×

GP6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GP6
Entrez Gene ID 51206
Full Name glycoprotein VI (platelet)
Synonyms BDPLT11, GPIV, GPVI
General protein information
Preferred Names
platelet glycoprotein VI
Names
platelet glycoprotein VI
glycoprotein 6
platelet collagen receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.4

Summary This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. lac of sum
Disorder MIM:

605546


mRNA and Protein(s)

mRNA Protein Name
NM_001083899 NP_001077368 platelet glycoprotein VI isoform 1 precursor
NM_001256017 NP_001242946 platelet glycoprotein VI isoform 3 precursor
NM_016363 NP_057447 platelet glycoprotein VI isoform 2 precursor



Homo sapiens (human) GP6 NP_001242946.2
Pan troglodytes (chimpanzee) GP6 XP_513024.3
Canis lupus familiaris (dog) GP6 XP_005616212.1
Mus musculus (house mouse) Gp6 NP_001156486.1
Rattus norvegicus (Norway rat) Gp6 XP_003748805.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20368 NM_001083899 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $363.30
$519.00
OHu20989 NM_001256017 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu21878 NM_016363 Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20368
Clone ID Related Accession (Same CDS sequence) NM_001083899
Accession Version NM_001083899.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1863bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet glycoprotein VI isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043821.1 and AC011476.8. On Dec 6, 2013 this sequence version replaced gi:143770740. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043821.1, BC069485.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTGAG
TCCTGCCCGC CAGTACTACA CCAAGGGCAA CCTGGTCCGG ATATGCCTCG GGGCTGTGAT
CCTAATAATC CTGGCGGGGT TTCTGGCAGA GGACTGGCAC AGCCGGAGGA AGCGCCTGCG
GCACAGGGGC AGGGCTGTGC AGAGGCCGCT TCCGCCCCTC CCGCCCCTCC CGCTGACCCG
GAAATCAAAC GGGGGTCAGG ATGGAGGCCG ACAGGATGTT CACAGCCGCG GGTTATGTTC
ATGACCGCTG AACCCCAGGC ACGGTCGTAT CCAAGGGAGG GATCATGGCA TGGGAGGCGA
CTCAAAGACT GGCGTGTGTG GAGCGTGGAA GCAGGAGGGC AGAGGCTACA GCTGTGGAAA
CGAGGCCATG CTGCCTCCTC CTGGTGTTCC ATCAGGGAGC CGTTCGGCCA GTGTCTGTCT
GTCTGTCTGC CTCTCTGTCT GAGGGCACCC TCCATTTGGG ATGGAAGGAA TCTGTGGAGA
CCCCATCCTC CTCCCTGCAC ACTGTGGATG ACATGGTACC CTGGCTGGAC CACATACTGG
CCTCTTTCTT CAACCTCTCT AATATGGGCT CCAGACGGAT CTCTAAGGTT CCCAGCTCTC
AGGGTTGACT CTGTTCCATC CTCTGTGCAA AATCCTCCCG TGCTTCCCTT TGGCCCTCTG
TGCTCTTGTC TGGTTTTCCC CAGAAACTCT CACCCTCACT CCATCTCCCA CTGCGGTCTA
ACAAATCTCC TTTCGTCTCT CAGAACGGGT CTTGCAGGCA GTTTGGGTAT GTCATTCATT
TTCCTTAGTG TAAAACTAGC ACGTTGCCCG CTTCCCTTCA CATTAGAAAA CAAGATCAGC
CTGTGCAACA TGGTGAAACC TCATCTCTAC CAACAAAACA AAAAAACACA AAAATTAGCC
AGGTGTGGTG GTGCATCCCT ATACTCCCAG CAACTCAGGG GGCTGAGGTG GGAGAATGGC
TTGAGCCTGG GAGGCAGAGG TTGCAGTGAG CTGAGATCAC ACCACTGCAC TCTAGCTCGG
GTGACGAAGC CTGACTTTGT CTCAAAAAAT ACAGGGATGA ATATGTCAAT TACCCTGATT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001077368.2
CDS29..1891
Misc Feature(1)20..22(+)
Misc Feature(2)104..352(+)
Misc Feature(3)206..316(+)
Misc Feature(4)365..634(+)
Exon (1)1..62
Gene:GP6
Gene Synonym:
Exon (2)63..95
Gene:GP6
Gene Synonym:
Exon (3)96..353
Gene:GP6
Gene Synonym:
Exon (4)354..638
Gene:GP6
Gene Synonym:
Exon (5)639..692
Gene:GP6
Gene Synonym:
Exon (6)693..752
Gene:GP6
Gene Synonym:
Exon (7)753..807
Gene:GP6
Gene Synonym:
Exon (8)808..2268
Gene:GP6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001083899
Organism Homo sapiens (human)
Definition Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001083899

