:559480799
427 427 a, c, g dbSNP:374545322
428 428 c, g dbSNP:565073649
437 437 a, c dbSNP:530978762
446 446 a, g dbSNP:75051637
447 447 a, g dbSNP:79066966
454 454 c, t dbSNP:768306808
480 480 c, t dbSNP:550895681
498 498 c, t dbSNP:776366175
501 501 c, t dbSNP:192956297
503 503 a, g dbSNP:535146147
532 532 a, g dbSNP:547317053
551 551 a, g dbSNP:750397935
553 553 a, g dbSNP:565517368
569 569 a, t dbSNP:534637718
609 609 c, t dbSNP:557853207
645 645 a, c dbSNP:184779179
652 652 a, g dbSNP:774566595
682 682 a, t dbSNP:759985617
688 688 a, g dbSNP:2033
697 697 a, g dbSNP:537197712
711 711 a, g dbSNP:547668149
770 770 a, g dbSNP:138440190
777 777 c, t dbSNP:573823349
809 809 a, c dbSNP:41310787
841 841 c, g dbSNP:753402592

Target ORF information:

RefSeq Version NM_022440
Organism Homo sapiens (human)
Definition Homo sapiens mal, T-cell differentiation protein (MAL), transcript variant d, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_022440

ORF Insert Sequence:

1
61
121
ATGGCCCCCG CAGCGGCGAC GGGGGGCAGC ACCCTGCCCA GTGGCTTCTC GGTCTTCACC 
ACCTTGCCCG ACTTGCTCTT CATCTTTGAG TTTGTGTTCT CCTACATAGC CACTCTGCTC
TACGTGGTCC ATGCGGTGTT CTCTTTAATC AGATGGAAGT CTTCATAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.