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TNFRSF11B tumor necrosis factor receptor superfamily, member 11b [Homo sapiens (human)]

Gene Symbol TNFRSF11B
Entrez Gene ID 4982
Full Name tumor necrosis factor receptor superfamily, member 11b
Synonyms OCIF, OPG, PDB5, TR1
General protein information
Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
tumor necrosis factor receptor superfamily member 11B
osteoprotegerin
osteoclastogenesis inhibitory factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24

Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602643

Disorder Html: Paget disease, juvenile, 239000 (3)





The following TNFRSF11B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNFRSF11B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23879 NM_002546 Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu23879
Accession Version NM_002546.3
Sequence Information ORF Nucleotide Sequence (Length: 1206bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-JUL-2015
Organism Homo sapiens (human)
Product tumor necrosis factor receptor superfamily member 11B precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA477521.1, AK223155.1 and CK903484.1. This sequence is a reference standard in the RefSeqGene project. On Jun 8, 2007 this sequence version replaced gi:22547122. Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223155.1, BC030155.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:9571159) ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAACAACT TGCTGTGCTG CGCGCTCGTG TTTCTGGACA TCTCCATTAA GTGGACCACC 
CAGGAAACGT TTCCTCCAAA GTACCTTCAT TATGACGAAG AAACCTCTCA TCAGCTGTTG
TGTGACAAAT GTCCTCCTGG TACCTACCTA AAACAACACT GTACAGCAAA GTGGAAGACC
GTGTGCGCCC CTTGCCCTGA CCACTACTAC ACAGACAGCT GGCACACCAG TGACGAGTGT
CTATACTGCA GCCCCGTGTG CAAGGAGCTG CAGTACGTCA AGCAGGAGTG CAATCGCACC
CACAACCGCG TGTGCGAATG CAAGGAAGGG CGCTACCTTG AGATAGAGTT CTGCTTGAAA
CATAGGAGCT GCCCTCCTGG ATTTGGAGTG GTGCAAGCTG GAACCCCAGA GCGAAATACA
GTTTGCAAAA GATGTCCAGA TGGGTTCTTC TCAAATGAGA CGTCATCTAA AGCACCCTGT
AGAAAACACA CAAATTGCAG TGTCTTTGGT CTCCTGCTAA CTCAGAAAGG AAATGCAACA
CACGACAACA TATGTTCCGG AAACAGTGAA TCAACTCAAA AATGTGGAAT AGATGTTACC
CTGTGTGAGG AGGCATTCTT CAGGTTTGCT GTTCCTACAA AGTTTACGCC TAACTGGCTT
AGTGTCTTGG TAGACAATTT GCCTGGCACC AAAGTAAACG CAGAGAGTGT AGAGAGGATA
AAACGGCAAC ACAGCTCACA AGAACAGACT TTCCAGCTGC TGAAGTTATG GAAACATCAA
AACAAAGACC AAGATATAGT CAAGAAGATC ATCCAAGATA TTGACCTCTG TGAAAACAGC
GTGCAGCGGC ACATTGGACA TGCTAACCTC ACCTTCGAGC AGCTTCGTAG CTTGATGGAA
AGCTTACCGG GAAAGAAAGT GGGAGCAGAA GACATTGAAA AAACAATAAA GGCATGCAAA
CCCAGTGACC AGATCCTGAA GCTGCTCAGT TTGTGGCGAA TAAAAAATGG CGACCAAGAC
ACCTTGAAGG GCCTAATGCA CGCACTAAAG CACTCAAAGA CGTACCACTT TCCCAAAACT
GTCACTCAGA GTCTAAAGAA GACCATCAGG TTCCTTCACA GCTTCACAAT GTACAAATTG
