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OTX2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol OTX2
Entrez Gene ID 5015
Full Name orthodenticle homeobox 2
Synonyms CPHD6, MCOPS5
General protein information
Preferred Names
homeobox protein OTX2
Names
homeobox protein OTX2
orthodenticle homolog 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q22.3

Summary This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]. lac of sum
Disorder MIM:

600037

Disorder Html: Microphthalmia, syndromic 5, 610125 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_021728 NP_068374 homeobox protein OTX2 isoform a
NM_172337 NP_758840 homeobox protein OTX2 isoform b
NM_001270523 NP_001257452 homeobox protein OTX2 isoform b
NM_001270524 NP_001257453 homeobox protein OTX2 isoform b
NM_001270525 NP_001257454 homeobox protein OTX2 isoform a



Homo sapiens (human) OTX2 NP_068374.1
Pan troglodytes (chimpanzee) OTX2 XP_001163043.2
Canis lupus familiaris (dog) OTX2 XP_003435187.1
Bos taurus (cattle) OTX2 NP_001180130.1
Mus musculus (house mouse) Otx2 NP_001273410.1
Rattus norvegicus (Norway rat) LOC100911492 XP_006251897.1
Danio rerio (zebrafish) otx2 NP_571326.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OTX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu16734
NM_021728 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
OHu16931 NM_172337 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu16931 NM_001270523 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu16931 NM_001270524 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu16734
NM_001270525 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99.50-$139.30
$199.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16734
Clone ID Related Accession (Same CDS sequence) NM_001270525 , NM_021728
Accession Version NM_021728.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 894bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein OTX2 isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593058.1 and BC032579.1. On Jul 14, 2012 this sequence version replaced gi:27436931. Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 5 encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032579.1, BE779002.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2148093, SAMEA2151119 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGGGC CCTGGGCTTC TTGTCCCGCA
GCCACCCCCC GGAAACAGCG CCGGGAGAGG ACGACGTTCA CTCGGGCGCA GCTAGATGTG
CTGGAAGCAC TGTTTGCCAA GACCCGGTAC CCAGACATCT TCATGCGAGA GGAGGTGGCA
CTGAAAATCA ACTTGCCCGA GTCGAGGGTG CAGGTATGGT TTAAGAATCG AAGAGCTAAG
TGCCGCCAAC AACAGCAACA ACAGCAGAAT GGAGGTCAAA ACAAAGTGAG ACCTGCCAAA
AAGAAGACAT CTCCAGCTCG GGAAGTGAGT TCAGAGAGTG GAACAAGTGG CCAATTCACT
CCCCCCTCTA GCACCTCAGT CCCGACCATT GCCAGCAGCA GTGCTCCTGT GTCTATCTGG
AGCCCAGCTT CCATCTCCCC ACTGTCAGAT CCCTTGTCCA CCTCCTCTTC CTGCATGCAG
AGGTCCTATC CCATGACCTA TACTCAGGCT TCAGGTTATA GTCAAGGATA TGCTGGCTCA
ACTTCCTACT TTGGGGGCAT GGACTGTGGA TCATATTTGA CCCCTATGCA TCACCAGCTT
CCCGGACCAG GGGCCACACT CAGTCCCATG GGTACCAATG CAGTCACCAG CCATCTCAAT
CAGTCCCCAG CTTCTCTTTC CACCCAGGGA TATGGAGCTT CAAGCTTGGG TTTTAACTCA
ACCACTGATT GCTTGGATTA TAAGGACCAA ACTGCCTCCT GGAAGCTTAA CTTCAATGCT
GACTGCTTGG ATTATAAAGA TCAGACATCC TCGTGGAAAT TCCAGGTTTT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068374.1
CDS285..1178
Misc Feature(1)162..164(+)
Misc Feature(2)423..590(+)
Misc Feature(3)423..590(+)
Misc Feature(4)429..581(+)
Misc Feature(5)765..1013(+)
Exon (1)1..101
Gene:OTX2
Gene Synonym:
Exon (2)102..165
Gene:OTX2
Gene Synonym:
Exon (3)166..381
Gene:OTX2
Gene Synonym:
Exon (4)382..557
Gene:OTX2
Gene Synonym:
Exon (5)558..2206
Gene:OTX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_021728
Organism Homo sapiens (human)
Definition Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021728

