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SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 [Homo sapiens (human)]

Gene Symbol SERPINC1
Entrez Gene ID 462
Full Name serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms AT3, AT3D, ATIII, THPH7
General protein information
Preferred Names
antithrombin-III
Names
antithrombin-III
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.1

Summary The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. lac of sum
Disorder MIM:

107300

Disorder Html: Antithrombin III deficiency, 613118 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu20572 NM_000488 Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu34399 XM_005245198 PREDICTED: Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu20572D
Sequence Information ORF Nucleotide Sequence (Length: 1395bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-AUG-2015
Organism Homo sapiens (human)
Product antithrombin-III precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136170.14, H62671.1 and H71210.1. This sequence is a reference standard in the RefSeqGene project. On Jul 23, 2009 this sequence version replaced gi:50541941. Summary: The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312654.1, D29832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTATTCCA ATGTGATAGG AACTGTAACC TCTGGAAAAA GGAAGGTTTA TCTTTTGTCC 
TTGCTGCTCA TTGGCTTCTG GGACTGCGTG ACCTGTCACG GGAGCCCTGT GGACATCTGC
ACAGCCAAGC CGCGGGACAT TCCCATGAAT CCCATGTGCA TTTACCGCTC CCCGGAGAAG
AAGGCAACTG AGGATGAGGG CTCAGAACAG AAGATCCCGG AGGCCACCAA CCGGCGTGTC
TGGGAACTGT CCAAGGCCAA TTCCCGCTTT GCTACCACTT TCTATCAGCA CCTGGCAGAT
TCCAAGAATG ACAATGATAA CATTTTCCTG TCACCCCTGA GTATCTCCAC GGCTTTTGCT
ATGACCAAGC TGGGTGCCTG TAATGACACC CTCCAGCAAC TGATGGAGGT ATTTAAGTTT
GACACCATAT CTGAGAAAAC ATCTGATCAG ATCCACTTCT TCTTTGCCAA ACTGAACTGC
CGACTCTATC GAAAAGCCAA CAAATCCTCC AAGTTAGTAT CAGCCAATCG CCTTTTTGGA
GACAAATCCC TTACCTTCAA TGAGACCTAC CAGGACATCA GTGAGTTGGT ATATGGAGCC
AAGCTCCAGC CCCTGGACTT CAAGGAAAAT GCAGAGCAAT CCAGAGCGGC CATCAACAAA
TGGGTGTCCA ATAAGACCGA AGGCCGAATC ACCGATGTCA TTCCCTCGGA AGCCATCAAT
GAGCTCACTG TTCTGGTGCT GGTTAACACC ATTTACTTCA AGGGCCTGTG GAAGTCAAAG
TTCAGCCCTG AGAACACAAG GAAGGAACTG TTCTACAAGG CTGATGGAGA GTCGTGTTCA
GCATCTATGA TGTACCAGGA AGGCAAGTTC CGTTATCGGC GCGTGGCTGA AGGCACCCAG
GTGCTTGAGT TGCCCTTCAA AGGTGATGAC ATCACCATGG TCCTCATCTT GCCCAAGCCT
GAGAAGAGCC TGGCCAAGGT AGAGAAGGAA CTCACCCCAG AGGTGCTGCA AGAGTGGCTG
GATGAATTGG AGGAGATGAT GCTGGTGGTC CACATGCCCC GCTTCCGCAT TGAGGACGGC
TTCAGTTTGA AGGAGCAGCT GCAAGACATG GGCCTTGTCG ATCTGTTCAG CCCTGAAAAG
TCCAAACTCC CAGGTATTGT TGCAGAAGGC CGAGATGACC TCTATGTCTC AGATGCATTC
CATAAGGCAT TTCTTGAGGT AAATGAAGAA GGCAGTGAAG CAGCTGCAAG TACCGCTGTT
GTGATTGCTG GCCGTTCGCT AAACCCCAAC AGGGTGACTT TCAAGGCCAA CAGGCCTTTC
CTGGTTTTTA TAAGAGAAGT TCCTCTGAAC ACTATTATCT TCATGGGCAG AGTAGCCAAC
CCTTGTGTTA AGTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000479.1
CDS120..1514
Misc Feature(1)237..599(+)
Misc Feature(2)276..500(+)
Misc Feature(3)321..323(+)
Misc Feature(4)354..1493(+)
Misc Feature(5)501..503(+)
Misc Feature(6)618..620(+)
Misc Feature(7)678..680(+)
Misc Feature(8)789..791(+)
Misc Feature(9)954..1505(+)
