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CISD2 CDGSH iron sulfur domain 2 [Homo sapiens (human)]

Gene Symbol CISD2
Entrez Gene ID 493856
Full Name CDGSH iron sulfur domain 2
Synonyms ERIS, Miner1, NAF-1, WFS2, ZCD2
General protein information
Preferred Names
CDGSH iron-sulfur domain-containing protein 2
Names
CDGSH iron-sulfur domain-containing protein 2
mitoNEET related 1
mitoNEET-related 1 protein
zinc finger, CDGSH-type domain 2
nutrient-deprivation autophagy factor-1
endoplasmic reticulum intermembrane small protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q24

Summary The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]. lac of sum
Disorder MIM:

611507

Disorder Html: Wolfram syndrome 2, 604928 (3)





The following CISD2 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CISD2 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23185 NM_001008388 Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu23185
Accession Version NM_001008388.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 408bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product CDGSH iron-sulfur domain-containing protein 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC018797.4, AK292134.1, BX537971.1 and AC083826.7. This sequence is a reference standard in the RefSeqGene project. On Jul 3, 2010 this sequence version replaced gi:197313633. Summary: The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DN993861.1, BX537971.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGGTGCTGG AGAGCGTGGC CCGTATCGTG AAGGTGCAGC TCCCTGCATA TCTGAAGCGG 
CTCCCAGTCC CTGAAAGCAT TACCGGGTTC GCTAGGCTCA CAGTTTCAGA ATGGCTTCGG
TTATTGCCTT TCCTTGGTGT ACTCGCACTT CTTGGCTACC TTGCAGTTCG TCCATTCCTC
CCGAAGAAGA AACAACAGAA GGATAGCTTG ATTAATCTTA AAATACAAAA GGAAAATCCG
AAAGTAGTGA ATGAAATAAA CATTGAAGAT TTGTGTCTTA CTAAAGCAGC TTATTGTAGG
TGTTGGCGTT CTAAAACGTT TCCTGCCTGC GATGGTTCAC ATAATAAACA CAATGAATTG
ACAGGAGATA ATGTGGGTCC ACTAATACTG AAGAAGAAAG AAGTATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001008389.1
CDS108..515
Misc Feature(1)114..305(+)
Misc Feature(2)219..287(+)
Misc Feature(3)348..464(+)
Exon (1)1..210
Gene:CISD2
Gene Synonym:
Exon (2)211..425
Gene:CISD2
Gene Synonym:
Exon (3)426..5892
Gene:CISD2
Gene Synonym:
Translation
Position Chain Variation Link
19 19 c, t dbSNP:572196276
24 24 c, t dbSNP:545449702
49 49 a, c dbSNP:548270434
52 52 g, t dbSNP:223332
61 61 g, t dbSNP:527237189
65 65 a, g dbSNP:746657323
67 67 a, g dbSNP:34403962
69 69 -, gga dbSNP:745626265
71 71 -, g dbSNP:772041686
74 74 a, g dbSNP:770429715
78 78 c, t dbSNP:776281350
79 79 c, t dbSNP:551895041
80 80 c, g dbSNP:769308187
84 84 a, g dbSNP:774974208
86 86 a, g dbSNP:762124130
90 90 c, t dbSNP:571899037
96 96 c, g dbSNP:773366048
97 97 a, c dbSNP:539010424
103 103 a, c, g, t dbSNP:374131019
103 103 -, c dbSNP:775480110
106 106 a, g dbSNP:557515732
117 117 a, g dbSNP:752651575
119 119 a, g dbSNP:145312923
121 121 a, g dbSNP:777634796
122 122 a, c dbSNP:751241670
149 149 c, t dbSNP:756961402
155 155 a, c, g dbSNP:374512796
159 159 c, t dbSNP:142339135
166 166 a, g dbSNP:779629996
167 167 c, g dbSNP:564095499
173 173 a, g dbSNP:772403549
175 175 a, t dbSNP:773631848
176 176 c, g dbSNP:760909526
181 181 a, t dbSNP:768377356
184 184 c, g dbSNP:771168860
