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NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [Homo sapiens (human)]

Gene Symbol NPM1
Entrez Gene ID 4869
Full Name nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Synonyms B23, NPM
General protein information
Preferred Names
nucleophosmin
Names
nucleophosmin
nucleolar protein NO38
nucleophosmin/nucleoplasmin family, member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]. lac of sum
Disorder MIM:

164040

Disorder Html: Leukemia, acute promyelocytic, NPM/RARA type (3); Leukemia, acute





The following NPM1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NPM1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu59316 XM_011534564 PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $199
OHu40015 XM_005265920 PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $199
OHu15843 NM_199185 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99
OHu15781 NM_001037738 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99
OHu21782 NM_002520 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.3
$309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu59316
Accession Version XM_011534564.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 693bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product nucleophosmin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_023133.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGAATTACG AAGGCAGTCC AATTAAAGTA ACACTGGCAA CTTTGAAAAT GTCTGTACAG 
CCAACGGTTT CCCTTGGGGG CTTTGAAATA ACACCACCAG TGGTCTTAAG GTTGAAGTGT
GGTTCAGGGC CAGTGCATAT TAGTGGACAG CACTTAGTAG CTGTGGAGGA AGATGCAGAG
TCAGAAGATG AAGAGGAGGA GGATGTGAAA CTCTTAAGTA TATCTGGAAA GCGGTCTGCC
CCTGGAGGTG GTAGCAAGGT TCCACAGAAA AAAGTAAAAC TTGCTGCTGA TGAAGATGAT
GACGATGATG ATGAAGAGGA TGATGATGAA GATGATGATG ATGATGATTT TGATGATGAG
GAAGCTGAAG AAAAAGCGCC AGTGAAGAAA TCTATACGAG ATACTCCAGC CAAAAATGCA
CAAAAGTCAA ATCAGAATGG AAAAGACTCA AAACCATCAT CAACACCAAG ATCAAAAGGA
CAAGAATCCT TCAAGAAACA GGAAAAAACT CCTAAAACAC CAAAAGGACC TAGTTCTGTA
GAAGACATTA AAGCAAAAAT GCAAGCAAGT ATAGAAAAAG GTGGTTCTCT TCCCAAAGTG
GAAGCCAAAT TCATCAATTA TGTGAAGAAT TGCTTCCGGA TGACTGACCA AGAGGCTATT
CAAGATCTCT GGCAGTGGAG GAAGTCTCTT TAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011532866.1
CDS258..950
Misc Feature(1)258..>422(+)
Translation
Position Chain Variation Link
7 7 a, g dbSNP:537112557
27 27 a, c dbSNP:374925391
32 32 g, t dbSNP:561702061
36 36 a, c dbSNP:540172836
38 38 c, g dbSNP:10069429
41 41 a, g, t dbSNP:573534099
42 42 c, t dbSNP:148722569
45 45 c, t dbSNP:555371632
46 46 c, t dbSNP:527309039
47 47 c, t dbSNP:112023099
49 49 g, t dbSNP:112330400
50 50 c, t dbSNP:543958094
52 52 c, g dbSNP:377340416
67 67 c, t dbSNP:577760802
70 70 a, g dbSNP:11551528
70 70 g, t dbSNP:540561427
71 71 c, t dbSNP:28411385
79 79 c, t dbSNP:749918542
81 81 c, t dbSNP:533273568
82 82 c, t dbSNP:180887715
83 83 c, g dbSNP:11551579
83 83 c, g dbSNP:185295288
86 86 a, g dbSNP:551273843
87 87 a, g dbSNP:561730798
89 89 c, t dbSNP:531062299
90 90 a, g dbSNP:189577643
92 92 c, t dbSNP:111426800
93 93 g, t dbSNP:531273939
96 96 c, t dbSNP:539652493
97 97 c, t dbSNP:11551555
98 98 c, t dbSNP:11551547
101 101 a, g dbSNP:757830185
102 102 c, t dbSNP:779663664
103 103 c, g, t dbSNP:375152584
104 104 c, t dbSNP:11551556
105 105 c, t dbSNP:754937690
106 106 c, g, t dbSNP:780914482
108 108 a, t dbSNP:769699299
109 109 c, g dbSNP:774422812
110 110 c, t dbSNP:200132495
117 117 c, t dbSNP:772017828
118 118 c, t dbSNP:202010899
119 119 c, t dbSNP:761217346
121 121 a, c, t dbSNP:11551523
124 124 -, ctaa dbSNP:752842004
124 124 a, c, t dbSNP:764467196
125 125 c, t dbSNP:35747006
127 127 -, aa dbSNP:758441268
132 132 c, g, t dbSNP:11551571
137 137 c, t dbSNP:750018655
139 139 c, g, t dbSNP:758108952
140 140 c, t dbSNP:751089518
142 142 c, g, t dbSNP:370439209
143 143 c, g dbSNP:368504792
145 145 c, g, t dbSNP:587777962
151 151 a, g dbSNP:373962671
157 157 -, atggac dbSNP:778077508
157 157 a, g dbSNP:368150213
164 164 a, g dbSNP:772365842
175 175 c, t dbSNP:775657228
181 181 a, g dbSNP:747086342
183 183 a, g dbSNP:768919750
184 184 a, g dbSNP:142254256
196 196 c, t dbSNP:762428128
199 199 c, t dbSNP:765486682
206 206 a, c dbSNP:771256760
220 220 a, g dbSNP:372208958
223 223 c, t dbSNP:774730997
234 234 c, t dbSNP:759143092
236 236 -, ttaga dbSNP:777646492
238 238 -, attt dbSNP:751818162
240 240 -, tc dbSNP:757476342
242 242 c, g, t dbSNP:142102985
256 256 c, t dbSNP:11551526
258 258 a, g dbSNP:11551576
266 266 c, t dbSNP:200294440
267 267 a, g dbSNP:763566520
290 290 a, g dbSNP:753788683
291 291 c, t dbSNP:536652743
299 299 c, t dbSNP:11551522
301 301 c, t dbSNP:11551525
303 303 a, g dbSNP:17851944
322 322 c, t dbSNP:147806769
323 323 a, g dbSNP:750264549
332 332 g, t dbSNP:11551553
335 335 g, t dbSNP:752933446
357 357 g, t dbSNP:756323205
359 359 c, g dbSNP:764187017
386 386 a, g dbSNP:201813873
395 395 c, t dbSNP:753931371
416 416 a, g dbSNP:141086340
427 427 a, g dbSNP:587778580
434 434 a, t dbSNP:568679648
440 440 -, aga dbSNP:772541920
446 446 c, t dbSNP:200558908
450 450 -, gag dbSNP:746516563
452 452 a, g dbSNP:780415062
468 468 c, t dbSNP:751882247
470 470 a, c dbSNP:754590863
471 471 c, t dbSNP:780986538
477 477 a, c dbSNP:747866671
479 479 a, g dbSNP:769397977
493 493 c, g dbSNP:375558588
500 500 c, t dbSNP:749202543
502 502 a, g dbSNP:770789271
523 523 a, g dbSNP:571071150
536 536 a, g dbSNP:535582867
539 539 -, tgc dbSNP:587778581
539 539 c, t dbSNP:61749648
540 540 c, g dbSNP:775291597
544 544 c, t dbSNP:748317624
545 545 -, tga dbSNP:759376175
546 546 a, g dbSNP:770013862
548 548 c, t dbSNP:773274787
549 549 -, gaa dbSNP:549146478
552 552 -, gatgatgacgat dbSNP:775410264
552 552 -, gat dbSNP:764976369
554 554 g, t dbSNP:762935997
557 557 c, t dbSNP:566156848
558 558 -, gac dbSNP:762739342
560 560 c, t dbSNP:146936311
561 561 -, gat dbSNP:751654967
561 561 a, g dbSNP:774697729
563 563 c, t dbSNP:147629377
570 570 -, gaa dbSNP:757325565
572 572 a, t dbSNP:767945148
576 576 -, gat dbSNP:767897913
577 577 a, t dbSNP:750633648
578 578 g, t dbSNP:753126733
587 587 a, g dbSNP:368269652
590 590 -, tga dbSNP:779471362
590 590 a, t dbSNP:747005016
593 593 a, t dbSNP:754744493
597 597 a, g dbSNP:267600552
598 598 a, g dbSNP:17856513
605 605 c, t dbSNP:140888436
608 608 -, tga dbSNP:770452718
608 608 c, t dbSNP:61755048
614 614 c, t dbSNP:771198652
617 617 a, g dbSNP:778792366
635 635 a, g dbSNP:368568545
639 639 a, g dbSNP:772337921
643 643 a, g dbSNP:183724988
644 644 g, t dbSNP:761307473
649 649 c, t dbSNP:544573727
651 651 a, g dbSNP:376742289
655 655 a, g dbSNP:762635721
656 656 a, t dbSNP:765835395
663 663 c, t dbSNP:751083124
666 666 g, t dbSNP:764419488
678 678 c, g dbSNP:759324510
680 680 a, g dbSNP:201906545
695 695 c, t dbSNP:752632627
705 705 c, t dbSNP:373068340
712 712 -, cat dbSNP:761817600
713 713 a, g, t dbSNP:777747760
728 728 a, g dbSNP:527378561
734 734 a, g dbSNP:780229057
739 739 a, g dbSNP:758630739
743 743 a, c, g dbSNP:766707224
765 765 a, t dbSNP:755065911
766 766 c, t dbSNP:781171336
772 772 a, c dbSNP:374517078
777 777 a, c dbSNP:756636316
779 779 a, g, t dbSNP:778045427
786 786 c, t dbSNP:771340939
789 789 a, g dbSNP:138586088
794 794 c, t dbSNP:745544920
795 795 a, g dbSNP:771568444
798 798 c, g dbSNP:143209617
801 801 g, t dbSNP:760598971
803 803 c, t dbSNP:773255144
811 811 c, t dbSNP:377348662
827 827 a, t dbSNP:11551532
828 828 a, g dbSNP:776780244
839 839 g, t dbSNP:764108222
842 842 c, t dbSNP:371199566
851 851 c, t dbSNP:556846930
853 853 a, g dbSNP:765654691
857 857 a, g dbSNP:575231413
860 860 a, g dbSNP:758672403
865 865 a, g dbSNP:766808881
866 866 a, g dbSNP:751219716
874 874 a, g dbSNP:754700741
877 877 a, g dbSNP:17851431
878 878 c, t dbSNP:373846371
879 879 g, t dbSNP:747666752
887 887 c, t dbSNP:149305908
895 895 a, g dbSNP:777550167
897 897 a, g dbSNP:757963772
899 899 a, g dbSNP:749286462
913 913 c, g dbSNP:371956477
924 924 -, tctg dbSNP:758959453
924 924 c, t dbSNP:17850940
928 928 -, catg, cctg, cgtg, tctg dbSNP:587776806
938 938 a, g dbSNP:565271245
959 959 c, t dbSNP:773366496
961 961 c, t dbSNP:201083444
964 964 a, g dbSNP:767000196
967 967 a, g dbSNP:376359773
973 973 -, a dbSNP:778247758
973 973 a, t dbSNP:3209214
979 979 a, c, g dbSNP:200638434
980 980 a, t dbSNP:768033269
984 984 c, t dbSNP:752355990
985 985 c, g, t dbSNP:760396612
986 986 a, g dbSNP:1059404
989 989 a, c, g, t dbSNP:756780247
991 991 -, atttc dbSNP:576436777
992 992 c, t dbSNP:758162516
1002 1002 a, g dbSNP:779857289
1039 1039 a, g dbSNP:6859650
1051 1051 c, t dbSNP:530255077
1056 1056 a, g dbSNP:549941909
1078 1078 a, c dbSNP:183613332
1084 1084 c, g dbSNP:146200852
1114 1114 -, t dbSNP:776882863
1115 1115 -, t dbSNP:34351976
1138 1138 g, t dbSNP:769724015
1141 1141 a, g dbSNP:558316376
1176 1176 a, g dbSNP:759833831
1197 1197 a, g dbSNP:1059683
1214 1214 a, c dbSNP:565674673
1224 1224 c, g dbSNP:139047811
1231 1231 -, t dbSNP:558186342
1231 1231 a, g dbSNP:554721005

