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PEPD cDNA ORF clone, Homo sapiens (human)

Gene Symbol PEPD
Entrez Gene ID 5184
Full Name peptidase D
Synonyms PROLIDASE
General protein information
Preferred Names
xaa-Pro dipeptidase
Names
xaa-Pro dipeptidase
imidodipeptidase
X-Pro dipeptidase
proline dipeptidase
aminoacyl-L-proline hydrolase
NP_000276.2
NP_001159528.1
NP_001159529.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.11

Summary This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

613230

Disorder Html: Prolidase deficiency, 170100 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000285 NP_000276 xaa-Pro dipeptidase isoform 1
NM_001166056 NP_001159528 xaa-Pro dipeptidase isoform 2
NM_001166057 NP_001159529 xaa-Pro dipeptidase isoform 3


Homo sapiens (human) PEPD NP_000276.2
Pan troglodytes (chimpanzee) PEPD XP_512574.3
Macaca mulatta (Rhesus monkey) PEPD XP_001108725.2
Canis lupus familiaris (dog) PEPD XP_533702.2
Bos taurus (cattle) PEPD NP_001073787.2
Mus musculus (house mouse) Pepd NP_032846.2
Rattus norvegicus (Norway rat) Pepd NP_001009641.1
Gallus gallus (chicken) PEPD NP_001073185.1
Danio rerio (zebrafish) pepd NP_944594.1
Drosophila melanogaster (fruit fly) Dip-C NP_650192.1
Caenorhabditis elegans K12C11.1 NP_490843.1
Arabidopsis thaliana (thale cress) AT4G29490 NP_194678.2
Xenopus (Silurana) tropicalis (western clawed frog) pepd NP_001008094.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PEPD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PEPD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24790
NM_000285 Homo sapiens peptidase D (PEPD), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu24752 NM_001166056 Homo sapiens peptidase D (PEPD), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu25079 NM_001166057 Homo sapiens peptidase D (PEPD), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $251.30
$359.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24790
Clone ID Related Accession (Same CDS sequence) NM_000285
Accession Version NM_000285.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1482bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product xaa-Pro dipeptidase isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395475.1, BC015027.1 and AW512991.1. This sequence is a reference standard in the RefSeqGene project. On Oct 6, 2009 this sequence version replaced gi:149589007. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015027.1, AK225037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GGAGTCCTTC TTTCACTGGG CGTTCGGTGT CACTGAGCCA
GGCTGCTATG GTGTCATCGA TGTTGACACT GGGAAGTCGA CCCTGTTTGT GCCCAGGCTT
CCTGCCAGCC ATGCCACCTG GATGGGAAAG ATCCATTCCA AGGAGCACTT CAAGGAGAAG
TATGCCGTGG ACGACGTCCA GTACGTAGAT GAGATTGCCA GCGTCCTGAC GTCACAGAAG
CCCTCTGTCC TCCTCACTTT GCGTGGCGTC AACACGGACA GCGGCAGTGT CTGCAGGGAG
GCCTCCTTTG ACGGCATCAG CAAGTTCGAA GTCAACAATA CCATTCTTCA CCCAGAGATC
GTTGAGTGCC GAGTGTTTAA GACGGATATG GAGCTGGAGG TTCTGCGCTA TACCAATAAA
ATCTCCAGCG AGGCCCACCG TGAGGTAATG AAGGCTGTAA AAGTGGGAAT GAAAGAATAT
GAGTTGGAAA GCCTCTTCGA GCACTACTGC TACTCCCGGG GCGGCATGCG CCACAGCTCC
TACACCTGCA TCTGCGGCAG TGGTGAGAAC TCAGCCGTGC TACACTACGG ACACGCCGGA
GCTCCCAACG ACCGAACGAT CCAGAATGGG GATATGTGCC TGTTCGACAT GGGCGGTGAG
TATTACTGCT TCGCTTCCGA CATCACCTGC TCCTTTCCCG CCAACGGCAA GTTCACTGCA
GACCAGAAGG CCGTCTATGA GGCAGTGCTG CGGAGCTCCC GTGCCGTCAT GGGTGCCATG
AAGCCAGGTG TCTGGTGGCC TGACATGCAC CGCCTGGCTG ACCGCATCCA CCTGGAGGAG
CTGGCCCACA TGGGCATCCT GAGCGGCAGC GTGGACGCCA TGGTCCAGGC TCACCTGGGG
GCCGTGTTTA TGCCTCACGG GCTTGGCCAC TTCCTGGGCA TTGACGTGCA CGACGTGGGA
GGCTACCCAG AGGGCGTGGA GCGCATCGAC GAGCCCGGCC TGCGGAGCCT GCGCACTGCA
CGGCACCTGC AGCCAGGCAT GGTGCTCACC GTGGAGCCGG GCATCTACTT CATCGACCAC
CTCCTGGATG AGGCCCTGGC GGACCCGGCC CGCGCCTCCT TCCTTAACCG CGAGGTCCTG
CAGCGCTTTC GCGGTTTTGG CGGGGTCCGC ATCGAGGAGG ACGTCGTGGT GACTGACAGC
GGCATAGAGC TGCTGACCTG CGTGCCCCGC ACTGTGGAAG AGATTGAAGC ATGCATGGCA
GGCTGTGACA AGGCCTTTAC CCCCTTCTCT GGCCCCAAGT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000276.2
CDS134..1615
Misc Feature(1)113..115(+)
Misc Feature(2)137..139(+)
Misc Feature(3)185..598(+)
Misc Feature(4)212..1576(+)
Misc Feature(5)707..1534(+)
Misc Feature(6)896..1489(+)
Exon (1)1..150
Gene:PEPD
Gene Synonym:
Exon (2)151..334
Gene:PEPD
Gene Synonym:
Exon (3)335..462
Gene:PEPD
Gene Synonym:
Exon (4)463..526
Gene:PEPD
Gene Synonym:
Exon (5)527..574
Gene:PEPD
Gene Synonym:
Exon (6)575..636
Gene:PEPD
Gene Synonym:
Exon (7)637..681
Gene:PEPD
Gene Synonym:
Exon (8)682..757
Gene:PEPD
Gene Synonym:
Exon (9)758..804
Gene:PEPD
Gene Synonym:
Exon (10)805..873
Gene:PEPD
Gene Synonym:
Exon (11)874..951
Gene:PEPD
Gene Synonym:
Exon (12)952..1100
Gene:PEPD
Gene Synonym:
Exon (13)1101..1285
Gene:PEPD
Gene Synonym:
Exon (14)1286..1477
Gene:PEPD
Gene Synonym:
Exon (15)1478..2010
Gene:PEPD
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000285
Organism Homo sapiens (human)
Definition Homo sapiens peptidase D (PEPD), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000285

