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ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide [Homo sapiens (human)]

Gene Symbol ATP1B1
Entrez Gene ID 481
Full Name ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms ATP1B
General protein information
Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
sodium/potassium-transporting ATPase subunit beta-1
adenosinetriphosphatase
sodium pump subunit beta-1
Na, K-ATPase beta-1 polypeptide
Beta 1-subunit of Na(+),K(+)-ATPase
sodium/potassium-dependent ATPase beta-1 subunit
sodium/potassium-transporting ATPase beta-1 chain
sodium-potassium ATPase subunit beta 1 (non-catalytic)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q24

Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]. lac of sum
Disorder MIM:

182330

Disorder Html: [Blood pressure regulation QTL], 145500 (2)





The following ATP1B1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP1B1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18298 NM_001677 Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18298
Accession Version NM_001677.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 912bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu18298D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product sodium/potassium-transporting ATPase subunit beta-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ934151.1, BC000006.2, CD722755.1, BM762099.1, AA514770.1, U16799.1 and BE223067.1. This sequence is a reference standard in the RefSeqGene project. On Jul 1, 2004 this sequence version replaced gi:37595556. Summary: The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX420567.2, BC000006.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA
GTTAAGAGCT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001668.1
CDS122..1033
Misc Feature(1)107..109(+)
Misc Feature(2)122..1030(+)
Misc Feature(3)224..307(+)
Misc Feature(4)692..1030(+)
Exon (1)1..218
Gene:ATP1B1
Gene Synonym:
Exon (2)219..347
Gene:ATP1B1
Gene Synonym:
Exon (3)348..503
Gene:ATP1B1
Gene Synonym:
Exon (4)504..688
Gene:ATP1B1
Gene Synonym:
Exon (5)689..769
Gene:ATP1B1
Gene Synonym:
Exon (6)770..2200
Gene:ATP1B1
Gene Synonym:
Translation
Position Chain Variation Link
4 4 c, t dbSNP:545562980
15 15 g, t dbSNP:560658320
54 54 a, g dbSNP:528004462
72 72 c, t dbSNP:549670564
73 73 c, t dbSNP:747735825
76 76 a, c dbSNP:368576961
81 81 a, c, t dbSNP:772836852
83 83 c, t dbSNP:772434243
85 85 a, c dbSNP:776015665
88 88 a, t dbSNP:760976745
89 89 c, g dbSNP:531700936
90 90 c, t dbSNP:550340374
91 91 a, g dbSNP:776847417
96 96 g, t dbSNP:762008819
100 100 c, t dbSNP:765366631
112 112 c, g, t dbSNP:750469787
113 113 a, g dbSNP:766251587
115 115 c, t dbSNP:776454459
121 121 a, c dbSNP:144750047
128 128 c, g, t dbSNP:11545852
132 132 g, t dbSNP:780987273
135 135 a, g dbSNP:747870653
160 160 a, c, g dbSNP:535529400
166 166 c, t dbSNP:753332289
175 175 c, t dbSNP:551536131
180 180 a, g dbSNP:770432036
182 182 a, g dbSNP:775861246
190 190 a, g dbSNP:147872554
199 199 a, c dbSNP:768959839
218 218 c, g, t dbSNP:776974246
223 223 a, g dbSNP:781688188
232 232 a, g dbSNP:748589298
239 239 a, g dbSNP:147107209
241 241 a, g dbSNP:778102602
244 244 a, t dbSNP:749543510
253 253 a, c dbSNP:771155986
256 256 c, g dbSNP:774346745
257 257 c, t dbSNP:759690035
258 258 c, t dbSNP:199629231
259 259 c, g dbSNP:201777374
275 275 a, g dbSNP:772208908
284 284 a, c, t dbSNP:11545848
287 287 a, g dbSNP:11545849
293 293 c, t dbSNP:775577670
310 310 a, c dbSNP:557213061
312 312 a, t dbSNP:764047553
313 313 c, t dbSNP:575198119
322 322 a, g dbSNP:761419307
325 325 c, t dbSNP:780168049
338 338 g, t dbSNP:764962595
339 339 c, t dbSNP:377341777
343 343 a, g dbSNP:144621395
345 345 c, t dbSNP:372183032
367 367 a, g dbSNP:764876165
392 392 c, t dbSNP:772932534
407 407 a, g dbSNP:762580778
409 409 a, g dbSNP:149479006
418 418 a, g dbSNP:560362746
421 421 a, g dbSNP:367624941
426 426 a, t dbSNP:199737584
442 442 a, g dbSNP:61742560
469 469 a, c dbSNP:372210037
476 476 a, g dbSNP:779129566
478 478 c, t dbSNP:746155696
501 501 a, g dbSNP:758661489
502 502 c, t dbSNP:146260113
503 503 a, g dbSNP:769851426
507 507 c, t dbSNP:748184135
512 512 a, c dbSNP:769591922
519 519 c, t dbSNP:141812161
520 520 a, g dbSNP:749105786
523 523 a, g dbSNP:201640017
527 527 a, c dbSNP:770676350
530 530 a, g dbSNP:774002236
535 535 c, t dbSNP:759095132
536 536 -, tt dbSNP:767040653
540 540 a, g dbSNP:532717504
544 544 a, t dbSNP:765177461
