||ORF Nucleotide Sequence (Length: 954bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||NF-kappa-B inhibitor alpha
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL133163.3, BC004983.1 and
This sequence is a reference standard in the RefSeqGene project.
On Feb 23, 2008 this sequence version replaced gi:10092618.
Summary: This gene encodes a member of the NF-kappa-B inhibitor
family, which contain multiple ankrin repeat domains. The encoded
protein interacts with REL dimers to inhibit NF-kappa-B/REL
complexes which are involved in inflammatory responses. The encoded
protein moves between the cytoplasm and the nucleus via a nuclear
localization signal and CRM1-mediated nuclear export. Mutations in
this gene have been found in ectodermal dysplasia anhidrotic with
T-cell immunodeficiency autosomal dominant disease. [provided by
RefSeq, Aug 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC002601.2, M69043.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.