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GLRX5 glutaredoxin 5 [Homo sapiens (human)]

Gene Symbol GLRX5
Entrez Gene ID 51218
Full Name glutaredoxin 5
Synonyms C14orf87, FLB4739, GRX5, PR01238, PRO1238, PRSA
General protein information
Preferred Names
glutaredoxin-related protein 5, mitochondrial
Names
glutaredoxin-related protein 5, mitochondrial
glutaredoxin 5 homolog
monothiol glutaredoxin-5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.13

Summary This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]. lac of sum
Disorder MIM:

609588

Disorder Html: Anemia, sideroblastic, pyridoxine-refractory, autosomal recessive,





The following GLRX5 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GLRX5 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18481 NM_016417 Homo sapiens glutaredoxin 5 (GLRX5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18481
Accession Version NM_016417.2
Sequence Information ORF Nucleotide Sequence (Length: 474bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product glutaredoxin-related protein 5, mitochondrial precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI259789.1, BX248075.1, BC047680.1, BI834047.1 and AI089763.1. This sequence is a reference standard in the RefSeqGene project. On Feb 10, 2004 this sequence version replaced gi:9994192. Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BI599990.1, BC047680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_057501.2
CDS105..578
Misc Feature(1)3..5(+)
Misc Feature(2)237..509(+)
Misc Feature(3)279..431(+)
Misc Feature(4)279..281(+)
Misc Feature(5)303..314(+)
Misc Feature(6)393..407(+)
Misc Feature(7)468..473(+)
Exon (1)1..399
Gene:GLRX5
Gene Synonym:
Exon (2)400..1171
Gene:GLRX5
Gene Synonym:
Translation
Position Chain Variation Link
36 36 g, t dbSNP:546146190
48 48 a, g dbSNP:571025127
51 51 a, c dbSNP:538318447
58 58 a, g dbSNP:779466262
60 60 c, t dbSNP:748678949
61 61 a, c dbSNP:911681
65 65 c, g dbSNP:778132643
70 70 c, g dbSNP:747226909
77 77 a, c dbSNP:569336771
83 83 g, t dbSNP:776972957
87 87 g, t dbSNP:746009921
88 88 a, c dbSNP:555474190
89 89 c, t dbSNP:554961847
96 96 c, t dbSNP:780737253
99 99 a, g dbSNP:761743525
111 111 a, g dbSNP:767242677
118 118 c, t dbSNP:573438674
127 127 c, g dbSNP:760361132
145 145 g, t dbSNP:375714975
200 200 a, g dbSNP:766056735
205 205 c, t dbSNP:753486590
212 212 -, ggc dbSNP:750771696
216 216 g, t dbSNP:754544048
219 219 a, g dbSNP:534195488
227 227 g, t dbSNP:753153633
233 233 c, g dbSNP:587776500
238 238 c, t dbSNP:758899397
242 242 c, g dbSNP:778023417
251 251 -, gaa dbSNP:758724838
255 255 a, g dbSNP:747458426
258 258 a, g dbSNP:757690699
272 272 c, t dbSNP:781621057
275 275 c, t dbSNP:746028473
284 284 a, g dbSNP:558960545
287 287 g, t dbSNP:7158346
289 289 c, t dbSNP:577438813
297 297 c, t dbSNP:748054600
302 302 a, g dbSNP:28680410
308 308 c, t dbSNP:71431696
317 317 c, t dbSNP:760533176
320 320 a, c dbSNP:766152520
323 323 a, g dbSNP:776282322
324 324 g, t dbSNP:759126777
332 332 c, t dbSNP:764758233
340 340 a, t dbSNP:752203652
344 344 c, t dbSNP:28611006
346 346 a, g dbSNP:373063118
347 347 c, t dbSNP:751994750
355 355 a, g dbSNP:375487410
369 369 a, g dbSNP:757707442
398 398 a, g dbSNP:121908584
402 402 a, g dbSNP:761380853
410 410 c, t dbSNP:61729799
418 418 a, g dbSNP:773847949
427 427 c, t dbSNP:761157052
429 429 a, g dbSNP:766597651
433 433 c, t dbSNP:754098542
434 434 a, g, t dbSNP:200453045
437 437 a, g dbSNP:765327777
448 448 a, g dbSNP:201686050
450 450 a, g dbSNP:758443007
452 452 c, t dbSNP:781174539
453 453 a, g dbSNP:745744944
459 459 a, g dbSNP:755939884
461 461 -, g dbSNP:35185835
464 464 a, g dbSNP:779672711
472 472 a, g dbSNP:748991738
485 485 c, g dbSNP:199687325
486 486 a, g dbSNP:556320353
490 490 a, g dbSNP:747725579
503 503 a, c dbSNP:771693723
509 509 a, g dbSNP:773872003
525 525 c, t dbSNP:761022523
538 538 c, t dbSNP:766798487
539 539 c, t dbSNP:141867720
540 540 a, g dbSNP:11628901
547 547 c, t dbSNP:765487627
563 563 a, c dbSNP:372534189
570 570 c, t dbSNP:758533267
574 574 a, g dbSNP:764091761
582 582 c, t dbSNP:541858398
583 583 a, g dbSNP:144334776
584 584 a, g dbSNP:780015334
588 588 a, c dbSNP:749077775
594 594 c, t dbSNP:202116612
595 595 a, g dbSNP:778764679
596 596 c, t dbSNP:371354810
601 601 c, t dbSNP:771714322
602 602 -, a dbSNP:749271371
602 602 a, g dbSNP:373992585
604 604 a, c, g dbSNP:747574945
606 606 a, t dbSNP:777169491
607 607 g, t dbSNP:759888657
611 611 a, g dbSNP:376333063
612 612 -, c dbSNP:770805454
613 613 c, t dbSNP:775692232
614 614 a, g dbSNP:763119187
623 623 a, g dbSNP:546221456
628 628 c, t dbSNP:751636390
629 629 g, t dbSNP:761921535
630 630 c, t dbSNP:185177970
675 675 c, t dbSNP:568595229
700 700 c, g dbSNP:767010516
705 705 a, g dbSNP:7120
707 707 g, t dbSNP:554212233
711 711 a, t dbSNP:550221604
767 767 a, c dbSNP:760117003
770 770 c, t dbSNP:189688360
782 782 a, c, g dbSNP:1044746
783 783 c, t dbSNP:752800796
796 796 a, g dbSNP:758590723
799 799 c, t dbSNP:547389264
800 800 c, t dbSNP:148638258
802 802 c, t dbSNP:778014019
821 821 a, g dbSNP:751331654
906 906 c, t dbSNP:181240214
913 913 c, t dbSNP:756987314
923 923 c, t dbSNP:186754477
940 940 c, t dbSNP:781112382
946 946 a, g dbSNP:570601760
982 982 a, c, g dbSNP:960
1011 1011 c, t dbSNP:189629851
1016 1016 g, t dbSNP:17092670
1028 1028 a, g dbSNP:180971970
1045 1045 a, g dbSNP:2236314
1069 1069 a, g dbSNP:748797629
1098 1098 c, t dbSNP:186127610
1123 1123 a, g dbSNP:571981256
1149 1149 a, g dbSNP:768218003
1167 1167 a, t dbSNP:546456975
1171 1171 c, t dbSNP:558189718