Target ORF information:

RefSeq Version XM_011534564
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011534564

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAATTACG AAGGCAGTCC AATTAAAGTA ACACTGGCAA CTTTGAAAAT GTCTGTACAG 
CCAACGGTTT CCCTTGGGGG CTTTGAAATA ACACCACCAG TGGTCTTAAG GTTGAAGTGT
GGTTCAGGGC CAGTGCATAT TAGTGGACAG CACTTAGTAG CTGTGGAGGA AGATGCAGAG
TCAGAAGATG AAGAGGAGGA GGATGTGAAA CTCTTAAGTA TATCTGGAAA GCGGTCTGCC
CCTGGAGGTG GTAGCAAGGT TCCACAGAAA AAAGTAAAAC TTGCTGCTGA TGAAGATGAT
GACGATGATG ATGAAGAGGA TGATGATGAA GATGATGATG ATGATGATTT TGATGATGAG
GAAGCTGAAG AAAAAGCGCC AGTGAAGAAA TCTATACGAG ATACTCCAGC CAAAAATGCA
CAAAAGTCAA ATCAGAATGG AAAAGACTCA AAACCATCAT CAACACCAAG ATCAAAAGGA
CAAGAATCCT TCAAGAAACA GGAAAAAACT CCTAAAACAC CAAAAGGACC TAGTTCTGTA
GAAGACATTA AAGCAAAAAT GCAAGCAAGT ATAGAAAAAG GTGGTTCTCT TCCCAAAGTG
GAAGCCAAAT TCATCAATTA TGTGAAGAAT TGCTTCCGGA TGACTGACCA AGAGGCTATT
CAAGATCTCT GGCAGTGGAG GAAGTCTCTT TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu40015
Accession Version XM_005265920.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 693bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product nucleophosmin isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_023133.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530381065. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AAGGACAAGA ATCCTTCAAG
AAACAGGAAA AAACTCCTAA AACACCAAAA GGACCTAGTT CTGTAGAAGA CATTAAAGCA
AAAATGCAAG CAAGTATAGA AAAAGCGCAT TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005265977.1
CDS302..994
Misc Feature(1)338..>658(+)
Translation
Position Chain Variation Link
7 7 a, c dbSNP:776384407
23 23 c, t dbSNP:184800850
26 26 a, c dbSNP:761434394
30 30 g, t dbSNP:541984711
45 45 -, g dbSNP:557898622
45 45 c, t dbSNP:764820461
51 51 c, t dbSNP:188037600
68 68 g, t dbSNP:530572595
78 78 c, g dbSNP:767905961
92 92 c, g dbSNP:544419881
105 105 c, g dbSNP:75828148
106 106 g, t dbSNP:533294099
108 108 c, g dbSNP:541595379
114 114 a, g dbSNP:566113295
117 117 c, t dbSNP:528457939
120 120 c, t dbSNP:548138598
153 153 a, c dbSNP:568219237
163 163 a, g dbSNP:537112557
183 183 a, c dbSNP:374925391
188 188 g, t dbSNP:561702061
192 192 a, c dbSNP:540172836
194 194 c, g dbSNP:10069429
197 197 a, g, t dbSNP:573534099
198 198 c, t dbSNP:148722569
201 201 c, t dbSNP:555371632
202 202 c, t dbSNP:527309039
203 203 c, t dbSNP:112023099
205 205 g, t dbSNP:112330400
206 206 c, t dbSNP:543958094
208 208 c, g dbSNP:377340416
223 223 c, t dbSNP:577760802
226 226 a, g dbSNP:11551528
226 226 g, t dbSNP:540561427
227 227 c, t dbSNP:28411385
235 235 c, t dbSNP:749918542
237 237 c, t dbSNP:533273568
238 238 c, t dbSNP:180887715
239 239 c, g dbSNP:11551579
239 239 c, g dbSNP:185295288
242 242 a, g dbSNP:551273843
243 243 a, g dbSNP:561730798
245 245 c, t dbSNP:531062299
246 246 a, g dbSNP:189577643
248 248 c, t dbSNP:111426800
249 249 g, t dbSNP:531273939
252 252 c, t dbSNP:539652493
253 253 c, t dbSNP:11551555
254 254 c, t dbSNP:11551547
257 257 a, g dbSNP:757830185
258 258 c, t dbSNP:779663664
259 259 c, g, t dbSNP:375152584
260 260 c, t dbSNP:11551556
261 261 c, t dbSNP:754937690
262 262 c, g, t dbSNP:780914482
264 264 a, t dbSNP:769699299
265 265 c, g dbSNP:774422812
266 266 c, t dbSNP:200132495
273 273 c, t dbSNP:772017828
274 274 c, t dbSNP:202010899
275 275 c, t dbSNP:761217346
277 277 a, c, t dbSNP:11551523
280 280 -, ctaa dbSNP:752842004
280 280 a, c, t dbSNP:764467196
281 281 c, t dbSNP:35747006
283 283 -, aa dbSNP:758441268
288 288 c, g, t dbSNP:11551571
293 293 c, t dbSNP:750018655
295 295 c, g, t dbSNP:758108952
296 296 c, t dbSNP:751089518
298 298 c, g, t dbSNP:370439209
299 299 c, g dbSNP:368504792
301 301 c, g, t dbSNP:587777962
307 307 a, g dbSNP:373962671
313 313 -, atggac dbSNP:778077508
313 313 a, g dbSNP:368150213
320 320 a, g dbSNP:772365842
331 331 c, t dbSNP:775657228
337 337 a, g dbSNP:747086342
339 339 a, g dbSNP:768919750
340 340 a, g dbSNP:142254256
352 352 c, t dbSNP:762428128
355 355 c, t dbSNP:765486682
368 368 c, t dbSNP:35979859
391 391 c, t dbSNP:773970096
398 398 a, g dbSNP:759228926
405 405 a, g dbSNP:766975341
442 442 a, c dbSNP:771256760
456 456 a, g dbSNP:372208958
459 459 c, t dbSNP:774730997
470 470 c, t dbSNP:759143092
472 472 -, ttaga dbSNP:777646492
474 474 -, attt dbSNP:751818162
476 476 -, tc dbSNP:757476342
478 478 c, g, t dbSNP:142102985
492 492 c, t dbSNP:11551526
494 494 a, g dbSNP:11551576
502 502 c, t dbSNP:200294440
503 503 a, g dbSNP:763566520
526 526 a, g dbSNP:753788683
527 527 c, t dbSNP:536652743
535 535 c, t dbSNP:11551522
537 537 c, t dbSNP:11551525
539 539 a, g dbSNP:17851944
558 558 c, t dbSNP:147806769
559 559 a, g dbSNP:750264549
568 568 g, t dbSNP:11551553
571 571 g, t dbSNP:752933446
593 593 g, t dbSNP:756323205
595 595 c, g dbSNP:764187017
622 622 a, g dbSNP:201813873
631 631 c, t dbSNP:753931371
652 652 a, g dbSNP:141086340
663 663 a, g dbSNP:587778580
670 670 a, t dbSNP:568679648
676 676 -, aga dbSNP:772541920
682 682 c, t dbSNP:200558908
686 686 -, gag dbSNP:746516563
688 688 a, g dbSNP:780415062
704 704 c, t dbSNP:751882247
706 706 a, c dbSNP:754590863
707 707 c, t dbSNP:780986538
713 713 a, c dbSNP:747866671
715 715 a, g dbSNP:769397977
729 729 c, g dbSNP:375558588
736 736 c, t dbSNP:749202543
738 738 a, g dbSNP:770789271
759 759 a, g dbSNP:571071150
772 772 a, g dbSNP:535582867
775 775 -, tgc dbSNP:587778581
775 775 c, t dbSNP:61749648
776 776 c, g dbSNP:775291597
780 780 c, t dbSNP:748317624
781 781 -, tga dbSNP:759376175
782 782 a, g dbSNP:770013862
784 784 c, t dbSNP:773274787
785 785 -, gaa dbSNP:549146478
788 788 -, gatgatgacgat dbSNP:775410264
788 788 -, gat dbSNP:764976369
790 790 g, t dbSNP:762935997
793 793 c, t dbSNP:566156848
794 794 -, gac dbSNP:762739342
796 796 c, t dbSNP:146936311
797 797 -, gat dbSNP:751654967
797 797 a, g dbSNP:774697729
799 799 c, t dbSNP:147629377
806 806 -, gaa dbSNP:757325565
808 808 a, t dbSNP:767945148
812 812 -, gat dbSNP:767897913
813 813 a, t dbSNP:750633648
814 814 g, t dbSNP:753126733
823 823 a, g dbSNP:368269652
826 826 -, tga dbSNP:779471362
826 826 a, t dbSNP:747005016
829 829 a, t dbSNP:754744493
833 833 a, g dbSNP:267600552
834 834 a, g dbSNP:17856513
841 841 c, t dbSNP:140888436
844 844 -, tga dbSNP:770452718
844 844 c, t dbSNP:61755048
850 850 c, t dbSNP:771198652
853 853 a, g dbSNP:778792366
871 871 a, g dbSNP:368568545
875 875 a, g dbSNP:772337921
879 879 a, g dbSNP:183724988
880 880 g, t dbSNP:761307473
888 888 a, g dbSNP:758630739
892 892 a, c, g dbSNP:766707224
914 914 a, t dbSNP:755065911
915 915 c, t dbSNP:781171336
921 921 a, c dbSNP:374517078
926 926 a, c dbSNP:756636316
928 928 a, g, t dbSNP:778045427
935 935 c, t dbSNP:771340939
938 938 a, g dbSNP:138586088
943 943 c, t dbSNP:745544920
944 944 a, g dbSNP:771568444
947 947 c, g dbSNP:143209617
950 950 g, t dbSNP:760598971
952 952 c, t dbSNP:773255144
960 960 c, t dbSNP:377348662
976 976 a, t dbSNP:11551532
977 977 a, g dbSNP:776780244
987 987 c, g dbSNP:375287524
988 988 a, g, t dbSNP:202084580
990 990 a, g dbSNP:747259799
993 993 a, g dbSNP:757780376
1000 1000 c, g dbSNP:779275963
1002 1002 c, t dbSNP:201213708
1006 1006 c, t dbSNP:200374433
1007 1007 a, g dbSNP:750754356
1016 1016 -, aa dbSNP:756764456
1024 1024 c, t dbSNP:202141313
1037 1037 a, t dbSNP:779563631
1038 1038 a, g dbSNP:746711871
1045 1045 a, t dbSNP:752530106
1093 1093 -, tgaa dbSNP:769549525
1099 1099 g, t dbSNP:779821869
1117 1117 a, g dbSNP:147082300
1164 1164 g, t dbSNP:760568553
1191 1191 c, t dbSNP:528965239
1225 1225 -, cttt dbSNP:541715193
1259 1259 a, g dbSNP:186933329
1271 1271 a, g dbSNP:768964425
1277 1277 g, t dbSNP:763765757
1298 1298 a, t dbSNP:568708497
1324 1324 c, t dbSNP:75508733
1380 1380 a, g dbSNP:776581672
1383 1383 -, g dbSNP:748202619
1443 1443 a, c dbSNP:73803328
1466 1466 a, g dbSNP:571415504
1491 1491 -, atta dbSNP:557494003
1574 1574 c, g dbSNP:565605256
1588 1588 g, t dbSNP:756915661
1594 1594 g, t dbSNP:539841213
1637 1637 -, c dbSNP:765920403
1649 1649 c, t dbSNP:778470616
1669 1669 a, g dbSNP:4513711
1673 1673 c, g dbSNP:573318059
1700 1700 a, t dbSNP:375709516
1714 1714 a, g dbSNP:191730107

Target ORF information:

RefSeq Version XM_005265920
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005265920