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGGGC CCTGGGCTTC TTGTCCCGCA
GCCACCCCCC GGAAACAGCG CCGGGAGAGG ACGACGTTCA CTCGGGCGCA GCTAGATGTG
CTGGAAGCAC TGTTTGCCAA GACCCGGTAC CCAGACATCT TCATGCGAGA GGAGGTGGCA
CTGAAAATCA ACTTGCCCGA GTCGAGGGTG CAGGTATGGT TTAAGAATCG AAGAGCTAAG
TGCCGCCAAC AACAGCAACA ACAGCAGAAT GGAGGTCAAA ACAAAGTGAG ACCTGCCAAA
AAGAAGACAT CTCCAGCTCG GGAAGTGAGT TCAGAGAGTG GAACAAGTGG CCAATTCACT
CCCCCCTCTA GCACCTCAGT CCCGACCATT GCCAGCAGCA GTGCTCCTGT GTCTATCTGG
AGCCCAGCTT CCATCTCCCC ACTGTCAGAT CCCTTGTCCA CCTCCTCTTC CTGCATGCAG
AGGTCCTATC CCATGACCTA TACTCAGGCT TCAGGTTATA GTCAAGGATA TGCTGGCTCA
ACTTCCTACT TTGGGGGCAT GGACTGTGGA TCATATTTGA CCCCTATGCA TCACCAGCTT
CCCGGACCAG GGGCCACACT CAGTCCCATG GGTACCAATG CAGTCACCAG CCATCTCAAT
CAGTCCCCAG CTTCTCTTTC CACCCAGGGA TATGGAGCTT CAAGCTTGGG TTTTAACTCA
ACCACTGATT GCTTGGATTA TAAGGACCAA ACTGCCTCCT GGAAGCTTAA CTTCAATGCT
GACTGCTTGG ATTATAAAGA TCAGACATCC TCGTGGAAAT TCCAGGTTTT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16931
Clone ID Related Accession (Same CDS sequence) NM_001270523 , NM_001270524 , NM_172337
Accession Version NM_172337.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 870bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein OTX2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593056.1, AB593057.1 and BC032579.1. On Jul 14, 2012 this sequence version replaced gi:27436932. Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1, and, compared to isoform a, encodes a shorter isoform (b). Variants 2-4 encode the same protein (isoform b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CX753473.1, AB593057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA962344 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_758840.1
CDS208..1077
Misc Feature(1)49..51(+)
Misc Feature(2)322..489(+)
Misc Feature(3)322..489(+)
Misc Feature(4)328..480(+)
Misc Feature(5)664..912(+)
Exon (1)1..304
Gene:OTX2
Gene Synonym:
Exon (2)305..456
Gene:OTX2
Gene Synonym:
Exon (3)457..2105
Gene:OTX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_172337
Organism Homo sapiens (human)
Definition Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_172337

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16931
Clone ID Related Accession (Same CDS sequence) NM_001270523 , NM_001270524 , NM_172337
Accession Version NM_001270523.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 870bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein OTX2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593058.1, CV812961.1 and BC032579.1. Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1, and, compared to isoform a, encodes a shorter isoform (b). Variants 2-4 encode the same protein (isoform b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CV812961.1, BY795606.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962344 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001257452.1
CDS285..1154
Misc Feature(1)162..164(+)
Misc Feature(2)399..566(+)
Misc Feature(3)399..566(+)
Misc Feature(4)405..557(+)
Misc Feature(5)741..989(+)
Exon (1)1..101
Gene:OTX2
Gene Synonym:
Exon (2)102..165
Gene:OTX2
Gene Synonym:
Exon (3)166..381
Gene:OTX2
Gene Synonym:
Exon (4)382..533
Gene:OTX2
Gene Synonym:
Exon (5)534..2182
Gene:OTX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001270523
Organism Homo sapiens (human)
Definition Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001270523

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16931
Clone ID Related Accession (Same CDS sequence) NM_001270523 , NM_001270524 , NM_172337
Accession Version NM_001270524.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 870bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein OTX2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593058.1, AK314271.1 and BC032579.1. Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1, and, compared to isoform a, encodes a shorter isoform (b). Variants 2-4 encode the same protein (isoform b). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK314271.1, BM564760.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962344 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001257453.1
CDS438..1307
Misc Feature(1)315..317(+)
Misc Feature(2)552..719(+)
Misc Feature(3)552..719(+)
Misc Feature(4)558..710(+)
Misc Feature(5)894..1142(+)
Exon (1)1..318
Gene:OTX2
Gene Synonym:
Exon (2)319..534
Gene:OTX2
Gene Synonym:
Exon (3)535..686
Gene:OTX2
Gene Synonym:
Exon (4)687..2335
Gene:OTX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001270524
Organism Homo sapiens (human)
Definition Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001270524