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GGAGTCCTTC TTTCACTGGG CGTTCGGTGT CACTGAGCCA
GGCTGCTATG GTGTCATCGA TGTTGACACT GGGAAGTCGA CCCTGTTTGT GCCCAGGCTT
CCTGCCAGCC ATGCCACCTG GATGGGAAAG ATCCATTCCA AGGAGCACTT CAAGGAGAAG
TATGCCGTGG ACGACGTCCA GTACGTAGAT GAGATTGCCA GCGTCCTGAC GTCACAGAAG
CCCTCTGTCC TCCTCACTTT GCGTGGCGTC AACACGGACA GCGGCAGTGT CTGCAGGGAG
GCCTCCTTTG ACGGCATCAG CAAGTTCGAA GTCAACAATA CCATTCTTCA CCCAGAGATC
GTTGAGTGCC GAGTGTTTAA GACGGATATG GAGCTGGAGG TTCTGCGCTA TACCAATAAA
ATCTCCAGCG AGGCCCACCG TGAGGTAATG AAGGCTGTAA AAGTGGGAAT GAAAGAATAT
GAGTTGGAAA GCCTCTTCGA GCACTACTGC TACTCCCGGG GCGGCATGCG CCACAGCTCC
TACACCTGCA TCTGCGGCAG TGGTGAGAAC TCAGCCGTGC TACACTACGG ACACGCCGGA
GCTCCCAACG ACCGAACGAT CCAGAATGGG GATATGTGCC TGTTCGACAT GGGCGGTGAG
TATTACTGCT TCGCTTCCGA CATCACCTGC TCCTTTCCCG CCAACGGCAA GTTCACTGCA
GACCAGAAGG CCGTCTATGA GGCAGTGCTG CGGAGCTCCC GTGCCGTCAT GGGTGCCATG
AAGCCAGGTG TCTGGTGGCC TGACATGCAC CGCCTGGCTG ACCGCATCCA CCTGGAGGAG
CTGGCCCACA TGGGCATCCT GAGCGGCAGC GTGGACGCCA TGGTCCAGGC TCACCTGGGG
GCCGTGTTTA TGCCTCACGG GCTTGGCCAC TTCCTGGGCA TTGACGTGCA CGACGTGGGA
GGCTACCCAG AGGGCGTGGA GCGCATCGAC GAGCCCGGCC TGCGGAGCCT GCGCACTGCA
CGGCACCTGC AGCCAGGCAT GGTGCTCACC GTGGAGCCGG GCATCTACTT CATCGACCAC
CTCCTGGATG AGGCCCTGGC GGACCCGGCC CGCGCCTCCT TCCTTAACCG CGAGGTCCTG
CAGCGCTTTC GCGGTTTTGG CGGGGTCCGC ATCGAGGAGG ACGTCGTGGT GACTGACAGC
GGCATAGAGC TGCTGACCTG CGTGCCCCGC ACTGTGGAAG AGATTGAAGC ATGCATGGCA
GGCTGTGACA AGGCCTTTAC CCCCTTCTCT GGCCCCAAGT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24752
Clone ID Related Accession (Same CDS sequence) NM_001166056
Accession Version NM_001166056.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1359bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product xaa-Pro dipeptidase isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395475.1, AK294619.1 and AW512991.1. Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159080 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GGAGTCCTTC TTTCACTGGG CGTTCGGTGT CACTGAGCCA
GGCTGCTATG GTGTCATCGA TGTTGACACT GGGAAGTCGA CCCTGTTTGT GCCCAGGCTT