Misc Feature(10)1350..1436(+)
Misc Feature(11)1392..1397(+)
Misc Feature(12)1392..1394(+)
Exon (1)1..160
Gene:SERPINC1
Gene Synonym:
Exon (2)161..527
Gene:SERPINC1
Gene Synonym:
Exon (3)528..743
Gene:SERPINC1
Gene Synonym:
Exon (4)744..881
Gene:SERPINC1
Gene Synonym:
Exon (5)882..1272
Gene:SERPINC1
Gene Synonym:
Exon (6)1273..1337
Gene:SERPINC1
Gene Synonym:
Exon (7)1338..1599
Gene:SERPINC1
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, t dbSNP:540487118
32 32 a, g dbSNP:376206880
48 48 a, t dbSNP:373264710
63 63 a, g dbSNP:372524963
73 73 a, g dbSNP:764606323
85 85 c, t dbSNP:200460215
89 89 a, g dbSNP:775919922
94 94 c, t dbSNP:770098298
108 108 -, aga dbSNP:777418425
109 109 a, g dbSNP:483352843
112 112 c, t dbSNP:776785547
115 115 c, t dbSNP:771146323
116 116 a, g dbSNP:370576783
122 122 a, g dbSNP:777886588
125 125 a, t dbSNP:199469506
131 131 c, t dbSNP:772040776
132 132 a, g dbSNP:750709130
133 133 c, t dbSNP:748072934
134 134 c, g dbSNP:778745435
136 136 a, c, t dbSNP:753713846
144 144 a, g dbSNP:779790099
148 148 a, c dbSNP:61736655
166 166 c, t dbSNP:531137446
169 169 a, g dbSNP:780733720
178 178 c, t dbSNP:369828221
187 187 c, t dbSNP:387906575
197 197 c, t dbSNP:751112370
206 206 c, t dbSNP:188274879
207 207 a, g dbSNP:532883680
208 208 a, t dbSNP:2227624
218 218 a, c, t dbSNP:147676453
219 219 a, g dbSNP:773254902
231 231 a, g dbSNP:145771113
235 235 -, tctgcaca dbSNP:483352844
235 235 a, t dbSNP:121909558
248 248 g, t dbSNP:761729771
251 251 a, g dbSNP:774506712
252 252 c, t dbSNP:768704768
253 253 a, g dbSNP:749308643
257 257 c, t dbSNP:775397662
261 261 c, t dbSNP:769761264
271 271 c, t dbSNP:745698642
279 279 a, g dbSNP:780670128
281 281 g, t dbSNP:756940594
285 285 c, t dbSNP:28929469
286 286 a, g dbSNP:777405542
292 292 c, t dbSNP:550247582
293 293 a, g dbSNP:754390483
300 300 -, aag dbSNP:752544767
320 320 c, t dbSNP:773751914
325 325 a, g, t dbSNP:377500819
330 330 a, t dbSNP:199469505
337 337 c, t dbSNP:121909551
338 338 a, c, g dbSNP:746429528
348 348 aaccggcg, ggga dbSNP:199469507
351 351 c, t dbSNP:374205395
352 352 a, g dbSNP:774294043
354 354 a, c, t dbSNP:121909547
355 355 a, g dbSNP:121909552
356 356 c, t dbSNP:781591817
382 382 a, c dbSNP:775520108
384 384 c, t dbSNP:147266200
385 385 a, g dbSNP:745583962
418 418 a, g dbSNP:369524182
421 421 c, g, t dbSNP:199895690
428 428 c, t dbSNP:747398942
430 430 a, t dbSNP:200118419
433 433 a, g dbSNP:757851817
434 434 a, g, t dbSNP:778100368
461 461 c, t dbSNP:369954987
464 464 c, t dbSNP:374763537
469 469 c, t dbSNP:139392083
470 470 a, g dbSNP:200810296
482 482 a, g dbSNP:371222224
489 489 c, t dbSNP:758698144
498 498 c, t dbSNP:121909573
510 510 c, t dbSNP:121909567
527 527 a, g dbSNP:763087077
541 541 a, t dbSNP:746430769
544 544 c, t dbSNP:532353637
545 545 a, c, t dbSNP:199525344
546 546 a, g dbSNP:571861448
558 558 a, g dbSNP:2227606
561 561 c, t dbSNP:121909569
564 564 a, g dbSNP:752818145
568 568 a, c dbSNP:765445413
577 577 a, t dbSNP:483352848
581 581 -, ctt dbSNP:786204063
587 587 c, t dbSNP:759369437
599 599 c, t dbSNP:753759247
600 600 c, t dbSNP:121909562
601 601 a, g, t dbSNP:121909563