TATCAGAAGT TATTTTTAGA AATGATAGGT AACCAGGTCC AATCAGTAAA AATAAGCTGC
TTATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002537.3
CDS324..1529
Misc Feature(1)192..194(+)
Misc Feature(2)257..257(+)
Misc Feature(3)339..779(+)
Misc Feature(4)339..509(+)
Misc Feature(5)393..509(+)
Misc Feature(6)516..638(+)
Misc Feature(7)516..638(+)
Misc Feature(8)642..758(+)
Misc Feature(9)642..749(+)
Misc Feature(10)693..>884(+)
Misc Feature(11)756..881(+)
Misc Feature(12)756..878(+)
Misc Feature(13)1290..1382(+)
Misc Feature(14)1521..1523(+)
Exon (1)1..353
Gene:TNFRSF11B
Gene Synonym:
Exon (2)354..723
Gene:TNFRSF11B
Gene Synonym:
Exon (3)724..915
Gene:TNFRSF11B
Gene Synonym:
Exon (4)916..1140
Gene:TNFRSF11B
Gene Synonym:
Exon (5)1141..2346
Gene:TNFRSF11B
Gene Synonym:
Translation
Position Chain Variation Link
13 13 g, t dbSNP:779000439
16 16 c, g dbSNP:113561777
23 23 g, t dbSNP:534233612
26 26 a, c dbSNP:11575930
40 40 c, t dbSNP:11575929
46 46 -, cctcacgccccacc dbSNP:768916472
61 61 c, t dbSNP:551785259
67 67 g, t dbSNP:368831724
101 101 c, t dbSNP:2073617
120 120 c, t dbSNP:570347828
123 123 c, g dbSNP:529381067
124 124 a, c dbSNP:11573807
136 136 a, g dbSNP:778570244
137 137 c, t dbSNP:535162623
157 157 a, g dbSNP:770647524
231 231 a, g dbSNP:369999091
272 272 g, t dbSNP:745750966
276 276 g, t dbSNP:527489842
277 277 c, t dbSNP:770711045
285 285 -, g dbSNP:752022160
292 292 a, c dbSNP:1050927
300 300 c, t dbSNP:746821871
301 301 c, t dbSNP:777461030
304 304 g, t dbSNP:757940562
305 305 a, g dbSNP:560436400
308 308 -, g dbSNP:764445967
314 314 a, g dbSNP:752426445
316 316 a, g dbSNP:199763003
317 317 a, g dbSNP:768721145
319 319 c, t dbSNP:754592341
330 330 -, aac dbSNP:763244881
332 332 c, g dbSNP:2073618
344 344 c, t dbSNP:373330021
346 346 c, t dbSNP:376517108
351 351 a, g dbSNP:762213334
367 367 a, c dbSNP:764312263
369 369 a, c dbSNP:758860013
370 370 c, t dbSNP:752915393
382 382 c, t dbSNP:140846266
392 392 a, g dbSNP:146450643
398 398 a, t dbSNP:776644606
401 401 a, g dbSNP:766512148
402 402 a, g dbSNP:760463291
409 409 c, t dbSNP:144062067
419 419 c, g, t dbSNP:4876870
420 420 a, c, g dbSNP:202090603
427 427 a, c dbSNP:150777320
440 440 c, g, t dbSNP:755659288
457 457 c, t dbSNP:747461694
471 471 a, c dbSNP:778414770
487 487 c, t dbSNP:758662133
488 488 a, t dbSNP:753111952
503 503 c, g, t dbSNP:755154434
504 504 a, g dbSNP:754063545
509 509 c, t dbSNP:142201380
510 510 a, g dbSNP:116321565
517 517 g, t dbSNP:786205594
518 518 c, t dbSNP:531660121
527 527 c, g dbSNP:767538379
549 549 a, g dbSNP:200071478
557 557 c, t dbSNP:144654126
558 558 a, g dbSNP:774246126
562 562 -, gtct dbSNP:770097032
564 564 c, g dbSNP:768572122
574 574 a, g dbSNP:762633243
