||ORF Nucleotide Sequence (Length: 5808bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BF834726.1, EU747717.1,
M58018.1 and BC112173.1.
On or before Jun 20, 2014 this sequence version replaced
Summary: Muscle myosin is a hexameric protein containing 2 heavy
chain subunits, 2 alkali light chain subunits, and 2 regulatory
light chain subunits. This gene encodes the beta (or slow) heavy
chain subunit of cardiac myosin. It is expressed predominantly in
normal human ventricle. It is also expressed in skeletal muscle
tissues rich in slow-twitch type I muscle fibers. Changes in the
relative abundance of this protein and the alpha (or fast) heavy
subunit of cardiac myosin correlate with the contractile velocity
of cardiac muscle. Its expression is also altered during thyroid
hormone depletion and hemodynamic overloading. Mutations in this
gene are associated with familial hypertrophic cardiomyopathy,
myosin storage myopathy, dilated cardiomyopathy, and Laing
early-onset distal myopathy. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: EU747717.1, M58018.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.