Email to GenScript

Human  Mouse  Rat  Other  

Search Help

Human  Mouse  Rat  Other  

  • THAT   AND
  • THAT   AND


MYL2 myosin, light chain 2, regulatory, cardiac, slow [Homo sapiens (human)]

Gene Symbol MYL2
Entrez Gene ID 4633
Full Name myosin, light chain 2, regulatory, cardiac, slow
Synonyms CMH10, MLC2
General protein information
Preferred Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Names
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
MLC-2
MLC-2v
RLC of myosin
myosin light chain 2
regulatory light chain of myosin
cardiac ventricular myosin light chain 2
slow cardiac myosin regulatory light chain 2
myosin, light polypeptide 2, regulatory, cardiac, slow
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.11

Summary Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

160781

Disorder Html: Cardiomyopathy, familial hypertrophic, 10, 608758 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu18354 NM_000432 Homo sapiens myosin, light chain 2, regulatory, cardiac, slow (MYL2), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu18354D
Sequence Information ORF Nucleotide Sequence (Length: 501bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA090235.1, BC015821.1 and BC031008.1. This sequence is a reference standard in the RefSeqGene project. On Jun 14, 2008 this sequence version replaced gi:94981552. Summary: Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP318509.1, BC031008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCACCTA AGAAAGCAAA GAAGAGAGCC GGGGGCGCCA ACTCCAACGT GTTCTCCATG 
TTCGAACAGA CCCAAATCCA GGAATTTAAG GAGGCCTTCA CTATCATGGA CCAGAACAGG
GATGGCTTCA TTGACAAGAA CGATCTGAGA GACACCTTTG CTGCCCTTGG GCGAGTGAAC
GTGAAAAATG AAGAAATTGA TGAAATGATC AAGGAGGCTC CGGGTCCAAT TAACTTTACT
GTGTTCCTCA CAATGTTTGG GGAGAAACTT AAGGGAGCGG ACCCTGAGGA AACCATTCTC
AACGCATTCA AAGTGTTTGA CCCTGAAGGC AAAGGGGTGC TGAAGGCTGA TTACGTTCGG
GAAATGCTGA CCACGCAGGC GGAGAGGTTT TCCAAGGAGG AGGTTGACCA GATGTTCGCC
GCCTTCCCCC CTGACGTGAC TGGCAACTTG GACTACAAGA ACCTGGTGCA CATCATCACC
CACGGAGAAG AGAAGGACTTA G
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000423.2
CDS72..572
Misc Feature(1)114..560(+)
Misc Feature(2)126..128(+)
Misc Feature(3)153..>290(+)
Misc Feature(4)180..215(+)
Misc Feature(5)375..551(+)
Misc Feature(6)390..533(+)
Exon (1)1..74
Gene:MYL2
Gene Synonym:
Exon (2)75..164
Gene:MYL2
Gene Synonym:
Exon (3)165..240
Gene:MYL2
Gene Synonym:
Exon (4)241..345
Gene:MYL2
Gene Synonym:
Exon (5)346..424
Gene:MYL2
Gene Synonym:
Exon (6)425..473
Gene:MYL2
Gene Synonym:
Exon (7)474..830
Gene:MYL2
Gene Synonym:
Translation
Position Chain Variation Link
1 1 g, t dbSNP:185700670
25 25 a, c, t dbSNP:771537704
26 26 a, g dbSNP:368048109
29 29 c, g dbSNP:370643759
30 30 c, t dbSNP:771288466
42 42 c, g dbSNP:2857718
44 44 c, t dbSNP:377590769
45 45 a, g dbSNP:374106618
51 51 c, t dbSNP:756621882
58 58 c, g dbSNP:371022137
68 68 c, t dbSNP:11538904
70 70 c, t dbSNP:730880938
78 78 a, c dbSNP:763957786
82 82 -, agaaa dbSNP:747082468
85 85 a, g dbSNP:730880941
99 99 a, g dbSNP:730880942
101 101 c, t dbSNP:752641375
102 102 a, g, t dbSNP:397516402
104 104 a, g dbSNP:199742269
105 105 g, t dbSNP:730880937
106 106 g, t dbSNP:762584624
107 107 c, t dbSNP:139794370
108 108 a, g dbSNP:104894363
116 116 ca, t dbSNP:727504300
116 116 c, t dbSNP:762185101
118 118 -, a dbSNP:781431079
119 119 c, t dbSNP:552004172
120 120 a, g dbSNP:730880943
123 123 c, t dbSNP:104894370
124 124 c, t dbSNP:730880944
129 129 a, c, g dbSNP:199474816
130 130 a, c, t dbSNP:113167834
134 134 c, t dbSNP:779983470
135 135 a, c, g, t dbSNP:104894368
149 149 c, t dbSNP:755926255
151 151 a, g dbSNP:397516408
153 153 a, g dbSNP:397516409
155 155 a, t dbSNP:397516410
168 168 c, t dbSNP:730880945
174 174 a, g dbSNP:730880946
184 184 a, g dbSNP:730880947
