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SERPINC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SERPINC1
Entrez Gene ID 462
Full Name serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms AT3, AT3D, ATIII, THPH7
General protein information
Preferred Names
antithrombin-III
Names
antithrombin-III
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q25.1

Summary The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]. lac of sum
Disorder MIM:

107300

Disorder Html: Antithrombin III deficiency, 613118 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000488 NP_000479 antithrombin-III precursor
XM_005245198 XP_005245255 antithrombin-III isoform X1



Homo sapiens (human) SERPINC1 NP_000479.1
Pan troglodytes (chimpanzee) SERPINC1 XP_001151521.1
Macaca mulatta (Rhesus monkey) SERPINC1 NP_001098053.1
Canis lupus familiaris (dog) SERPINC1 XP_537187.4
Bos taurus (cattle) SERPINC1 NP_001029870.1
Mus musculus (house mouse) Serpinc1 NP_543120.1
Rattus norvegicus (Norway rat) Serpinc1 NP_001012027.1
Gallus gallus (chicken) SERPINC1 XP_422282.3
Danio rerio (zebrafish) serpinc1 NP_878283.1
Xenopus (Silurana) tropicalis (western clawed frog) serpinc1 NP_001008153.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SERPINC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20572
NM_000488 Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$194.50-$272.30
$389.00
OHu34399 XM_005245198 PREDICTED: Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20572
Clone ID Related Accession (Same CDS sequence) NM_000488
Accession Version NM_000488.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1395bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-AUG-2015
Organism Homo sapiens (human)
Product antithrombin-III precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL136170.14, H62671.1 and H71210.1. This sequence is a reference standard in the RefSeqGene project. On Jul 23, 2009 this sequence version replaced gi:50541941. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312654.1, D29832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTATTCCA ATGTGATAGG AACTGTAACC TCTGGAAAAA GGAAGGTTTA TCTTTTGTCC 
TTGCTGCTCA TTGGCTTCTG GGACTGCGTG ACCTGTCACG GGAGCCCTGT GGACATCTGC
ACAGCCAAGC CGCGGGACAT TCCCATGAAT CCCATGTGCA TTTACCGCTC CCCGGAGAAG
AAGGCAACTG AGGATGAGGG CTCAGAACAG AAGATCCCGG AGGCCACCAA CCGGCGTGTC
TGGGAACTGT CCAAGGCCAA TTCCCGCTTT GCTACCACTT TCTATCAGCA CCTGGCAGAT
TCCAAGAATG ACAATGATAA CATTTTCCTG TCACCCCTGA GTATCTCCAC GGCTTTTGCT
ATGACCAAGC TGGGTGCCTG TAATGACACC CTCCAGCAAC TGATGGAGGT ATTTAAGTTT
GACACCATAT CTGAGAAAAC ATCTGATCAG ATCCACTTCT TCTTTGCCAA ACTGAACTGC
CGACTCTATC GAAAAGCCAA CAAATCCTCC AAGTTAGTAT CAGCCAATCG CCTTTTTGGA
GACAAATCCC TTACCTTCAA TGAGACCTAC CAGGACATCA GTGAGTTGGT ATATGGAGCC
AAGCTCCAGC CCCTGGACTT CAAGGAAAAT GCAGAGCAAT CCAGAGCGGC CATCAACAAA
TGGGTGTCCA ATAAGACCGA AGGCCGAATC ACCGATGTCA TTCCCTCGGA AGCCATCAAT
GAGCTCACTG TTCTGGTGCT GGTTAACACC ATTTACTTCA AGGGCCTGTG GAAGTCAAAG
TTCAGCCCTG AGAACACAAG GAAGGAACTG TTCTACAAGG CTGATGGAGA GTCGTGTTCA
GCATCTATGA TGTACCAGGA AGGCAAGTTC CGTTATCGGC GCGTGGCTGA AGGCACCCAG
GTGCTTGAGT TGCCCTTCAA AGGTGATGAC ATCACCATGG TCCTCATCTT GCCCAAGCCT
GAGAAGAGCC TGGCCAAGGT AGAGAAGGAA CTCACCCCAG AGGTGCTGCA AGAGTGGCTG
GATGAATTGG AGGAGATGAT GCTGGTGGTC CACATGCCCC GCTTCCGCAT TGAGGACGGC
TTCAGTTTGA AGGAGCAGCT GCAAGACATG GGCCTTGTCG ATCTGTTCAG CCCTGAAAAG
TCCAAACTCC CAGGTATTGT TGCAGAAGGC CGAGATGACC TCTATGTCTC AGATGCATTC
CATAAGGCAT TTCTTGAGGT AAATGAAGAA GGCAGTGAAG CAGCTGCAAG TACCGCTGTT
GTGATTGCTG GCCGTTCGCT AAACCCCAAC AGGGTGACTT TCAAGGCCAA CAGGCCTTTC
CTGGTTTTTA TAAGAGAAGT TCCTCTGAAC ACTATTATCT TCATGGGCAG AGTAGCCAAC
CCTTGTGTTA AGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000479.1
CDS120..1514
Misc Feature(1)237..599(+)
Misc Feature(2)276..500(+)
Misc Feature(3)321..323(+)
Misc Feature(4)354..1493(+)
Misc Feature(5)501..503(+)
Misc Feature(6)618..620(+)
Misc Feature(7)678..680(+)
Misc Feature(8)789..791(+)
Misc Feature(9)954..1505(+)
Misc Feature(10)1350..1436(+)
Misc Feature(11)1392..1397(+)
Misc Feature(12)1392..1394(+)
Exon (1)1..160
Gene:SERPINC1
Gene Synonym:
Exon (2)161..527
Gene:SERPINC1
Gene Synonym:
Exon (3)528..743
Gene:SERPINC1
Gene Synonym:
Exon (4)744..881
Gene:SERPINC1
Gene Synonym:
Exon (5)882..1272
Gene:SERPINC1
Gene Synonym:
Exon (6)1273..1337
Gene:SERPINC1
Gene Synonym:
Exon (7)1338..1599
Gene:SERPINC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000488
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000488