CCTGCCAGCC ATGCCACCTG GATGGGAAAG ATCCATTCCA AGGAGCACTT CAAGGAGAAG
TATGCCGTGG ACGACGTCCA GTACGTAGAT GAGATTGCCA GCGTCCTGAC GTCACAGAAG
CCCTCTGTCC TCCTCACTTT GCGTGGCGTC AACACGGACA GCGGCAGTGT CTGCAGGGAG
GCCTCCTTTG ACGGCATCAG CAAGTTCGAA GTCAACAATA CCATTCTTCA CCCAGAGATC
GTTGAGTGCC TCTTCGAGCA CTACTGCTAC TCCCGGGGCG GCATGCGCCA CAGCTCCTAC
ACCTGCATCT GCGGCAGTGG TGAGAACTCA GCCGTGCTAC ACTACGGACA CGCCGGAGCT
CCCAACGACC GAACGATCCA GAATGGGGAT ATGTGCCTGT TCGACATGGG CGGTGAGTAT
TACTGCTTCG CTTCCGACAT CACCTGCTCC TTTCCCGCCA ACGGCAAGTT CACTGCAGAC
CAGAAGGCCG TCTATGAGGC AGTGCTGCGG AGCTCCCGTG CCGTCATGGG TGCCATGAAG
CCAGGTGTCT GGTGGCCTGA CATGCACCGC CTGGCTGACC GCATCCACCT GGAGGAGCTG
GCCCACATGG GCATCCTGAG CGGCAGCGTG GACGCCATGG TCCAGGCTCA CCTGGGGGCC
GTGTTTATGC CTCACGGGCT TGGCCACTTC CTGGGCATTG ACGTGCACGA CGTGGGAGGC
TACCCAGAGG GCGTGGAGCG CATCGACGAG CCCGGCCTGC GGAGCCTGCG CACTGCACGG
CACCTGCAGC CAGGCATGGT GCTCACCGTG GAGCCGGGCA TCTACTTCAT CGACCACCTC
CTGGATGAGG CCCTGGCGGA CCCGGCCCGC GCCTCCTTCC TTAACCGCGA GGTCCTGCAG
CGCTTTCGCG GTTTTGGCGG GGTCCGCATC GAGGAGGACG TCGTGGTGAC TGACAGCGGC
ATAGAGCTGC TGACCTGCGT GCCCCGCACT GTGGAAGAGA TTGAAGCATG CATGGCAGGC
TGTGACAAGG CCTTTACCCC CTTCTCTGGC CCCAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159528.1
CDS134..1492
Misc Feature(1)113..115(+)
Misc Feature(2)185..541(+)
Misc Feature(3)311..1438(+)
Misc Feature(4)611..1411(+)
Misc Feature(5)773..1366(+)
Exon (1)1..150
Gene:PEPD
Gene Synonym:
Exon (2)151..334
Gene:PEPD
Gene Synonym:
Exon (3)335..462
Gene:PEPD
Gene Synonym:
Exon (4)463..526
Gene:PEPD
Gene Synonym:
Exon (5)527..574
Gene:PEPD
Gene Synonym:
Exon (6)575..636
Gene:PEPD
Gene Synonym:
Exon (7)637..681
Gene:PEPD
Gene Synonym:
Exon (8)682..750
Gene:PEPD
Gene Synonym:
Exon (9)751..828
Gene:PEPD
Gene Synonym:
Exon (10)829..977
Gene:PEPD
Gene Synonym:
Exon (11)978..1162
Gene:PEPD
Gene Synonym:
Exon (12)1163..1354
Gene:PEPD
Gene Synonym:
Exon (13)1355..1887
Gene:PEPD
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001166056
Organism Homo sapiens (human)
Definition Homo sapiens peptidase D (PEPD), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166056

