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TNFRSF11B cDNA ORF clone, Homo sapiens (human)

Gene Symbol TNFRSF11B
Entrez Gene ID 4982
Full Name tumor necrosis factor receptor superfamily, member 11b
Synonyms OCIF, OPG, PDB5, TR1
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
tumor necrosis factor receptor superfamily member 11B
osteoprotegerin
osteoclastogenesis inhibitory factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602643

Disorder Html: Paget disease, juvenile, 239000 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_002546 NP_002537 tumor necrosis factor receptor superfamily member 11B precursor



Homo sapiens (human) TNFRSF11B NP_002537.3
Pan troglodytes (chimpanzee) TNFRSF11B XP_519921.2
Macaca mulatta (Rhesus monkey) TNFRSF11B XP_001096915.1
Canis lupus familiaris (dog) TNFRSF11B XP_003639496.1
Bos taurus (cattle) TNFRSF11B NP_001091525.1
Mus musculus (house mouse) Tnfrsf11b NP_032790.3
Rattus norvegicus (Norway rat) Tnfrsf11b NP_037002.1
Gallus gallus (chicken) TNFRSF11B NP_001028813.1
Xenopus (Silurana) tropicalis (western clawed frog) tnfrsf11b XP_002938025.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TNFRSF11B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF11B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23879
NM_002546 Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23879
Clone ID Related Accession (Same CDS sequence) NM_002546
Accession Version NM_002546.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1206bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-JUL-2015
Organism Homo sapiens (human)
Product tumor necrosis factor receptor superfamily member 11B precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA477521.1, AK223155.1 and CK903484.1. This sequence is a reference standard in the RefSeqGene project. On Jun 8, 2007 this sequence version replaced gi:22547122. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223155.1, BC030155.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:9571159) ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAACAACT TGCTGTGCTG CGCGCTCGTG TTTCTGGACA TCTCCATTAA GTGGACCACC 
CAGGAAACGT TTCCTCCAAA GTACCTTCAT TATGACGAAG AAACCTCTCA TCAGCTGTTG
TGTGACAAAT GTCCTCCTGG TACCTACCTA AAACAACACT GTACAGCAAA GTGGAAGACC
GTGTGCGCCC CTTGCCCTGA CCACTACTAC ACAGACAGCT GGCACACCAG TGACGAGTGT
CTATACTGCA GCCCCGTGTG CAAGGAGCTG CAGTACGTCA AGCAGGAGTG CAATCGCACC
CACAACCGCG TGTGCGAATG CAAGGAAGGG CGCTACCTTG AGATAGAGTT CTGCTTGAAA
CATAGGAGCT GCCCTCCTGG ATTTGGAGTG GTGCAAGCTG GAACCCCAGA GCGAAATACA
GTTTGCAAAA GATGTCCAGA TGGGTTCTTC TCAAATGAGA CGTCATCTAA AGCACCCTGT
AGAAAACACA CAAATTGCAG TGTCTTTGGT CTCCTGCTAA CTCAGAAAGG AAATGCAACA
CACGACAACA TATGTTCCGG AAACAGTGAA TCAACTCAAA AATGTGGAAT AGATGTTACC
CTGTGTGAGG AGGCATTCTT CAGGTTTGCT GTTCCTACAA AGTTTACGCC TAACTGGCTT
AGTGTCTTGG TAGACAATTT GCCTGGCACC AAAGTAAACG CAGAGAGTGT AGAGAGGATA
AAACGGCAAC ACAGCTCACA AGAACAGACT TTCCAGCTGC TGAAGTTATG GAAACATCAA
AACAAAGACC AAGATATAGT CAAGAAGATC ATCCAAGATA TTGACCTCTG TGAAAACAGC
GTGCAGCGGC ACATTGGACA TGCTAACCTC ACCTTCGAGC AGCTTCGTAG CTTGATGGAA
AGCTTACCGG GAAAGAAAGT GGGAGCAGAA GACATTGAAA AAACAATAAA GGCATGCAAA
CCCAGTGACC AGATCCTGAA GCTGCTCAGT TTGTGGCGAA TAAAAAATGG CGACCAAGAC
ACCTTGAAGG GCCTAATGCA CGCACTAAAG CACTCAAAGA CGTACCACTT TCCCAAAACT
GTCACTCAGA GTCTAAAGAA GACCATCAGG TTCCTTCACA GCTTCACAAT GTACAAATTG
TATCAGAAGT TATTTTTAGA AATGATAGGT AACCAGGTCC AATCAGTAAA AATAAGCTGC
TTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002537.3
CDS324..1529
Misc Feature(1)192..194(+)
Misc Feature(2)257..257(+)
Misc Feature(3)339..779(+)
Misc Feature(4)339..509(+)
Misc Feature(5)393..509(+)
Misc Feature(6)516..638(+)
Misc Feature(7)516..638(+)
Misc Feature(8)642..758(+)
Misc Feature(9)642..749(+)
Misc Feature(10)693..>884(+)
Misc Feature(11)756..881(+)
Misc Feature(12)756..878(+)
Misc Feature(13)1290..1382(+)
Misc Feature(14)1521..1523(+)
Exon (1)1..353
Gene:TNFRSF11B
Gene Synonym:
Exon (2)354..723
Gene:TNFRSF11B
Gene Synonym:
Exon (3)724..915
Gene:TNFRSF11B
Gene Synonym:
Exon (4)916..1140
Gene:TNFRSF11B
Gene Synonym:
Exon (5)1141..2346
Gene:TNFRSF11B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002546
Organism Homo sapiens (human)
Definition Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002546