575 575 c, t dbSNP:199830002
578 578 c, t dbSNP:769186979
579 579 a, g dbSNP:371566584
583 583 a, g dbSNP:104894091
599 599 c, t dbSNP:546710840
600 600 a, g dbSNP:369646136
602 602 a, c dbSNP:748687558
608 608 a, g dbSNP:775116631
609 609 a, g dbSNP:755350563
619 619 a, g dbSNP:529894410
626 626 a, c dbSNP:780363937
630 630 c, t dbSNP:756124545
631 631 a, g dbSNP:375274060
632 632 c, t dbSNP:372009662
633 633 a, g dbSNP:11573906
638 638 c, t dbSNP:751552719
639 639 a, g dbSNP:746791412
651 651 g, t dbSNP:762911895
653 653 a, g dbSNP:774979470
654 654 a, c, t dbSNP:201167408
655 655 a, g dbSNP:200629343
657 657 c, t dbSNP:770435026
665 665 c, g dbSNP:748597515
672 672 c, t dbSNP:104894092
685 685 a, g dbSNP:370759767
687 687 a, c dbSNP:772995755
689 689 -, g dbSNP:771971014
699 699 a, c dbSNP:149349985
700 700 a, c dbSNP:768977312
711 711 a, g dbSNP:749701904
712 712 c, t dbSNP:780302337
721 721 c, g dbSNP:756316405
730 730 c, g dbSNP:758373849
736 736 a, g dbSNP:752583333
745 745 c, t dbSNP:765026405
756 756 g, t dbSNP:794727494
766 766 a, g dbSNP:754787940
767 767 g, t dbSNP:753526066
772 772 -, tct dbSNP:776795303
782 782 c, g dbSNP:766068733
784 784 c, t dbSNP:149778739
785 785 a, g dbSNP:772668399
796 796 c, t dbSNP:767018116
800 800 c, t dbSNP:763455575
803 803 c, t dbSNP:775916414
806 806 a, g dbSNP:140021481
807 807 a, g dbSNP:746261898
809 809 a, g dbSNP:761726087
814 814 c, t dbSNP:776973170
821 821 c, t dbSNP:771233882
824 824 c, t dbSNP:747270017
843 843 a, g dbSNP:777933852
851 851 a, g dbSNP:200748751
858 858 a, g dbSNP:370819355
862 862 c, t dbSNP:748104783
865 865 a, t dbSNP:550681267
866 866 c, t dbSNP:146588847
867 867 a, g dbSNP:753578962
881 881 c, t dbSNP:11573923
882 882 a, g dbSNP:372458728
913 913 c, t dbSNP:750086178
921 921 a, g dbSNP:528308716
926 926 a, c, g dbSNP:750987558
930 930 c, g dbSNP:763694902
942 942 c, t dbSNP:759897062
944 944 c, t dbSNP:376708982
946 946 c, g dbSNP:766836970
963 963 a, g dbSNP:761190753
970 970 c, t dbSNP:773538970
971 971 a, g, t dbSNP:371614996
977 977 c, t dbSNP:546127798
985 985 c, g dbSNP:530867123
992 992 a, g dbSNP:547836403
998 998 c, t dbSNP:760714285
1007 1007 c, t dbSNP:780028766
1013 1013 c, g dbSNP:769545395
1015 1015 a, c, g dbSNP:781066936
1017 1017 a, g dbSNP:756823120
1022 1022 a, c, t dbSNP:150457771
1023 1023 a, g dbSNP:201393730
1031 1031 c, t dbSNP:754392133
1032 1032 a, g dbSNP:767035135
1036 1036 a, g dbSNP:756526392
1037 1037 a, g dbSNP:11573930
1043 1043 a, g dbSNP:767927201
1045 1045 a, g dbSNP:761883178
1047 1047 c, t dbSNP:774691067
1052 1052 a, t dbSNP:374594601
1055 1055 c, t dbSNP:763057283
1072 1072 c, t dbSNP:199810725
1089 1089 g, t dbSNP:368397401
1091 1091 a, g dbSNP:2228568
1092 1092 a, t dbSNP:776225644