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GGAGTCCTTC TTTCACTGGG CGTTCGGTGT CACTGAGCCA
GGCTGCTATG GTGTCATCGA TGTTGACACT GGGAAGTCGA CCCTGTTTGT GCCCAGGCTT
CCTGCCAGCC ATGCCACCTG GATGGGAAAG ATCCATTCCA AGGAGCACTT CAAGGAGAAG
TATGCCGTGG ACGACGTCCA GTACGTAGAT GAGATTGCCA GCGTCCTGAC GTCACAGAAG
CCCTCTGTCC TCCTCACTTT GCGTGGCGTC AACACGGACA GCGGCAGTGT CTGCAGGGAG
GCCTCCTTTG ACGGCATCAG CAAGTTCGAA GTCAACAATA CCATTCTTCA CCCAGAGATC
GTTGAGTGCC TCTTCGAGCA CTACTGCTAC TCCCGGGGCG GCATGCGCCA CAGCTCCTAC
ACCTGCATCT GCGGCAGTGG TGAGAACTCA GCCGTGCTAC ACTACGGACA CGCCGGAGCT
CCCAACGACC GAACGATCCA GAATGGGGAT ATGTGCCTGT TCGACATGGG CGGTGAGTAT
TACTGCTTCG CTTCCGACAT CACCTGCTCC TTTCCCGCCA ACGGCAAGTT CACTGCAGAC
CAGAAGGCCG TCTATGAGGC AGTGCTGCGG AGCTCCCGTG CCGTCATGGG TGCCATGAAG
CCAGGTGTCT GGTGGCCTGA CATGCACCGC CTGGCTGACC GCATCCACCT GGAGGAGCTG
GCCCACATGG GCATCCTGAG CGGCAGCGTG GACGCCATGG TCCAGGCTCA CCTGGGGGCC
GTGTTTATGC CTCACGGGCT TGGCCACTTC CTGGGCATTG ACGTGCACGA CGTGGGAGGC
TACCCAGAGG GCGTGGAGCG CATCGACGAG CCCGGCCTGC GGAGCCTGCG CACTGCACGG
CACCTGCAGC CAGGCATGGT GCTCACCGTG GAGCCGGGCA TCTACTTCAT CGACCACCTC
CTGGATGAGG CCCTGGCGGA CCCGGCCCGC GCCTCCTTCC TTAACCGCGA GGTCCTGCAG
CGCTTTCGCG GTTTTGGCGG GGTCCGCATC GAGGAGGACG TCGTGGTGAC TGACAGCGGC
ATAGAGCTGC TGACCTGCGT GCCCCGCACT GTGGAAGAGA TTGAAGCATG CATGGCAGGC
TGTGACAAGG CCTTTACCCC CTTCTCTGGC CCCAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25079
Clone ID Related Accession (Same CDS sequence) NM_001166057
Accession Version NM_001166057.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1290bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product xaa-Pro dipeptidase isoform 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC395475.1, AK293126.1, BC015027.1 and AW512991.1. Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK293126.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GATTGCCAGC GTCCTGACGT CACAGAAGCC CTCTGTCCTC
CTCACTTTGC GTGGCGTCAA CACGGACAGC GGCAGTGTCT GCAGGGAGGC CTCCTTTGAC
GGCATCAGCA AGTTCGAAGT CAACAATACC ATTCTTCACC CAGAGATCGT TGAGTGCCGA
GTGTTTAAGA CGGATATGGA GCTGGAGGTT CTGCGCTATA CCAATAAAAT CTCCAGCGAG
GCCCACCGTG AGGTAATGAA GGCTGTAAAA GTGGGAATGA AAGAATATGA GTTGGAAAGC
CTCTTCGAGC ACTACTGCTA CTCCCGGGGC GGCATGCGCC ACAGCTCCTA CACCTGCATC
TGCGGCAGTG GTGAGAACTC AGCCGTGCTA CACTACGGAC ACGCCGGAGC TCCCAACGAC
CGAACGATCC AGAATGGGGA TATGTGCCTG TTCGACATGG GCGGTGAGTA TTACTGCTTC
GCTTCCGACA TCACCTGCTC CTTTCCCGCC AACGGCAAGT TCACTGCAGA CCAGAAGGCC
GTCTATGAGG CAGTGCTGCG GAGCTCCCGT GCCGTCATGG GTGCCATGAA GCCAGGTGTC
TGGTGGCCTG ACATGCACCG CCTGGCTGAC CGCATCCACC TGGAGGAGCT GGCCCACATG
GGCATCCTGA GCGGCAGCGT GGACGCCATG GTCCAGGCTC ACCTGGGGGC CGTGTTTATG
CCTCACGGGC TTGGCCACTT CCTGGGCATT GACGTGCACG ACGTGGGAGG CTACCCAGAG
GGCGTGGAGC GCATCGACGA GCCCGGCCTG CGGAGCCTGC GCACTGCACG GCACCTGCAG
CCAGGCATGG TGCTCACCGT GGAGCCGGGC ATCTACTTCA TCGACCACCT CCTGGATGAG
GCCCTGGCGG ACCCGGCCCG CGCCTCCTTC CTTAACCGCG AGGTCCTGCA GCGCTTTCGC
GGTTTTGGCG GGGTCCGCAT CGAGGAGGAC GTCGTGGTGA CTGACAGCGG CATAGAGCTG
CTGACCTGCG TGCCCCGCAC TGTGGAAGAG ATTGAAGCAT GCATGGCAGG CTGTGACAAG
GCCTTTACCC CCTTCTCTGG CCCCAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001159529.1
CDS134..1423
Misc Feature(1)113..115(+)
Misc Feature(2)137..139(+)
Misc Feature(3)185..>334(+)
Misc Feature(4)515..1342(+)
Misc Feature(5)704..1297(+)
Exon (1)1..150
Gene:PEPD
Gene Synonym:
Exon (2)151..334
Gene:PEPD
Gene Synonym:
Exon (3)335..382
Gene:PEPD
Gene Synonym:
Exon (4)383..444
Gene:PEPD
Gene Synonym:
Exon (5)445..489
Gene:PEPD
Gene Synonym:
Exon (6)490..565
Gene:PEPD
Gene Synonym:
Exon (7)566..612
Gene:PEPD
Gene Synonym:
Exon (8)613..681
Gene:PEPD
Gene Synonym:
Exon (9)682..759
Gene:PEPD
Gene Synonym:
Exon (10)760..908
Gene:PEPD
Gene Synonym:
Exon (11)909..1093
Gene:PEPD
Gene Synonym:
Exon (12)1094..1285
Gene:PEPD
Gene Synonym:
Exon (13)1286..1818
Gene:PEPD
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001166057
Organism Homo sapiens (human)
Definition Homo sapiens peptidase D (PEPD), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001166057

