The following TNFRSF11B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF11B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1206bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||tumor necrosis factor receptor superfamily member 11B precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA477521.1, AK223155.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jun 8, 2007 this sequence version replaced gi:22547122.
Summary: The protein encoded by this gene is a member of the
TNF-receptor superfamily. This protein is an osteoblast-secreted
decoy receptor that functions as a negative regulator of bone
resorption. This protein specifically binds to its ligand,
osteoprotegerin ligand, both of which are key extracellular
regulators of osteoclast development. Studies of the mouse
counterpart also suggest that this protein and its ligand play a
role in lymph-node organogenesis and vascular calcification.
Alternatively spliced transcript variants of this gene have been
reported, but their full length nature has not been determined.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK223155.1, BC030155.2 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
CDS uses downstream in-frame AUG :: downstream AUG is associated
with N-terminal localization
COMPLETENESS: full length.