185 185 a, g dbSNP:749595978
190 190 a, g, t dbSNP:727503299
191 191 a, g dbSNP:571489007
195 195 g, t dbSNP:754854401
203 203 c, t dbSNP:2301610
206 206 c, t dbSNP:199474807
212 212 a, c, t dbSNP:199474808
213 213 g, t dbSNP:727504405
218 218 a, g dbSNP:749936467
224 224 c, t dbSNP:764791110
227 227 a, c dbSNP:761358011
234 234 g, t dbSNP:727504425
236 236 c, g dbSNP:753574542
240 240 c, g dbSNP:2428140
241 241 a, g dbSNP:199474809
243 243 -, ag dbSNP:35049558
243 243 a, c, t dbSNP:756671869
244 244 a, g dbSNP:104894369
245 245 a, g dbSNP:777225996
252 252 a, g dbSNP:730880949
255 255 a, t dbSNP:201728041
264 264 a, g dbSNP:397516398
269 269 c, t dbSNP:755787766
274 274 a, g dbSNP:752456288
287 287 a, g dbSNP:376506450
293 293 a, g dbSNP:372644111
299 299 a, g dbSNP:752075835
300 300 a, g dbSNP:373475989
308 308 c, t dbSNP:727503298
310 310 a, c dbSNP:587782965
311 311 a, t dbSNP:35714558
312 312 a, g dbSNP:762872370
314 314 g, t dbSNP:368851472
327 327 c, t dbSNP:765287559
328 328 c, t dbSNP:730880950
331 331 c, g dbSNP:397516399
346 346 g, t dbSNP:727503297
347 347 a, g dbSNP:759261779
349 349 c, t dbSNP:774193307
350 350 a, g dbSNP:28645088
354 354 c, g dbSNP:121913658
363 363 a, c dbSNP:555501707
369 369 c, g dbSNP:573898913
372 372 a, g dbSNP:773066925
375 375 a, g dbSNP:369868176
379 379 g, t dbSNP:547860537
381 381 a, g dbSNP:199474811
384 384 a, g dbSNP:397516401
386 386 c, g dbSNP:768415509
392 392 a, c dbSNP:746693351
395 395 c, t dbSNP:397516403
407 407 g, t dbSNP:780439833
408 408 g, t dbSNP:758729568
410 410 g, t dbSNP:750901433
413 413 a, g dbSNP:199572927
425 425 c, t dbSNP:750193844
426 426 a, g dbSNP:730880940
429 429 c, g, t dbSNP:397516404
430 430 a, g dbSNP:192057022
437 437 g, t dbSNP:374439285
445 445 c, t dbSNP:375667565
446 446 a, g dbSNP:190020833
451 451 c, t dbSNP:141878747
452 452 a, g dbSNP:2233261
458 458 a, g dbSNP:774686046
460 460 g, t dbSNP:727505071
463 463 c, g dbSNP:727504357
464 464 c, g dbSNP:778630692
472 472 a, c dbSNP:143139258
473 473 c, g dbSNP:727504408
474 474 g, t dbSNP:770211004
484 484 a, t dbSNP:748760581
488 488 c, t dbSNP:781107246
489 489 a, g dbSNP:4683
491 491 a, c dbSNP:369489428
492 492 a, g dbSNP:727504559
495 495 g, t dbSNP:747192296
497 497 -, c dbSNP:786205430
499 499 c, t dbSNP:727504341
500 500 c, g dbSNP:374328118
501 501 a, c, g dbSNP:777689913
502 502 -, c dbSNP:760390353
502 502 c, g dbSNP:755993281
504 504 a, g dbSNP:199567559
506 506 c, t dbSNP:766907447
507 507 a, g dbSNP:370075755
508 508 c, t dbSNP:751166975
518 518 c, t dbSNP:397516405
525 525 c, t dbSNP:766036025
527 527 c, t dbSNP:199815885
530 530 c, g dbSNP:149078011
537 537 g, t dbSNP:770239898
539 539 a, g dbSNP:137984206
540 540 c, t dbSNP:777223055
541 541 a, g dbSNP:730880951
542 542 c, t dbSNP:768565749
546 546 a, g dbSNP:747098269
551 551 c, t dbSNP:727505065
553 553 a, g dbSNP:727503296
555 555 a, g dbSNP:199474814
556 556 a, g dbSNP:397516406
559 559 a, c, g dbSNP:397516407
567 567 g, t dbSNP:730880952
568 568 a, t dbSNP:199474815
575 575 a, g dbSNP:530713211
580 580 a, c dbSNP:746149572
582 582 c, t dbSNP:193922452
583 583 a, g dbSNP:145437002
590 590 c, t dbSNP:550546518
591 591 a, c, g dbSNP:2520215
597 597 c, g dbSNP:754431001
599 599 a, c, g, t dbSNP:529267733
601 601 c, t dbSNP:371503244
602 602 a, g dbSNP:201099141
614 614 c, t dbSNP:762258262
616 616 a, g dbSNP:776941988
626 626 c, t dbSNP:1803295
632 632 a, c dbSNP:187600820
648 648 a, g dbSNP:573317144
654 654 g, t dbSNP:14881
674 674 a, c dbSNP:542961456
685 685 c, g dbSNP:562977292
689 689 a, c dbSNP:192821062
699 699 c, t dbSNP:546464364
708 708 c, t dbSNP:14880
738 738 a, g dbSNP:376236989
746 746 a, c dbSNP:557718125
751 751 c, t dbSNP:1803294
800 800 a, g dbSNP:182109599
802 802 -, a dbSNP:35115498
805 805 -, t dbSNP:35511065