186 186 a, g dbSNP:776816073
190 190 c, t dbSNP:759654427
193 193 g, t dbSNP:573009141
199 199 c, t dbSNP:765299352
201 201 a, g dbSNP:752659038
209 209 a, g dbSNP:762949777
215 215 a, c dbSNP:766107276
216 216 c, g dbSNP:63749888
225 225 c, t dbSNP:753403300
226 226 a, g dbSNP:146299528
227 227 a, g dbSNP:763904771
246 246 g, t dbSNP:764643608
251 251 c, t dbSNP:371712100
252 252 a, g dbSNP:757788592
258 258 c, t dbSNP:781626534
265 265 a, g dbSNP:746277672
272 272 a, c dbSNP:756402482
273 273 g, t dbSNP:770471638
277 277 a, g dbSNP:780388471
279 279 a, c dbSNP:374058087
289 289 c, g, t dbSNP:142253163
290 290 a, g dbSNP:199702688
297 297 a, c dbSNP:772159844
302 302 a, g dbSNP:375816656
332 332 a, g dbSNP:577064952
333 333 c, g dbSNP:766086013
347 347 a, g dbSNP:375529885
363 363 a, g dbSNP:370219158
366 366 a, g dbSNP:764899307
370 370 c, t dbSNP:752222512
401 401 c, t dbSNP:151223492
404 404 c, t dbSNP:768049003
407 407 a, g dbSNP:750923436
410 410 c, t dbSNP:756559515
437 437 c, g, t dbSNP:587780892
442 442 a, g dbSNP:587780893
443 443 c, t dbSNP:199992363
447 447 c, t dbSNP:201294540
465 465 c, t dbSNP:587780894
500 500 a, g dbSNP:3974627
512 512 -, ataata dbSNP:761545507
520 520 -, atatt dbSNP:764939021
523 523 -, ttata dbSNP:3974628
746 746 a, t dbSNP:113520032
763 763 c, t dbSNP:574935569
779 779 a, t dbSNP:542097737
786 786 a, g dbSNP:560567283
790 790 c, t dbSNP:7439174
843 843 a, g dbSNP:3974630
913 913 c, g dbSNP:4583764
941 941 a, c dbSNP:527815582
958 958 c, t dbSNP:552589871
970 970 a, g dbSNP:181140079
973 973 -, ttac dbSNP:766208295
984 984 c, t dbSNP:200929867
987 987 -, acaga dbSNP:200907667
990 990 a, g dbSNP:531632296
992 992 g, t dbSNP:202177149
995 995 a, c dbSNP:200335385
1022 1022 g, t dbSNP:4404547
1107 1107 -, aag dbSNP:759295696
1117 1117 g, t dbSNP:111285950
1128 1128 a, c dbSNP:565271927
1139 1139 -, tg dbSNP:386626799
1139 1139 -, tg dbSNP:759915486
1140 1140 -, tg dbSNP:35045951
1141 1141 -, tg dbSNP:772044999
1145 1145 g, t dbSNP:201534173
1151 1151 -, gt dbSNP:140674520
1161 1161 a, g dbSNP:371588195
1168 1168 -, gt, gtgt dbSNP:201652008
1245 1245 g, t dbSNP:79809177
1251 1251 -, c dbSNP:35331282
1299 1299 a, g dbSNP:184219643
1322 1322 c, t dbSNP:115292237
1376 1376 c, t dbSNP:529080686
1385 1385 c, t dbSNP:188111609
1490 1490 a, g dbSNP:565419679
1496 1496 -, at dbSNP:763660791
1499 1499 a, g dbSNP:539109037
1512 1512 a, t dbSNP:557453240
1534 1534 g, t dbSNP:200660717
1539 1539 c, t dbSNP:566280798
1546 1546 a, g dbSNP:536651109
1550 1550 a, g dbSNP:530278309
1557 1557 a, c dbSNP:548945887
1566 1566 c, t dbSNP:112196870
1573 1573 g, t dbSNP:7254
1574 1574 c, t dbSNP:554440776
1593 1593 c, t dbSNP:572694065
1605 1605 g, t dbSNP:751473599
1623 1623 a, g dbSNP:546294667
1638 1638 a, g dbSNP:751632330
1666 1666 a, c dbSNP:536680822
1688 1688 -, tctt dbSNP:758952755
1743 1743 a, t dbSNP:112503466
1745 1745 c, g dbSNP:374112419
1761 1761 a, t dbSNP:564576513
1774 1774 c, t dbSNP:531693287
1778 1778 -, agat dbSNP:780624545
1791 1791 a, g dbSNP:543494475
1808 1808 a, g dbSNP:367544831
1842 1842 a, c dbSNP:223311
1852 1852 a, g dbSNP:547302822
1863 1863 a, g dbSNP:565508103
1869 1869 c, t dbSNP:188244827
1882 1882 -, tgt dbSNP:755303169
1882 1882 c, g dbSNP:145075446
