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MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow [Homo sapiens (human)]

Gene Symbol MYL3
Entrez Gene ID 4634
Full Name myosin, light chain 3, alkali; ventricular, skeletal, slow
Synonyms CMH8, MLC1SB, MLC1V, VLC1
General protein information
Preferred Names
myosin light chain 3
Names
myosin light chain 3
CMLC1
cardiac myosin light chain 1
ventricular/slow twitch myosin alkali light chain
myosin light chain 1, slow-twitch muscle B/ventricular isoform
myosin, light polypeptide 3, alkali; ventricular, skeletal, slow
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.3-p21.2

Summary MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

160790

Disorder Html: Cardiomyopathy, familial hypertrophic, 8, 608751 (3)





The following MYL3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYL3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18259 NM_000258 Homo sapiens myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18259
Accession Version NM_000258.2
Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product myosin light chain 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP316922.1 and AJ709328.1. This sequence is a reference standard in the RefSeqGene project. On Oct 4, 2006 this sequence version replaced gi:4557776. Summary: MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009790.1, CF552959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154361, SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GATGATGCCA AGGCAGCCCC CAAGGCAGCT 
CCAGCTCCCG CACCTCCCCC TGAGCCTGAG CGCCCTAAGG AGGTCGAGTT TGATGCTTCC
AAGATCAAGA TTGAGTTCAC ACCTGAGCAG ATTGAAGAGT TCAAGGAAGC CTTCATGCTG
TTCGACCGCA CACCCAAGTG TGAGATGAAG ATCACCTACG GGCAGTGTGG GGATGTCCTG
CGGGCGCTGG GCCAGAACCC CACACAGGCA GAAGTGCTCC GTGTCCTGGG GAAGCCAAGA
CAGGAAGAGC TCAATACCAA GATGATGGAC TTTGAAACTT TCCTGCCTAT GCTCCAGCAC
ATTTCCAAGA ACAAGGACAC AGGCACCTAT GAGGACTTCG TGGAGGGGCT GCGGGTCTTC
GACAAGGAGG GCAATGGCAC TGTCATGGGT GCTGAGCTTC GCCACGTGCT GGCCACGCTG
GGTGAGAGGC TGACAGAAGA CGAAGTGGAG AAGTTGATGG CTGGGCAAGA GGACTCCAAT
GGCTGCATCA ACTATGAAGC ATTTGTGAAG CACATCATGT CCAGCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000249.1
CDS94..681
Misc Feature(1)25..27(+)
Misc Feature(2)223..675(+)
Misc Feature(3)487..672(+)
Misc Feature(4)496..498(+)
Misc Feature(5)514..654(+)
Exon (1)1..222
Gene:MYL3
Gene Synonym:
Exon (2)223..250
Gene:MYL3
Gene Synonym:
Exon (3)251..400
Gene:MYL3
Gene Synonym:
Exon (4)401..574
Gene:MYL3
Gene Synonym:
Exon (5)575..652
Gene:MYL3
Gene Synonym:
Exon (6)653..694
Gene:MYL3
Gene Synonym:
Exon (7)695..929
Gene:MYL3
Gene Synonym:
Translation
Position Chain Variation Link
4 4 c, t dbSNP:372094875
18 18 a, g dbSNP:754608065
19 19 c, t dbSNP:536922744
30 30 c, t dbSNP:569977636
45 45 a, g dbSNP:754532112
46 46 -, ctt dbSNP:750609744
60 60 c, g, t dbSNP:765979557
62 62 c, g dbSNP:762615785
66 66 a, t dbSNP:376139990
67 67 c, t dbSNP:201910884
70 70 c, g dbSNP:1042407
79 79 a, t dbSNP:370969543
85 85 c, t dbSNP:762263801
87 87 a, g dbSNP:777330879
93 93 a, c dbSNP:769260803
94 94 a, g dbSNP:760875293
95 95 -, t dbSNP:772489469
97 97 c, g dbSNP:148310342
101 101 a, c dbSNP:536404643
102 102 c, g dbSNP:397516280
104 104 a, g dbSNP:727503301
108 108 -, gccagagcc dbSNP:759666920
110 110 c, g dbSNP:730880959
121 121 -, aag dbSNP:774336537
123 123 c, g dbSNP:779002620
129 129 c, g, t dbSNP:138567316
132 132 c, t dbSNP:781149220
140 140 c, t dbSNP:754871327
148 148 g, t dbSNP:141778691
154 154 c, t dbSNP:779557153
162 162 -, c dbSNP:748060568
162 162 c, t dbSNP:2233264
163 163 a, g dbSNP:758048820
164 164 c, t dbSNP:373278317
166 166 c, t dbSNP:369256548
171 171 c, t dbSNP:764784092
174 174 c, t dbSNP:147584015
175 175 a, g dbSNP:754220375
178 178 c, g dbSNP:764726427
184 184 c, g, t dbSNP:377026344
185 185 a, g dbSNP:199639940
187 187 c, t dbSNP:759524973
192 192 a, g dbSNP:774688582
198 198 c, t dbSNP:771114109
199 199 a, g dbSNP:749941468
229 229 c, t dbSNP:730880953
233 233 c, t dbSNP:778515428
245 245 c, g, t dbSNP:749017586
253 253 g, t dbSNP:775106506
258 258 a, g dbSNP:397516277
260 260 a, g dbSNP:199474702
263 263 a, c, g, t dbSNP:139794067
269 269 c, t dbSNP:774428107
276 276 c, t dbSNP:368118534
277 277 a, g dbSNP:730880954
280 280 c, t dbSNP:565312070
281 281 a, c, g dbSNP:139354105
286 286 c, t dbSNP:730880960
287 287 c, g dbSNP:730880955
291 291 a, g dbSNP:781357657
295 295 c, g dbSNP:755516554
302 302 -, aga dbSNP:768447523
312 312 c, t dbSNP:780500137
313 313 a, g dbSNP:730880956
315 315 a, g dbSNP:144543453
320 320 a, g dbSNP:370857205
328 328 a, g dbSNP:150634297
334 334 c, t dbSNP:761891361
338 338 c, t dbSNP:752549068
339 339 a, g dbSNP:368364468
351 351 c, t dbSNP:759363076
354 354 c, t dbSNP:556711370
367 367 a, g dbSNP:770961856
373 373 c, t dbSNP:730880961
374 374 a, g dbSNP:199474703
379 379 c, t dbSNP:772804040
385 385 a, g dbSNP:730880957
387 387 g, t dbSNP:769503169
394 394 c, g dbSNP:747691982
402 402 a, g dbSNP:746306290
404 404 c, t dbSNP:779469144
410 410 a, c dbSNP:757333002
429 429 a, g dbSNP:749357074
431 431 c, t dbSNP:397516278
440 440 c, t dbSNP:777888933
454 454 -, actcc dbSNP:746876692
456 456 -, ccagggaca dbSNP:779671276
460 460 a, g dbSNP:536445081
467 467 a, g dbSNP:377597439
471 471 c, t dbSNP:766213238
473 473 c, g dbSNP:730880958
474 474 a, c dbSNP:758267230
475 475 g, t dbSNP:199474704
482 482 a, t dbSNP:750382223
486 486 a, g dbSNP:765196173
492 492 c, t dbSNP:112992334
493 493 g, t dbSNP:776163180
501 501 g, t dbSNP:763675765
503 503 -, t dbSNP:745346844
504 504 a, g, t dbSNP:2233265
513 513 c, t dbSNP:201138698
520 520 a, g dbSNP:104893750
522 522 a, g dbSNP:746210438
528 528 c, t dbSNP:774762882
532 532 a, g dbSNP:771429520
538 538 a, g dbSNP:104893748
539 539 c, t dbSNP:202141423
540 540 a, g, t dbSNP:730880162
547 547 a, g dbSNP:199474705
549 549 g, t dbSNP:777855362
553 553 c, t dbSNP:143852164
554 554 a, g, t dbSNP:104893749
556 556 c, g dbSNP:199474706
558 558 c, t dbSNP:147125759
559 559 a, g, t dbSNP:199474707
569 569 c, t dbSNP:748832105
570 570 a, g, t dbSNP:148365503
577 577 a, g dbSNP:371642547
578 578 a, g dbSNP:755662818
581 581 c, g dbSNP:752165383
582 582 a, g dbSNP:267599847
583 583 c, t dbSNP:767179578
586 586 a, g dbSNP:759172091
594 594 c, t dbSNP:552824036
609 609 a, g dbSNP:367761724
610 610 a, g dbSNP:199474708
611 611 a, t dbSNP:730880962
613 613 c, g dbSNP:397516279
614 614 c, t dbSNP:763216044
618 618 a, c, g dbSNP:770390012
623 623 a, g dbSNP:193922391
625 625 a, g dbSNP:145520567
645 645 c, t dbSNP:140829951
648 648 c, t dbSNP:769009588
650 650 a, c dbSNP:374329098
663 663 c, g dbSNP:374293766
668 668 -, t dbSNP:757730888
684 684 c, t dbSNP:748154150
686 686 c, t dbSNP:727505197
687 687 a, g dbSNP:754568155
689 689 a, g dbSNP:201092907
690 690 c, t dbSNP:202234617
693 693 a, t dbSNP:780536817
694 694 a, g, t dbSNP:750826728
708 708 a, g dbSNP:199474710
722 722 g, t dbSNP:567490162
738 738 a, g dbSNP:565610572
754 754 c, t dbSNP:546418537
770 770 a, g dbSNP:1042973
793 793 a, c dbSNP:546968708
807 807 c, t dbSNP:757528575
819 819 c, t dbSNP:754150859
821 821 c, t dbSNP:764865767
830 830 c, t dbSNP:556971059
841 841 c, t dbSNP:756462246
857 857 c, t dbSNP:756317670