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AAGGACAAGA ATCCTTCAAG
AAACAGGAAA AAACTCCTAA AACACCAAAA GGACCTAGTT CTGTAGAAGA CATTAAAGCA
AAAATGCAAG CAAGTATAGA AAAAGCGCAT TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15843
Accession Version NM_199185.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 798bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product nucleophosmin isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC091980.4, BC009623.2 and AC093246.3. On Nov 3, 2009 this sequence version replaced gi:83641867. Summary: This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]. Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC009623.2, AL537010.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AAGGACAAGA ATCCTTCAAG
AAACAGGAAA AAACTCCTAA AACACCAAAA GGACCTAGTT CTGTAGAAGA CATTAAAGCA
AAAATGCAAG CAAGTATAGA AAAAGGTGGT TCTCTTCCCA AAGTGGAAGC CAAATTCATC
AATTATGTGA AGAATTGCTT CCGGATGACT GACCAAGAGG CTATTCAAGA TCTCTGGCAG
TGGAGGAAGT CTCTTTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_954654.1
CDS246..1043
Misc Feature(1)255..257(+)
Misc Feature(2)273..275(+)
Misc Feature(3)282..>602(+)
Misc Feature(4)444..446(+)
Misc Feature(5)453..455(+)
Misc Feature(6)453..455(+)
Misc Feature(7)528..530(+)
Misc Feature(8)618..620(+)
Misc Feature(9)618..620(+)
Misc Feature(10)858..860(+)
Misc Feature(11)867..869(+)
Misc Feature(12)918..920(+)
Misc Feature(13)918..920(+)
Exon (1)1..303
Gene:NPM1
Gene Synonym:
Exon (2)304..383
Gene:NPM1
Gene Synonym:
Exon (3)384..503
Gene:NPM1
Gene Synonym:
Exon (4)504..597
Gene:NPM1
Gene Synonym:
Exon (5)598..704
Gene:NPM1
Gene Synonym:
Exon (6)705..769
Gene:NPM1
Gene Synonym:
Exon (7)770..827
Gene:NPM1
Gene Synonym:
Exon (8)828..929
Gene:NPM1
Gene Synonym:
Exon (9)930..1004
Gene:NPM1
Gene Synonym:
Exon (10)1005..1362
Gene:NPM1
Gene Synonym:
Translation
Position Chain Variation Link
12 12 g, t dbSNP:530572595
22 22 c, g dbSNP:767905961
36 36 c, g dbSNP:544419881
49 49 c, g dbSNP:75828148
50 50 g, t dbSNP:533294099
52 52 c, g dbSNP:541595379
58 58 a, g dbSNP:566113295
61 61 c, t dbSNP:528457939
64 64 c, t dbSNP:548138598
97 97 a, c dbSNP:568219237
107 107 a, g dbSNP:537112557
127 127 a, c dbSNP:374925391
132 132 g, t dbSNP:561702061
136 136 a, c dbSNP:540172836
138 138 c, g dbSNP:10069429
141 141 a, g, t dbSNP:573534099
142 142 c, t dbSNP:148722569
145 145 c, t dbSNP:555371632
146 146 c, t dbSNP:527309039
147 147 c, t dbSNP:112023099
149 149 g, t dbSNP:112330400
150 150 c, t dbSNP:543958094
152 152 c, g dbSNP:377340416
167 167 c, t dbSNP:577760802
170 170 a, g dbSNP:11551528
170 170 g, t dbSNP:540561427
171 171 c, t dbSNP:28411385
179 179 c, t dbSNP:749918542
181 181 c, t dbSNP:533273568
182 182 c, t dbSNP:180887715
183 183 c, g dbSNP:11551579
183 183 c, g dbSNP:185295288
186 186 a, g dbSNP:551273843
187 187 a, g dbSNP:561730798
189 189 c, t dbSNP:531062299
190 190 a, g dbSNP:189577643
192 192 c, t dbSNP:111426800
193 193 g, t dbSNP:531273939
196 196 c, t dbSNP:539652493
197 197 c, t dbSNP:11551555
198 198 c, t dbSNP:11551547
201 201 a, g dbSNP:757830185
202 202 c, t dbSNP:779663664
203 203 c, g, t dbSNP:375152584
204 204 c, t dbSNP:11551556
205 205 c, t dbSNP:754937690
206 206 c, g, t dbSNP:780914482
208 208 a, t dbSNP:769699299
209 209 c, g dbSNP:774422812
210 210 c, t dbSNP:200132495
217 217 c, t dbSNP:772017828
218 218 c, t dbSNP:202010899
219 219 c, t dbSNP:761217346
221 221 a, c, t dbSNP:11551523
224 224 -, ctaa dbSNP:752842004
224 224 a, c, t dbSNP:764467196
225 225 c, t dbSNP:35747006
227 227 -, aa dbSNP:758441268
232 232 c, g, t dbSNP:11551571
237 237 c, t dbSNP:750018655
239 239 c, g, t dbSNP:758108952
240 240 c, t dbSNP:751089518
242 242 c, g, t dbSNP:370439209
243 243 c, g dbSNP:368504792
245 245 c, g, t dbSNP:587777962
251 251 a, g dbSNP:373962671
257 257 -, atggac dbSNP:778077508
257 257 a, g dbSNP:368150213
264 264 a, g dbSNP:772365842
275 275 c, t dbSNP:775657228
281 281 a, g dbSNP:747086342
283 283 a, g dbSNP:768919750
284 284 a, g dbSNP:142254256
296 296 c, t dbSNP:762428128
299 299 c, t dbSNP:765486682
312 312 c, t dbSNP:35979859
335 335 c, t dbSNP:773970096
342 342 a, g dbSNP:759228926
349 349 a, g dbSNP:766975341
386 386 a, c dbSNP:771256760
400 400 a, g dbSNP:372208958
403 403 c, t dbSNP:774730997
414 414 c, t dbSNP:759143092
416 416 -, ttaga dbSNP:777646492
418 418 -, attt dbSNP:751818162
420 420 -, tc dbSNP:757476342
422 422 c, g, t dbSNP:142102985
436 436 c, t dbSNP:11551526
438 438 a, g dbSNP:11551576
446 446 c, t dbSNP:200294440
447 447 a, g dbSNP:763566520
470 470 a, g dbSNP:753788683
471 471 c, t dbSNP:536652743
479 479 c, t dbSNP:11551522
481 481 c, t dbSNP:11551525
483 483 a, g dbSNP:17851944
502 502 c, t dbSNP:147806769
503 503 a, g dbSNP:750264549
512 512 g, t dbSNP:11551553
515 515 g, t dbSNP:752933446
537 537 g, t dbSNP:756323205
539 539 c, g dbSNP:764187017
566 566 a, g dbSNP:201813873
575 575 c, t dbSNP:753931371
596 596 a, g dbSNP:141086340
607 607 a, g dbSNP:587778580
614 614 a, t dbSNP:568679648
620 620 -, aga dbSNP:772541920
626 626 c, t dbSNP:200558908
630 630 -, gag dbSNP:746516563
632 632 a, g dbSNP:780415062
648 648 c, t dbSNP:751882247
650 650 a, c dbSNP:754590863
651 651 c, t dbSNP:780986538
657 657 a, c dbSNP:747866671
659 659 a, g dbSNP:769397977
673 673 c, g dbSNP:375558588
680 680 c, t dbSNP:749202543
682 682 a, g dbSNP:770789271
703 703 a, g dbSNP:571071150
716 716 a, g dbSNP:535582867
719 719 -, tgc dbSNP:587778581
719 719 c, t dbSNP:61749648
720 720 c, g dbSNP:775291597
724 724 c, t dbSNP:748317624
725 725 -, tga dbSNP:759376175
726 726 a, g dbSNP:770013862
728 728 c, t dbSNP:773274787
729 729 -, gaa dbSNP:549146478
732 732 -, gatgatgacgat dbSNP:775410264
732 732 -, gat dbSNP:764976369
734 734 g, t dbSNP:762935997
737 737 c, t dbSNP:566156848
738 738 -, gac dbSNP:762739342
740 740 c, t dbSNP:146936311
741 741 -, gat dbSNP:751654967
741 741 a, g dbSNP:774697729
743 743 c, t dbSNP:147629377
750 750 -, gaa dbSNP:757325565
752 752 a, t dbSNP:767945148
756 756 -, gat dbSNP:767897913
757 757 a, t dbSNP:750633648
758 758 g, t dbSNP:753126733
767 767 a, g dbSNP:368269652
770 770 -, tga dbSNP:779471362
770 770 a, t dbSNP:747005016
773 773 a, t dbSNP:754744493
777 777 a, g dbSNP:267600552
778 778 a, g dbSNP:17856513
785 785 c, t dbSNP:140888436
788 788 -, tga dbSNP:770452718
788 788 c, t dbSNP:61755048
794 794 c, t dbSNP:771198652
797 797 a, g dbSNP:778792366
815 815 a, g dbSNP:368568545
819 819 a, g dbSNP:772337921
823 823 a, g dbSNP:183724988
824 824 g, t dbSNP:761307473
832 832 a, g dbSNP:758630739
836 836 a, c, g dbSNP:766707224
858 858 a, t dbSNP:755065911
859 859 c, t dbSNP:781171336
865 865 a, c dbSNP:374517078
870 870 a, c dbSNP:756636316
872 872 a, g, t dbSNP:778045427
879 879 c, t dbSNP:771340939
882 882 a, g dbSNP:138586088
887 887 c, t dbSNP:745544920
888 888 a, g dbSNP:771568444
891 891 c, g dbSNP:143209617
894 894 g, t dbSNP:760598971
896 896 c, t dbSNP:773255144
904 904 c, t dbSNP:377348662
920 920 a, t dbSNP:11551532
921 921 a, g dbSNP:776780244
932 932 g, t dbSNP:764108222
935 935 c, t dbSNP:371199566
944 944 c, t dbSNP:556846930
946 946 a, g dbSNP:765654691
950 950 a, g dbSNP:575231413
953 953 a, g dbSNP:758672403
958 958 a, g dbSNP:766808881
959 959 a, g dbSNP:751219716
967 967 a, g dbSNP:754700741
970 970 a, g dbSNP:17851431
971 971 c, t dbSNP:373846371
972 972 g, t dbSNP:747666752
980 980 c, t dbSNP:149305908
988 988 a, g dbSNP:777550167
990 990 a, g dbSNP:757963772
992 992 a, g dbSNP:749286462
1006 1006 c, g dbSNP:371956477
1017 1017 -, tctg dbSNP:758959453
1017 1017 c, t dbSNP:17850940
1021 1021 -, catg, cctg, cgtg, tctg dbSNP:587776806
1031 1031 a, g dbSNP:565271245
1052 1052 c, t dbSNP:773366496
1054 1054 c, t dbSNP:201083444
1057 1057 a, g dbSNP:767000196
1060 1060 a, g dbSNP:376359773
1066 1066 -, a dbSNP:778247758
1066 1066 a, t dbSNP:3209214
1072 1072 a, c, g dbSNP:200638434
1073 1073 a, t dbSNP:768033269
1077 1077 c, t dbSNP:752355990
1078 1078 c, g, t dbSNP:760396612
1079 1079 a, g dbSNP:1059404
1082 1082 a, c, g, t dbSNP:756780247
1084 1084 -, atttc dbSNP:576436777
1085 1085 c, t dbSNP:758162516
1095 1095 a, g dbSNP:779857289
1132 1132 a, g dbSNP:6859650
1144 1144 c, t dbSNP:530255077
1149 1149 a, g dbSNP:549941909
1171 1171 a, c dbSNP:183613332
1177 1177 c, g dbSNP:146200852
1207 1207 -, t dbSNP:776882863
1208 1208 -, t dbSNP:34351976
1231 1231 g, t dbSNP:769724015
1234 1234 a, g dbSNP:558316376
1269 1269 a, g dbSNP:759833831
1290 1290 a, g dbSNP:1059683
1307 1307 a, c dbSNP:565674673
1317 1317 c, g dbSNP:139047811
1324 1324 -, t dbSNP:558186342
1324 1324 a, g dbSNP:554721005

