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TMEM216 cDNA ORF clone, Homo sapiens (human)

Gene Symbol TMEM216
Entrez Gene ID 51259
Full Name transmembrane protein 216
Synonyms HSPC244
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.1

Summary This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. [provided by RefSeq, Aug 2010]. lac of sum
Disorder MIM:

613277

Disorder Html: Joubert syndrome 2, 608091 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_005274039 XP_005274096 transmembrane protein 216 isoform X1
NM_016499 NP_057583 transmembrane protein 216 isoform 1
NM_001173991 NP_001167462 transmembrane protein 216 isoform 3
NM_001173990 NP_001167461 transmembrane protein 216 isoform 2



Homo sapiens (human) TMEM216 NP_001167462.1
Pan troglodytes (chimpanzee) TMEM216 NP_001229497.1
Macaca mulatta (Rhesus monkey) TMEM216 XP_001082614.2
Canis lupus familiaris (dog) TMEM216 XP_005631719.1
Mus musculus (house mouse) Tmem216 NP_001264789.1
Rattus norvegicus (Norway rat) Tmem216 NP_001257968.1
Gallus gallus (chicken) TMEM216 XP_001236892.2
Danio rerio (zebrafish) LOC555988 XP_683769.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100490116 XP_002943747.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TMEM216 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM216 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20599
XM_005274039 PREDICTED: Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20599
NM_016499 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu20600 NM_001173991 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu20850 NM_001173990 Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20599
Clone ID Related Accession (Same CDS sequence) NM_016499 , XM_005274039
Accession Version XM_005274039.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 264bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 216 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167190.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578821493. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005274096.1
CDS1277..1540
Misc Feature(1)1280..1474(+)
Translation

Target ORF information:

RefSeq Version XM_005274039
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens transmembrane protein 216 (TMEM216), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005274039

ORF Insert Sequence:

1
61
121
181
241
ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20599
Clone ID Related Accession (Same CDS sequence) NM_016499 , XM_005274039
Accession Version NM_016499.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 264bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 216 isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG759319.1, BC011010.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced gi:291219930. Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC011010.1, AF151078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057583.2
CDS437..700
Misc Feature(1)275..277(+)
Misc Feature(2)440..634(+)
Exon (1)1..287
Gene:TMEM216
Gene Synonym:
Exon (2)288..389
Gene:TMEM216
Gene Synonym:
Exon (3)390..482
Gene:TMEM216
Gene Synonym:
Exon (4)483..684
Gene:TMEM216
Gene Synonym:
Exon (5)685..1287
Gene:TMEM216
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_016499
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016499

ORF Insert Sequence:

1
61
121
181
241
ATGCTCCTCC TTTATCTTGG AATTGAAGTA ATTCGCCTGT TTTTTGGTAC AAAGGGAAAC 
CTCTGCCAGC GAAAGATGCC GCTCAGTATT AGCGTGGCCT TGACCTTCCC ATCTGCCATG
ATGGCCTCCT ATTACCTGCT GCTGCAGACC TACGTACTCC GCCTGGAAGC CATCATGAAT
GGCATCTTGC TCTTCTTCTG TGGCTCAGAG CTTTTACTTG AGGTGCTCAC CTTGGCTGCT
TTCTCCAGTA TGGACAGGAT TTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20600
Clone ID Related Accession (Same CDS sequence) NM_001173991
Accession Version NM_001173991.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 447bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 216 isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, DN998400.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced gi:291219933. Transcript Variant: This variant (3) uses an alternate splice site and initiates translation at an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BI910875.1, BG498893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT
GCTTTCTCCA GTATGGACAG GATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001167462.1
CDS273..719
Misc Feature(1)102..104(+)
Misc Feature(2)336..653(+)
Misc Feature(3)336..398(+)
Misc Feature(4)438..500(+)
Misc Feature(5)537..599(+)
Misc Feature(6)636..698(+)
Exon (1)1..306
Gene:TMEM216
Gene Synonym:
Exon (2)307..408
Gene:TMEM216
Gene Synonym:
Exon (3)409..501
Gene:TMEM216
Gene Synonym:
Exon (4)502..703
Gene:TMEM216
Gene Synonym:
Exon (5)704..1306
Gene:TMEM216
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001173991
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001173991

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT
GCTTTCTCCA GTATGGACAG GATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20850
Clone ID Related Accession (Same CDS sequence) NM_001173990
Accession Version NM_001173990.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transmembrane protein 216 isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303687.1, AP003108.3 and AA022661.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2010 this sequence version replaced gi:291219931. Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an upstream start codon compared to variant 1. This variant also uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer N-terminus and lacks a short segment in the C-terminus, compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: AK303687.1, HY076134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001167461.1
CDS273..710
Misc Feature(1)102..104(+)
Misc Feature(2)336..653(+)
Misc Feature(3)336..398(+)
Misc Feature(4)438..500(+)
Misc Feature(5)537..599(+)
Misc Feature(6)636..698(+)
Exon (1)1..306
Gene:TMEM216
Gene Synonym:
Exon (2)307..408
Gene:TMEM216
Gene Synonym:
Exon (3)409..501
Gene:TMEM216
Gene Synonym:
Exon (4)502..703
Gene:TMEM216
Gene Synonym:
Exon (5)704..1297
Gene:TMEM216
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001173990
Organism Homo sapiens (human)
Definition Homo sapiens transmembrane protein 216 (TMEM216), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001173990

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCTGCCAC GGGGACTGAA GATGGCGCCG CGAGGTAAAC GGTTGTCCTC CACCCCGCTG 
GAAATCCTGT TCTTTCTGAA CGGGTGGTAT AATGCTACCT ATTTCCTGCT GGAACTTTTC
ATATTTCTGT ATAAAGGTGT CCTGCTACCA TATCCAACAG CTAACCTAGT ACTGGATGTG
GTGATGCTCC TCCTTTATCT TGGAATTGAA GTAATTCGCC TGTTTTTTGG TACAAAGGGA
AACCTCTGCC AGCGAAAGAT GCCGCTCAGT ATTAGCGTGG CCTTGACCTT CCCATCTGCC
ATGATGGCCT CCTATTACCT GCTGCTGCAG ACCTACGTAC TCCGCCTGGA AGCCATCATG
AATGGCATCT TGCTCTTCTT CTGTGGCTCA GAGCTTTTAC TTGAGGTGCT CACCTTGGCT
GCTTTCTCCA GGATTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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