548 548 c, g, t dbSNP:80176946
553 553 a, t dbSNP:76396666
558 558 a, g dbSNP:774828234
564 564 c, t dbSNP:762431794
574 574 c, t dbSNP:547810622
583 583 a, g dbSNP:72706956
586 586 g, t dbSNP:376981775
591 591 c, g dbSNP:370098063
592 592 a, g dbSNP:766793080
594 594 a, g dbSNP:139587518
602 602 c, g dbSNP:200684046
618 618 c, g dbSNP:751890173
628 628 a, c dbSNP:755150934
632 632 a, g dbSNP:781373416
634 634 g, t dbSNP:752700157
637 637 a, c dbSNP:377019756
642 642 c, t dbSNP:754593629
643 643 a, c, g, t dbSNP:144685960
650 650 a, t dbSNP:368950948
653 653 a, g dbSNP:373429168
661 661 c, t dbSNP:145356218
668 668 a, g dbSNP:566377603
671 671 c, t dbSNP:746531824
672 672 a, t dbSNP:768212893
673 673 a, c dbSNP:773868132
675 675 c, g dbSNP:763542726
676 676 c, t dbSNP:751382996
692 692 c, t dbSNP:267598155
699 699 a, g dbSNP:771542745
704 704 a, t dbSNP:371385406
721 721 a, c dbSNP:61803314
733 733 c, t dbSNP:767859580
751 751 c, t dbSNP:151290623
752 752 a, g dbSNP:368014776
771 771 a, g dbSNP:758593381
783 783 a, c dbSNP:754647648
785 785 a, g dbSNP:780898639
806 806 c, t dbSNP:747684470
822 822 a, g dbSNP:769392006
853 853 a, g dbSNP:140674456
884 884 c, g dbSNP:746330517
901 901 c, t dbSNP:769110755
902 902 a, g, t dbSNP:772382642
911 911 a, g dbSNP:760933888
913 913 c, g dbSNP:768885456
915 915 a, g dbSNP:369488918
920 920 a, t dbSNP:533593487
925 925 g, t dbSNP:761884207
937 937 c, t dbSNP:377755946
941 941 a, g dbSNP:140309868
944 944 c, g dbSNP:762945277
946 946 a, g dbSNP:572413471
954 954 c, t dbSNP:766128818
955 955 a, g dbSNP:143722809
958 958 c, t dbSNP:145238933
959 959 a, g dbSNP:781025471
961 961 c, t dbSNP:752333549
982 982 a, c, g dbSNP:755703117
985 985 a, g dbSNP:746398744
988 988 c, t dbSNP:772604662
1002 1002 a, g dbSNP:780373747
1010 1010 a, g dbSNP:144160193
1027 1027 a, g dbSNP:768940702
1034 1034 g, t dbSNP:561496578
1054 1054 a, c dbSNP:14824
1058 1058 a, g dbSNP:372894803
1063 1063 c, t dbSNP:762008881
1067 1067 -, at dbSNP:777820973
1067 1067 a, g dbSNP:769829944
1074 1074 -, aaaa dbSNP:376402959
1081 1081 g, t dbSNP:773311235
1084 1084 -, acaaaa dbSNP:757120674
1102 1102 c, t dbSNP:573607502
1112 1112 c, g dbSNP:542160645
1117 1117 -, tg dbSNP:756348360
1118 1118 a, g dbSNP:761596404
1198 1198 g, t dbSNP:764733211
1217 1217 a, g dbSNP:544091729
1218 1218 -, tatt dbSNP:374342138
1237 1237 c, g dbSNP:772796362
1269 1269 c, t dbSNP:751815876
1270 1270 a, g dbSNP:762401742
1284 1284 c, t dbSNP:766335015
1300 1300 a, g dbSNP:12079745
1340 1340 a, g dbSNP:367551064
1351 1351 g, t dbSNP:781639799
1403 1403 a, g dbSNP:111349429
1410 1410 g, t dbSNP:754889439
1422 1422 c, g dbSNP:748565613
1425 1425 g, t dbSNP:12565299
1470 1470 c, t dbSNP:140526593
1486 1486 -, t dbSNP:770465542
1493 1493 a, g dbSNP:560210233
1497 1497 -, t, tttttttttt dbSNP:34447553
1498 1498 -, t dbSNP:56167655
1508 1508 -, g dbSNP:202172887
1509 1509 -, g dbSNP:199593766
1509 1509 g, t dbSNP:200351363
1512 1512 g, t dbSNP:1779795
1513 1513 a, g, t dbSNP:1779796
1520 1520 g, t dbSNP:184990529
1529 1529 -, tct dbSNP:142552777
1535 1535 c, g dbSNP:192644106
1552 1552 c, t dbSNP:142647779
1553 1553 c, g dbSNP:538581539
1605 1605 a, t dbSNP:1061319
1611 1611 a, t dbSNP:1061321
1619 1619 -, c dbSNP:778809564
1619 1619 c, t dbSNP:762847882
1626 1626 a, g dbSNP:766364889
1627 1627 c, t dbSNP:368906439
1637 1637 a, g dbSNP:778545795
1642 1642 c, g dbSNP:759411700
1643 1643 a, t dbSNP:767366022
1645 1645 a, t dbSNP:752460099
1662 1662 -, taa dbSNP:746114699
1668 1668 -, taag dbSNP:556425172
1668 1668 g, t dbSNP:755757297
1669 1669 -, aag dbSNP:775544330
1675 1675 a, g dbSNP:763558073
1677 1677 a, g dbSNP:753407875
1680 1680 a, g dbSNP:756678337
1698 1698 -, atca dbSNP:747181214
1703 1703 c, g dbSNP:184534924
1710 1710 a, g dbSNP:747455617
1719 1719 a, g dbSNP:752018640
1729 1729 a, c dbSNP:372178427
1738 1738 c, g dbSNP:115129472
1757 1757 c, t dbSNP:574767137
1763 1763 a, g dbSNP:376994787
1766 1766 c, t dbSNP:9765
1797 1797 a, g dbSNP:151010602
1833 1833 g, t dbSNP:771847045
1850 1850 -, ctttc dbSNP:763502821
1929 1929 g, t dbSNP:536305635
1942 1942 a, g dbSNP:774938656
1957 1957 -, tta dbSNP:560419871
2044 2044 a, g dbSNP:112941951
2071 2071 a, g dbSNP:150136713
2087 2087 a, g dbSNP:138857215
2111 2111 a, g dbSNP:757513803
2128 2128 g, t dbSNP:12091
2134 2134 c, t dbSNP:562787161
2140 2140 c, t dbSNP:113442279
2175 2175 c, g, t dbSNP:1138486
2176 2176 a, g dbSNP:545011906
2195 2195 a, c dbSNP:3180378