Target ORF information:

RefSeq Version NM_199185
Organism Homo sapiens (human)
Definition Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_199185

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AAGGACAAGA ATCCTTCAAG
AAACAGGAAA AAACTCCTAA AACACCAAAA GGACCTAGTT CTGTAGAAGA CATTAAAGCA
AAAATGCAAG CAAGTATAGA AAAAGGTGGT TCTCTTCCCA AAGTGGAAGC CAAATTCATC
AATTATGTGA AGAATTGCTT CCGGATGACT GACCAAGAGG CTATTCAAGA TCTCTGGCAG
TGGAGGAAGT CTCTTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu15781
Accession Version NM_001037738.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 780bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product nucleophosmin isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC091980.4 and BC107754.1. On Nov 3, 2009 this sequence version replaced gi:83641869. Summary: This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]. Transcript Variant: This variant (3) utilizes an alternate 3'-terminal exon, compared to variant 1, resulting in a shorter protein (isoform 3) with a distinct C-terminus. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107754.1, BX438353.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AATCTATACG AGATACTCCA
GCCAAAAATG CACAAAAGTC AAATCAGAAT GGAAAAGACT CAAAACCATC ATCAACACCA
AGATCAAAAG GACAAGAATC CTTCAAGAAA CAGGAAAAAA CTCCTAAAAC ACCAAAAGGA
CCTAGTTCTG TAGAAGACAT TAAAGCAAAA ATGCAAGCAA GTATAGAAAA AGCGCATTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001032827.1
CDS246..1025
Misc Feature(1)246..803(+)
Misc Feature(2)246..596(+)
Misc Feature(3)246..248(+)
Misc Feature(4)255..257(+)
Misc Feature(5)255..257(+)
Misc Feature(6)273..275(+)
Misc Feature(7)273..275(+)
Misc Feature(8)282..>602(+)
Misc Feature(9)339..341(+)
Misc Feature(10)408..410(+)
Misc Feature(11)444..446(+)
Misc Feature(12)453..455(+)
Misc Feature(13)453..455(+)
Misc Feature(14)468..470(+)
Misc Feature(15)483..485(+)
Misc Feature(16)528..530(+)
Misc Feature(17)528..530(+)
Misc Feature(18)618..620(+)
Misc Feature(19)618..620(+)
Misc Feature(20)654..656(+)
Misc Feature(21)660..662(+)
Misc Feature(22)693..695(+)
Misc Feature(23)699..716(+)
Misc Feature(24)705..707(+)
Misc Feature(25)768..773(+)
Misc Feature(26)816..836(+)
Misc Feature(27)840..842(+)
Misc Feature(28)879..881(+)
Misc Feature(29)900..902(+)
Misc Feature(30)924..926(+)
Misc Feature(31)930..932(+)
Misc Feature(32)933..935(+)
Misc Feature(33)945..947(+)
Misc Feature(34)954..956(+)
Misc Feature(35)969..971(+)
Misc Feature(36)972..974(+)
Misc Feature(37)993..995(+)
Misc Feature(38)1005..1007(+)
Misc Feature(39)1005..1007(+)
Misc Feature(40)1014..1016(+)
Exon (1)1..303
Gene:NPM1
Gene Synonym:
Exon (2)304..383
Gene:NPM1
Gene Synonym:
Exon (3)384..503
Gene:NPM1
Gene Synonym:
Exon (4)504..597
Gene:NPM1
Gene Synonym:
Exon (5)598..704
Gene:NPM1
Gene Synonym:
Exon (6)705..769
Gene:NPM1
Gene Synonym:
Exon (7)770..827
Gene:NPM1
Gene Synonym:
Exon (8)828..914
Gene:NPM1
Gene Synonym:
Exon (9)915..1016
Gene:NPM1
Gene Synonym:
Exon (10)1017..1347
Gene:NPM1
Gene Synonym:
Translation
Position Chain Variation Link
12 12 g, t dbSNP:530572595
22 22 c, g dbSNP:767905961
36 36 c, g dbSNP:544419881
49 49 c, g dbSNP:75828148
50 50 g, t dbSNP:533294099
52 52 c, g dbSNP:541595379
58 58 a, g dbSNP:566113295
61 61 c, t dbSNP:528457939
64 64 c, t dbSNP:548138598
97 97 a, c dbSNP:568219237
107 107 a, g dbSNP:537112557
127 127 a, c dbSNP:374925391
132 132 g, t dbSNP:561702061
136 136 a, c dbSNP:540172836
138 138 c, g dbSNP:10069429
141 141 a, g, t dbSNP:573534099
142 142 c, t dbSNP:148722569
145 145 c, t dbSNP:555371632
146 146 c, t dbSNP:527309039
147 147 c, t dbSNP:112023099
149 149 g, t dbSNP:112330400
150 150 c, t dbSNP:543958094
152 152 c, g dbSNP:377340416
167 167 c, t dbSNP:577760802
170 170 a, g dbSNP:11551528
170 170 g, t dbSNP:540561427
171 171 c, t dbSNP:28411385
179 179 c, t dbSNP:749918542
181 181 c, t dbSNP:533273568
182 182 c, t dbSNP:180887715
183 183 c, g dbSNP:11551579
183 183 c, g dbSNP:185295288
186 186 a, g dbSNP:551273843
187 187 a, g dbSNP:561730798
189 189 c, t dbSNP:531062299
190 190 a, g dbSNP:189577643
192 192 c, t dbSNP:111426800
193 193 g, t dbSNP:531273939
196 196 c, t dbSNP:539652493
197 197 c, t dbSNP:11551555
198 198 c, t dbSNP:11551547
201 201 a, g dbSNP:757830185
202 202 c, t dbSNP:779663664
203 203 c, g, t dbSNP:375152584
204 204 c, t dbSNP:11551556
205 205 c, t dbSNP:754937690
206 206 c, g, t dbSNP:780914482
208 208 a, t dbSNP:769699299
209 209 c, g dbSNP:774422812
210 210 c, t dbSNP:200132495
217 217 c, t dbSNP:772017828
218 218 c, t dbSNP:202010899
219 219 c, t dbSNP:761217346
221 221 a, c, t dbSNP:11551523
224 224 -, ctaa dbSNP:752842004
224 224 a, c, t dbSNP:764467196
225 225 c, t dbSNP:35747006
227 227 -, aa dbSNP:758441268
232 232 c, g, t dbSNP:11551571