605 605 -, ct dbSNP:483352850
609 609 a, c, t dbSNP:199469504
610 610 a, g dbSNP:483352852
619 619 a, c dbSNP:121909570
625 625 c, t dbSNP:483352851
628 628 c, t dbSNP:771696386
648 648 c, t dbSNP:143521873
654 654 g, t dbSNP:773822689
655 655 a, t dbSNP:483352847
672 672 a, g dbSNP:574547491
687 687 c, t dbSNP:748774160
692 692 a, g dbSNP:267598177
705 705 c, t dbSNP:781696456
708 708 c, g dbSNP:771347278
713 713 c, t dbSNP:183416252
714 714 a, g dbSNP:778341415
717 717 c, g dbSNP:483352853
718 718 a, c, t dbSNP:748428859
722 722 g, t dbSNP:779025291
744 744 a, g dbSNP:267598176
752 752 a, g dbSNP:780062808
753 753 a, g dbSNP:756016928
760 760 a, c dbSNP:483352854
766 766 c, t dbSNP:750413071
767 767 a, g dbSNP:767468032
774 774 a, g dbSNP:121909571
779 779 a, g dbSNP:757009890
786 786 c, t dbSNP:121909572
788 788 a, c dbSNP:749583360
789 789 a, g dbSNP:146733468
797 797 c, g, t dbSNP:2227627
805 805 a, g dbSNP:775062927
812 812 c, g, t dbSNP:140452859
813 813 c, g dbSNP:773814831
823 823 c, t dbSNP:772710258
825 825 c, t dbSNP:769911947
826 826 c, t dbSNP:368419985
827 827 a, g dbSNP:774632265
832 832 c, t dbSNP:768914754
835 835 c, t dbSNP:749510661
838 838 a, g dbSNP:200861147
850 850 a, t dbSNP:769820027
851 851 c, t dbSNP:572252151
857 857 a, g dbSNP:558726250
860 860 c, g dbSNP:757200092
867 867 a, g dbSNP:751357562
868 868 c, t dbSNP:144084678
875 875 c, t dbSNP:745970800
885 885 c, t dbSNP:770852197
896 896 a, g dbSNP:746961120
903 903 a, g dbSNP:777786232
924 924 a, g dbSNP:758087836
927 927 c, t dbSNP:139275128
935 935 c, t dbSNP:758329697
941 941 c, t dbSNP:745879490
952 952 c, t dbSNP:778650224
953 953 a, g, t dbSNP:753390084
972 972 -, gatgt dbSNP:483352857
977 977 c, g dbSNP:139463995
983 983 c, g dbSNP:762356452
989 989 c, t dbSNP:370190321
990 990 c, t dbSNP:764695432
991 991 a, g dbSNP:377588972
992 992 c, t dbSNP:775845871
993 993 c, t dbSNP:769991153
994 994 a, t dbSNP:759821949
996 996 c, t dbSNP:776662899
997 997 a, g dbSNP:572313182
999 999 c, t dbSNP:747142328
1000 1000 a, g, t dbSNP:587776397
1001 1001 c, t dbSNP:184508490
1002 1002 a, g dbSNP:201381904
1004 1004 g, t dbSNP:778915564
1005 1005 c, g dbSNP:372820797
1029 1029 c, t dbSNP:150507232
1033 1033 a, c, t dbSNP:549991084
1046 1046 c, t dbSNP:749956661
1054 1054 c, t dbSNP:764455436
1055 1055 a, c dbSNP:759002598
1057 1057 c, t dbSNP:753056696
1060 1060 c, t dbSNP:765632646
1071 1071 c, g dbSNP:759734009
1077 1077 c, t dbSNP:776791729
1086 1086 -, ag dbSNP:121909560
1089 1089 a, c dbSNP:766626880
1094 1094 c, g dbSNP:200857896
1099 1099 c, t dbSNP:773399107
1100 1100 a, g dbSNP:5877
1114 1114 c, t dbSNP:567550044
1115 1115 c, t dbSNP:774262708
1124 1124 a, g dbSNP:192187532
1127 1127 c, g dbSNP:749129128
1130 1130 a, g dbSNP:5878
1135 1135 a, g dbSNP:483352856
1140 1140 -, gatg dbSNP:121909561
1141 1141 a, g dbSNP:755808418
1148 1148 g, t dbSNP:745357314
1149 1149 a, g dbSNP:780821947
1152 1152 -, gag dbSNP:483352855
1156 1156 c, t dbSNP:758801372
1169 1169 c, t dbSNP:777398332
1178 1178 a, c dbSNP:753254708
1179 1179 a, c dbSNP:765761813
1180 1180 a, g dbSNP:758316459