1899 1899 c, g dbSNP:764261016
1975 1975 a, c dbSNP:551020965
1982 1982 a, g dbSNP:200694706
2010 2010 c, g dbSNP:181085468
2012 2012 a, g dbSNP:368582286
2041 2041 a, g dbSNP:537045752
2059 2059 -, caga dbSNP:372068088
2090 2090 -, taat dbSNP:748360250
2099 2099 c, t dbSNP:555098699
2102 2102 a, g dbSNP:372309407
2104 2104 a, c dbSNP:375157177
2107 2107 g, t dbSNP:568722495
2123 2123 c, t dbSNP:536121429
2130 2130 a, c dbSNP:147549214
2143 2143 a, g dbSNP:768069569
2153 2153 g, t dbSNP:572627797
2206 2206 -, a dbSNP:551662019
2269 2269 a, t dbSNP:141865431
2277 2277 -, att dbSNP:750825762
2308 2308 c, t dbSNP:558276521
2324 2324 c, t dbSNP:369656042
2328 2328 -, ctt dbSNP:148078599
2328 2328 c, g dbSNP:576486602
2331 2331 -, ctt dbSNP:564677391
2345 2345 a, g dbSNP:62327287
2359 2359 a, t dbSNP:62327288
2372 2372 -, tgtt dbSNP:767735387
2381 2381 a, g dbSNP:112418987
2390 2390 c, g dbSNP:111303980
2421 2421 g, t dbSNP:79727311
2428 2428 a, g dbSNP:77526189
2473 2473 c, t dbSNP:746299352
2491 2491 -, t dbSNP:552769196
2505 2505 a, c dbSNP:758820919
2539 2539 c, t dbSNP:780757383
2581 2581 c, t dbSNP:374896684
2597 2597 -, gag dbSNP:769899852
2601 2601 a, c dbSNP:534716647
2617 2617 c, t dbSNP:187157550
2643 2643 c, t dbSNP:552606339
2647 2647 -, aat dbSNP:749279154
2661 2661 a, t dbSNP:529307966
2694 2694 c, t dbSNP:540879345
2699 2699 a, g dbSNP:374662941
2717 2717 -, t dbSNP:386626801
2718 2718 -, t dbSNP:34550207
2719 2719 -, t dbSNP:138483883
2722 2722 -, t dbSNP:199992730
2722 2722 -, t dbSNP:397994774
2767 2767 c, t dbSNP:559232483
2784 2784 a, g dbSNP:532951253
2803 2803 g, t dbSNP:551207619
2811 2811 c, g dbSNP:780310582
2881 2881 c, t dbSNP:563375888
2954 2954 a, g dbSNP:747489058
2983 2983 c, t dbSNP:530555552
2984 2984 c, g dbSNP:549078128
2992 2992 a, g dbSNP:74632941
3030 3030 c, t dbSNP:567124023
3037 3037 c, t dbSNP:534608418
3055 3055 a, g dbSNP:574330193
3060 3060 a, g dbSNP:548072334
3075 3075 -, att dbSNP:35840247
3077 3077 -, tat dbSNP:70937578
3192 3192 g, t dbSNP:113787390
3238 3238 a, g dbSNP:541623382
3241 3241 c, g dbSNP:566418032
3277 3277 a, g dbSNP:540036719
3305 3305 a, c dbSNP:223310
3312 3312 a, g dbSNP:113008381
3336 3336 a, g dbSNP:190765542
3370 3370 c, g dbSNP:555830953
3383 3383 c, t dbSNP:573910212
3385 3385 a, g dbSNP:541067227
3386 3386 c, g dbSNP:776228466
3394 3394 -, att dbSNP:545747426
3443 3443 -, agag dbSNP:565303571
3513 3513 c, t dbSNP:559218368
3531 3531 c, t dbSNP:577542582
3539 3539 -, tact dbSNP:142131629
3541 3541 -, tt dbSNP:532358002
3547 3547 a, c dbSNP:181627301
3596 3596 a, g dbSNP:563305910
3605 3605 c, g dbSNP:530754883
3629 3629 a, g dbSNP:223309
3659 3659 g, t dbSNP:374612556
3673 3673 c, g dbSNP:185744666
3674 3674 c, t dbSNP:528084894
3675 3675 a, c dbSNP:559877191
3680 3680 c, g dbSNP:546666948
3726 3726 c, t dbSNP:747557788
3741 3741 c, t dbSNP:769495231
3759 3759 c, g dbSNP:772850139
3782 3782 c, t dbSNP:566358752
3783 3783 c, t dbSNP:113360567
3792 3792 c, t dbSNP:552069722
3796 3796 a, g dbSNP:766128128
3828 3828 a, g dbSNP:570100789
3907 3907 a, t dbSNP:190561512
3909 3909 a, g dbSNP:370868415
3925 3925 -, aaaaaaaaaaaa dbSNP:756757274
3926 3926 -, aaaaaaaaaaaa dbSNP:199492699
3942 3942 -, t dbSNP:759661787
3981 3981 a, t dbSNP:747723156