237 237 c, t dbSNP:750018655
239 239 c, g, t dbSNP:758108952
240 240 c, t dbSNP:751089518
242 242 c, g, t dbSNP:370439209
243 243 c, g dbSNP:368504792
245 245 c, g, t dbSNP:587777962
251 251 a, g dbSNP:373962671
257 257 -, atggac dbSNP:778077508
257 257 a, g dbSNP:368150213
264 264 a, g dbSNP:772365842
275 275 c, t dbSNP:775657228
281 281 a, g dbSNP:747086342
283 283 a, g dbSNP:768919750
284 284 a, g dbSNP:142254256
296 296 c, t dbSNP:762428128
299 299 c, t dbSNP:765486682
312 312 c, t dbSNP:35979859
335 335 c, t dbSNP:773970096
342 342 a, g dbSNP:759228926
349 349 a, g dbSNP:766975341
386 386 a, c dbSNP:771256760
400 400 a, g dbSNP:372208958
403 403 c, t dbSNP:774730997
414 414 c, t dbSNP:759143092
416 416 -, ttaga dbSNP:777646492
418 418 -, attt dbSNP:751818162
420 420 -, tc dbSNP:757476342
422 422 c, g, t dbSNP:142102985
436 436 c, t dbSNP:11551526
438 438 a, g dbSNP:11551576
446 446 c, t dbSNP:200294440
447 447 a, g dbSNP:763566520
470 470 a, g dbSNP:753788683
471 471 c, t dbSNP:536652743
479 479 c, t dbSNP:11551522
481 481 c, t dbSNP:11551525
483 483 a, g dbSNP:17851944
502 502 c, t dbSNP:147806769
503 503 a, g dbSNP:750264549
512 512 g, t dbSNP:11551553
515 515 g, t dbSNP:752933446
537 537 g, t dbSNP:756323205
539 539 c, g dbSNP:764187017
566 566 a, g dbSNP:201813873
575 575 c, t dbSNP:753931371
596 596 a, g dbSNP:141086340
607 607 a, g dbSNP:587778580
614 614 a, t dbSNP:568679648
620 620 -, aga dbSNP:772541920
626 626 c, t dbSNP:200558908
630 630 -, gag dbSNP:746516563
632 632 a, g dbSNP:780415062
648 648 c, t dbSNP:751882247
650 650 a, c dbSNP:754590863
651 651 c, t dbSNP:780986538
657 657 a, c dbSNP:747866671
659 659 a, g dbSNP:769397977
673 673 c, g dbSNP:375558588
680 680 c, t dbSNP:749202543
682 682 a, g dbSNP:770789271
703 703 a, g dbSNP:571071150
716 716 a, g dbSNP:535582867
719 719 -, tgc dbSNP:587778581
719 719 c, t dbSNP:61749648
720 720 c, g dbSNP:775291597
724 724 c, t dbSNP:748317624
725 725 -, tga dbSNP:759376175
726 726 a, g dbSNP:770013862
728 728 c, t dbSNP:773274787
729 729 -, gaa dbSNP:549146478
732 732 -, gatgatgacgat dbSNP:775410264
732 732 -, gat dbSNP:764976369
734 734 g, t dbSNP:762935997
737 737 c, t dbSNP:566156848
738 738 -, gac dbSNP:762739342
740 740 c, t dbSNP:146936311
741 741 -, gat dbSNP:751654967
741 741 a, g dbSNP:774697729
743 743 c, t dbSNP:147629377
750 750 -, gaa dbSNP:757325565
752 752 a, t dbSNP:767945148
756 756 -, gat dbSNP:767897913
757 757 a, t dbSNP:750633648
758 758 g, t dbSNP:753126733
767 767 a, g dbSNP:368269652
770 770 -, tga dbSNP:779471362
770 770 a, t dbSNP:747005016
773 773 a, t dbSNP:754744493
777 777 a, g dbSNP:267600552
778 778 a, g dbSNP:17856513
785 785 c, t dbSNP:140888436
788 788 -, tga dbSNP:770452718
788 788 c, t dbSNP:61755048
794 794 c, t dbSNP:771198652
797 797 a, g dbSNP:778792366
815 815 a, g dbSNP:368568545
819 819 a, g dbSNP:772337921
823 823 a, g dbSNP:183724988
824 824 g, t dbSNP:761307473
829 829 c, t dbSNP:544573727
831 831 a, g dbSNP:376742289
835 835 a, g dbSNP:762635721
836 836 a, t dbSNP:765835395
843 843 c, t dbSNP:751083124
846 846 g, t dbSNP:764419488
858 858 c, g dbSNP:759324510
860 860 a, g dbSNP:201906545
875 875 c, t dbSNP:752632627
885 885 c, t dbSNP:373068340
892 892 -, cat dbSNP:761817600
893 893 a, g, t dbSNP:777747760
908 908 a, g dbSNP:527378561
914 914 a, g dbSNP:780229057
919 919 a, g dbSNP:758630739
923 923 a, c, g dbSNP:766707224
945 945 a, t dbSNP:755065911
946 946 c, t dbSNP:781171336
952 952 a, c dbSNP:374517078
957 957 a, c dbSNP:756636316
959 959 a, g, t dbSNP:778045427
966 966 c, t dbSNP:771340939
969 969 a, g dbSNP:138586088
974 974 c, t dbSNP:745544920
975 975 a, g dbSNP:771568444
978 978 c, g dbSNP:143209617
981 981 g, t dbSNP:760598971
983 983 c, t dbSNP:773255144
991 991 c, t dbSNP:377348662
1007 1007 a, t dbSNP:11551532
1008 1008 a, g dbSNP:776780244
1018 1018 c, g dbSNP:375287524
1019 1019 a, g, t dbSNP:202084580
1021 1021 a, g dbSNP:747259799
1024 1024 a, g dbSNP:757780376
1031 1031 c, g dbSNP:779275963
1033 1033 c, t dbSNP:201213708
1037 1037 c, t dbSNP:200374433
1038 1038 a, g dbSNP:750754356
1047 1047 -, aa dbSNP:756764456
1055 1055 c, t dbSNP:202141313
1068 1068 a, t dbSNP:779563631
1069 1069 a, g dbSNP:746711871
1076 1076 a, t dbSNP:752530106
1124 1124 -, tgaa dbSNP:769549525
1130 1130 g, t dbSNP:779821869
1148 1148 a, g dbSNP:147082300
1195 1195 g, t dbSNP:760568553
1222 1222 c, t dbSNP:528965239
1256 1256 -, cttt dbSNP:541715193
1290 1290 a, g dbSNP:186933329
1302 1302 a, g dbSNP:768964425
1308 1308 g, t dbSNP:763765757
1329 1329 a, t dbSNP:568708497

Target ORF information:

RefSeq Version NM_001037738
Organism Homo sapiens (human)
Definition Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001037738

