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Home » Species Summary » Homo sapiens » CXCL9 cDNA ORF clone
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CXCL9 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CXCL9
Entrez Gene ID 4283
Full Name chemokine (C-X-C motif) ligand 9
Synonyms CMK, Humig, MIG, SCYB9, crg-10
General protein information
Preferred Names
C-X-C motif chemokine 9
Names
C-X-C motif chemokine 9
small-inducible cytokine B9
gamma-interferon-induced monokine
monokine induced by gamma interferon
monokine induced by interferon-gamma
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

601704

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_002416 NP_002407 C-X-C motif chemokine 9 precursor

KEGG
hsa04060 Cytokine-cytokine receptor interaction
hsa04620 Toll-like receptor signaling pathway
hsa04062 Chemokine signaling pathway
Reactome
R-HSA-162582 Signal Transduction
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signaling
R-HSA-418594 G alpha (i) signalling events
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-375276 Peptide ligand-binding receptors
Pathway Interaction Database
cxcr3pathway CXCR3-mediated signaling events
il23pathway IL23-mediated signaling events
WikiPathways
WP75 Toll-like receptor signaling pathway
WP619 Type II interferon signaling (IFNG)
WP1449 Regulation of toll-like receptor signaling pathway


Homo sapiens (human) CXCL9 NP_002407.1
Pan troglodytes (chimpanzee) CXCL9 XP_526582.1
Macaca mulatta (Rhesus monkey) CXCL9 NP_001028108.1
Bos taurus (cattle) CXCL9 NP_001106643.1

Component

ID Name Evidence
GO:0005576 extracellular region EXP
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IEA
GO:0009897 external side of plasma membrane IEA

Function

ID Name Evidence
GO:0005125 cytokine activity TAS
GO:0008009 chemokine activity IEA

Process

ID Name Evidence
GO:0006935 chemotaxis TAS
GO:0006952 defense response TAS
GO:0006954 inflammatory response IEA
GO:0006955 immune response IEA
GO:0006968 cellular defense response TAS
GO:0007165 signal transduction TAS
GO:0007186 G-protein coupled receptor protein signaling pathway TAS
GO:0007267 cell-cell signaling TAS

