||ORF Nucleotide Sequence (Length: 1416bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||collagenase 3 preproprotein
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK292211.1, AK222748.1,
X75308.1 and CA413743.1.
This sequence is a reference standard in the RefSeqGene project.
On May 13, 2010 this sequence version replaced gi:13027796.
Summary: Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The protein encoded by this gene
cleaves type II collagen more efficiently than types I and III. It
may be involved in articular cartilage turnover and cartilage
pathophysiology associated with osteoarthritis. The gene is part of
a cluster of MMP genes which localize to chromosome 11q22.3.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK222748.1, X75308.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.