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MSX2 msh homeobox 2 [Homo sapiens (human)]

Gene Symbol MSX2
Entrez Gene ID 4488
Full Name msh homeobox 2
Synonyms CRS2, FPP, HOX8, MSH, PFM, PFM1
General protein information
Preferred Names
homeobox protein MSX-2
Names
homeobox protein MSX-2
msh homeo box 2
homeobox protein Hox-8
msh homeobox homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.2

Summary This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

123101

Disorder Html: Craniosynostosis, type 2, 604757 (3); Parietal foramina 1, 168500
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu21502 NM_002449 Homo sapiens msh homeobox 2 (MSX2), mRNA. pcDNA3.1-C-(k)DYK In stock -1 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu21502D
Sequence Information ORF Nucleotide Sequence (Length: 804bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein MSX-2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL552909.3, AC117531.2, W38629.1 and D89377.1. This sequence is a reference standard in the RefSeqGene project. On Jan 5, 2006 this sequence version replaced gi:27886556. Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D89377.1, D26145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA
TATGGCATGT ACCACCTGTC CTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_002440.2
CDS89..892
Misc Feature(1)74..76(+)
Misc Feature(2)515..691(+)
Misc Feature(3)515..685(+)
Misc Feature(4)521..673(+)
Exon (1)1..467
Gene:MSX2
Gene Synonym:
Exon (2)468..2208
Gene:MSX2
Gene Synonym:
Translation
Position Chain Variation Link
4 4 a, c dbSNP:373735781
22 22 -, t dbSNP:749151467
33 33 a, c dbSNP:113874536
38 38 c, t dbSNP:761284440
39 39 c, t dbSNP:371076863
41 41 a, g dbSNP:191789843
47 47 c, t dbSNP:758437365
48 48 a, g dbSNP:766231752
56 56 c, t dbSNP:751417663
60 60 c, t dbSNP:756340517
63 63 c, t dbSNP:777926970
64 64 g, t dbSNP:749375554
72 72 c, g dbSNP:4647952
75 75 a, g dbSNP:544165273
79 79 c, t dbSNP:549708071
83 83 g, t dbSNP:772580584
84 84 a, g dbSNP:775764061
96 96 c, t dbSNP:201724372
98 98 c, g dbSNP:768338363
99 99 c, t dbSNP:776192704
100 100 a, g dbSNP:761351358
104 104 a, g dbSNP:764608651
111 111 a, g dbSNP:367636705
118 118 a, g dbSNP:371794345
127 127 c, t dbSNP:766427771
135 135 a, t dbSNP:751397598
137 137 a, g dbSNP:754789827
152 152 a, g dbSNP:764356797
153 153 c, g dbSNP:754048064
155 155 a, g dbSNP:757530512
161 161 c, g dbSNP:778800326
165 165 c, t dbSNP:745950729
175 175 a, g dbSNP:758900089
183 183 a, t dbSNP:780593593
187 187 a, g dbSNP:747350286
188 188 -, g dbSNP:34093690
205 205 c, t dbSNP:376630472
206 206 c, g dbSNP:779030275
219 219 a, g dbSNP:560526842
225 225 c, t dbSNP:781641392
242 242 a, c dbSNP:35902803
264 264 c, t dbSNP:747702409
271 271 g, t dbSNP:769505079
280 280 g, t dbSNP:772785766
285 285 c, g dbSNP:527786984
288 288 c, t dbSNP:552575619
289 289 c, t dbSNP:770982369
304 304 c, t dbSNP:774481366
319 319 a, g dbSNP:759346366
322 322 a, g dbSNP:570873552
340 340 c, t dbSNP:531764887
343 343 c, t dbSNP:367614252
344 344 g, t dbSNP:765510086
347 347 c, t dbSNP:750488190
348 348 a, g dbSNP:758520726
353 353 gc, ta dbSNP:121912971
358 358 c, g dbSNP:752778789
359 359 a, g, t dbSNP:751966362
361 361 c, t dbSNP:781357847
368 368 c, t dbSNP:748554134
374 374 g, t dbSNP:769329948
381 381 c, t dbSNP:777629041
382 382 c, g, t dbSNP:748786766
387 387 a, c dbSNP:774030950
389 389 a, g dbSNP:550184107
392 392 a, g dbSNP:772051040
397 397 a, g dbSNP:775142998
403 403 c, g dbSNP:760574628
405 405 c, t dbSNP:765421666
406 406 a, g dbSNP:750681902
415 415 a, g dbSNP:763190795
420 420 a, t dbSNP:766394089
421 421 c, t dbSNP:751668827
426 426 c, t dbSNP:367897914
433 433 -, g dbSNP:121912972
436 436 g, t dbSNP:781782134
437 437 c, g dbSNP:752992492
439 439 a, g dbSNP:756598126
444 444 a, c, t dbSNP:777537313
445 445 c, t dbSNP:756992471
448 448 c, t dbSNP:778509123
449 449 a, c dbSNP:745449870
450 450 a, g dbSNP:771889290
461 461 c, t dbSNP:372131169
462 462 c, t dbSNP:746748359
466 466 a, g dbSNP:756898579
467 467 a, g dbSNP:776428406
474 474 a, c, g, t dbSNP:4242182
475 475 a, c, g dbSNP:186769394
480 480 c, g dbSNP:765584496
511 511 a, c dbSNP:750764615
513 513 a, g dbSNP:762595550
514 514 c, t dbSNP:766010243
516 516 a, g dbSNP:751060486
522 522 c, t dbSNP:754536048
523 523 a, g, t dbSNP:189666650
524 524 c, t dbSNP:756030049
529 529 a, g, t dbSNP:780693712
531 531 a, c dbSNP:104893895
532 532 c, t dbSNP:200762790
543 543 c, t dbSNP:780471460
554 554 a, g dbSNP:747053672