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTATTCCA ATGTGATAGG AACTGTAACC TCTGGAAAAA GGAAGGTTTA TCTTTTGTCC 
TTGCTGCTCA TTGGCTTCTG GGACTGCGTG ACCTGTCACG GGAGCCCTGT GGACATCTGC
ACAGCCAAGC CGCGGGACAT TCCCATGAAT CCCATGTGCA TTTACCGCTC CCCGGAGAAG
AAGGCAACTG AGGATGAGGG CTCAGAACAG AAGATCCCGG AGGCCACCAA CCGGCGTGTC
TGGGAACTGT CCAAGGCCAA TTCCCGCTTT GCTACCACTT TCTATCAGCA CCTGGCAGAT
TCCAAGAATG ACAATGATAA CATTTTCCTG TCACCCCTGA GTATCTCCAC GGCTTTTGCT
ATGACCAAGC TGGGTGCCTG TAATGACACC CTCCAGCAAC TGATGGAGGT ATTTAAGTTT
GACACCATAT CTGAGAAAAC ATCTGATCAG ATCCACTTCT TCTTTGCCAA ACTGAACTGC
CGACTCTATC GAAAAGCCAA CAAATCCTCC AAGTTAGTAT CAGCCAATCG CCTTTTTGGA
GACAAATCCC TTACCTTCAA TGAGACCTAC CAGGACATCA GTGAGTTGGT ATATGGAGCC
AAGCTCCAGC CCCTGGACTT CAAGGAAAAT GCAGAGCAAT CCAGAGCGGC CATCAACAAA
TGGGTGTCCA ATAAGACCGA AGGCCGAATC ACCGATGTCA TTCCCTCGGA AGCCATCAAT
GAGCTCACTG TTCTGGTGCT GGTTAACACC ATTTACTTCA AGGGCCTGTG GAAGTCAAAG
TTCAGCCCTG AGAACACAAG GAAGGAACTG TTCTACAAGG CTGATGGAGA GTCGTGTTCA
GCATCTATGA TGTACCAGGA AGGCAAGTTC CGTTATCGGC GCGTGGCTGA AGGCACCCAG
GTGCTTGAGT TGCCCTTCAA AGGTGATGAC ATCACCATGG TCCTCATCTT GCCCAAGCCT
GAGAAGAGCC TGGCCAAGGT AGAGAAGGAA CTCACCCCAG AGGTGCTGCA AGAGTGGCTG
GATGAATTGG AGGAGATGAT GCTGGTGGTC CACATGCCCC GCTTCCGCAT TGAGGACGGC
TTCAGTTTGA AGGAGCAGCT GCAAGACATG GGCCTTGTCG ATCTGTTCAG CCCTGAAAAG
TCCAAACTCC CAGGTATTGT TGCAGAAGGC CGAGATGACC TCTATGTCTC AGATGCATTC
CATAAGGCAT TTCTTGAGGT AAATGAAGAA GGCAGTGAAG CAGCTGCAAG TACCGCTGTT
GTGATTGCTG GCCGTTCGCT AAACCCCAAC AGGGTGACTT TCAAGGCCAA CAGGCCTTTC
CTGGTTTTTA TAAGAGAAGT TCCTCTGAAC ACTATTATCT TCATGGGCAG AGTAGCCAAC
CCTTGTGTTA AGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu34399
Clone ID Related Accession (Same CDS sequence) XM_005245198