1185 1185 -, cgcattgaggacggcttc dbSNP:199469509
1185 1185 c, t dbSNP:376752370
1186 1186 a, g dbSNP:373515340
1189 1189 c, t dbSNP:761024265
1196 1196 c, t dbSNP:773134244
1197 1197 a, g dbSNP:767683540
1204 1204 g, t dbSNP:762004419
1213 1213 a, g dbSNP:774393305
1215 1215 c, g dbSNP:565091601
1224 1224 a, g dbSNP:762780270
1239 1239 a, g dbSNP:775413132
1242 1242 a, c dbSNP:149006854
1256 1256 a, g dbSNP:745578147
1260 1260 c, t dbSNP:121909565
1263 1263 a, c dbSNP:780549243
1270 1270 c, t dbSNP:770381981
1278 1278 a, g dbSNP:560610974
1283 1283 a, c dbSNP:759275331
1286 1286 a, g dbSNP:776277707
1287 1287 c, g dbSNP:770580443
1291 1291 a, g dbSNP:201541724
1298 1298 a, c dbSNP:746504812
1303 1303 a, g dbSNP:777327592
1304 1304 c, t dbSNP:769120458
1312 1312 a, g dbSNP:749848792
1313 1313 a, t dbSNP:372611817
1326 1326 g, t dbSNP:756459428
1332 1332 a, c dbSNP:483352859
1335 1335 c, g dbSNP:540730281
1337 1337 a, g dbSNP:368902256
1340 1340 a, t dbSNP:781733242
1343 1343 c, t dbSNP:201411353
1356 1356 a, g dbSNP:747288413
1359 1359 a, g dbSNP:121909557
1361 1361 a, t dbSNP:778165875
1365 1365 c, g, t dbSNP:121909548
1369 1369 a, g dbSNP:752730597
1372 1372 c, t dbSNP:765204251
1373 1373 c, t dbSNP:559277597
1374 1374 a, g dbSNP:552064073
1375 1375 c, t dbSNP:121909568
1377 1377 c, g dbSNP:372319633
1384 1384 c, t dbSNP:772809607
1390 1390 a, g dbSNP:121909566
1391 1391 a, c dbSNP:767159321
1392 1392 c, t dbSNP:121909554
1393 1393 a, c, g dbSNP:121909549
1396 1396 c, t dbSNP:121909550
1397 1397 a, g dbSNP:773792958
1406 1406 c, t dbSNP:770330164
1409 1409 a, c dbSNP:746402824
1425 1425 a, g dbSNP:121909546
1435 1435 c, t dbSNP:121909555
1449 1449 a, g dbSNP:777118044
1459 1459 a, t dbSNP:368586812
1461 1461 c, t dbSNP:376029223
1467 1467 a, g dbSNP:747412993
1469 1469 c, t dbSNP:5879
1474 1474 c, t dbSNP:758603270
1489 1489 a, g dbSNP:748251829
1490 1490 a, g dbSNP:778896348
1492 1492 c, t dbSNP:754917785
1501 1501 c, t dbSNP:121909564
1502 1502 c, t dbSNP:374122877
1526 1526 g, t dbSNP:753725301
1531 1531 c, g dbSNP:766334816
1532 1532 a, c dbSNP:755838660
1543 1543 a, g dbSNP:370533988
1548 1548 -, t dbSNP:761064819
1548 1548 c, t dbSNP:377120264
1548 1548 -, t dbSNP:775742595
1564 1564 a, g dbSNP:767187085

Target ORF information:

RefSeq Version NM_000488
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_000488

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTATTCCA ATGTGATAGG AACTGTAACC TCTGGAAAAA GGAAGGTTTA TCTTTTGTCC 
TTGCTGCTCA TTGGCTTCTG GGACTGCGTG ACCTGTCACG GGAGCCCTGT GGACATCTGC
ACAGCCAAGC CGCGGGACAT TCCCATGAAT CCCATGTGCA TTTACCGCTC CCCGGAGAAG
AAGGCAACTG AGGATGAGGG CTCAGAACAG AAGATCCCGG AGGCCACCAA CCGGCGTGTC
TGGGAACTGT CCAAGGCCAA TTCCCGCTTT GCTACCACTT TCTATCAGCA CCTGGCAGAT
TCCAAGAATG ACAATGATAA CATTTTCCTG TCACCCCTGA GTATCTCCAC GGCTTTTGCT
ATGACCAAGC TGGGTGCCTG TAATGACACC CTCCAGCAAC TGATGGAGGT ATTTAAGTTT
GACACCATAT CTGAGAAAAC ATCTGATCAG ATCCACTTCT TCTTTGCCAA ACTGAACTGC
CGACTCTATC GAAAAGCCAA CAAATCCTCC AAGTTAGTAT CAGCCAATCG CCTTTTTGGA
GACAAATCCC TTACCTTCAA TGAGACCTAC CAGGACATCA GTGAGTTGGT ATATGGAGCC
AAGCTCCAGC CCCTGGACTT CAAGGAAAAT GCAGAGCAAT CCAGAGCGGC CATCAACAAA