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAACAACT TGCTGTGCTG CGCGCTCGTG TTTCTGGACA TCTCCATTAA GTGGACCACC 
CAGGAAACGT TTCCTCCAAA GTACCTTCAT TATGACGAAG AAACCTCTCA TCAGCTGTTG
TGTGACAAAT GTCCTCCTGG TACCTACCTA AAACAACACT GTACAGCAAA GTGGAAGACC
GTGTGCGCCC CTTGCCCTGA CCACTACTAC ACAGACAGCT GGCACACCAG TGACGAGTGT
CTATACTGCA GCCCCGTGTG CAAGGAGCTG CAGTACGTCA AGCAGGAGTG CAATCGCACC
CACAACCGCG TGTGCGAATG CAAGGAAGGG CGCTACCTTG AGATAGAGTT CTGCTTGAAA
CATAGGAGCT GCCCTCCTGG ATTTGGAGTG GTGCAAGCTG GAACCCCAGA GCGAAATACA
GTTTGCAAAA GATGTCCAGA TGGGTTCTTC TCAAATGAGA CGTCATCTAA AGCACCCTGT
AGAAAACACA CAAATTGCAG TGTCTTTGGT CTCCTGCTAA CTCAGAAAGG AAATGCAACA
CACGACAACA TATGTTCCGG AAACAGTGAA TCAACTCAAA AATGTGGAAT AGATGTTACC
CTGTGTGAGG AGGCATTCTT CAGGTTTGCT GTTCCTACAA AGTTTACGCC TAACTGGCTT
AGTGTCTTGG TAGACAATTT GCCTGGCACC AAAGTAAACG CAGAGAGTGT AGAGAGGATA
AAACGGCAAC ACAGCTCACA AGAACAGACT TTCCAGCTGC TGAAGTTATG GAAACATCAA
AACAAAGACC AAGATATAGT CAAGAAGATC ATCCAAGATA TTGACCTCTG TGAAAACAGC
GTGCAGCGGC ACATTGGACA TGCTAACCTC ACCTTCGAGC AGCTTCGTAG CTTGATGGAA
AGCTTACCGG GAAAGAAAGT GGGAGCAGAA GACATTGAAA AAACAATAAA GGCATGCAAA
CCCAGTGACC AGATCCTGAA GCTGCTCAGT TTGTGGCGAA TAAAAAATGG CGACCAAGAC
ACCTTGAAGG GCCTAATGCA CGCACTAAAG CACTCAAAGA CGTACCACTT TCCCAAAACT
GTCACTCAGA GTCTAAAGAA GACCATCAGG TTCCTTCACA GCTTCACAAT GTACAAATTG
TATCAGAAGT TATTTTTAGA AATGATAGGT AACCAGGTCC AATCAGTAAA AATAAGCTGC
TTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women
J. Appl. Genet. 56 (1), 57-63 (2015)
Boronova I, Bernasovska J, Macekova S, Petrejcikova E, Tomkova Z, Kloc J, Poracova J, Blascakova MM and Litavcova E.


book

Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis
Oncol. Rep. 32 (6), 2605-2611 (2014)
Li X, Liu Y, Wu B, Dong Z, Wang Y, Lu J, Shi P, Bai W and Wang Z.


book

Are OPG and RANKL involved in human fracture healing?
J. Orthop. Res. 32 (12), 1557-1561 (2014)
Kottstorfer J, Thomas A, Gregori M, Kecht M, Kaiser G, Eipeldauer S and Sarahrudi K.


book

Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability
PLoS ONE 9 (9), E107642 (2014)
Davaine JM, Quillard T, Brion R, Laperine O, Guyomarch B, Merlini T, Chatelais M, Guilbaud F, Brennan MA, Charrier C, Heymann D, Goueffic Y and Heymann MF.


book

Osteoprotegerin correlates with disease activity and endothelial activation in non-diabetic ankylosing spondylitis patients undergoing TNF-alpha antagonist therapy
Clin. Exp. Rheumatol. 32 (5), 640-646 (2014)
Genre F, Lopez-Mejias R, Miranda-Filloy JA, Ubilla B, Carnero-Lopez B, Palmou-Fontana N, Gomez-Acebo I, Blanco R, Rueda-Gotor J, Pina T, Gonzalez-Juanatey C, Llorca J and Gonzalez-Gay MA.


book

Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor
Biochem. Biophys. Res. Commun. 245 (2), 382-387 (1998)
Tomoyasu A, Goto M, Fujise N, Mochizuki S, Yasuda H, Morinaga T, Tsuda E and Higashio K.


book

Characterization of structural domains of human osteoclastogenesis inhibitory factor
J. Biol. Chem. 273 (9), 5117-5123 (1998)
Yamaguchi K, Kinosaki M, Goto M, Kobayashi F, Tsuda E, Morinaga T and Higashio K.


book

Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells
Gene 204 (1-2), 35-46 (1997)
Tan KB, Harrop J, Reddy M, Young P, Terrett J, Emery J, Moore G and Truneh A.


book

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
Biochem. Biophys. Res. Commun. 234 (1), 137-142 (1997)
Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T and Higashio K.


book

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
Cell 89 (2), 309-319 (1997)
Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R and Boyle WJ.


 
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