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AATCTATACG AGATACTCCA
GCCAAAAATG CACAAAAGTC AAATCAGAAT GGAAAAGACT CAAAACCATC ATCAACACCA
AGATCAAAAG GACAAGAATC CTTCAAGAAA CAGGAAAAAA CTCCTAAAAC ACCAAAAGGA
CCTAGTTCTG TAGAAGACAT TAAAGCAAAA ATGCAAGCAA GTATAGAAAA AGCGCATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21782
Accession Version NM_002520.6 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 885bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product nucleophosmin isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC091980.4 and BC002398.2. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2009 this sequence version replaced gi:83641868. Summary: This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]. Transcript Variant: This predominant variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ303464.1, BC008495.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AATCTATACG AGATACTCCA
GCCAAAAATG CACAAAAGTC AAATCAGAAT GGAAAAGACT CAAAACCATC ATCAACACCA
AGATCAAAAG GACAAGAATC CTTCAAGAAA CAGGAAAAAA CTCCTAAAAC ACCAAAAGGA
CCTAGTTCTG TAGAAGACAT TAAAGCAAAA ATGCAAGCAA GTATAGAAAA AGGTGGTTCT
CTTCCCAAAG TGGAAGCCAA ATTCATCAAT TATGTGAAGA ATTGCTTCCG GATGACTGAC
CAAGAGGCTA TTCAAGATCT CTGGCAGTGG AGGAAGTCTC TTTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002511.1
CDS246..1130
Misc Feature(1)246..803(+)
Misc Feature(2)246..596(+)
Misc Feature(3)246..248(+)
Misc Feature(4)255..257(+)
Misc Feature(5)255..257(+)
Misc Feature(6)273..275(+)
Misc Feature(7)273..275(+)
Misc Feature(8)282..>602(+)
Misc Feature(9)339..341(+)
Misc Feature(10)408..410(+)
Misc Feature(11)444..446(+)
Misc Feature(12)453..455(+)
Misc Feature(13)453..455(+)
Misc Feature(14)453..455(+)
Misc Feature(15)468..470(+)
Misc Feature(16)483..485(+)
Misc Feature(17)528..530(+)
Misc Feature(18)528..530(+)
Misc Feature(19)618..620(+)
Misc Feature(20)618..620(+)
Misc Feature(21)618..620(+)
Misc Feature(22)654..656(+)
Misc Feature(23)660..662(+)
Misc Feature(24)693..695(+)
Misc Feature(25)699..716(+)
Misc Feature(26)705..707(+)
Misc Feature(27)768..773(+)
Misc Feature(28)816..836(+)
Misc Feature(29)840..842(+)
Misc Feature(30)840..842(+)
Misc Feature(31)879..881(+)
Misc Feature(32)900..902(+)
Misc Feature(33)900..902(+)
Misc Feature(34)924..926(+)
Misc Feature(35)930..932(+)
Misc Feature(36)933..935(+)
Misc Feature(37)945..947(+)
Misc Feature(38)945..947(+)
Misc Feature(39)954..956(+)
Misc Feature(40)954..956(+)
Misc Feature(41)969..971(+)
Misc Feature(42)972..1127(+)
Misc Feature(43)972..974(+)
Misc Feature(44)993..995(+)
Misc Feature(45)1005..1007(+)
Misc Feature(46)1005..1007(+)
Misc Feature(47)1005..1007(+)
Misc Feature(48)1014..1016(+)
Misc Feature(49)1023..1025(+)
Misc Feature(50)1044..1046(+)
Misc Feature(51)1062..1064(+)
Misc Feature(52)1080..1082(+)
Misc Feature(53)1119..1121(+)
Exon (1)1..303
Gene:NPM1
Gene Synonym:
Exon (2)304..383
Gene:NPM1
Gene Synonym:
Exon (3)384..503
Gene:NPM1
Gene Synonym:
Exon (4)504..597
Gene:NPM1
Gene Synonym:
Exon (5)598..704
Gene:NPM1
Gene Synonym:
Exon (6)705..769
Gene:NPM1
Gene Synonym:
Exon (7)770..827
Gene:NPM1
Gene Synonym:
Exon (8)828..914
Gene:NPM1
Gene Synonym:
Exon (9)915..1016
Gene:NPM1
Gene Synonym:
Exon (10)1017..1091
Gene:NPM1
Gene Synonym:
Exon (11)1092..1449
Gene:NPM1
Gene Synonym:
Translation
Position Chain Variation Link
12 12 g, t dbSNP:530572595
22 22 c, g dbSNP:767905961
36 36 c, g dbSNP:544419881
49 49 c, g dbSNP:75828148
50 50 g, t dbSNP:533294099
52 52 c, g dbSNP:541595379
58 58 a, g dbSNP:566113295
61 61 c, t dbSNP:528457939
64 64 c, t dbSNP:548138598
97 97 a, c dbSNP:568219237
107 107 a, g dbSNP:537112557
127 127 a, c dbSNP:374925391
132 132 g, t dbSNP:561702061
136 136 a, c dbSNP:540172836
138 138 c, g dbSNP:10069429
141 141 a, g, t dbSNP:573534099
142 142 c, t dbSNP:148722569
145 145 c, t dbSNP:555371632
146 146 c, t dbSNP:527309039
147 147 c, t dbSNP:112023099
149 149 g, t dbSNP:112330400
150 150 c, t dbSNP:543958094
152 152 c, g dbSNP:377340416
167 167 c, t dbSNP:577760802
170 170 a, g dbSNP:11551528
170 170 g, t dbSNP:540561427
171 171 c, t dbSNP:28411385
179 179 c, t dbSNP:749918542
181 181 c, t dbSNP:533273568
182 182 c, t dbSNP:180887715
183 183 c, g dbSNP:11551579
183 183 c, g dbSNP:185295288
186 186 a, g dbSNP:551273843
187 187 a, g dbSNP:561730798
189 189 c, t dbSNP:531062299
190 190 a, g dbSNP:189577643
192 192 c, t dbSNP:111426800
193 193 g, t dbSNP:531273939
196 196 c, t dbSNP:539652493
197 197 c, t dbSNP:11551555
198 198 c, t dbSNP:11551547
201 201 a, g dbSNP:757830185
202 202 c, t dbSNP:779663664
203 203 c, g, t dbSNP:375152584
204 204 c, t dbSNP:11551556
205 205 c, t dbSNP:754937690
206 206 c, g, t dbSNP:780914482
208 208 a, t dbSNP:769699299
209 209 c, g dbSNP:774422812
210 210 c, t dbSNP:200132495
217 217 c, t dbSNP:772017828
218 218 c, t dbSNP:202010899
219 219 c, t dbSNP:761217346
221 221 a, c, t dbSNP:11551523
224 224 -, ctaa dbSNP:752842004
224 224 a, c, t dbSNP:764467196
225 225 c, t dbSNP:35747006
227 227 -, aa dbSNP:758441268
232 232 c, g, t dbSNP:11551571
237 237 c, t dbSNP:750018655
239 239 c, g, t dbSNP:758108952
240 240 c, t dbSNP:751089518
242 242 c, g, t dbSNP:370439209
243 243 c, g dbSNP:368504792
245 245 c, g, t dbSNP:587777962
251 251 a, g dbSNP:373962671
