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MMP13 matrix metallopeptidase 13 [Homo sapiens (human)]

Gene Symbol MMP13
Entrez Gene ID 4322
Full Name matrix metallopeptidase 13
Synonyms CLG3, MANDP1, MMP-13
General protein information
Preferred Names
collagenase 3
Names
collagenase 3
MMP-13
matrix metalloproteinase 13 (collagenase 3)
NP_002418.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22.3

Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600108

Disorder Html: Spondyloepimetaphyseal dysplasia, Missouri type, 602111 (3);
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu19625 NM_002427 Homo sapiens matrix metallopeptidase 13 (MMP13), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu19625D
Sequence Information ORF Nucleotide Sequence (Length: 1416bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product collagenase 3 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292211.1, AK222748.1, X75308.1 and CA413743.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2010 this sequence version replaced gi:13027796. Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222748.1, X75308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962338 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCATCCAG GGGTCCTGGC TGCCTTCCTC TTCTTGAGCT GGACTCATTG TCGGGCCCTG 
CCCCTTCCCA GTGGTGGTGA TGAAGATGAT TTGTCTGAGG AAGACCTCCA GTTTGCAGAG
CGCTACCTGA GATCATACTA CCATCCTACA AATCTCGCGG GAATCCTGAA GGAGAATGCA
GCAAGCTCCA TGACTGAGAG GCTCCGAGAA ATGCAGTCTT TCTTCGGCTT AGAGGTGACT
GGCAAACTTG ACGATAACAC CTTAGATGTC ATGAAAAAGC CAAGATGCGG GGTTCCTGAT
GTGGGTGAAT ACAATGTTTT CCCTCGAACT CTTAAATGGT CCAAAATGAA TTTAACCTAC
AGAATTGTGA ATTACACCCC TGATATGACT CATTCTGAAG TCGAAAAGGC ATTCAAAAAA
GCCTTCAAAG TTTGGTCCGA TGTAACTCCT CTGAATTTTA CCAGACTTCA CGATGGCATT
GCTGACATCA TGATCTCTTT TGGAATTAAG GAGCATGGCG ACTTCTACCC ATTTGATGGG
CCCTCTGGCC TGCTGGCTCA TGCTTTTCCT CCTGGGCCAA ATTATGGAGG AGATGCCCAT
TTTGATGATG ATGAAACCTG GACAAGTAGT TCCAAAGGCT ACAACTTGTT TCTTGTTGCT
GCGCATGAGT TCGGCCACTC CTTAGGTCTT GACCACTCCA AGGACCCTGG AGCACTCATG
TTTCCTATCT ACACCTACAC CGGCAAAAGC CACTTTATGC TTCCTGATGA CGATGTACAA
GGGATCCAGT CTCTCTATGG TCCAGGAGAT GAAGACCCCA ACCCTAAACA TCCAAAAACG
CCAGACAAAT GTGACCCTTC CTTATCCCTT GATGCCATTA CCAGTCTCCG AGGAGAAACA
ATGATCTTTA AAGACAGATT CTTCTGGCGC CTGCATCCTC AGCAGGTTGA TGCGGAGCTG
TTTTTAACGA AATCATTTTG GCCAGAACTT CCCAACCGTA TTGATGCTGC ATATGAGCAC
CCTTCTCATG ACCTCATCTT CATCTTCAGA GGTAGAAAAT TTTGGGCTCT TAATGGTTAT
GACATTCTGG AAGGTTATCC CAAAAAAATA TCTGAACTGG GTCTTCCAAA AGAAGTTAAG
AAGATAAGTG CAGCTGTTCA CTTTGAGGAT ACAGGCAAGA CTCTCCTGTT CTCAGGAAAC
CAGGTCTGGA GATATGATGA TACTAACCAT ATTATGGATA AAGACTATCC GAGACTAATA
GAAGAAGACT TCCCAGGAAT TGGTGATAAA GTAGATGCTG TCTATGAGAA AAATGGTTAT
ATCTATTTTT TCAACGGACC CATACAGTTT GAATACAGCA TCTGGAGTAA CCGTATTGTT
CGCGTCATGC CAGCAAATTC CATTTTGTGG TGTTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_002418.1
CDS30..1445
Misc Feature(1)123..302(+)
Misc Feature(2)189..191(+)
Misc Feature(3)309..332(+)
Misc Feature(4)336..338(+)
Misc Feature(5)363..830(+)
Misc Feature(6)363..830(+)
Misc Feature(7)519..761(+)
Misc Feature(8)555..767(+)
Misc Feature(9)693..725(+)
Misc Feature(10)831..1442(+)
Misc Feature(11)870..1442(+)
Misc Feature(12)900..1331(+)
Misc Feature(13)1125..1127(+)
Exon (1)1..149
Gene:MMP13
Gene Synonym:
Exon (2)150..391
Gene:MMP13
Gene Synonym:
Exon (3)392..540
Gene:MMP13
Gene Synonym:
Exon (4)541..666
Gene:MMP13
Gene Synonym:
Exon (5)667..828
Gene:MMP13
Gene Synonym:
Exon (6)829..946
Gene:MMP13
Gene Synonym:
Exon (7)947..1080
Gene:MMP13
Gene Synonym:
Exon (8)1081..1240
Gene:MMP13
Gene Synonym:
Exon (9)1241..1344
Gene:MMP13
Gene Synonym:
Exon (10)1345..2719
Gene:MMP13
Gene Synonym:
Translation
Position Chain Variation Link
1 1 a, g dbSNP:745819561
4 4 a, t dbSNP:56263074
10 10 c, t dbSNP:757137395
15 15 a, g dbSNP:748892496
17 17 a, g dbSNP:777612831
18 18 a, t dbSNP:755664192
21 21 c, t dbSNP:752206910
29 29 a, g dbSNP:780882166
30 30 a, g, t dbSNP:143446525