4024 4024 g, t dbSNP:112056340
4045 4045 a, t dbSNP:573842580
4076 4076 c, g dbSNP:759488759
4098 4098 a, c dbSNP:534675590
4107 4107 a, c dbSNP:570114934
4146 4146 c, g dbSNP:753955073
4157 4157 a, t dbSNP:577632757
4161 4161 c, t dbSNP:544946357
4176 4176 c, g dbSNP:373666209
4177 4177 a, g dbSNP:757279249
4218 4218 a, g dbSNP:549716095
4273 4273 g, t dbSNP:116373301
4286 4286 -, t dbSNP:545165372
4319 4319 g, t dbSNP:386508451
4329 4329 -, ctta dbSNP:548688719
4338 4338 c, t dbSNP:750652878
4351 4351 c, g dbSNP:575308152
4357 4357 c, t dbSNP:542850610
4358 4358 a, g dbSNP:560819777
4359 4359 a, g dbSNP:528226646
4396 4396 c, g dbSNP:113836479
4421 4421 a, t dbSNP:780598224
4427 4427 a, g dbSNP:223308
4451 4451 -, ag dbSNP:759042390
4457 4457 a, g dbSNP:532145258
4474 4474 a, g dbSNP:72935554
4510 4510 c, t dbSNP:570434082
4523 4523 a, g dbSNP:572347704
4585 4585 g, t dbSNP:531008309
4601 4601 c, t dbSNP:7660301
4612 4612 a, c dbSNP:7682231
4613 4613 -, a dbSNP:36086281
4727 4727 c, t dbSNP:534761064
4736 4736 c, g dbSNP:146833214
4751 4751 a, g dbSNP:769176917
4760 4760 c, g dbSNP:571261072
4796 4796 c, t dbSNP:539032633
4825 4825 a, c dbSNP:114168354
4895 4895 a, c dbSNP:182392254
4924 4924 a, g dbSNP:72935555
4954 4954 c, t dbSNP:185479449
4981 4981 a, c dbSNP:774142931
5048 5048 c, t dbSNP:776339845
5049 5049 g, t dbSNP:6822658
5086 5086 c, t dbSNP:374553853
5119 5119 a, g dbSNP:190764358
5125 5125 a, g dbSNP:759185144
5156 5156 c, t dbSNP:540280829
5180 5180 a, g dbSNP:367736367
5199 5199 a, g dbSNP:767556541
5211 5211 a, g dbSNP:575318615
5223 5223 a, t dbSNP:564979814
5231 5231 c, t dbSNP:539724743
5232 5232 c, g dbSNP:763204500
5241 5241 -, t dbSNP:752056542
5243 5243 a, t dbSNP:532134921
5246 5246 c, t dbSNP:10452178
5305 5305 a, g dbSNP:563804881
5322 5322 c, t dbSNP:563651445
5331 5331 c, t dbSNP:765378221
5351 5351 c, t dbSNP:531268911
5402 5402 c, g dbSNP:36038242
5404 5404 -, c dbSNP:35599629
5424 5424 c, g dbSNP:182994503
5441 5441 g, t dbSNP:774400647
5445 5445 a, t dbSNP:188693384
5447 5447 a, t dbSNP:193226502
5478 5478 c, t dbSNP:546649729
5494 5494 a, g dbSNP:750491319
5500 5500 c, t dbSNP:183447777
5516 5516 a, g dbSNP:538656604
5522 5522 c, t dbSNP:6823625
5613 5613 c, g dbSNP:569044261
5662 5662 c, t dbSNP:6846762
5700 5700 a, g dbSNP:559920232
5734 5734 a, g dbSNP:561960425
5746 5746 a, c dbSNP:199627415
5753 5753 a, g dbSNP:750886516
5773 5773 a, t dbSNP:534016541
5809 5809 c, t dbSNP:4699032
5861 5861 a, g dbSNP:542313738

Target ORF information:

RefSeq Version NM_001008388
Organism Homo sapiens (human)
Definition Homo sapiens CDGSH iron sulfur domain 2 (CISD2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001008388

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGTGCTGG AGAGCGTGGC CCGTATCGTG AAGGTGCAGC TCCCTGCATA TCTGAAGCGG 
CTCCCAGTCC CTGAAAGCAT TACCGGGTTC GCTAGGCTCA CAGTTTCAGA ATGGCTTCGG
TTATTGCCTT TCCTTGGTGT ACTCGCACTT CTTGGCTACC TTGCAGTTCG TCCATTCCTC
CCGAAGAAGA AACAACAGAA GGATAGCTTG ATTAATCTTA AAATACAAAA GGAAAATCCG
AAAGTAGTGA ATGAAATAAA CATTGAAGAT TTGTGTCTTA CTAAAGCAGC TTATTGTAGG
TGTTGGCGTT CTAAAACGTT TCCTGCCTGC GATGGTTCAC ATAATAAACA CAATGAATTG
ACAGGAGATA ATGTGGGTCC ACTAATACTG AAGAAGAAAG AAGTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.