257 257 -, atggac dbSNP:778077508
257 257 a, g dbSNP:368150213
264 264 a, g dbSNP:772365842
275 275 c, t dbSNP:775657228
281 281 a, g dbSNP:747086342
283 283 a, g dbSNP:768919750
284 284 a, g dbSNP:142254256
296 296 c, t dbSNP:762428128
299 299 c, t dbSNP:765486682
312 312 c, t dbSNP:35979859
335 335 c, t dbSNP:773970096
342 342 a, g dbSNP:759228926
349 349 a, g dbSNP:766975341
386 386 a, c dbSNP:771256760
400 400 a, g dbSNP:372208958
403 403 c, t dbSNP:774730997
414 414 c, t dbSNP:759143092
416 416 -, ttaga dbSNP:777646492
418 418 -, attt dbSNP:751818162
420 420 -, tc dbSNP:757476342
422 422 c, g, t dbSNP:142102985
436 436 c, t dbSNP:11551526
438 438 a, g dbSNP:11551576
446 446 c, t dbSNP:200294440
447 447 a, g dbSNP:763566520
470 470 a, g dbSNP:753788683
471 471 c, t dbSNP:536652743
479 479 c, t dbSNP:11551522
481 481 c, t dbSNP:11551525
483 483 a, g dbSNP:17851944
502 502 c, t dbSNP:147806769
503 503 a, g dbSNP:750264549
512 512 g, t dbSNP:11551553
515 515 g, t dbSNP:752933446
537 537 g, t dbSNP:756323205
539 539 c, g dbSNP:764187017
566 566 a, g dbSNP:201813873
575 575 c, t dbSNP:753931371
596 596 a, g dbSNP:141086340
607 607 a, g dbSNP:587778580
614 614 a, t dbSNP:568679648
620 620 -, aga dbSNP:772541920
626 626 c, t dbSNP:200558908
630 630 -, gag dbSNP:746516563
632 632 a, g dbSNP:780415062
648 648 c, t dbSNP:751882247
650 650 a, c dbSNP:754590863
651 651 c, t dbSNP:780986538
657 657 a, c dbSNP:747866671
659 659 a, g dbSNP:769397977
673 673 c, g dbSNP:375558588
680 680 c, t dbSNP:749202543
682 682 a, g dbSNP:770789271
703 703 a, g dbSNP:571071150
716 716 a, g dbSNP:535582867
719 719 -, tgc dbSNP:587778581
719 719 c, t dbSNP:61749648
720 720 c, g dbSNP:775291597
724 724 c, t dbSNP:748317624
725 725 -, tga dbSNP:759376175
726 726 a, g dbSNP:770013862
728 728 c, t dbSNP:773274787
729 729 -, gaa dbSNP:549146478
732 732 -, gatgatgacgat dbSNP:775410264
732 732 -, gat dbSNP:764976369
734 734 g, t dbSNP:762935997
737 737 c, t dbSNP:566156848
738 738 -, gac dbSNP:762739342
740 740 c, t dbSNP:146936311
741 741 -, gat dbSNP:751654967
741 741 a, g dbSNP:774697729
743 743 c, t dbSNP:147629377
750 750 -, gaa dbSNP:757325565
752 752 a, t dbSNP:767945148
756 756 -, gat dbSNP:767897913
757 757 a, t dbSNP:750633648
758 758 g, t dbSNP:753126733
767 767 a, g dbSNP:368269652
770 770 -, tga dbSNP:779471362
770 770 a, t dbSNP:747005016
773 773 a, t dbSNP:754744493
777 777 a, g dbSNP:267600552
778 778 a, g dbSNP:17856513
785 785 c, t dbSNP:140888436
788 788 -, tga dbSNP:770452718
788 788 c, t dbSNP:61755048
794 794 c, t dbSNP:771198652
797 797 a, g dbSNP:778792366
815 815 a, g dbSNP:368568545
819 819 a, g dbSNP:772337921
823 823 a, g dbSNP:183724988
824 824 g, t dbSNP:761307473
829 829 c, t dbSNP:544573727
831 831 a, g dbSNP:376742289
835 835 a, g dbSNP:762635721
836 836 a, t dbSNP:765835395
843 843 c, t dbSNP:751083124
846 846 g, t dbSNP:764419488
858 858 c, g dbSNP:759324510
860 860 a, g dbSNP:201906545
875 875 c, t dbSNP:752632627
885 885 c, t dbSNP:373068340
892 892 -, cat dbSNP:761817600
893 893 a, g, t dbSNP:777747760
908 908 a, g dbSNP:527378561
914 914 a, g dbSNP:780229057
919 919 a, g dbSNP:758630739
923 923 a, c, g dbSNP:766707224
945 945 a, t dbSNP:755065911
946 946 c, t dbSNP:781171336
952 952 a, c dbSNP:374517078
957 957 a, c dbSNP:756636316
959 959 a, g, t dbSNP:778045427
966 966 c, t dbSNP:771340939
969 969 a, g dbSNP:138586088
974 974 c, t dbSNP:745544920
975 975 a, g dbSNP:771568444
978 978 c, g dbSNP:143209617
981 981 g, t dbSNP:760598971
983 983 c, t dbSNP:773255144
991 991 c, t dbSNP:377348662
1007 1007 a, t dbSNP:11551532
1008 1008 a, g dbSNP:776780244
1019 1019 g, t dbSNP:764108222
1022 1022 c, t dbSNP:371199566
1031 1031 c, t dbSNP:556846930
1033 1033 a, g dbSNP:765654691
1037 1037 a, g dbSNP:575231413
1040 1040 a, g dbSNP:758672403
1045 1045 a, g dbSNP:766808881
1046 1046 a, g dbSNP:751219716
1054 1054 a, g dbSNP:754700741
1057 1057 a, g dbSNP:17851431
1058 1058 c, t dbSNP:373846371
1059 1059 g, t dbSNP:747666752
1067 1067 c, t dbSNP:149305908
1075 1075 a, g dbSNP:777550167
1077 1077 a, g dbSNP:757963772
1079 1079 a, g dbSNP:749286462
1093 1093 c, g dbSNP:371956477
1104 1104 -, tctg dbSNP:758959453
1104 1104 c, t dbSNP:17850940
1108 1108 -, catg, cctg, cgtg, tctg dbSNP:587776806
1118 1118 a, g dbSNP:565271245
1139 1139 c, t dbSNP:773366496
1141 1141 c, t dbSNP:201083444
1144 1144 a, g dbSNP:767000196
1147 1147 a, g dbSNP:376359773
1153 1153 -, a dbSNP:778247758
1153 1153 a, t dbSNP:3209214
1159 1159 a, c, g dbSNP:200638434
1160 1160 a, t dbSNP:768033269
1164 1164 c, t dbSNP:752355990
1165 1165 c, g, t dbSNP:760396612
1166 1166 a, g dbSNP:1059404
1169 1169 a, c, g, t dbSNP:756780247
1171 1171 -, atttc dbSNP:576436777
1172 1172 c, t dbSNP:758162516
1182 1182 a, g dbSNP:779857289
1219 1219 a, g dbSNP:6859650
1231 1231 c, t dbSNP:530255077
1236 1236 a, g dbSNP:549941909
1258 1258 a, c dbSNP:183613332
1264 1264 c, g dbSNP:146200852
1294 1294 -, t dbSNP:776882863
1295 1295 -, t dbSNP:34351976
1318 1318 g, t dbSNP:769724015
1321 1321 a, g dbSNP:558316376
1356 1356 a, g dbSNP:759833831
1377 1377 a, g dbSNP:1059683
1394 1394 a, c dbSNP:565674673
1404 1404 c, g dbSNP:139047811
1411 1411 -, t dbSNP:558186342
1411 1411 a, g dbSNP:554721005