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CXCL9 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXCL9 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26807
NM_002416 Homo sapiens chemokine (C-X-C motif) ligand 9 (CXCL9), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu26807
Accession Version NM_002416.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 378bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-X-C motif chemokine 9 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB141449.1, X72755.1 and BC042178.1. On Oct 1, 2014 this sequence version replaced gi:4505186. Summary: This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC042178.1, BC063122.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGAAGAAAA GTGGTGTTCT TTTCCTCTTG GGCATCATCT TGCTGGTTCT GATTGGAGTG 
CAAGGAACCC CAGTAGTGAG AAAGGGTCGC TGTTCCTGCA TCAGCACCAA CCAAGGGACT
ATCCACCTAC AATCCTTGAA AGACCTTAAA CAATTTGCCC CAAGCCCTTC CTGCGAGAAA
ATTGAAATCA TTGCTACACT GAAGAATGGA GTTCAAACAT GTCTAAACCC AGATTCAGCA
GATGTGAAGG AACTGATTAA AAAGTGGGAG AAACAGGTCA GCCAAAAGAA AAAGCAAAAG
AATGGGAAAA AACATCAAAA AAAGAAAGTT CTGAAAGTTC GAAAATCTCA ACGTTCTCGT
CAAAAGAAGA CTACATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_002407.1
CDS75..452
Misc Feature(1)144..146(+)
Misc Feature(2)156..344(+)
Misc Feature(3)156..326(+)
Misc Feature(4)156..164(+)
Misc Feature(5)159..344(+)
Misc Feature(6)159..290(+)
Misc Feature(7)162..173(+)
Misc Feature(8)168..212(+)
Misc Feature(9)174..293(+)
Misc Feature(10)198..338(+)
Misc Feature(11)204..290(+)
Misc Feature(12)210..344(+)
Misc Feature(13)237..245(+)
Misc Feature(14)237..245(+)
Misc Feature(15)276..284(+)
Exon (1)1..138
Gene:CXCL9
Gene Synonym:
Exon (2)139..265
Gene:CXCL9
Gene Synonym:
Exon (3)266..350
Gene:CXCL9
Gene Synonym:
Exon (4)351..2708
Gene:CXCL9
Gene Synonym:
Translation
Position Chain Variation Link
6 6 a, g dbSNP:371607962
34 34 a, g dbSNP:758004149
57 57 g, t dbSNP:753097276
58 58 a, t dbSNP:765556357
60 60 c, g dbSNP:755486724
63 63 -, c dbSNP:747909938
67 67 c, g dbSNP:754344963
70 70 c, t dbSNP:767022882
73 73 -, c dbSNP:780860302
75 75 a, g dbSNP:536469764
82 82 a, g dbSNP:529239167
112 112 a, t dbSNP:767765394
115 115 c, t dbSNP:762009700
117 117 a, c dbSNP:775325063
119 119 g, t dbSNP:769528250
120 120 a, c, g dbSNP:776514039
136 136 a, g dbSNP:770862403
142 142 a, c dbSNP:747019343
146 146 a, c dbSNP:140548865
148 148 c, t dbSNP:771431360
150 150 g, t dbSNP:747721834
154 154 c, g dbSNP:778361046
160 160 a, g, t dbSNP:749657288
162 162 c, t dbSNP:780630877
163 163 a, g dbSNP:772025698
166 166 a, g dbSNP:750941174
170 170 -, c dbSNP:751701970
173 173 c, t dbSNP:377485242
176 176 c, t dbSNP:542705344
181 181 a, c dbSNP:757244544
183 183 a, g dbSNP:751666778
189 189 a, g dbSNP:375701976
193 193 c, g dbSNP:145442311
197 197 c, t dbSNP:753629888
200 200 c, t dbSNP:766206461
201 201 c, g dbSNP:760481907
203 203 a, g dbSNP:111816429
205 205 a, t dbSNP:762679625
206 206 a, g dbSNP:772980982
208 208 c, t dbSNP:370953150
225 225 c, t dbSNP:761169708
228 228 g, t dbSNP:773967412
232 232 c, t dbSNP:768419249
233 233 c, t dbSNP:79440907
235 235 -, c dbSNP:766638255
238 238 c, g dbSNP:780544856
239 239 c, g dbSNP:770234658
242 242 a, t dbSNP:746277278
263 263 a, c dbSNP:143141978
265 265 c, t dbSNP:781486748
269 269 c, t dbSNP:773702858
286 286 g, t dbSNP:569336277
292 292 c, t dbSNP:762574216
310 310 c, g, t dbSNP:769576198
313 313 a, c dbSNP:746164300
314 314 a, g dbSNP:781665039
317 317 c, t dbSNP:551057545
363 363 a, g dbSNP:773638666
365 365 a, g dbSNP:751580551
367 367 -, a dbSNP:761138595
377 377 g, t dbSNP:556754372
388 388 a, g dbSNP:779030631
