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MYL1 myosin, light chain 1, alkali; skeletal, fast [Homo sapiens (human)]

Gene Symbol MYL1
Entrez Gene ID 4632
Full Name myosin, light chain 1, alkali; skeletal, fast
Synonyms MLC1F, MLC3F
General protein information
Preferred Names
myosin light chain 1/3, skeletal muscle isoform
Names
myosin light chain 1/3, skeletal muscle isoform
MLC1/MLC3
MLC1F/MLC3F
A1 catalytic
A2 catalytic
myosin light chain A1/A2
myosin light chain alkali 1/2
myosin, light polypeptide 1, alkali; skeletal, fast
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q34

Summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

160780

Disorder Html:





The following MYL1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYL1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu13487 NM_079422 Homo sapiens myosin, light chain 1, alkali; skeletal, fast (MYL1), transcript variant 3f, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99
OHu13342 NM_079420 Homo sapiens myosin, light chain 1, alkali; skeletal, fast (MYL1), transcript variant 1f, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu13487
Accession Version NM_079422.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 453bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 28-APR-2015
Organism Homo sapiens (human)
Product myosin light chain 1/3, skeletal muscle isoform isoform 3f
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005318.1 and AA705167.1. On Oct 4, 2006 this sequence version replaced gi:17986274. Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3f) encodes a protein that is 44 aa shorter than isoform 1f. Transcript variants 3f and 1f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005318.1, BX436371.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2162946 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_524146.1
CDS72..524
Misc Feature(1)81..518(+)
Misc Feature(2)99..293(+)
Misc Feature(3)126..275(+)
Misc Feature(4)330..515(+)
Misc Feature(5)357..497(+)
Exon (1)1..74
Gene:MYL1
Gene Synonym:
Exon (2)75..99
Gene:MYL1
Gene Synonym:
Exon (3)100..243
Gene:MYL1
Gene Synonym:
Exon (4)244..417
Gene:MYL1
Gene Synonym:
Exon (5)418..495
Gene:MYL1
Gene Synonym:
Exon (6)496..538
Gene:MYL1
Gene Synonym:
Exon (7)539..862
Gene:MYL1
Gene Synonym:
Translation
Position Chain Variation Link
11 11 c, t dbSNP:144118989
12 12 a, g dbSNP:561274656
15 15 a, g dbSNP:544500095
22 22 a, t dbSNP:757776776
33 33 c, g, t dbSNP:764624044
35 35 c, t dbSNP:575275473
44 44 g, t dbSNP:752344235
54 54 a, c dbSNP:764896970
58 58 c, t dbSNP:759001004
61 61 a, g dbSNP:776140670
63 63 c, t dbSNP:181132123
64 64 a, g dbSNP:200303195
73 73 c, t dbSNP:138512142
74 74 a, g dbSNP:771902691
79 79 g, t dbSNP:149277744
85 85 c, t dbSNP:754601142
89 89 a, c dbSNP:184563845
96 96 g, t dbSNP:765913439
105 105 a, g dbSNP:758302123
107 107 g, t dbSNP:138478671
121 121 g, t dbSNP:766723318
122 122 c, g dbSNP:1135254
126 126 g, t dbSNP:761037368
129 129 a, g dbSNP:773302523
135 135 a, g dbSNP:11554011
150 150 a, t dbSNP:145897731
152 152 a, c dbSNP:761750127
164 164 c, t dbSNP:774952508
165 165 a, g, t dbSNP:199843326
168 168 a, g dbSNP:775888493
170 170 c, t dbSNP:143274393
174 174 c, t dbSNP:145275381
178 178 a, g dbSNP:141590730
182 182 c, t dbSNP:1057219
183 183 c, t dbSNP:756816293
186 186 a, g dbSNP:746464441
192 192 a, t dbSNP:777771898
195 195 c, t dbSNP:758355281
203 203 a, c, t dbSNP:145306902
206 206 a, g dbSNP:11554008
209 209 a, g dbSNP:754796854
215 215 a, g dbSNP:750680519
219 219 a, g dbSNP:767592290
229 229 a, t dbSNP:761956126
230 230 a, c dbSNP:774234588
239 239 c, t dbSNP:764143295
245 245 c, g dbSNP:753507577
265 265 -, ag dbSNP:781219009
268 268 c, t dbSNP:371995777
269 269 g, t dbSNP:757476111
285 285 a, g dbSNP:751799521
297 297 a, t dbSNP:551715536
306 306 a, g dbSNP:367816223
308 308 a, c dbSNP:762994238
323 323 a, c dbSNP:139637576
325 325 a, g dbSNP:116054444
335 335 c, t dbSNP:759953059
341 341 a, g dbSNP:149445418
348 348 c, t dbSNP:146383845
349 349 a, g dbSNP:139030210
371 371 c, t dbSNP:772968528
374 374 a, c dbSNP:550520343
375 375 a, g dbSNP:771728814
376 376 a, c dbSNP:532473895
386 386 g, t dbSNP:747621589
387 387 a, g dbSNP:374842955
393 393 c, g dbSNP:773635355
396 396 c, t dbSNP:370058858
397 397 a, g dbSNP:150240747
400 400 a, c dbSNP:779776928
406 406 -, tagccac dbSNP:754858934
409 409 c, t dbSNP:772171298
413 413 a, c dbSNP:377511663
415 415 c, t dbSNP:755903302
418 418 a, g dbSNP:769239527
419 419 a, t dbSNP:769495546
434 434 c, g dbSNP:745626223
435 435 a, g dbSNP:762762655
446 446 a, g dbSNP:143710089
461 461 g, t dbSNP:777977796
464 464 a, g dbSNP:758561571
469 469 a, t dbSNP:748358398
475 475 a, g dbSNP:778929003
476 476 c, t dbSNP:755055452
478 478 a, c, g dbSNP:766868066
482 482 c, t dbSNP:567520577
491 491 a, c, t dbSNP:750757172
492 492 a, g dbSNP:767979740
509 509 c, t dbSNP:200558852
514 514 a, g, t dbSNP:754942775
516 516 a, t dbSNP:372225011
519 519 a, t dbSNP:780245631
522 522 c, t dbSNP:769959608
529 529 a, c dbSNP:746421901
533 533 c, t dbSNP:369883035
536 536 a, g dbSNP:757725469
562 562 a, g dbSNP:553889868
593 593 a, c dbSNP:11554010
614 614 c, t dbSNP:533989831
645 645 a, g dbSNP:181484899
646 646 a, g dbSNP:532167031
647 647 c, t dbSNP:555243761
666 666 c, t dbSNP:1803984
680 680 a, g dbSNP:191693602
681 681 c, t dbSNP:759923445
723 723 a, t dbSNP:569888528
741 741 a, t dbSNP:186770286
761 761 c, g dbSNP:533006797
780 780 c, t dbSNP:564704074
798 798 a, g dbSNP:765205955
815 815 a, c dbSNP:570420412
844 844 a, g dbSNP:770290665
860 860 c, t dbSNP:547516448