Accession Version XM_005245198.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1251bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product antithrombin-III isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_004487.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 3, 2014 this sequence version replaced gi:530364786. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAATCCCA TGTGCATTTA CCGCTCCCCG GAGAAGAAGG CAACTGAGGA TGAGGGCTCA 
GAACAGAAGA TCCCGGAGGC CACCAACCGG CGTGTCTGGG AACTGTCCAA GGCCAATTCC
CGCTTTGCTA CCACTTTCTA TCAGCACCTG GCAGATTCCA AGAATGACAA TGATAACATT
TTCCTGTCAC CCCTGAGTAT CTCCACGGCT TTTGCTATGA CCAAGCTGGG TGCCTGTAAT
GACACCCTCC AGCAACTGAT GGAGGTATTT AAGTTTGACA CCATATCTGA GAAAACATCT
GATCAGATCC ACTTCTTCTT TGCCAAACTG AACTGCCGAC TCTATCGAAA AGCCAACAAA
TCCTCCAAGT TAGTATCAGC CAATCGCCTT TTTGGAGACA AATCCCTTAC CTTCAATGAG
ACCTACCAGG ACATCAGTGA GTTGGTATAT GGAGCCAAGC TCCAGCCCCT GGACTTCAAG
GAAAATGCAG AGCAATCCAG AGCGGCCATC AACAAATGGG TGTCCAATAA GACCGAAGGC
CGAATCACCG ATGTCATTCC CTCGGAAGCC ATCAATGAGC TCACTGTTCT GGTGCTGGTT
AACACCATTT ACTTCAAGGG CCTGTGGAAG TCAAAGTTCA GCCCTGAGAA CACAAGGAAG
GAACTGTTCT ACAAGGCTGA TGGAGAGTCG TGTTCAGCAT CTATGATGTA CCAGGAAGGC
AAGTTCCGTT ATCGGCGCGT GGCTGAAGGC ACCCAGGTGC TTGAGTTGCC CTTCAAAGGT
GATGACATCA CCATGGTCCT CATCTTGCCC AAGCCTGAGA AGAGCCTGGC CAAGGTAGAG
AAGGAACTCA CCCCAGAGGT GCTGCAAGAG TGGCTGGATG AATTGGAGGA GATGATGCTG
GTGGTCCACA TGCCCCGCTT CCGCATTGAG GACGGCTTCA GTTTGAAGGA GCAGCTGCAA
GACATGGGCC TTGTCGATCT GTTCAGCCCT GAAAAGTCCA AACTCCCAGG TATTGTTGCA
GAAGGCCGAG ATGACCTCTA TGTCTCAGAT GCATTCCATA AGGCATTTCT TGAGGTAAAT
GAAGAAGGCA GTGAAGCAGC TGCAAGTACC GCTGTTGTGA TTGCTGGCCG TTCGCTAAAC
CCCAACAGGG TGACTTTCAA GGCCAACAGG CCTTTCCTGG TTTTTATAAG AGAAGTTCCT
CTGAACACTA TTATCTTCAT GGGCAGAGTA GCCAACCCTT GTGTTAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005245255.1
CDS396..1646
Misc Feature(1)486..1625(+)
Misc Feature(2)1482..1568(+)
Translation