395 395 -, aaa dbSNP:773850350
397 397 -, a dbSNP:770761582
399 399 a, c dbSNP:755124039
402 402 a, g dbSNP:764804734
403 403 c, t dbSNP:749573598
412 412 c, t dbSNP:780162229
414 414 c, t dbSNP:757038649
415 415 a, g dbSNP:139830877
425 425 a, g dbSNP:78048652
427 427 a, g dbSNP:764068063
430 430 a, c dbSNP:758470330
433 433 a, g dbSNP:752253991
447 447 a, g dbSNP:61750813
449 449 a, g dbSNP:138184008
451 451 -, aa dbSNP:762544016
454 454 a, g dbSNP:776303850
465 465 c, t dbSNP:765948753
468 468 a, g dbSNP:760968600
481 481 a, g dbSNP:773622239
495 495 a, c, g dbSNP:762346520
500 500 a, g dbSNP:374288711
503 503 c, t dbSNP:768732548
506 506 a, g dbSNP:527924058
509 509 a, g dbSNP:557305539
535 535 a, c dbSNP:539064382
546 546 c, g dbSNP:115116604
559 559 a, t dbSNP:192154610
625 625 a, g dbSNP:535584232
628 628 a, g dbSNP:146434302
632 632 a, g dbSNP:10031051
676 676 a, c dbSNP:531591067
678 678 a, c dbSNP:373509194
689 689 a, g dbSNP:531719839
693 693 g, t dbSNP:116751816
703 703 ca, tg dbSNP:386676191
703 703 c, t dbSNP:543086705
704 704 a, g dbSNP:530913249
711 711 c, t dbSNP:771361822
760 760 a, c dbSNP:548380357
795 795 c, t dbSNP:41490646
819 819 c, t dbSNP:562891129
820 820 g, t dbSNP:189193108
833 833 a, g dbSNP:777268431
864 864 a, g dbSNP:563801628
865 865 g, t dbSNP:769433114
897 897 c, t dbSNP:116345824
919 919 c, t dbSNP:185541502
928 928 c, g dbSNP:540554894
984 984 c, t dbSNP:545507719
1001 1001 a, c dbSNP:193117940
1004 1004 a, t dbSNP:747857421
1007 1007 a, c dbSNP:535163984
1064 1064 g, t dbSNP:750042117
1069 1069 a, g dbSNP:143824398
1081 1081 c, t dbSNP:111956854
1106 1106 g, t dbSNP:754846025
1116 1116 a, t dbSNP:538022410
1118 1118 g, t dbSNP:187688326
1166 1166 a, g dbSNP:182603102
1167 1167 c, t dbSNP:534134388
1170 1170 a, g dbSNP:566710095
1177 1177 a, t dbSNP:751345620
1205 1205 c, t dbSNP:3733236
1237 1237 a, g dbSNP:369577234
1335 1335 c, t dbSNP:758286042
1360 1360 c, t dbSNP:143711436
1400 1400 g, t dbSNP:369441150
1404 1404 a, c dbSNP:550697087
1405 1405 c, t dbSNP:532549301
1555 1555 c, t dbSNP:565188736
1671 1671 c, t dbSNP:540515956
1719 1719 c, t dbSNP:546265910
1720 1720 a, g dbSNP:74454210
1735 1735 c, t dbSNP:148944642
1736 1736 a, g dbSNP:760955174
1756 1756 a, t dbSNP:541833050
1774 1774 c, t dbSNP:753005874
1833 1833 c, t dbSNP:574382075
1838 1838 a, t dbSNP:767663473
1852 1852 c, t dbSNP:759893960
1853 1853 c, t dbSNP:572210393
1857 1857 c, t dbSNP:41484052
1921 1921 a, g dbSNP:537986420
1923 1923 a, g dbSNP:577102023
1954 1954 c, t dbSNP:558792192
1964 1964 c, t dbSNP:774593017
1969 1969 a, g dbSNP:771401249
1989 1989 c, g dbSNP:191438271
2036 2036 c, t dbSNP:41462147
2051 2051 c, t dbSNP:41527544
2085 2085 c, t dbSNP:548256548
2113 2113 a, g dbSNP:776000188
2116 2116 c, t dbSNP:372283651
2140 2140 a, g dbSNP:772696818
2156 2156 a, g dbSNP:41469350
2166 2166 a, g dbSNP:377181515
2187 2187 c, g dbSNP:190434490
2215 2215 c, t dbSNP:10336
2243 2243 c, t dbSNP:41457447
2247 2247 c, t dbSNP:371926690
2248 2248 a, g dbSNP:112123906
2258 2258 c, t dbSNP:528753543
2267 2267 c, t dbSNP:747769252
2275 2275 a, c dbSNP:145094605
2281 2281 a, g dbSNP:542977945
2363 2363 c, t dbSNP:183941374
2376 2376 a, g dbSNP:34488931
2386 2386 c, t dbSNP:35324603
2437 2437 a, c dbSNP:571211225
2444 2444 c, t dbSNP:10337
2454 2454 c, t dbSNP:1050176
2480 2480 a, g dbSNP:572277376
2520 2520 -, taatttgaaa dbSNP:368071695
2526 2526 a, t dbSNP:772388746
2536 2536 c, t dbSNP:540436109
2560 2560 a, g dbSNP:35934571
2570 2570 a, c dbSNP:555276509
2636 2636 a, g dbSNP:758339704
2663 2663 a, t dbSNP:528689910
2683 2683 -, a dbSNP:748724670