Target ORF information:

RefSeq Version NM_079422
Organism Homo sapiens (human)
Definition Homo sapiens myosin, light chain 1, alkali; skeletal, fast (MYL1), transcript variant 3f, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_079422

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGTCCTTCA GTGCTGACCA GATTGCTGAA TTCAAGGAGG CATTTCTCCT GTTTGACAGA 
ACAGGTGATT CCAAGATCAC CTTAAGCCAG GTCGGTGATG TCCTTCGAGC TCTGGGCACA
AATCCCACCA ATGCAGAGGT CAGGAAAGTT CTGGGAAACC CCAGCAATGA AGAGCTGAAT
GCCAAGAAAA TTGAGTTTGA ACAATTTCTG CCTATGATGC AAGCCATTTC CAACAACAAG
GACCAGGCCA CCTATGAAGA CTTTGTTGAG GGTCTGCGTG TCTTTGACAA GGAAGGCAAT
GGCACAGTCA TGGGTGCTGA ACTCCGCCAT GTTCTAGCCA CCCTGGGTGA AAAGATGAAA
GAGGAAGAAG TGGAAGCCCT GATGGCAGGT CAAGAAGACT CCAATGGCTG CATCAACTAC
GAAGCTTTTG TCAAGCACAT CATGTCTATC TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu13342
Accession Version NM_079420.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 585bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 28-APR-2015
Organism Homo sapiens (human)
Product myosin light chain 1/3, skeletal muscle isoform isoform 1f
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA898482.1, CR456869.1 and AA705167.1. On Oct 4, 2006 this sequence version replaced gi:17986272. Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1f) encodes a protein that is 44 aa longer than isoform 3f. Transcript variants 1f and 3f differ in their first two exons. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL598805.1, BF693841.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1970526, SAMEA2142348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_524144.1
CDS130..714
Misc Feature(1)106..108(+)
Misc Feature(2)133..135(+)
Misc Feature(3)262..708(+)
Misc Feature(4)289..483(+)
Misc Feature(5)289..378(+)
Misc Feature(6)316..465(+)
Misc Feature(7)520..705(+)
Misc Feature(8)547..687(+)
Exon (1)1..261
Gene:MYL1
Gene Synonym:
Exon (2)262..289
Gene:MYL1
Gene Synonym:
Exon (3)290..433
Gene:MYL1
Gene Synonym:
Exon (4)434..607
Gene:MYL1
Gene Synonym:
Exon (5)608..685
Gene:MYL1
Gene Synonym:
Exon (6)686..728
Gene:MYL1
Gene Synonym:
Exon (7)729..1052
Gene:MYL1
Gene Synonym:
Translation
Position Chain Variation Link
5 5 c, t dbSNP:564470289
10 10 a, c dbSNP:541581724
51 51 c, t dbSNP:572534980
56 56 c, t dbSNP:553137163
78 78 g, t dbSNP:772471757
85 85 c, t dbSNP:761626233
89 89 a, g dbSNP:774118904
90 90 g, t dbSNP:368041553
114 114 c, g, t dbSNP:780076132
115 115 c, g, t dbSNP:375080949
119 119 a, t dbSNP:542431706
119 119 -, t dbSNP:750554844
120 120 a, t dbSNP:757038593
125 125 a, g dbSNP:752954497
128 128 -, aaa dbSNP:756009924
129 129 -, aa dbSNP:752675933
130 130 -, a, aa, aaaa dbSNP:544557603
130 130 -, a dbSNP:751314196
133 133 a, g dbSNP:779083826
141 141 g, t dbSNP:374726336
145 145 g, t dbSNP:755072317
146 146 a, c dbSNP:62001907
152 152 a, g dbSNP:753874303
161 161 -, tggctg dbSNP:766040193
161 161 c, t dbSNP:62001905
164 164 c, t dbSNP:199528600
166 166 a, g, t dbSNP:143705321
167 167 c, g, t dbSNP:142821726
168 168 g, t dbSNP:774172250
173 173 a, c, t dbSNP:762562092
174 174 a, g, t dbSNP:372051162
175 175 a, g dbSNP:745857501
178 178 -, g dbSNP:370550332
179 179 -, ggctgc dbSNP:772599264
181 181 c, g dbSNP:781150952
188 188 c, t dbSNP:570955358
189 189 a, g, t dbSNP:148686005
192 192 a, g dbSNP:374355345
194 194 c, t dbSNP:200875603
195 195 a, g dbSNP:370260390
200 200 -, ggcacc dbSNP:769339608
200 200 c, t dbSNP:756189605