Target ORF information:

RefSeq Version XM_005245198
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005245198

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAATCCCA TGTGCATTTA CCGCTCCCCG GAGAAGAAGG CAACTGAGGA TGAGGGCTCA 
GAACAGAAGA TCCCGGAGGC CACCAACCGG CGTGTCTGGG AACTGTCCAA GGCCAATTCC
CGCTTTGCTA CCACTTTCTA TCAGCACCTG GCAGATTCCA AGAATGACAA TGATAACATT
TTCCTGTCAC CCCTGAGTAT CTCCACGGCT TTTGCTATGA CCAAGCTGGG TGCCTGTAAT
GACACCCTCC AGCAACTGAT GGAGGTATTT AAGTTTGACA CCATATCTGA GAAAACATCT
GATCAGATCC ACTTCTTCTT TGCCAAACTG AACTGCCGAC TCTATCGAAA AGCCAACAAA
TCCTCCAAGT TAGTATCAGC CAATCGCCTT TTTGGAGACA AATCCCTTAC CTTCAATGAG
ACCTACCAGG ACATCAGTGA GTTGGTATAT GGAGCCAAGC TCCAGCCCCT GGACTTCAAG
GAAAATGCAG AGCAATCCAG AGCGGCCATC AACAAATGGG TGTCCAATAA GACCGAAGGC
CGAATCACCG ATGTCATTCC CTCGGAAGCC ATCAATGAGC TCACTGTTCT GGTGCTGGTT
AACACCATTT ACTTCAAGGG CCTGTGGAAG TCAAAGTTCA GCCCTGAGAA CACAAGGAAG
GAACTGTTCT ACAAGGCTGA TGGAGAGTCG TGTTCAGCAT CTATGATGTA CCAGGAAGGC
AAGTTCCGTT ATCGGCGCGT GGCTGAAGGC ACCCAGGTGC TTGAGTTGCC CTTCAAAGGT
GATGACATCA CCATGGTCCT CATCTTGCCC AAGCCTGAGA AGAGCCTGGC CAAGGTAGAG
AAGGAACTCA CCCCAGAGGT GCTGCAAGAG TGGCTGGATG AATTGGAGGA GATGATGCTG
GTGGTCCACA TGCCCCGCTT CCGCATTGAG GACGGCTTCA GTTTGAAGGA GCAGCTGCAA
GACATGGGCC TTGTCGATCT GTTCAGCCCT GAAAAGTCCA AACTCCCAGG TATTGTTGCA
GAAGGCCGAG ATGACCTCTA TGTCTCAGAT GCATTCCATA AGGCATTTCT TGAGGTAAAT
GAAGAAGGCA GTGAAGCAGC TGCAAGTACC GCTGTTGTGA TTGCTGGCCG TTCGCTAAAC
CCCAACAGGG TGACTTTCAA GGCCAACAGG CCTTTCCTGG TTTTTATAAG AGAAGTTCCT
CTGAACACTA TTATCTTCAT GGGCAGAGTA GCCAACCCTT GTGTTAAGTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Clinical and laboratory characteristics of paediatric and adolescent index cases with venous thromboembolism and antithrombin deficiency. An observational multicentre cohort study
Thromb. Haemost. 112 (3), 478-485 (2014)
Limperger V, Franke A, Kenet G, Holzhauer S, Picard V, Junker R, Heller C, Gille C, Manner D, Kurnik K, Knoefler R, Mesters R, Halimeh S and Nowak-Gottl U.


book

Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes
Thromb. Haemost. 111 (3), 438-446 (2014)
Segers O, Simioni P, Tormene D and Castoldi E.


book

Antithrombin-p.Ala416Pro: the second reported case in Japan
Intern. Med. 53 (5), 477-481 (2014)
Shigekiyo T, Sekimoto E, Shibata H, Ozaki S, Kurushima A and Aihara K.


book

Molecular basis of inherited human antithrombin deficiency
Blood 80 (9), 2159-2171 (1992)
Blajchman MA, Austin RC, Fernandez-Rachubinski F and Sheffield WP.


book

Insertions/deletions in the antithrombin gene: 3 mutations associated with non-expression
Thromb. Haemost. 67 (5), 521-525 (1992)
Daly M, Perry DJ, Harper PL, Daly HM, Roques AW and Carrell RW.


book

Natural anticoagulant pathways in normal and transplanted human hearts
J. Heart Lung Transplant. 11 (2 PT 1), 342-347 (1992)
Labarrere CA, Pitts D, Halbrook H and Faulk WP.


book

Intron structure of the human antithrombin III gene differs from that of other members of the serine protease inhibitor superfamily
J. Biol. Chem. 260 (17), 9608-9612 (1985)
Prochownik,E.V., Bock,S.C. and Orkin,S.H.


book

Isolation of a cDNA clone for human antithrombin III
J. Biol. Chem. 258 (13), 8389-8394 (1983)
Prochownik,E.V., Markham,A.F. and Orkin,S.H.


book

Isolation and sequence characterization of a cDNA clone of human antithrombin III
Proc. Natl. Acad. Sci. U.S.A. 80 (7), 1845-1848 (1983)
Chandra,T., Stackhouse,R., Kidd,V.J. and Woo,S.L.


book

Cloning and expression of the cDNA for human antithrombin III
Nucleic Acids Res. 10 (24), 8113-8125 (1982)
Bock,S.C., Wion,K.L., Vehar,G.A. and Lawn,R.M.


 
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