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ATP1B1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ATP1B1
Entrez Gene ID 481
Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms ATP1B
General protein information
Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
sodium/potassium-transporting ATPase subunit beta-1
adenosinetriphosphatase
sodium pump subunit beta-1
Na, K-ATPase beta-1 polypeptide
Beta 1-subunit of Na(+),K(+)-ATPase
sodium/potassium-dependent ATPase beta-1 subunit
sodium/potassium-transporting ATPase beta-1 chain
sodium-potassium ATPase subunit beta 1 (non-catalytic)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q24

Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]. lac of sum
Disorder MIM:

182330

Disorder Html: [Blood pressure regulation QTL], 145500 (2)

mRNA and Protein(s)

mRNA Protein Name
NM_001677 NP_001668 sodium/potassium-transporting ATPase subunit beta-1



Homo sapiens (human) ATP1B1 NP_001668.1
Pan troglodytes (chimpanzee) ATP1B1 NP_001092025.1
Macaca mulatta (Rhesus monkey) ATP1B1 XP_001093541.1
Canis lupus familiaris (dog) ATP1B1 NP_001003283.1
Bos taurus (cattle) ATP1B1 NP_001030411.1
Mus musculus (house mouse) Atp1b1 NP_033851.1
Rattus norvegicus (Norway rat) Atp1b1 NP_037245.2
Gallus gallus (chicken) ATP1B1 NP_990851.1
Danio rerio (zebrafish) atp1b1b NP_571746.1
Danio rerio (zebrafish) atp1b1a NP_571743.3
Drosophila melanogaster (fruit fly) nrv3 NP_001260675.1
Xenopus (Silurana) tropicalis (western clawed frog) atp1b1 NP_001016488.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ATP1B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18298
NM_001677 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$99.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18298
Clone ID Related Accession (Same CDS sequence) NM_001677
Accession Version NM_001677.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 912bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product sodium/potassium-transporting ATPase subunit beta-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ934151.1, BC000006.2, CD722755.1, BM762099.1, AA514770.1, U16799.1 and BE223067.1. This sequence is a reference standard in the RefSeqGene project. On Jul 1, 2004 this sequence version replaced gi:37595556. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX420567.2, BC000006.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001668.1
CDS122..1033
Misc Feature(1)107..109(+)
Misc Feature(2)122..1030(+)
Misc Feature(3)224..307(+)
Misc Feature(4)692..1030(+)
Exon (1)1..218
Gene:ATP1B1
Gene Synonym:
Exon (2)219..347
Gene:ATP1B1
Gene Synonym:
Exon (3)348..503
Gene:ATP1B1
Gene Synonym:
Exon (4)504..688
Gene:ATP1B1
Gene Synonym:
Exon (5)689..769
Gene:ATP1B1
Gene Synonym:
Exon (6)770..2200
Gene:ATP1B1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001677
Organism Homo sapiens (human)
Definition Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001677

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Na(+)/K(+)-ATPase expression changes in the rabbit lacrimal glands during pregnancy
Curr. Eye Res. 38 (1), 18-26 (2013)
Huang J, Lu M and Ding C.


book

Impact of ancestry and common genetic variants on QT interval in African Americans
Circ Cardiovasc Genet 5 (6), 647-655 (2012)
Smith JG, Avery CL, Evans DS, Nalls MA, Meng YA, Smith EN, Palmer C, Tanaka T, Mehra R, Butler AM, Young T, Buxbaum SG, Kerr KF, Berenson GS, Schnabel RB, Li G, Ellinor PT, Magnani JW, Chen W, Bis JC, Curb JD, Hsueh WC, Rotter JI, Liu Y, Newman AB, Limacher MC, North KE, Reiner AP, Quibrera PM, Schork NJ, Singleton AB, Psaty BM, Soliman EZ, Solomon AJ, Srinivasan SR, Alonso A, Wallace R, Redline S, Zhang ZM, Post WS, Zonderman AB, Taylor HA, Murray SS, Ferrucci L, Arking DE, Evans MK, Fox ER, Sotoodehnia N, Heckbert SR, Whitsel EA and Newton-Cheh C.


book

Regulation of Na(+)/K(+)-ATPase by nuclear respiratory factor 1: implication in the tight coupling of neuronal activity, energy generation, and energy consumption
J. Biol. Chem. 287 (48), 40381-40390 (2012)
Johar K, Priya A and Wong-Riley MT.


book

Protein kinase A (PKA) phosphorylation of Na+/K+-ATPase opens intracellular C-terminal water pathway leading to third Na+-binding site in molecular dynamics simulations
J. Biol. Chem. 287 (19), 15959-15965 (2012)
Poulsen H, Nissen P, Mouritsen OG and Khandelia H.


book

Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans
J. Hypertens. 29 (10), 1906-1912 (2011)
Faruque MU, Chen G, Doumatey A, Huang H, Zhou J, Dunston GM, Rotimi CN and Adeyemo AA.


book

Molecular genetics of Na,K-ATPase
Prog. Nucleic Acid Res. Mol. Biol. 38, 37-89 (1990)
Lingrel JB, Orlowski J, Shull MM and Price EM.


book

Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene
FEBS Lett. 257 (2), 439-442 (1989)
Ushkaryov YuA, Monastyrskaya GS, Broude NE, Nikiforova NN, Bessarab DA, Orlova MYu, Petrukhin KE, Modyanov NN and Sverdlov ED.


book

Characterization of two genes for the human Na,K-ATPase beta subunit
Genomics 5 (3), 445-453 (1989)
Lane LK, Shull MM, Whitmer KR and Lingrel JB.


book

Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression
J. Biol. Chem. 264 (8), 4613-4618 (1989)
Martin-Vasallo P, Dackowski W, Emanuel JR and Levenson R.


book

Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes
Genomics 2 (2), 128-138 (1988)
Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ Jr, Lingrel JB and Francke U.


 
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