204 204 a, c dbSNP:750943225
208 208 g, t dbSNP:768023114
209 209 -, acctgc dbSNP:762281555
215 215 c, t dbSNP:565388768
217 217 c, t dbSNP:751910373
218 218 -, tgcccc dbSNP:777177851
222 222 c, t dbSNP:763857482
226 226 c, t dbSNP:748911666
230 230 a, g dbSNP:762755983
235 235 c, g dbSNP:549574831
240 240 a, t dbSNP:764696271
246 246 c, g, t dbSNP:376404409
259 259 a, g dbSNP:770817233
264 264 c, g, t dbSNP:140441697
265 265 a, g dbSNP:753537507
270 270 a, c dbSNP:201406310
273 273 c, t dbSNP:755650575
276 276 c, g dbSNP:749866889
278 278 a, g dbSNP:767367029
280 280 a, c dbSNP:761864154
282 282 a, g dbSNP:368042681
286 286 a, g dbSNP:373883357
295 295 a, g dbSNP:758302123
297 297 g, t dbSNP:138478671
311 311 g, t dbSNP:766723318
312 312 c, g dbSNP:1135254
316 316 g, t dbSNP:761037368
319 319 a, g dbSNP:773302523
325 325 a, g dbSNP:11554011
340 340 a, t dbSNP:145897731
342 342 a, c dbSNP:761750127
354 354 c, t dbSNP:774952508
355 355 a, g, t dbSNP:199843326
358 358 a, g dbSNP:775888493
360 360 c, t dbSNP:143274393
364 364 c, t dbSNP:145275381
368 368 a, g dbSNP:141590730
372 372 c, t dbSNP:1057219
373 373 c, t dbSNP:756816293
376 376 a, g dbSNP:746464441
382 382 a, t dbSNP:777771898
385 385 c, t dbSNP:758355281
393 393 a, c, t dbSNP:145306902
396 396 a, g dbSNP:11554008
399 399 a, g dbSNP:754796854
405 405 a, g dbSNP:750680519
409 409 a, g dbSNP:767592290
419 419 a, t dbSNP:761956126
420 420 a, c dbSNP:774234588
429 429 c, t dbSNP:764143295
435 435 c, g dbSNP:753507577
455 455 -, ag dbSNP:781219009
458 458 c, t dbSNP:371995777
459 459 g, t dbSNP:757476111
475 475 a, g dbSNP:751799521
487 487 a, t dbSNP:551715536
496 496 a, g dbSNP:367816223
498 498 a, c dbSNP:762994238
513 513 a, c dbSNP:139637576
515 515 a, g dbSNP:116054444
525 525 c, t dbSNP:759953059
531 531 a, g dbSNP:149445418
538 538 c, t dbSNP:146383845
539 539 a, g dbSNP:139030210
561 561 c, t dbSNP:772968528
564 564 a, c dbSNP:550520343
565 565 a, g dbSNP:771728814
566 566 a, c dbSNP:532473895
576 576 g, t dbSNP:747621589
577 577 a, g dbSNP:374842955
583 583 c, g dbSNP:773635355
586 586 c, t dbSNP:370058858
587 587 a, g dbSNP:150240747
590 590 a, c dbSNP:779776928
596 596 -, tagccac dbSNP:754858934
599 599 c, t dbSNP:772171298
603 603 a, c dbSNP:377511663
605 605 c, t dbSNP:755903302
608 608 a, g dbSNP:769239527
609 609 a, t dbSNP:769495546
624 624 c, g dbSNP:745626223
625 625 a, g dbSNP:762762655
636 636 a, g dbSNP:143710089
651 651 g, t dbSNP:777977796
654 654 a, g dbSNP:758561571
659 659 a, t dbSNP:748358398
665 665 a, g dbSNP:778929003
666 666 c, t dbSNP:755055452
668 668 a, c, g dbSNP:766868066
672 672 c, t dbSNP:567520577
681 681 a, c, t dbSNP:750757172
682 682 a, g dbSNP:767979740
699 699 c, t dbSNP:200558852
704 704 a, g, t dbSNP:754942775
706 706 a, t dbSNP:372225011
709 709 a, t dbSNP:780245631
712 712 c, t dbSNP:769959608
719 719 a, c dbSNP:746421901
723 723 c, t dbSNP:369883035
726 726 a, g dbSNP:757725469
752 752 a, g dbSNP:553889868
783 783 a, c dbSNP:11554010
804 804 c, t dbSNP:533989831
835 835 a, g dbSNP:181484899
836 836 a, g dbSNP:532167031
837 837 c, t dbSNP:555243761
856 856 c, t dbSNP:1803984
870 870 a, g dbSNP:191693602
871 871 c, t dbSNP:759923445
913 913 a, t dbSNP:569888528
931 931 a, t dbSNP:186770286
951 951 c, g dbSNP:533006797
970 970 c, t dbSNP:564704074
988 988 a, g dbSNP:765205955
1005 1005 a, c dbSNP:570420412
1034 1034 a, g dbSNP:770290665
1050 1050 c, t dbSNP:547516448