TGGGTGTCCA ATAAGACCGA AGGCCGAATC ACCGATGTCA TTCCCTCGGA AGCCATCAAT
GAGCTCACTG TTCTGGTGCT GGTTAACACC ATTTACTTCA AGGGCCTGTG GAAGTCAAAG
TTCAGCCCTG AGAACACAAG GAAGGAACTG TTCTACAAGG CTGATGGAGA GTCGTGTTCA
GCATCTATGA TGTACCAGGA AGGCAAGTTC CGTTATCGGC GCGTGGCTGA AGGCACCCAG
GTGCTTGAGT TGCCCTTCAA AGGTGATGAC ATCACCATGG TCCTCATCTT GCCCAAGCCT
GAGAAGAGCC TGGCCAAGGT AGAGAAGGAA CTCACCCCAG AGGTGCTGCA AGAGTGGCTG
GATGAATTGG AGGAGATGAT GCTGGTGGTC CACATGCCCC GCTTCCGCAT TGAGGACGGC
TTCAGTTTGA AGGAGCAGCT GCAAGACATG GGCCTTGTCG ATCTGTTCAG CCCTGAAAAG
TCCAAACTCC CAGGTATTGT TGCAGAAGGC CGAGATGACC TCTATGTCTC AGATGCATTC
CATAAGGCAT TTCTTGAGGT AAATGAAGAA GGCAGTGAAG CAGCTGCAAG TACCGCTGTT
GTGATTGCTG GCCGTTCGCT AAACCCCAAC AGGGTGACTT TCAAGGCCAA CAGGCCTTTC
CTGGTTTTTA TAAGAGAAGT TCCTCTGAAC ACTATTATCT TCATGGGCAG AGTAGCCAAC
CCTTGTGTTA AGTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu34399D
Sequence Information ORF Nucleotide Sequence (Length: 1251bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product antithrombin-III isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_004487.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 3, 2014 this sequence version replaced gi:530364786. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAATCCCA TGTGCATTTA CCGCTCCCCG GAGAAGAAGG CAACTGAGGA TGAGGGCTCA 
GAACAGAAGA TCCCGGAGGC CACCAACCGG CGTGTCTGGG AACTGTCCAA GGCCAATTCC
CGCTTTGCTA CCACTTTCTA TCAGCACCTG GCAGATTCCA AGAATGACAA TGATAACATT
TTCCTGTCAC CCCTGAGTAT CTCCACGGCT TTTGCTATGA CCAAGCTGGG TGCCTGTAAT
GACACCCTCC AGCAACTGAT GGAGGTATTT AAGTTTGACA CCATATCTGA GAAAACATCT
GATCAGATCC ACTTCTTCTT TGCCAAACTG AACTGCCGAC TCTATCGAAA AGCCAACAAA
TCCTCCAAGT TAGTATCAGC CAATCGCCTT TTTGGAGACA AATCCCTTAC CTTCAATGAG
ACCTACCAGG ACATCAGTGA GTTGGTATAT GGAGCCAAGC TCCAGCCCCT GGACTTCAAG
GAAAATGCAG AGCAATCCAG AGCGGCCATC AACAAATGGG TGTCCAATAA GACCGAAGGC
CGAATCACCG ATGTCATTCC CTCGGAAGCC ATCAATGAGC TCACTGTTCT GGTGCTGGTT
AACACCATTT ACTTCAAGGG CCTGTGGAAG TCAAAGTTCA GCCCTGAGAA CACAAGGAAG
GAACTGTTCT ACAAGGCTGA TGGAGAGTCG TGTTCAGCAT CTATGATGTA CCAGGAAGGC
AAGTTCCGTT ATCGGCGCGT GGCTGAAGGC ACCCAGGTGC TTGAGTTGCC CTTCAAAGGT
GATGACATCA CCATGGTCCT CATCTTGCCC AAGCCTGAGA AGAGCCTGGC CAAGGTAGAG
AAGGAACTCA CCCCAGAGGT GCTGCAAGAG TGGCTGGATG AATTGGAGGA GATGATGCTG
GTGGTCCACA TGCCCCGCTT CCGCATTGAG GACGGCTTCA GTTTGAAGGA GCAGCTGCAA
GACATGGGCC TTGTCGATCT GTTCAGCCCT GAAAAGTCCA AACTCCCAGG TATTGTTGCA
GAAGGCCGAG ATGACCTCTA TGTCTCAGAT GCATTCCATA AGGCATTTCT TGAGGTAAAT
GAAGAAGGCA GTGAAGCAGC TGCAAGTACC GCTGTTGTGA TTGCTGGCCG TTCGCTAAAC
CCCAACAGGG TGACTTTCAA GGCCAACAGG CCTTTCCTGG TTTTTATAAG AGAAGTTCCT
CTGAACACTA TTATCTTCAT GGGCAGAGTA GCCAACCCTT GTGTTAAGTTA A
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_005245255.1
CDS396..1646
Misc Feature(1)486..1625(+)
Misc Feature(2)1482..1568(+)
Translation
Position Chain Variation Link
11 11 a, t dbSNP:373264710
26 26 a, g dbSNP:372524963
36 36 a, g dbSNP:764606323
48 48 c, t dbSNP:200460215
52 52 a, g dbSNP:775919922
57 57 c, t dbSNP:770098298
71 71 -, aga dbSNP:777418425
72 72 a, g dbSNP:483352843
75 75 c, t dbSNP:776785547
78 78 c, t dbSNP:771146323
79 79 a, g dbSNP:370576783
85 85 a, g dbSNP:777886588
88 88 a, t dbSNP:199469506
94 94 c, t dbSNP:772040776