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGCCA CCCCCCGGAA ACAGCGCCGG
GAGAGGACGA CGTTCACTCG GGCGCAGCTA GATGTGCTGG AAGCACTGTT TGCCAAGACC
CGGTACCCAG ACATCTTCAT GCGAGAGGAG GTGGCACTGA AAATCAACTT GCCCGAGTCG
AGGGTGCAGG TATGGTTTAA GAATCGAAGA GCTAAGTGCC GCCAACAACA GCAACAACAG
CAGAATGGAG GTCAAAACAA AGTGAGACCT GCCAAAAAGA AGACATCTCC AGCTCGGGAA
GTGAGTTCAG AGAGTGGAAC AAGTGGCCAA TTCACTCCCC CCTCTAGCAC CTCAGTCCCG
ACCATTGCCA GCAGCAGTGC TCCTGTGTCT ATCTGGAGCC CAGCTTCCAT CTCCCCACTG
TCAGATCCCT TGTCCACCTC CTCTTCCTGC ATGCAGAGGT CCTATCCCAT GACCTATACT
CAGGCTTCAG GTTATAGTCA AGGATATGCT GGCTCAACTT CCTACTTTGG GGGCATGGAC
TGTGGATCAT ATTTGACCCC TATGCATCAC CAGCTTCCCG GACCAGGGGC CACACTCAGT
CCCATGGGTA CCAATGCAGT CACCAGCCAT CTCAATCAGT CCCCAGCTTC TCTTTCCACC
CAGGGATATG GAGCTTCAAG CTTGGGTTTT AACTCAACCA CTGATTGCTT GGATTATAAG
GACCAAACTG CCTCCTGGAA GCTTAACTTC AATGCTGACT GCTTGGATTA TAAAGATCAG
ACATCCTCGT GGAAATTCCA GGTTTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16734
Clone ID Related Accession (Same CDS sequence) NM_001270525 , NM_021728
Accession Version NM_001270525.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 894bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein OTX2 isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593056.1, BU176852.1 and BC032579.1. Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes the longer isoform (a). Variants 1 and 5 encode the same protein (isoform a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU176441.1, BU176852.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2148093, SAMEA2151119 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGGGC CCTGGGCTTC TTGTCCCGCA
GCCACCCCCC GGAAACAGCG CCGGGAGAGG ACGACGTTCA CTCGGGCGCA GCTAGATGTG
CTGGAAGCAC TGTTTGCCAA GACCCGGTAC CCAGACATCT TCATGCGAGA GGAGGTGGCA
CTGAAAATCA ACTTGCCCGA GTCGAGGGTG CAGGTATGGT TTAAGAATCG AAGAGCTAAG
TGCCGCCAAC AACAGCAACA ACAGCAGAAT GGAGGTCAAA ACAAAGTGAG ACCTGCCAAA
AAGAAGACAT CTCCAGCTCG GGAAGTGAGT TCAGAGAGTG GAACAAGTGG CCAATTCACT
CCCCCCTCTA GCACCTCAGT CCCGACCATT GCCAGCAGCA GTGCTCCTGT GTCTATCTGG
AGCCCAGCTT CCATCTCCCC ACTGTCAGAT CCCTTGTCCA CCTCCTCTTC CTGCATGCAG
AGGTCCTATC CCATGACCTA TACTCAGGCT TCAGGTTATA GTCAAGGATA TGCTGGCTCA
ACTTCCTACT TTGGGGGCAT GGACTGTGGA TCATATTTGA CCCCTATGCA TCACCAGCTT
CCCGGACCAG GGGCCACACT CAGTCCCATG GGTACCAATG CAGTCACCAG CCATCTCAAT
CAGTCCCCAG CTTCTCTTTC CACCCAGGGA TATGGAGCTT CAAGCTTGGG TTTTAACTCA
ACCACTGATT GCTTGGATTA TAAGGACCAA ACTGCCTCCT GGAAGCTTAA CTTCAATGCT
GACTGCTTGG ATTATAAAGA TCAGACATCC TCGTGGAAAT TCCAGGTTTT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001257454.1
CDS208..1101
Misc Feature(1)49..51(+)
Misc Feature(2)346..513(+)
Misc Feature(3)346..513(+)
Misc Feature(4)352..504(+)
Misc Feature(5)688..936(+)
Exon (1)1..304
Gene:OTX2
Gene Synonym:
Exon (2)305..480
Gene:OTX2
Gene Synonym:
Exon (3)481..2129
Gene:OTX2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001270525
Organism Homo sapiens (human)
Definition Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001270525