1098 1098 c, t dbSNP:770777429
1106 1106 a, c, g dbSNP:61761330
1111 1111 a, c dbSNP:1131380
1113 1113 c, g dbSNP:757952532
1115 1115 a, c dbSNP:747711082
1135 1135 c, t dbSNP:558927039
1136 1136 c, t dbSNP:756620500
1154 1154 c, t dbSNP:368019227
1157 1157 a, c dbSNP:747805341
1160 1160 c, g dbSNP:778507017
1161 1161 -, a dbSNP:778940294
1162 1162 a, g dbSNP:201748894
1163 1163 c, t dbSNP:143414212
1164 1164 a, g dbSNP:140782326
1171 1171 a, g dbSNP:781740245
1176 1176 a, g dbSNP:373848556
1177 1177 g, t dbSNP:751899813
1181 1181 a, t dbSNP:778143928
1186 1186 a, c dbSNP:758553245
1199 1199 c, g dbSNP:752933989
1200 1200 c, g dbSNP:765292859
1201 1201 a, g dbSNP:759728343
1208 1208 a, t dbSNP:11573942
1209 1209 c, t dbSNP:145316984
1226 1226 c, t dbSNP:760554913
1231 1231 c, t dbSNP:370157044
1232 1232 a, g dbSNP:772004669
1258 1258 c, t dbSNP:376914808
1263 1263 a, c dbSNP:774213257
1269 1269 a, g dbSNP:768245778
1275 1275 g, t dbSNP:748875103
1280 1280 c, t dbSNP:140297643
1286 1286 c, g dbSNP:771427366
1306 1306 c, t dbSNP:200218935
1314 1314 a, t dbSNP:747478054
1316 1316 g, t dbSNP:1804853
1321 1321 a, g dbSNP:145544246
1323 1323 a, g dbSNP:200140054
1325 1325 a, g dbSNP:758824253
1335 1335 a, g dbSNP:556636514
1345 1345 c, t dbSNP:779145957
1349 1349 c, g dbSNP:754991346
1361 1361 g, t dbSNP:758025708
1364 1364 c, t dbSNP:766402871
1365 1365 a, g dbSNP:760601102
1370 1370 a, c, g dbSNP:767415247
1372 1372 a, g dbSNP:761740481
1375 1375 a, g dbSNP:774121001
1378 1378 c, g dbSNP:768301534
1384 1384 c, t dbSNP:762541362
1385 1385 a, g dbSNP:774995576
1399 1399 a, c dbSNP:769203476
1407 1407 a, g dbSNP:201475481
1413 1413 a, g dbSNP:201965016
1414 1414 a, g dbSNP:747505927
1420 1420 a, g dbSNP:773779681
1425 1425 a, c, t dbSNP:149720389
1427 1427 c, g dbSNP:779272711
1428 1428 a, c dbSNP:574213881
1432 1432 a, g dbSNP:749484101
1434 1434 g, t dbSNP:34353469
1448 1448 c, t dbSNP:756214536
1451 1451 a, t dbSNP:750354488
1457 1457 c, t dbSNP:767607488
1461 1461 c, t dbSNP:373470752
1463 1463 c, g dbSNP:751356592
1468 1468 a, g dbSNP:763798418
1471 1471 a, c dbSNP:555814834
1473 1473 c, g, t dbSNP:1804854
1476 1476 c, t dbSNP:764803075
1496 1496 c, g dbSNP:759091942
1505 1505 a, g dbSNP:151008182
1515 1515 a, c dbSNP:772520936
1516 1516 c, t dbSNP:748687430
1527 1527 c, t dbSNP:774713244
1530 1530 c, t dbSNP:768958012
1540 1540 c, t dbSNP:749520478
1551 1551 c, t dbSNP:11573943
1559 1559 a, c dbSNP:756195933
1562 1562 c, t dbSNP:745889592
1565 1565 a, g dbSNP:781448583
1566 1566 c, t dbSNP:757191991
1569 1569 a, g dbSNP:200332093
1589 1589 c, t dbSNP:553787539
1596 1596 c, t dbSNP:11573944
1618 1618 a, g dbSNP:767866427
1640 1640 a, c dbSNP:571198078
1655 1655 a, g dbSNP:538794143