Target ORF information:

RefSeq Version NM_001677
Organism Homo sapiens (human)
Definition Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide (ATP1B1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001677

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGCCCGCG GGAAAGCCAA GGAGGAGGGC AGCTGGAAGA AATTCATCTG GAACTCAGAG 
AAGAAGGAGT TTCTGGGCAG GACCGGTGGC AGTTGGTTTA AGATCCTTCT ATTCTACGTA
ATATTTTATG GCTGCCTGGC TGGCATCTTC ATCGGAACCA TCCAAGTGAT GCTGCTCACC
ATCAGTGAAT TTAAGCCCAC ATATCAGGAC CGAGTGGCCC CGCCAGGATT AACACAGATT
CCTCAGATCC AGAAGACTGA AATTTCCTTT CGTCCTAATG ATCCCAAGAG CTATGAGGCA
TATGTACTGA ACATAGTTAG GTTCCTGGAA AAGTACAAAG ATTCAGCCCA GAGGGATGAC
ATGATTTTTG AAGATTGTGG CGATGTGCCC AGTGAACCGA AAGAACGAGG AGACTTTAAT
CATGAACGAG GAGAGCGAAA GGTCTGCAGA TTCAAGCTTG AATGGCTGGG AAATTGCTCT
GGATTAAATG ATGAAACTTA TGGCTACAAA GAGGGCAAAC CGTGCATTAT TATAAAGCTC
AACCGAGTTC TAGGCTTCAA ACCTAAGCCT CCCAAGAATG AGTCCTTGGA GACTTACCCA
GTGATGAAGT ATAACCCAAA TGTCCTTCCC GTTCAGTGCA CTGGCAAGCG AGATGAAGAT
AAGGATAAAG TTGGAAATGT GGAGTATTTT GGACTGGGCA ACTCCCCTGG TTTTCCTCTG
CAGTATTATC CGTACTATGG CAAACTCCTG CAGCCCAAAT ACCTGCAGCC CCTGCTGGCC
GTACAGTTCA CCAATCTTAC CATGGACACT GAAATTCGCA TAGAGTGTAA GGCGTACGGT
GAGAACATTG GGTACAGTGA GAAAGACCGT TTTCAGGGAC GTTTTGATGT AAAAATTGAA
GTTAAGAGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.