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTGAG
TCCTGCCCGC CAGTACTACA CCAAGGGCAA CCTGGTCCGG ATATGCCTCG GGGCTGTGAT
CCTAATAATC CTGGCGGGGT TTCTGGCAGA GGACTGGCAC AGCCGGAGGA AGCGCCTGCG
GCACAGGGGC AGGGCTGTGC AGAGGCCGCT TCCGCCCCTC CCGCCCCTCC CGCTGACCCG
GAAATCAAAC GGGGGTCAGG ATGGAGGCCG ACAGGATGTT CACAGCCGCG GGTTATGTTC
ATGACCGCTG AACCCCAGGC ACGGTCGTAT CCAAGGGAGG GATCATGGCA TGGGAGGCGA
CTCAAAGACT GGCGTGTGTG GAGCGTGGAA GCAGGAGGGC AGAGGCTACA GCTGTGGAAA
CGAGGCCATG CTGCCTCCTC CTGGTGTTCC ATCAGGGAGC CGTTCGGCCA GTGTCTGTCT
GTCTGTCTGC CTCTCTGTCT GAGGGCACCC TCCATTTGGG ATGGAAGGAA TCTGTGGAGA
CCCCATCCTC CTCCCTGCAC ACTGTGGATG ACATGGTACC CTGGCTGGAC CACATACTGG
CCTCTTTCTT CAACCTCTCT AATATGGGCT CCAGACGGAT CTCTAAGGTT CCCAGCTCTC
AGGGTTGACT CTGTTCCATC CTCTGTGCAA AATCCTCCCG TGCTTCCCTT TGGCCCTCTG
TGCTCTTGTC TGGTTTTCCC CAGAAACTCT CACCCTCACT CCATCTCCCA CTGCGGTCTA
ACAAATCTCC TTTCGTCTCT CAGAACGGGT CTTGCAGGCA GTTTGGGTAT GTCATTCATT
TTCCTTAGTG TAAAACTAGC ACGTTGCCCG CTTCCCTTCA CATTAGAAAA CAAGATCAGC
CTGTGCAACA TGGTGAAACC TCATCTCTAC CAACAAAACA AAAAAACACA AAAATTAGCC
AGGTGTGGTG GTGCATCCCT ATACTCCCAG CAACTCAGGG GGCTGAGGTG GGAGAATGGC
TTGAGCCTGG GAGGCAGAGG TTGCAGTGAG CTGAGATCAC ACCACTGCAC TCTAGCTCGG
GTGACGAAGC CTGACTTTGT CTCAAAAAAT ACAGGGATGA ATATGTCAAT TACCCTGATT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20989
Clone ID Related Accession (Same CDS sequence) NM_001256017
Accession Version NM_001256017.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 966bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet glycoprotein VI isoform 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043820.1 and AC011476.8. On Dec 6, 2013 this sequence version replaced gi:365192547. Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043820.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG AATTCTCAGA AGCCACCGCT GAACTGACCG TCTCATTCAC AAACGAAGTC
TTCACAACTG AGACTTCTAG GAGTATCACC GCCAGTCCAA AGGAGTCAGA CTCTCCAGCT
GGTCCTGCCC GCCAGTACTA CACCAAGGGC AACCTGGTCC GGATATGCCT CGGGGCTGTG
ATCCTAATAA TCCTGGCGGG GTTTCTGGCA GAGGACTGGC ACAGCCGGAG GAAGCGCCTG
CGGCACAGGG GCAGGGCTGT GCAGAGGCCG CTTCCGCCCC TCCCGCCCCT CCCGCTGACC
CGGAAATCAA ACGGGGGTCA GGATGGAGGC CGACAGGATG TTCACAGCCG CGGGTTATGT
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001242946.2
CDS29..994
Misc Feature(1)20..22(+)
Misc Feature(2)104..352(+)
Misc Feature(3)206..316(+)
Misc Feature(4)365..634(+)
Exon (1)1..62
Gene:GP6
Gene Synonym:
Exon (2)63..95
Gene:GP6
Gene Synonym:
Exon (3)96..353
Gene:GP6
Gene Synonym:
Exon (4)354..638
Gene:GP6
Gene Synonym:
Exon (5)639..698
Gene:GP6
Gene Synonym:
Exon (6)699..749
Gene:GP6
Gene Synonym:
Exon (7)750..2210
Gene:GP6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001256017
Organism Homo sapiens (human)
Definition Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001256017