Target ORF information:

RefSeq Version NM_000432
Organism Homo sapiens (human)
Definition Homo sapiens myosin, light chain 2, regulatory, cardiac, slow (MYL2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_000432

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCACCTA AGAAAGCAAA GAAGAGAGCC GGGGGCGCCA ACTCCAACGT GTTCTCCATG 
TTCGAACAGA CCCAAATCCA GGAATTTAAG GAGGCCTTCA CTATCATGGA CCAGAACAGG
GATGGCTTCA TTGACAAGAA CGATCTGAGA GACACCTTTG CTGCCCTTGG GCGAGTGAAC
GTGAAAAATG AAGAAATTGA TGAAATGATC AAGGAGGCTC CGGGTCCAAT TAACTTTACT
GTGTTCCTCA CAATGTTTGG GGAGAAACTT AAGGGAGCGG ACCCTGAGGA AACCATTCTC
AACGCATTCA AAGTGTTTGA CCCTGAAGGC AAAGGGGTGC TGAAGGCTGA TTACGTTCGG
GAAATGCTGA CCACGCAGGC GGAGAGGTTT TCCAAGGAGG AGGTTGACCA GATGTTCGCC
GCCTTCCCCC CTGACGTGAC TGGCAACTTG GACTACAAGA ACCTGGTGCA CATCATCACC
CACGGAGAAG AGAAGGACTTA G

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.