32 32 a, g dbSNP:765513560
34 34 a, t dbSNP:554797
37 37 a, c dbSNP:762278457
38 38 a, g dbSNP:754032807
43 43 c, t dbSNP:764247687
46 46 c, t dbSNP:771778188
49 49 a, c dbSNP:760915237
52 52 c, t dbSNP:2276093
61 61 g, t dbSNP:772208586
63 63 c, t dbSNP:759381709
71 71 c, g dbSNP:774417428
80 80 c, t dbSNP:770605402
81 81 c, t dbSNP:61733406
82 82 a, g dbSNP:777733493
83 83 a, c, g dbSNP:554644078
85 85 c, t dbSNP:143427641
96 96 c, t dbSNP:754580422
97 97 c, t dbSNP:148856037
99 99 a, g dbSNP:779518494
100 100 a, c, g, t dbSNP:138415943
103 103 -, g dbSNP:748468302
105 105 a, g dbSNP:760827302
114 114 a, c, g dbSNP:150142500
116 116 c, t dbSNP:759702190
117 117 a, g dbSNP:774134193
120 120 c, t dbSNP:369622822
127 127 a, t dbSNP:777270631
129 129 -, g dbSNP:781201913
138 138 c, g dbSNP:770857273
147 147 a, g dbSNP:369436172
150 150 c, t dbSNP:767829684
152 152 c, t dbSNP:755181539
153 153 c, t dbSNP:112742775
155 155 a, c dbSNP:575844026
158 158 a, g dbSNP:751621886
161 161 a, g dbSNP:540951198
164 164 a, g dbSNP:17860524
167 167 c, t dbSNP:200537937
175 175 a, c dbSNP:773347006
178 178 c, t dbSNP:765090200
185 185 c, t dbSNP:761744865
186 186 a, g dbSNP:776309041
187 187 c, t dbSNP:748106896
188 188 a, g dbSNP:746644344
193 193 a, t dbSNP:775005629
203 203 c, g, t dbSNP:749793838
208 208 c, t dbSNP:183292652
219 219 a, c dbSNP:111947721
230 230 g, t dbSNP:541024120
231 231 c, t dbSNP:576963788
235 235 a, g dbSNP:558630699
240 240 a, c dbSNP:146526422
250 250 c, t dbSNP:121909498
253 253 c, t dbSNP:121909497
254 254 c, t dbSNP:145545704
255 255 a, g, t dbSNP:755164262
257 257 c, t dbSNP:751746911
262 262 a, c dbSNP:766473955
269 269 c, t dbSNP:376105726
273 273 a, c dbSNP:371513455
277 277 c, t dbSNP:201603479
286 286 a, g dbSNP:765212942
287 287 c, g dbSNP:761873360
292 292 c, t dbSNP:776419636
293 293 a, g dbSNP:763808154
294 294 c, g dbSNP:12295719
301 301 c, t dbSNP:121909499
317 317 a, c dbSNP:760359971
327 327 a, g dbSNP:148152034
330 330 g, t dbSNP:151254531
332 332 g, t dbSNP:771541007
335 335 c, t dbSNP:533776098
336 336 a, g dbSNP:773873638
344 344 a, c, t dbSNP:748610569
345 345 c, g dbSNP:781565326
347 347 c, t dbSNP:553953391
354 354 c, t dbSNP:369083541
355 355 a, g, t dbSNP:189974040
373 373 a, c dbSNP:548322553
380 380 c, t dbSNP:750487115
384 384 -, a dbSNP:768791927
386 386 c, t dbSNP:754917545
400 400 a, g dbSNP:779122021
405 405 a, t dbSNP:757345664
408 408 c, t dbSNP:753779683
416 416 c, g dbSNP:777621918
431 431 a, c, t dbSNP:576919878
432 432 a, c, g dbSNP:759134930
435 435 a, g dbSNP:751273414
445 445 a, c dbSNP:765872542
452 452 -, c dbSNP:779994162
456 456 a, g dbSNP:762416563
458 458 a, g dbSNP:772798651
466 466 c, g dbSNP:769000690
467 467 c, t dbSNP:17860530
468 468 a, g dbSNP:368343121
472 472 a, t dbSNP:374419716
476 476 g, t dbSNP:746081572
477 477 c, g dbSNP:371894268
490 490 c, t dbSNP:771022798
494 494 a, c dbSNP:143292324
498 498 c, t dbSNP:777940207
500 500 c, t dbSNP:368161332
501 501 a, g dbSNP:181426884
524 524 c, g dbSNP:148746302
526 526 c, t dbSNP:780955466
538 538 a, c dbSNP:145243532
541 541 a, g dbSNP:202231908
545 545 c, t dbSNP:775773373
548 548 c, t dbSNP:189379640
557 557 c, t dbSNP:376889562
568 568 c, g dbSNP:764647902
571 571 c, g dbSNP:756865618
604 604 a, g dbSNP:753232756
606 606 a, c dbSNP:768090194
617 617 a, c dbSNP:760153834
622 622 a, t dbSNP:150048151
626 626 c, t dbSNP:766780242
633 633 g, t dbSNP:763075525
642 642 a, g dbSNP:773554450
646 646 c, t dbSNP:769733639
648 648 c, g, t dbSNP:140059558
658 658 a, g dbSNP:768511359
723 723 a, c dbSNP:121909500
885 885 a, c dbSNP:149330684
982 982 c, t dbSNP:199992289
983 983 a, g dbSNP:759581047
1115 1115 -, t dbSNP:756429723
1731 1731 a, g dbSNP:112821768
1789 1789 a, g dbSNP:775427867
2048 2048 c, t dbSNP:770044566
2073 2073 a, g dbSNP:114428333
2330 2330 a, g dbSNP:1042840
2509 2509 a, c dbSNP:17860586
2583 2583 a, g dbSNP:113572120
2664 2664 a, c dbSNP:188511209