Target ORF information:

RefSeq Version NM_002520
Organism Homo sapiens (human)
Definition Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002520

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGAAGATT CGATGGACAT GGACATGAGC CCCCTGAGGC CCCAGAACTA TCTTTTCGGT 
TGTGAACTAA AGGCCGACAA AGATTATCAC TTTAAGGTGG ATAATGATGA AAATGAGCAC
CAGTTATCTT TAAGAACGGT CAGTTTAGGG GCTGGTGCAA AGGATGAGTT GCACATTGTT
GAAGCAGAGG CAATGAATTA CGAAGGCAGT CCAATTAAAG TAACACTGGC AACTTTGAAA
ATGTCTGTAC AGCCAACGGT TTCCCTTGGG GGCTTTGAAA TAACACCACC AGTGGTCTTA
AGGTTGAAGT GTGGTTCAGG GCCAGTGCAT ATTAGTGGAC AGCACTTAGT AGCTGTGGAG
GAAGATGCAG AGTCAGAAGA TGAAGAGGAG GAGGATGTGA AACTCTTAAG TATATCTGGA
AAGCGGTCTG CCCCTGGAGG TGGTAGCAAG GTTCCACAGA AAAAAGTAAA ACTTGCTGCT
GATGAAGATG ATGACGATGA TGATGAAGAG GATGATGATG AAGATGATGA TGATGATGAT
TTTGATGATG AGGAAGCTGA AGAAAAAGCG CCAGTGAAGA AATCTATACG AGATACTCCA
GCCAAAAATG CACAAAAGTC AAATCAGAAT GGAAAAGACT CAAAACCATC ATCAACACCA
AGATCAAAAG GACAAGAATC CTTCAAGAAA CAGGAAAAAA CTCCTAAAAC ACCAAAAGGA
CCTAGTTCTG TAGAAGACAT TAAAGCAAAA ATGCAAGCAA GTATAGAAAA AGGTGGTTCT
CTTCCCAAAG TGGAAGCCAA ATTCATCAAT TATGTGAAGA ATTGCTTCCG GATGACTGAC
CAAGAGGCTA TTCAAGATCT CTGGCAGTGG AGGAAGTCTC TTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.