95 95 a, g dbSNP:750709130
96 96 c, t dbSNP:748072934
97 97 c, g dbSNP:778745435
99 99 a, c, t dbSNP:753713846
107 107 a, g dbSNP:779790099
111 111 a, c dbSNP:61736655
129 129 a, g dbSNP:538275042
138 138 c, t dbSNP:776470508
153 153 a, t dbSNP:2227623
271 271 a, g dbSNP:77439367
277 277 c, t dbSNP:2227598
292 292 a, g dbSNP:535340009
298 298 c, t dbSNP:531137446
301 301 a, g dbSNP:780733720
310 310 c, t dbSNP:369828221
319 319 c, t dbSNP:387906575
329 329 c, t dbSNP:751112370
338 338 c, t dbSNP:188274879
339 339 a, g dbSNP:532883680
340 340 a, t dbSNP:2227624
350 350 a, c, t dbSNP:147676453
351 351 a, g dbSNP:773254902
363 363 a, g dbSNP:145771113
367 367 -, tctgcaca dbSNP:483352844
367 367 a, t dbSNP:121909558
380 380 g, t dbSNP:761729771
383 383 a, g dbSNP:774506712
384 384 c, t dbSNP:768704768
385 385 a, g dbSNP:749308643
389 389 c, t dbSNP:775397662
393 393 c, t dbSNP:769761264
403 403 c, t dbSNP:745698642
411 411 a, g dbSNP:780670128
413 413 g, t dbSNP:756940594
417 417 c, t dbSNP:28929469
418 418 a, g dbSNP:777405542
424 424 c, t dbSNP:550247582
425 425 a, g dbSNP:754390483
432 432 -, aag dbSNP:752544767
452 452 c, t dbSNP:773751914
457 457 a, g, t dbSNP:377500819
462 462 a, t dbSNP:199469505
469 469 c, t dbSNP:121909551
470 470 a, c, g dbSNP:746429528
480 480 aaccggcg, ggga dbSNP:199469507
483 483 c, t dbSNP:374205395
484 484 a, g dbSNP:774294043
486 486 a, c, t dbSNP:121909547
487 487 a, g dbSNP:121909552
488 488 c, t dbSNP:781591817
514 514 a, c dbSNP:775520108
516 516 c, t dbSNP:147266200
517 517 a, g dbSNP:745583962
550 550 a, g dbSNP:369524182
553 553 c, g, t dbSNP:199895690
560 560 c, t dbSNP:747398942
562 562 a, t dbSNP:200118419
565 565 a, g dbSNP:757851817
566 566 a, g, t dbSNP:778100368
593 593 c, t dbSNP:369954987
596 596 c, t dbSNP:374763537
601 601 c, t dbSNP:139392083
602 602 a, g dbSNP:200810296
614 614 a, g dbSNP:371222224
621 621 c, t dbSNP:758698144
630 630 c, t dbSNP:121909573
642 642 c, t dbSNP:121909567
659 659 a, g dbSNP:763087077
673 673 a, t dbSNP:746430769
676 676 c, t dbSNP:532353637
677 677 a, c, t dbSNP:199525344
678 678 a, g dbSNP:571861448
690 690 a, g dbSNP:2227606
693 693 c, t dbSNP:121909569
696 696 a, g dbSNP:752818145
700 700 a, c dbSNP:765445413
709 709 a, t dbSNP:483352848
713 713 -, ctt dbSNP:786204063
719 719 c, t dbSNP:759369437
731 731 c, t dbSNP:753759247
732 732 c, t dbSNP:121909562
733 733 a, g, t dbSNP:121909563
737 737 -, ct dbSNP:483352850
741 741 a, c, t dbSNP:199469504
742 742 a, g dbSNP:483352852
751 751 a, c dbSNP:121909570
757 757 c, t dbSNP:483352851
760 760 c, t dbSNP:771696386
780 780 c, t dbSNP:143521873
786 786 g, t dbSNP:773822689
787 787 a, t dbSNP:483352847
804 804 a, g dbSNP:574547491
819 819 c, t dbSNP:748774160
824 824 a, g dbSNP:267598177
837 837 c, t dbSNP:781696456
840 840 c, g dbSNP:771347278
845 845 c, t dbSNP:183416252
846 846 a, g dbSNP:778341415
849 849 c, g dbSNP:483352853
850 850 a, c, t dbSNP:748428859
854 854 g, t dbSNP:779025291
876 876 a, g dbSNP:267598176
884 884 a, g dbSNP:780062808
885 885 a, g dbSNP:756016928
892 892 a, c dbSNP:483352854
898 898 c, t dbSNP:750413071
899 899 a, g dbSNP:767468032