Target ORF information:

RefSeq Version NM_002427
Organism Homo sapiens (human)
Definition Homo sapiens matrix metallopeptidase 13 (MMP13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_002427

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGCATCCAG GGGTCCTGGC TGCCTTCCTC TTCTTGAGCT GGACTCATTG TCGGGCCCTG 
CCCCTTCCCA GTGGTGGTGA TGAAGATGAT TTGTCTGAGG AAGACCTCCA GTTTGCAGAG
CGCTACCTGA GATCATACTA CCATCCTACA AATCTCGCGG GAATCCTGAA GGAGAATGCA
GCAAGCTCCA TGACTGAGAG GCTCCGAGAA ATGCAGTCTT TCTTCGGCTT AGAGGTGACT
GGCAAACTTG ACGATAACAC CTTAGATGTC ATGAAAAAGC CAAGATGCGG GGTTCCTGAT
GTGGGTGAAT ACAATGTTTT CCCTCGAACT CTTAAATGGT CCAAAATGAA TTTAACCTAC
AGAATTGTGA ATTACACCCC TGATATGACT CATTCTGAAG TCGAAAAGGC ATTCAAAAAA
GCCTTCAAAG TTTGGTCCGA TGTAACTCCT CTGAATTTTA CCAGACTTCA CGATGGCATT
GCTGACATCA TGATCTCTTT TGGAATTAAG GAGCATGGCG ACTTCTACCC ATTTGATGGG
CCCTCTGGCC TGCTGGCTCA TGCTTTTCCT CCTGGGCCAA ATTATGGAGG AGATGCCCAT
TTTGATGATG ATGAAACCTG GACAAGTAGT TCCAAAGGCT ACAACTTGTT TCTTGTTGCT
GCGCATGAGT TCGGCCACTC CTTAGGTCTT GACCACTCCA AGGACCCTGG AGCACTCATG
TTTCCTATCT ACACCTACAC CGGCAAAAGC CACTTTATGC TTCCTGATGA CGATGTACAA
GGGATCCAGT CTCTCTATGG TCCAGGAGAT GAAGACCCCA ACCCTAAACA TCCAAAAACG
CCAGACAAAT GTGACCCTTC CTTATCCCTT GATGCCATTA CCAGTCTCCG AGGAGAAACA
ATGATCTTTA AAGACAGATT CTTCTGGCGC CTGCATCCTC AGCAGGTTGA TGCGGAGCTG
TTTTTAACGA AATCATTTTG GCCAGAACTT CCCAACCGTA TTGATGCTGC ATATGAGCAC
CCTTCTCATG ACCTCATCTT CATCTTCAGA GGTAGAAAAT TTTGGGCTCT TAATGGTTAT
GACATTCTGG AAGGTTATCC CAAAAAAATA TCTGAACTGG GTCTTCCAAA AGAAGTTAAG
AAGATAAGTG CAGCTGTTCA CTTTGAGGAT ACAGGCAAGA CTCTCCTGTT CTCAGGAAAC
CAGGTCTGGA GATATGATGA TACTAACCAT ATTATGGATA AAGACTATCC GAGACTAATA
GAAGAAGACT TCCCAGGAAT TGGTGATAAA GTAGATGCTG TCTATGAGAA AAATGGTTAT
ATCTATTTTT TCAACGGACC CATACAGTTT GAATACAGCA TCTGGAGTAA CCGTATTGTT
CGCGTCATGC CAGCAAATTC CATTTTGTGG TGTTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.