Target ORF information:

RefSeq Version NM_016417
Organism Homo sapiens (human)
Definition Homo sapiens glutaredoxin 5 (GLRX5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016417

ORF Insert Sequence:

1
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121
181
241
301
361
421
ATGAGCGGGT CCCTCGGCCG AGCTGCGGCG GCTCTGCTCC GCTGGGGGCG CGGCGCGGGC 
GGCGGTGGCC TTTGGGGTCC GGGCGTGCGG GCGGCGGGCT CGGGCGCGGG CGGCGGCGGC
TCGGCGGAGC AGTTGGACGC GCTGGTGAAG AAGGACAAGG TGGTGGTCTT CCTCAAGGGG
ACGCCGGAGC AGCCCCAGTG CGGCTTCAGC AACGCCGTGG TGCAGATCCT GCGGCTGCAC
GGCGTCCGCG ATTACGCGGC CTACAACGTG CTGGACGACC CGGAGCTCCG ACAAGGCATT
AAAGACTATT CCAACTGGCC CACCATCCCG CAAGTGTACC TCAATGGCGA GTTTGTAGGG
GGCTGTGACA TTCTTCTGCA GATGCACCAG AATGGGGACT TGGTGGAAGA ACTGAAAAAG
CTGGGGATCC ACTCCGCCCT TTTAGATGAA AAGAAAGACC AAGACTCCAA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.