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCGGCGG CCACCGGACC CTCGTTTTGG CTGGGGAATG AAACCCTGAA GGTGCCGCTG 
GCGCTCTTTG CCTTGAACCG GCAGCGCCTG TGTGAGCGGC TGCGGAAGAA CCCTGCTGTG
CAGGCCGGCT CCATCGTGGT CCTGCAGGGC GGGGAGGAGA CTCAGCGCTA CTGCACCGAC
ACCGGGGTCC TCTTCCGCCA GATTGCCAGC GTCCTGACGT CACAGAAGCC CTCTGTCCTC
CTCACTTTGC GTGGCGTCAA CACGGACAGC GGCAGTGTCT GCAGGGAGGC CTCCTTTGAC
GGCATCAGCA AGTTCGAAGT CAACAATACC ATTCTTCACC CAGAGATCGT TGAGTGCCGA
GTGTTTAAGA CGGATATGGA GCTGGAGGTT CTGCGCTATA CCAATAAAAT CTCCAGCGAG
GCCCACCGTG AGGTAATGAA GGCTGTAAAA GTGGGAATGA AAGAATATGA GTTGGAAAGC
CTCTTCGAGC ACTACTGCTA CTCCCGGGGC GGCATGCGCC ACAGCTCCTA CACCTGCATC
TGCGGCAGTG GTGAGAACTC AGCCGTGCTA CACTACGGAC ACGCCGGAGC TCCCAACGAC
CGAACGATCC AGAATGGGGA TATGTGCCTG TTCGACATGG GCGGTGAGTA TTACTGCTTC
GCTTCCGACA TCACCTGCTC CTTTCCCGCC AACGGCAAGT TCACTGCAGA CCAGAAGGCC
GTCTATGAGG CAGTGCTGCG GAGCTCCCGT GCCGTCATGG GTGCCATGAA GCCAGGTGTC
TGGTGGCCTG ACATGCACCG CCTGGCTGAC CGCATCCACC TGGAGGAGCT GGCCCACATG
GGCATCCTGA GCGGCAGCGT GGACGCCATG GTCCAGGCTC ACCTGGGGGC CGTGTTTATG
CCTCACGGGC TTGGCCACTT CCTGGGCATT GACGTGCACG ACGTGGGAGG CTACCCAGAG
GGCGTGGAGC GCATCGACGA GCCCGGCCTG CGGAGCCTGC GCACTGCACG GCACCTGCAG
CCAGGCATGG TGCTCACCGT GGAGCCGGGC ATCTACTTCA TCGACCACCT CCTGGATGAG
GCCCTGGCGG ACCCGGCCCG CGCCTCCTTC CTTAACCGCG AGGTCCTGCA GCGCTTTCGC
GGTTTTGGCG GGGTCCGCAT CGAGGAGGAC GTCGTGGTGA CTGACAGCGG CATAGAGCTG
CTGACCTGCG TGCCCCGCAC TGTGGAAGAG ATTGAAGCAT GCATGGCAGG CTGTGACAAG
GCCTTTACCC CCTTCTCTGG CCCCAAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2
Hum. Mol. Genet. 23 (4), 1108-1119 (2014)
Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL and Tai ES.