563 563 c, t dbSNP:773491812
564 564 a, g, t dbSNP:776872613
567 567 a, g dbSNP:770204721
570 570 a, t dbSNP:200519800
572 572 c, t dbSNP:555293970
573 573 a, g dbSNP:766037353
574 574 g, t dbSNP:751255003
582 582 a, g, t dbSNP:759220876
589 589 c, g dbSNP:752218690
591 591 c, t dbSNP:756013230
602 602 c, t dbSNP:764005351
603 603 a, g dbSNP:104893896
608 608 g, t dbSNP:757042034
610 610 a, g dbSNP:370893406
640 640 c, g dbSNP:747178118
643 643 a, g dbSNP:755261600
654 654 g, t dbSNP:61743524
658 658 c, t dbSNP:781352134
673 673 c, g dbSNP:567183663
678 678 a, c, t dbSNP:770317741
679 679 a, g dbSNP:150352201
684 684 g, t dbSNP:199732800
690 690 -, g dbSNP:762455738
692 692 c, g dbSNP:182690432
701 701 c, t dbSNP:111542301
703 703 a, g dbSNP:774723279
718 718 a, g dbSNP:759131123
720 720 c, g dbSNP:767161367
723 723 c, g dbSNP:775062909
731 731 a, g dbSNP:577629417
741 741 c, t dbSNP:760162567
748 748 c, t dbSNP:544759609
749 749 a, g dbSNP:753676458
758 758 c, t dbSNP:747590116
764 764 a, g dbSNP:757239934
771 771 c, t dbSNP:373857075
772 772 a, g dbSNP:750244140
781 781 c, g dbSNP:755243046
782 782 a, g dbSNP:781619692
786 786 c, t dbSNP:138053303
787 787 a, g dbSNP:201880865
798 798 a, g dbSNP:777944422
808 808 c, t dbSNP:749713244
810 810 c, t dbSNP:368570722
811 811 a, g dbSNP:201103544
814 814 a, c dbSNP:371825159
824 824 c, g dbSNP:771700671
828 828 c, t dbSNP:775044825
831 831 a, c dbSNP:61739543
837 837 c, t dbSNP:374244313
838 838 a, c, g dbSNP:760404926
839 839 c, t dbSNP:776218196
844 844 a, g dbSNP:542254664
847 847 a, g dbSNP:765329097
849 849 c, t dbSNP:750227762
850 850 c, g dbSNP:560807345
857 857 a, g dbSNP:767820021
858 858 c, t dbSNP:752824647
859 859 a, g dbSNP:756385707
867 867 a, g, t dbSNP:528373280
876 876 g, t dbSNP:757757709
877 877 a, g, t dbSNP:199856192
880 880 c, t dbSNP:772384677
892 892 a, g dbSNP:780486877
897 897 g, t dbSNP:368747209
900 900 c, g dbSNP:768358565
905 905 c, t dbSNP:775996170
907 907 a, g dbSNP:372223571
915 915 c, g dbSNP:769830511
924 924 c, t dbSNP:773320207
935 935 a, g dbSNP:763019404
938 938 g, t dbSNP:375964205
952 952 c, g dbSNP:532365387
957 957 c, t dbSNP:550795412
967 967 a, c dbSNP:369125868
998 998 c, t dbSNP:747163618
1014 1014 a, c, t dbSNP:541008828
1016 1016 a, g dbSNP:775306704
1027 1027 a, g dbSNP:557598517
1036 1036 c, g dbSNP:530005338
1037 1037 a, g dbSNP:548607704
1049 1049 a, g, t dbSNP:17063878
1054 1054 c, t dbSNP:777389065
1058 1058 g, t dbSNP:3087539
1064 1064 a, g dbSNP:577291689
1075 1075 g, t dbSNP:771167296
1078 1078 c, t dbSNP:3087537
1113 1113 c, t dbSNP:3087538
1149 1149 c, t dbSNP:187794452
1160 1160 a, g dbSNP:563103519
1197 1197 c, t dbSNP:143672195
1211 1211 c, t dbSNP:538476597
1241 1241 c, t dbSNP:114567531
1255 1255 a, g dbSNP:376258231
1258 1258 g, t dbSNP:193163747
1259 1259 c, t dbSNP:775783810
1308 1308 a, c dbSNP:10038500
1357 1357 c, t dbSNP:554165494
1358 1358 a, g dbSNP:148083483
1387 1387 -, aaag dbSNP:531338994
1400 1400 c, t dbSNP:540115605
1402 1402 a, g dbSNP:2381939
1418 1418 c, t dbSNP:532200136
1434 1434 a, t dbSNP:528504366
1455 1455 a, g dbSNP:143924110
1478 1478 c, t dbSNP:185029831
1490 1490 c, t dbSNP:189138878
1501 1501 a, g dbSNP:753566277
1520 1520 -, t dbSNP:765805297
1526 1526 c, t dbSNP:548570932
1527 1527 a, g dbSNP:192627117
1537 1537 a, g dbSNP:766110807
1539 1539 c, t dbSNP:751312423
1550 1550 c, t dbSNP:10044147
1580 1580 a, g dbSNP:184884082
1615 1615 a, c dbSNP:115604243
1673 1673 a, g dbSNP:188468287
1696 1696 c, g dbSNP:180684930
1710 1710 a, c dbSNP:568830886
1759 1759 g, t dbSNP:34342523
1767 1767 c, g dbSNP:535956934
1770 1770 c, t dbSNP:554272174
1771 1771 c, t dbSNP:572502901
1817 1817 g, t dbSNP:533584141
1889 1889 -, a dbSNP:59205443
1898 1898 -, a dbSNP:397692104
1899 1899 a, t dbSNP:74292295
1942 1942 c, t dbSNP:184931219
1956 1956 a, g dbSNP:189444818
1972 1972 -, g dbSNP:145784193
1988 1988 a, g dbSNP:530984915
1998 1998 -, ttgac dbSNP:572556594
2017 2017 a, g dbSNP:14459
2018 2018 c, t dbSNP:574716431
2038 2038 c, t dbSNP:2890848
2068 2068 c, g dbSNP:2890849
2070 2070 -, c dbSNP:754477149
2070 2070 c, t dbSNP:182072112
2081 2081 a, g dbSNP:146501739
2098 2098 c, t dbSNP:77229212
2116 2116 a, c dbSNP:373056463
2122 2122 a, g dbSNP:567135134
2124 2124 a, g dbSNP:756881447
2134 2134 -, gaa dbSNP:543710932
2141 2141 c, t dbSNP:139249455
2142 2142 a, g dbSNP:143253235
2143 2143 c, t dbSNP:746242647
2150 2150 c, t dbSNP:767461937
2161 2161 a, g dbSNP:568292848
2199 2199 -, gct dbSNP:200120254