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG AATTCTCAGA AGCCACCGCT GAACTGACCG TCTCATTCAC AAACGAAGTC
TTCACAACTG AGACTTCTAG GAGTATCACC GCCAGTCCAA AGGAGTCAGA CTCTCCAGCT
GGTCCTGCCC GCCAGTACTA CACCAAGGGC AACCTGGTCC GGATATGCCT CGGGGCTGTG
ATCCTAATAA TCCTGGCGGG GTTTCTGGCA GAGGACTGGC ACAGCCGGAG GAAGCGCCTG
CGGCACAGGG GCAGGGCTGT GCAGAGGCCG CTTCCGCCCC TCCCGCCCCT CCCGCTGACC
CGGAAATCAA ACGGGGGTCA GGATGGAGGC CGACAGGATG TTCACAGCCG CGGGTTATGT
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21878
Clone ID Related Accession (Same CDS sequence) NM_016363
Accession Version NM_016363.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1020bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet glycoprotein VI isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB043819.1 and AC011476.8. On Dec 6, 2013 this sequence version replaced gi:143770754. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB043819.1, BC104832.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTCCT
GCCCGCCAGT ACTACACCAA GGGCAACCTG GTCCGGATAT GCCTCGGGGC TGTGATCCTA
ATAATCCTGG CGGGGTTTCT GGCAGAGGAC TGGCACAGCC GGAGGAAGCG CCTGCGGCAC
AGGGGCAGGG CTGTGCAGAG GCCGCTTCCG CCCCTCCCGC CCCTCCCGCT GACCCGGAAA
TCAAACGGGG GTCAGGATGG AGGCCGACAG GATGTTCACA GCCGCGGGTT ATGTTCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057447.5
CDS29..1048
Misc Feature(1)20..22(+)
Misc Feature(2)104..352(+)
Misc Feature(3)206..316(+)
Misc Feature(4)365..634(+)
Misc Feature(5)830..892(+)
Exon (1)1..62
Gene:GP6
Gene Synonym:
Exon (2)63..95
Gene:GP6
Gene Synonym:
Exon (3)96..353
Gene:GP6
Gene Synonym:
Exon (4)354..638
Gene:GP6
Gene Synonym:
Exon (5)639..692
Gene:GP6
Gene Synonym:
Exon (6)693..752
Gene:GP6
Gene Synonym:
Exon (7)753..803
Gene:GP6
Gene Synonym:
Exon (8)804..2264
Gene:GP6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_016363
Organism Homo sapiens (human)
Definition Homo sapiens glycoprotein VI (platelet) (GP6), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016363