Target ORF information:

RefSeq Version NM_002416
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-X-C motif) ligand 9 (CXCL9), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002416

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGAAGAAAA GTGGTGTTCT TTTCCTCTTG GGCATCATCT TGCTGGTTCT GATTGGAGTG 
CAAGGAACCC CAGTAGTGAG AAAGGGTCGC TGTTCCTGCA TCAGCACCAA CCAAGGGACT
ATCCACCTAC AATCCTTGAA AGACCTTAAA CAATTTGCCC CAAGCCCTTC CTGCGAGAAA
ATTGAAATCA TTGCTACACT GAAGAATGGA GTTCAAACAT GTCTAAACCC AGATTCAGCA
GATGTGAAGG AACTGATTAA AAAGTGGGAG AAACAGGTCA GCCAAAAGAA AAAGCAAAAG
AATGGGAAAA AACATCAAAA AAAGAAAGTT CTGAAAGTTC GAAAATCTCA ACGTTCTCGT
CAAAAGAAGA CTACATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Higher levels of circulating CXCL-9 and CXCL-11 in euthyroid women with autoimmune thyroiditis and recurrent spontaneous abortions
Gynecol. Endocrinol. 30 (2), 157-160 (2014)
Aktas A, Berberoglu Z, Fidan Y, Yazici AC, Koc G, Aral Y, Ademoglu E, Bekdemir H and Alphan Z.


book

Plasma CXCL9 elevations correlate with chronic GVHD diagnosis
Blood 123 (5), 786-793 (2014)
Kitko CL, Levine JE, Storer BE, Chai X, Fox DA, Braun TM, Couriel DR, Martin PJ, Flowers ME, Hansen JA, Chang L, Conlon M, Fiema BJ, Morgan R, Pongtornpipat P, Lamiman K, Ferrara JL, Lee SJ and Paczesny S.


book

CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 are variably expressed in patients with sickle cell disease and carriers: are they predictive tools for disease complications?
Clin. Lab. 60 (1), 99-104 (2014)
Ostadebrahimi H, Jamali Z, Nazari M, Bahri M, Farahmandnia Z, Khandany BK, Taheri M, Khorramdelazad H, Hakimizadeh E, Zaker F, Rezaeian M and Hassanshahi G.


book

Serum CXCL9 levels are associated with tumor progression and treatment outcome in patients with nasopharyngeal carcinoma
PLoS ONE 8 (11), E80052 (2013)
Hsin LJ, Kao HK, Chen IH, Tsang NM, Hsu CL, Liu SC, Chang YS and Chang KP.


book

CXCL9 associated with sustained virological response in chronic hepatitis B patients receiving peginterferon alfa-2a therapy: a pilot study
PLoS ONE 8 (10), E76798 (2013)
Lee IC, Huang YH, Su CW, Wang YJ, Huo TI, Lee KC and Lin HC.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Human Mig chemokine: biochemical and functional characterization
J. Exp. Med. 182 (5), 1301-1314 (1995)
Liao F, Rabin RL, Yannelli JR, Koniaris LG, Vanguri P and Farber JM.


book

HuMig: a new human member of the chemokine family of cytokines
Biochem. Biophys. Res. Commun. 192 (1), 223-230 (1993)
Farber JM.


book

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines
Proc. Natl. Acad. Sci. U.S.A. 87 (14), 5238-5242 (1990)
Farber JM.


book

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
J. Biol. Chem. 263 (14), 6656-6664 (1988)
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M and Kaziro Y.


 
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