Target ORF information:

RefSeq Version NM_079420
Organism Homo sapiens (human)
Definition Homo sapiens myosin, light chain 1, alkali; skeletal, fast (MYL1), transcript variant 1f, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_079420

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCACCAA AGAAAGACGT GAAGAAACCT GTGGCTGCGG CTGCGGCTGC CCCAGCCCCG 
GCACCGGCAC CTGCACCTGC CCCTGCCCCA GCCAAACCCA AAGAAGAAAA AATTGACCTC
TCTGCCATTA AGATCGAGTT CTCTAAGGAA CAGCAGGATG AATTCAAGGA GGCATTTCTC
CTGTTTGACA GAACAGGTGA TTCCAAGATC ACCTTAAGCC AGGTCGGTGA TGTCCTTCGA
GCTCTGGGCA CAAATCCCAC CAATGCAGAG GTCAGGAAAG TTCTGGGAAA CCCCAGCAAT
GAAGAGCTGA ATGCCAAGAA AATTGAGTTT GAACAATTTC TGCCTATGAT GCAAGCCATT
TCCAACAACA AGGACCAGGC CACCTATGAA GACTTTGTTG AGGGTCTGCG TGTCTTTGAC
AAGGAAGGCA ATGGCACAGT CATGGGTGCT GAACTCCGCC ATGTTCTAGC CACCCTGGGT
GAAAAGATGA AAGAGGAAGA AGTGGAAGCC CTGATGGCAG GTCAAGAAGA CTCCAATGGC
TGCATCAACT ACGAAGCTTT TGTCAAGCAC ATCATGTCTA TCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.