1684 1684 a, g dbSNP:549411571
1726 1726 a, g dbSNP:376569300
1733 1733 g, t dbSNP:531183941
1742 1742 c, t dbSNP:569762226
1746 1746 a, g dbSNP:567053743
1786 1786 a, t dbSNP:186535296
1798 1798 g, t dbSNP:183331643
1811 1811 -, a dbSNP:112977670
1822 1822 c, t dbSNP:3134039
1825 1825 g, t dbSNP:3094021
1848 1848 c, g dbSNP:560688163
1866 1866 a, g dbSNP:3134038
1871 1871 c, t dbSNP:3134037
1896 1896 a, g dbSNP:7815884
1897 1897 a, t dbSNP:533717887
1901 1901 a, c dbSNP:11573945
1942 1942 a, c dbSNP:186788358
1974 1974 a, c dbSNP:544652637
1986 1986 g, t dbSNP:3094022
1992 1992 a, t dbSNP:574050965
2053 2053 a, t dbSNP:372828890
2056 2056 a, g dbSNP:11573946
2074 2074 c, t dbSNP:11573947
2076 2076 c, t dbSNP:540677019
2077 2077 a, g dbSNP:572158364
2112 2112 a, t dbSNP:7815440
2138 2138 a, g dbSNP:529941362
2191 2191 a, g dbSNP:538441212
2211 2211 c, t dbSNP:189721016
2217 2217 c, t dbSNP:143388345
2227 2227 -, at dbSNP:551354363
2235 2235 c, t dbSNP:537462720
2241 2241 a, g dbSNP:11573948
2288 2288 c, g dbSNP:548806357
2306 2306 c, t dbSNP:547796238
2318 2318 c, t dbSNP:533843332
2342 2342 c, t dbSNP:566442059

Target ORF information:

RefSeq Version NM_002546
Organism Homo sapiens (human)
Definition Homo sapiens tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002546

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGAACAACT TGCTGTGCTG CGCGCTCGTG TTTCTGGACA TCTCCATTAA GTGGACCACC 
CAGGAAACGT TTCCTCCAAA GTACCTTCAT TATGACGAAG AAACCTCTCA TCAGCTGTTG
TGTGACAAAT GTCCTCCTGG TACCTACCTA AAACAACACT GTACAGCAAA GTGGAAGACC
GTGTGCGCCC CTTGCCCTGA CCACTACTAC ACAGACAGCT GGCACACCAG TGACGAGTGT
CTATACTGCA GCCCCGTGTG CAAGGAGCTG CAGTACGTCA AGCAGGAGTG CAATCGCACC
CACAACCGCG TGTGCGAATG CAAGGAAGGG CGCTACCTTG AGATAGAGTT CTGCTTGAAA
CATAGGAGCT GCCCTCCTGG ATTTGGAGTG GTGCAAGCTG GAACCCCAGA GCGAAATACA
GTTTGCAAAA GATGTCCAGA TGGGTTCTTC TCAAATGAGA CGTCATCTAA AGCACCCTGT
AGAAAACACA CAAATTGCAG TGTCTTTGGT CTCCTGCTAA CTCAGAAAGG AAATGCAACA
CACGACAACA TATGTTCCGG AAACAGTGAA TCAACTCAAA AATGTGGAAT AGATGTTACC
CTGTGTGAGG AGGCATTCTT CAGGTTTGCT GTTCCTACAA AGTTTACGCC TAACTGGCTT
AGTGTCTTGG TAGACAATTT GCCTGGCACC AAAGTAAACG CAGAGAGTGT AGAGAGGATA
AAACGGCAAC ACAGCTCACA AGAACAGACT TTCCAGCTGC TGAAGTTATG GAAACATCAA
AACAAAGACC AAGATATAGT CAAGAAGATC ATCCAAGATA TTGACCTCTG TGAAAACAGC
GTGCAGCGGC ACATTGGACA TGCTAACCTC ACCTTCGAGC AGCTTCGTAG CTTGATGGAA
AGCTTACCGG GAAAGAAAGT GGGAGCAGAA GACATTGAAA AAACAATAAA GGCATGCAAA
CCCAGTGACC AGATCCTGAA GCTGCTCAGT TTGTGGCGAA TAAAAAATGG CGACCAAGAC
ACCTTGAAGG GCCTAATGCA CGCACTAAAG CACTCAAAGA CGTACCACTT TCCCAAAACT
GTCACTCAGA GTCTAAAGAA GACCATCAGG TTCCTTCACA GCTTCACAAT GTACAAATTG
TATCAGAAGT TATTTTTAGA AATGATAGGT AACCAGGTCC AATCAGTAAA AATAAGCTGC
TTATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.