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGTCTT ATCTTAAGCA ACCGCCTTAC GCAGTCAATG GGCTGAGTCT GACCACTTCG 
GGTATGGACT TGCTGCACCC CTCCGTGGGC TACCCGGGGC CCTGGGCTTC TTGTCCCGCA
GCCACCCCCC GGAAACAGCG CCGGGAGAGG ACGACGTTCA CTCGGGCGCA GCTAGATGTG
CTGGAAGCAC TGTTTGCCAA GACCCGGTAC CCAGACATCT TCATGCGAGA GGAGGTGGCA
CTGAAAATCA ACTTGCCCGA GTCGAGGGTG CAGGTATGGT TTAAGAATCG AAGAGCTAAG
TGCCGCCAAC AACAGCAACA ACAGCAGAAT GGAGGTCAAA ACAAAGTGAG ACCTGCCAAA
AAGAAGACAT CTCCAGCTCG GGAAGTGAGT TCAGAGAGTG GAACAAGTGG CCAATTCACT
CCCCCCTCTA GCACCTCAGT CCCGACCATT GCCAGCAGCA GTGCTCCTGT GTCTATCTGG
AGCCCAGCTT CCATCTCCCC ACTGTCAGAT CCCTTGTCCA CCTCCTCTTC CTGCATGCAG
AGGTCCTATC CCATGACCTA TACTCAGGCT TCAGGTTATA GTCAAGGATA TGCTGGCTCA
ACTTCCTACT TTGGGGGCAT GGACTGTGGA TCATATTTGA CCCCTATGCA TCACCAGCTT
CCCGGACCAG GGGCCACACT CAGTCCCATG GGTACCAATG CAGTCACCAG CCATCTCAAT
CAGTCCCCAG CTTCTCTTTC CACCCAGGGA TATGGAGCTT CAAGCTTGGG TTTTAACTCA
ACCACTGATT GCTTGGATTA TAAGGACCAA ACTGCCTCCT GGAAGCTTAA CTTCAATGCT
GACTGCTTGG ATTATAAAGA TCAGACATCC TCGTGGAAAT TCCAGGTTTT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Autosomal dominant oculoauriculovertebral spectrum and 14q23.1 microduplication
Am. J. Med. Genet. A 161A (8), 2030-2035 (2013)
Ballesta-Martinez MJ, Lopez-Gonzalez V, Dulcet LA, Rodriguez-Santiago B, Garcia-Minaur S and Guillen-Navarro E.


book

Specific expression pattern of a novel Otx2 splicing variant during neural differentiation
Gene 523 (1), 33-38 (2013)
Liu Z, Chi L, Fang Y, Liu L and Zhang X.


book

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels
Acta Neuropathol. 125 (3), 385-394 (2013)
Bunt J, Hasselt NA, Zwijnenburg DA, Koster J, Versteeg R and Kool M.


book

OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells
Cancer Res. 72 (22), 5988-6001 (2012)
Bai RY, Staedtke V, Lidov HG, Eberhart CG and Riggins GJ.


book

Brain development is a multi-level regulated process--the case of the OTX2 gene
Pediatr Endocrinol Rev 9 (1), 422-430 (2011)
Gat-Yablonski G.


book

Elements regulating the transcription of human interstitial retinoid-binding protein (IRBP) gene in cultured retinoblastoma cells
Curr. Eye Res. 18 (4), 283-291 (1999)
Fong SL and Fong WB.


book

OTX2 homeodomain protein binds a DNA element necessary for interphotoreceptor retinoid binding protein gene expression
Mech. Dev. 82 (1-2), 165-169 (1999)
Bobola N, Briata P, Ilengo C, Rosatto N, Craft C, Corte G and Ravazzolo R.


book

Developmental rescue of Drosophila cephalic defects by the human Otx genes
Proc. Natl. Acad. Sci. U.S.A. 95 (7), 3737-3742 (1998)
Nagao T, Leuzinger S, Acampora D, Simeone A, Finkelstein R, Reichert H and Furukubo-Tokunaga K.


book

Chromosome locations of human EMX and OTX genes
Genomics 22 (1), 41-45 (1994)
Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A and Boncinelli E.


book

Anophthalmia/Microphthalmia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bardakjian,T., Weiss,A. and Schneider,A.S.


 
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