906 906 a, g dbSNP:121909571
911 911 a, g dbSNP:757009890
918 918 c, t dbSNP:121909572
920 920 a, c dbSNP:749583360
921 921 a, g dbSNP:146733468
929 929 c, g, t dbSNP:2227627
937 937 a, g dbSNP:775062927
944 944 c, g, t dbSNP:140452859
945 945 c, g dbSNP:773814831
955 955 c, t dbSNP:772710258
957 957 c, t dbSNP:769911947
958 958 c, t dbSNP:368419985
959 959 a, g dbSNP:774632265
964 964 c, t dbSNP:768914754
967 967 c, t dbSNP:749510661
970 970 a, g dbSNP:200861147
982 982 a, t dbSNP:769820027
983 983 c, t dbSNP:572252151
989 989 a, g dbSNP:558726250
992 992 c, g dbSNP:757200092
999 999 a, g dbSNP:751357562
1000 1000 c, t dbSNP:144084678
1007 1007 c, t dbSNP:745970800
1017 1017 c, t dbSNP:770852197
1028 1028 a, g dbSNP:746961120
1035 1035 a, g dbSNP:777786232
1056 1056 a, g dbSNP:758087836
1059 1059 c, t dbSNP:139275128
1067 1067 c, t dbSNP:758329697
1073 1073 c, t dbSNP:745879490
1084 1084 c, t dbSNP:778650224
1085 1085 a, g, t dbSNP:753390084
1104 1104 -, gatgt dbSNP:483352857
1109 1109 c, g dbSNP:139463995
1115 1115 c, g dbSNP:762356452
1121 1121 c, t dbSNP:370190321
1122 1122 c, t dbSNP:764695432
1123 1123 a, g dbSNP:377588972
1124 1124 c, t dbSNP:775845871
1125 1125 c, t dbSNP:769991153
1126 1126 a, t dbSNP:759821949
1128 1128 c, t dbSNP:776662899
1129 1129 a, g dbSNP:572313182
1131 1131 c, t dbSNP:747142328
1132 1132 a, g, t dbSNP:587776397
1133 1133 c, t dbSNP:184508490
1134 1134 a, g dbSNP:201381904
1136 1136 g, t dbSNP:778915564
1137 1137 c, g dbSNP:372820797
1161 1161 c, t dbSNP:150507232
1165 1165 a, c, t dbSNP:549991084
1178 1178 c, t dbSNP:749956661
1186 1186 c, t dbSNP:764455436
1187 1187 a, c dbSNP:759002598
1189 1189 c, t dbSNP:753056696
1192 1192 c, t dbSNP:765632646
1203 1203 c, g dbSNP:759734009
1209 1209 c, t dbSNP:776791729
1218 1218 -, ag dbSNP:121909560
1221 1221 a, c dbSNP:766626880
1226 1226 c, g dbSNP:200857896
1231 1231 c, t dbSNP:773399107
1232 1232 a, g dbSNP:5877
1246 1246 c, t dbSNP:567550044
1247 1247 c, t dbSNP:774262708
1256 1256 a, g dbSNP:192187532
1259 1259 c, g dbSNP:749129128
1262 1262 a, g dbSNP:5878
1267 1267 a, g dbSNP:483352856
1272 1272 -, gatg dbSNP:121909561
1273 1273 a, g dbSNP:755808418
1280 1280 g, t dbSNP:745357314
1281 1281 a, g dbSNP:780821947
1284 1284 -, gag dbSNP:483352855
1288 1288 c, t dbSNP:758801372
1301 1301 c, t dbSNP:777398332
1310 1310 a, c dbSNP:753254708
1311 1311 a, c dbSNP:765761813
1312 1312 a, g dbSNP:758316459
1317 1317 -, cgcattgaggacggcttc dbSNP:199469509
1317 1317 c, t dbSNP:376752370
1318 1318 a, g dbSNP:373515340
1321 1321 c, t dbSNP:761024265
1328 1328 c, t dbSNP:773134244
1329 1329 a, g dbSNP:767683540
1336 1336 g, t dbSNP:762004419
1345 1345 a, g dbSNP:774393305
1347 1347 c, g dbSNP:565091601
1356 1356 a, g dbSNP:762780270
1371 1371 a, g dbSNP:775413132
1374 1374 a, c dbSNP:149006854
1388 1388 a, g dbSNP:745578147
1392 1392 c, t dbSNP:121909565
1395 1395 a, c dbSNP:780549243
1402 1402 c, t dbSNP:770381981
1410 1410 a, g dbSNP:560610974
1415 1415 a, c dbSNP:759275331
1418 1418 a, g dbSNP:776277707
1419 1419 c, g dbSNP:770580443
1423 1423 a, g dbSNP:201541724
1430 1430 a, c dbSNP:746504812
1435 1435 a, g dbSNP:777327592