Target ORF information:

RefSeq Version NM_002449
Organism Homo sapiens (human)
Definition Homo sapiens msh homeobox 2 (MSX2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_002449

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGCTTCTC CGTCCAAAGG CAATGACTTG TTTTCGCCCG ACGAGGAGGG CCCAGCAGTG 
GTGGCCGGAC CAGGCCCGGG GCCTGGGGGC GCCGAGGGGG CCGCGGAGGA GCGCCGCGTC
AAGGTCTCCA GCCTGCCCTT CAGCGTGGAG GCGCTCATGT CCGACAAGAA GCCGCCCAAG
GAGGCGTCCC CGCTGCCGGC CGAAAGCGCC TCGGCCGGGG CCACCCTGCG GCCACTGCTG
CTGTCGGGGC ACGGCGCTCG GGAAGCGCAC AGCCCCGGGC CGCTGGTGAA GCCCTTCGAG
ACCGCCTCGG TCAAGTCGGA AAATTCAGAA GATGGAGCGG CGTGGATGCA GGAACCCGGC
CGATATTCGC CGCCGCCAAG ACATATGAGC CCTACCACCT GCACCCTGAG GAAACACAAG
ACCAATCGGA AGCCGCGCAC GCCCTTTACC ACATCCCAGC TCCTCGCCCT GGAGCGCAAG
TTCCGTCAGA AACAGTACCT CTCCATTGCA GAGCGTGCAG AGTTCTCCAG CTCTCTGAAC
CTCACAGAGA CCCAGGTCAA AATCTGGTTC CAGAACCGAA GGGCCAAGGC GAAAAGACTG
CAGGAGGCAG AACTGGAAAA GCTGAAAATG GCTGCAAAAC CTATGCTGCC CTCCAGCTTC
AGTCTCCCTT TCCCCATCAG CTCGCCCCTG CAGGCAGCGT CCATATATGG AGCATCCTAC
CCGTTCCATA GACCTGTGCT TCCCATCCCG CCTGTGGGAC TCTATGCCAC GCCAGTGGGA
TATGGCATGT ACCACCTGTC CTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.