book

Discovery and refinement of loci associated with lipid levels
Nat. Genet. 45 (11), 1274-1283 (2013)
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Doring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR.


book

Fibrosis in heart failure subtypes
Eur Rev Med Pharmacol Sci 17 (17), 2302-2309 (2013)
Toprak G, Yuksel H, Demirpence O, Islamoglu Y, Evliyaoglu O and Mete N.


book

The effect of estrogen on prolidase-dependent regulation of HIF-1alpha expression in breast cancer cells
Mol. Cell. Biochem. 379 (1-2), 29-36 (2013)
Surazynski A, Miltyk W, Prokop I and Palka J.


book

Four novel PEPD alleles causing prolidase deficiency
Am. J. Hum. Genet. 54 (6), 1014-1021 (1994)
Ledoux P, Scriver C and Hechtman P.


book

Structural organization of the gene for human prolidase (peptidase D) and demonstration of a partial gene deletion in a patient with prolidase deficiency
J. Biol. Chem. 265 (19), 11306-11311 (1990)
Tanoue A, Endo F and Matsuda I.


book

A single nucleotide change in the prolidase gene in fibroblasts from two patients with polypeptide positive prolidase deficiency. Expression of the mutant enzyme in NIH 3T3 cells
J. Clin. Invest. 86 (1), 351-355 (1990)
Tanoue A, Endo F, Kitano A and Matsuda I.


book

Prolidase deficiency: biochemical classification of alleles
Am. J. Hum. Genet. 44 (5), 731-740 (1989)
Boright AP, Scriver CR, Lancaster GA and Choy F.


book

Primary structure and gene localization of human prolidase
J. Biol. Chem. 264 (8), 4476-4481 (1989)
Endo F, Tanoue A, Nakai H, Hata A, Indo Y, Titani K and Matsuda I.


book

Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q
Hum. Genet. 75 (3), 291-293 (1987)
Friedrich,U., Brunner,H., Smeets,D., Lambermon,E. and Ropers,H.H.


 
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