1436 1436 c, t dbSNP:769120458
1444 1444 a, g dbSNP:749848792
1445 1445 a, t dbSNP:372611817
1458 1458 g, t dbSNP:756459428
1464 1464 a, c dbSNP:483352859
1467 1467 c, g dbSNP:540730281
1469 1469 a, g dbSNP:368902256
1472 1472 a, t dbSNP:781733242
1475 1475 c, t dbSNP:201411353
1488 1488 a, g dbSNP:747288413
1491 1491 a, g dbSNP:121909557
1493 1493 a, t dbSNP:778165875
1497 1497 c, g, t dbSNP:121909548
1501 1501 a, g dbSNP:752730597
1504 1504 c, t dbSNP:765204251
1505 1505 c, t dbSNP:559277597
1506 1506 a, g dbSNP:552064073
1507 1507 c, t dbSNP:121909568
1509 1509 c, g dbSNP:372319633
1516 1516 c, t dbSNP:772809607
1522 1522 a, g dbSNP:121909566
1523 1523 a, c dbSNP:767159321
1524 1524 c, t dbSNP:121909554
1525 1525 a, c, g dbSNP:121909549
1528 1528 c, t dbSNP:121909550
1529 1529 a, g dbSNP:773792958
1538 1538 c, t dbSNP:770330164
1541 1541 a, c dbSNP:746402824
1557 1557 a, g dbSNP:121909546
1567 1567 c, t dbSNP:121909555
1581 1581 a, g dbSNP:777118044
1591 1591 a, t dbSNP:368586812
1593 1593 c, t dbSNP:376029223
1599 1599 a, g dbSNP:747412993
1601 1601 c, t dbSNP:5879
1606 1606 c, t dbSNP:758603270
1621 1621 a, g dbSNP:748251829
1622 1622 a, g dbSNP:778896348
1624 1624 c, t dbSNP:754917785
1633 1633 c, t dbSNP:121909564
1634 1634 c, t dbSNP:374122877
1658 1658 g, t dbSNP:753725301
1663 1663 c, g dbSNP:766334816
1664 1664 a, c dbSNP:755838660
1675 1675 a, g dbSNP:370533988
1680 1680 -, t dbSNP:761064819
1680 1680 c, t dbSNP:377120264
1680 1680 -, t dbSNP:775742595
1696 1696 a, g dbSNP:767187085

Target ORF information:

RefSeq Version XM_005245198
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_005245198

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAATCCCA TGTGCATTTA CCGCTCCCCG GAGAAGAAGG CAACTGAGGA TGAGGGCTCA 
GAACAGAAGA TCCCGGAGGC CACCAACCGG CGTGTCTGGG AACTGTCCAA GGCCAATTCC
CGCTTTGCTA CCACTTTCTA TCAGCACCTG GCAGATTCCA AGAATGACAA TGATAACATT
TTCCTGTCAC CCCTGAGTAT CTCCACGGCT TTTGCTATGA CCAAGCTGGG TGCCTGTAAT
GACACCCTCC AGCAACTGAT GGAGGTATTT AAGTTTGACA CCATATCTGA GAAAACATCT
GATCAGATCC ACTTCTTCTT TGCCAAACTG AACTGCCGAC TCTATCGAAA AGCCAACAAA
TCCTCCAAGT TAGTATCAGC CAATCGCCTT TTTGGAGACA AATCCCTTAC CTTCAATGAG
ACCTACCAGG ACATCAGTGA GTTGGTATAT GGAGCCAAGC TCCAGCCCCT GGACTTCAAG
GAAAATGCAG AGCAATCCAG AGCGGCCATC AACAAATGGG TGTCCAATAA GACCGAAGGC
CGAATCACCG ATGTCATTCC CTCGGAAGCC ATCAATGAGC TCACTGTTCT GGTGCTGGTT
AACACCATTT ACTTCAAGGG CCTGTGGAAG TCAAAGTTCA GCCCTGAGAA CACAAGGAAG
GAACTGTTCT ACAAGGCTGA TGGAGAGTCG TGTTCAGCAT CTATGATGTA CCAGGAAGGC
AAGTTCCGTT ATCGGCGCGT GGCTGAAGGC ACCCAGGTGC TTGAGTTGCC CTTCAAAGGT
GATGACATCA CCATGGTCCT CATCTTGCCC AAGCCTGAGA AGAGCCTGGC CAAGGTAGAG
AAGGAACTCA CCCCAGAGGT GCTGCAAGAG TGGCTGGATG AATTGGAGGA GATGATGCTG
GTGGTCCACA TGCCCCGCTT CCGCATTGAG GACGGCTTCA GTTTGAAGGA GCAGCTGCAA
GACATGGGCC TTGTCGATCT GTTCAGCCCT GAAAAGTCCA AACTCCCAGG TATTGTTGCA
GAAGGCCGAG ATGACCTCTA TGTCTCAGAT GCATTCCATA AGGCATTTCT TGAGGTAAAT
GAAGAAGGCA GTGAAGCAGC TGCAAGTACC GCTGTTGTGA TTGCTGGCCG TTCGCTAAAC
CCCAACAGGG TGACTTTCAA GGCCAACAGG CCTTTCCTGG TTTTTATAAG AGAAGTTCCT
CTGAACACTA TTATCTTCAT GGGCAGAGTA GCCAACCCTT GTGTTAAGTTA A

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.