Target ORF information:

RefSeq Version NM_000258
Organism Homo sapiens (human)
Definition Homo sapiens myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000258

ORF Insert Sequence:

1
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181
241
301
361
421
481
541
ATGGCCCCCA AAAAGCCAGA GCCCAAGAAG GATGATGCCA AGGCAGCCCC CAAGGCAGCT 
CCAGCTCCCG CACCTCCCCC TGAGCCTGAG CGCCCTAAGG AGGTCGAGTT TGATGCTTCC
AAGATCAAGA TTGAGTTCAC ACCTGAGCAG ATTGAAGAGT TCAAGGAAGC CTTCATGCTG
TTCGACCGCA CACCCAAGTG TGAGATGAAG ATCACCTACG GGCAGTGTGG GGATGTCCTG
CGGGCGCTGG GCCAGAACCC CACACAGGCA GAAGTGCTCC GTGTCCTGGG GAAGCCAAGA
CAGGAAGAGC TCAATACCAA GATGATGGAC TTTGAAACTT TCCTGCCTAT GCTCCAGCAC
ATTTCCAAGA ACAAGGACAC AGGCACCTAT GAGGACTTCG TGGAGGGGCT GCGGGTCTTC
GACAAGGAGG GCAATGGCAC TGTCATGGGT GCTGAGCTTC GCCACGTGCT GGCCACGCTG
GGTGAGAGGC TGACAGAAGA CGAAGTGGAG AAGTTGATGG CTGGGCAAGA GGACTCCAAT
GGCTGCATCA ACTATGAAGC ATTTGTGAAG CACATCATGT CCAGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.