||ORF Nucleotide Sequence (Length: 1209bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||plasminogen activator inhibitor 1 precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CN309001.1, BC010860.1,
M16006.1 and AI752990.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 5, 2012 this sequence version replaced gi:259155304.
Summary: This gene encodes a member of the serine proteinase
inhibitor (serpin) superfamily. This member is the principal
inhibitor of tissue plasminogen activator (tPA) and urokinase
(uPA), and hence is an inhibitor of fibrinolysis. Defects in this
gene are the cause of plasminogen activator inhibitor-1 deficiency
(PAI-1 deficiency), and high concentrations of the gene product are
associated with thrombophilia. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Sep 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: M16006.1, BC010860.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.