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTCCAT CCCCGACCGC CCTCTTCTGT CTTGGGCTGT GTCTGGGGCG TGTGCCAGCG 
CAGAGTGGAC CGCTCCCCAA GCCCTCCCTC CAGGCTCTGC CCAGCTCCCT GGTGCCCCTG
GAGAAGCCAG TGACCCTCCG GTGCCAGGGA CCTCCGGGCG TGGACCTGTA CCGCCTGGAG
AAGCTGAGTT CCAGCAGGTA CCAGGATCAG GCAGTCCTCT TCATCCCGGC CATGAAGAGA
AGTCTGGCTG GACGCTACCG CTGCTCCTAC CAGAACGGAA GCCTCTGGTC CCTGCCCAGC
GACCAGCTGG AGCTCGTTGC CACGGGAGTT TTTGCCAAAC CCTCGCTCTC AGCCCAGCCC
GGCCCGGCGG TGTCGTCAGG AGGGGACGTA ACCCTACAGT GTCAGACTCG GTATGGCTTT
GACCAATTTG CTCTGTACAA GGAAGGGGAC CCTGCGCCCT ACAAGAATCC CGAGAGATGG
TACAGGGCTA GTTTTCCCAT CATCACGGTG ACCGCCGCCC ACAGCGGAAC CTACCGATGC
TACAGCTTCT CCAGCAGGGA CCCATACCTG TGGTCAGCCC CCAGCGACCC CCTGGAGCTT
GTGGTCACAG GAACCTCTGT GACCCCCAGC CGGTTACCAA CAGAACCACC TTCCCCGGTA
GCAGAATTCT CAGAAGCCAC CGCTGAACTG ACCGTCTCAT TCACAAACGA AGTCTTCACA
ACTGAGACTT CTAGGAGTAT CACCGCCAGT CCAAAGGAGT CAGACTCTCC AGCTGGTCCT
GCCCGCCAGT ACTACACCAA GGGCAACCTG GTCCGGATAT GCCTCGGGGC TGTGATCCTA
ATAATCCTGG CGGGGTTTCT GGCAGAGGAC TGGCACAGCC GGAGGAAGCG CCTGCGGCAC
AGGGGCAGGG CTGTGCAGAG GCCGCTTCCG CCCCTCCCGC CCCTCCCGCT GACCCGGAAA
TCAAACGGGG GTCAGGATGG AGGCCGACAG GATGTTCACA GCCGCGGGTT ATGTTCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

RhoG protein regulates glycoprotein VI-Fc receptor gamma-chain complex-mediated platelet activation and thrombus formation
J. Biol. Chem. 288 (47), 34230-34238 (2013)
Kim S, Dangelmaier C, Bhavanasi D, Meng S, Wang H, Goldfinger LE and Kunapuli SP.


book

An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean families
J. Thromb. Haemost. 11 (9), 1751-1759 (2013)
Matus V, Valenzuela G, Saez CG, Hidalgo P, Lagos M, Aranda E, Panes O, Pereira J, Pillois X, Nurden AT and Mezzano D.


book

12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity
Thromb. Haemost. 110 (3), 569-581 (2013)
Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR and Holinstat M.


book

Diagnostic and therapeutic potentials of platelet glycoprotein VI
Semin. Thromb. Hemost. 36 (2), 203-211 (2010)
Bigalke B, Kramer BF, Seizer P, Fateh-Moghadam S, Gawaz M and Lindemann S.


book

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations
Blood 114 (9), 1900-1903 (2009)
Dumont B, Lasne D, Rothschild C, Bouabdelli M, Ollivier V, Oudin C, Ajzenberg N, Grandchamp B and Jandrot-Perrus M.


book

Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI
Biochem. Biophys. Res. Commun. 277 (1), 27-36 (2000)
Ezumi Y, Uchiyama T and Takayama H.


book

Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily
Blood 96 (5), 1798-1807 (2000)
Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W and Villeval JL.


book

Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine
J. Biol. Chem. 271 (9), 4755-4762 (1996)
Peters JD, Furlong MT, Asai DJ, Harrison ML and Geahlen RL.


book

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets
Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7844-7848 (1991)
Huang MM, Bolen JB, Barnwell JW, Shattil SJ and Brugge JS.


book

A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion
J. Clin. Invest. 84 (5), 1440-1445 (1989)
Moroi M, Jung SM, Okuma M and Shinmyozu K.


 
*
*
*
*