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MSX2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MSX2
Entrez Gene ID 4488
Full Name msh homeobox 2
Synonyms CRS2, FPP, HOX8, MSH, PFM, PFM1
General protein information
Preferred Names
homeobox protein MSX-2
Names
homeobox protein MSX-2
msh homeo box 2
homeobox protein Hox-8
msh homeobox homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.2

Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

123101

Disorder Html: Craniosynostosis, type 2, 604757 (3); Parietal foramina 1, 168500

mRNA and Protein(s)

mRNA Protein Name
NM_002449 NP_002440 homeobox protein MSX-2



Homo sapiens (human) MSX2 NP_002440.2
Pan troglodytes (chimpanzee) MSX2 NP_001129097.2
Macaca mulatta (Rhesus monkey) MSX2 XP_001082405.1
Canis lupus familiaris (dog) MSX2 NP_001003098.1
Bos taurus (cattle) MSX2 NP_001073082.1
Mus musculus (house mouse) Msx2 NP_038629.2
Rattus norvegicus (Norway rat) Msx2 NP_037114.2
Gallus gallus (chicken) MSX2 NP_989890.1
Danio rerio (zebrafish) msxd NP_571351.2
Xenopus (Silurana) tropicalis (western clawed frog) msx2 XP_002936749.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MSX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21502
NM_002449 Homo sapiens msh homeobox 2 (MSX2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21502
Clone ID Related Accession (Same CDS sequence) NM_002449
Accession Version NM_002449.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein MSX-2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL552909.3, AC117531.2, W38629.1 and D89377.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2006 this sequence version replaced gi:27886556. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D89377.1, D26145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002440.2
CDS89..892
Misc Feature(1)74..76(+)
Misc Feature(2)515..691(+)
Misc Feature(3)515..685(+)
Misc Feature(4)521..673(+)
Exon (1)1..467
Gene:MSX2
Gene Synonym:
Exon (2)468..2208
Gene:MSX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002449
Organism Homo sapiens (human)
Definition Homo sapiens msh homeobox 2 (MSX2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002449

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

PKC signaling inhibits osteogenic differentiation through the regulation of Msx2 function
Biochim. Biophys. Acta 1823 (8), 1225-1232 (2012)
Jeong HM, Jin YH, Choi YH, Yum J, Choi JK, Yeo CY and Lee KY.


book

Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia
J. Med. Genet. 49 (7), 437-441 (2012)
Ott CE, Hein H, Lohan S, Hoogeboom J, Foulds N, Grunhagen J, Stricker S, Villavicencio-Lorini P, Klopocki E and Mundlos S.


book

[Expression and significance of Msx2 and topo II-alpha in sinonasal inverted papilloma]
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 26 (8), 343-346 (2012)
Wu Q, Yang Y, Wu X, Zhao C, Cong L, Ruan B and Zhang J.


book

[Changes in the expression of Dlx5, Msx2, and Dlx5/Msx2 in hPDLSCs loaded with cyclic tensile stress]
Sichuan Da Xue Xue Bao Yi Xue Ban 42 (6), 823-826 (2011)
Sun CX, Zhang LK, Feng XX and Zhao ZH.


book

Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma
Br. J. Cancer 105 (4), 565-574 (2011)
Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, Lavelle M, Murphy I, Unwin L, Joyce C, Faller W, McDermott EW, Sheahan K, Ponten F and Gallagher WM.


book

DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2
Biochem. Biophys. Res. Commun. 209 (1), 257-262 (1995)
Semenza GL, Wang GL and Kundu R.


book

[Molecular cloning and expression of homeobox-containing genes during hard tissue development]
Kokubyo Gakkai Zasshi 61 (4), 590-604 (1994)
Iimura T.


book

Expression of a human homeobox-containing gene is regulated by 1,25(OH)2D3 in bone cells
Biochim. Biophys. Acta 1174 (1), 11-16 (1993)
Hodgkinson JE, Davidson CL, Beresford J and Sharpe PT.


book

Over-expression of HOX-8, the human homologue of the mouse Hox-8 homeobox gene, in human tumors
Biochem. Biophys. Res. Commun. 194 (1), 187-193 (1993)
Suzuki M, Tanaka M, Iwase T, Naito Y, Sugimura H and Kino I.


book

Enlarged Parietal Foramina
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Wilkie,A.O.M. and Mavrogiannis,L.A.


 
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