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PF4 platelet factor 4 [Homo sapiens (human)]

Gene Symbol PF4
Entrez Gene ID 5196
Full Name platelet factor 4
Synonyms CXCL4, PF-4, SCYB4
General protein information
Preferred Names
platelet factor 4
Names
platelet factor 4
iroplact
oncostatin-A
C-X-C motif chemokine 4
chemokine (C-X-C motif) ligand 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12-q21

Summary This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]. lac of sum
Disorder MIM:

173460

Disorder Html:





The following PF4 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PF4 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu38968 XM_005265696 PREDICTED: Homo sapiens platelet factor 4 (PF4), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99
OHu21626 NM_002619 Homo sapiens platelet factor 4 (PF4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$69.3
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu38968
Accession Version XM_005265696.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 333bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product platelet factor 4 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_016354.20) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530376992. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
ATGATCACAG CCACACTTAA CGGAGAGCCT GCTGAGTGTC TGGCCACAGT GCCAGGCGCT 
GCACCTGCAC CTCCCACCTG GTTAGAACAA CTTCTGTCTG GGGGAGGTGT GATTTATGCT
GAAGCTGAAG AAGATGGGGA CCTGCAGTGC CTGTGTGTGA AGACCACCTC CCAGGTCCGT
CCCAGGCACA TCACCAGCCT GGAGGTGATC AAGGCCGGAC CCCACTGCCC CACTGCCCAA
CTGATAGCCA CGCTGAAGAA TGGAAGGAAA ATTTGCTTGG ACCTGCAAGC CCCGCTGTAC
AAGAAAATAA TTAAGAAACT TTTGGAGAGT TAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_005265753.1
CDS61..393
Misc Feature(1)199..387(+)
Misc Feature(2)199..366(+)
Misc Feature(3)199..207(+)
Misc Feature(4)202..384(+)
Misc Feature(5)202..330(+)
Misc Feature(6)205..216(+)
Misc Feature(7)211..252(+)
Misc Feature(8)217..333(+)
Misc Feature(9)238..387(+)
Misc Feature(10)244..330(+)
Misc Feature(11)250..384(+)
Misc Feature(12)277..285(+)
Misc Feature(13)277..285(+)
Misc Feature(14)316..324(+)
Translation
Position Chain Variation Link
6 6 a, g dbSNP:780198582
12 12 a, g dbSNP:556603582
26 26 a, g dbSNP:370685679
41 41 g, t dbSNP:199749239
43 43 a, g dbSNP:534256446
65 65 c, t dbSNP:544229952
103 103 g, t dbSNP:577292882
113 113 a, c dbSNP:558749835
119 119 c, t dbSNP:534287142
130 130 c, t dbSNP:565568106
154 154 c, g dbSNP:45606832
160 160 a, g, t dbSNP:553548589
182 182 a, t dbSNP:763456646
204 204 -, g dbSNP:752500140
205 205 c, t dbSNP:371761255
210 210 c, t dbSNP:769939662
213 213 c, g dbSNP:745985720
214 214 c, t dbSNP:781299844
215 215 a, g dbSNP:771346319
228 228 c, t dbSNP:747219092
229 229 c, t dbSNP:570410040
231 231 a, c dbSNP:778862826
232 232 c, t dbSNP:552013857
247 247 c, t dbSNP:753842279
249 249 c, t dbSNP:779803294
251 251 c, t dbSNP:756052383
252 252 c, g dbSNP:749971685
254 254 a, c dbSNP:367951530
258 258 a, c dbSNP:756919582
259 259 c, t dbSNP:751148599
262 262 c, g dbSNP:764474600
275 275 a, c dbSNP:763257073
276 276 c, t dbSNP:144253863
277 277 a, g dbSNP:765704070
281 281 c, t dbSNP:374382692
289 289 c, t dbSNP:776632658
292 292 a, g dbSNP:370792656
296 296 a, c, t dbSNP:139635008
300 300 a, g dbSNP:747237488
301 301 c, g dbSNP:773524830
303 303 c, g dbSNP:2233648
305 305 g, t dbSNP:749081610
309 309 c, g dbSNP:755329363
311 311 a, c, t dbSNP:142397385
313 313 -, ct dbSNP:767187533
324 324 a, g dbSNP:116188786
326 326 a, g dbSNP:750593879
327 327 a, g dbSNP:4694
332 332 a, t dbSNP:767579474
335 335 g, t dbSNP:114655702
337 337 c, g, t dbSNP:201899718
338 338 -, t dbSNP:754856155
339 339 a, c, g dbSNP:199976537
342 342 c, t dbSNP:62313967
345 345 a, g dbSNP:759426259
350 350 c, g dbSNP:776380939
353 353 c, t dbSNP:753905048
361 361 a, c dbSNP:746934074
369 369 a, c dbSNP:778270423
384 384 a, g dbSNP:771544036
386 386 a, g dbSNP:200691269
389 389 c, g, t dbSNP:111283987
396 396 a, g dbSNP:778575894
398 398 c, t dbSNP:754560965
399 399 a, g, t dbSNP:780559042
401 401 c, t dbSNP:770725817
408 408 c, t dbSNP:201608869
409 409 a, c, g dbSNP:556219221
411 411 a, g dbSNP:751569874
415 415 a, g, t dbSNP:763159986
417 417 a, g dbSNP:776469211
420 420 c, t dbSNP:770653921
424 424 a, g dbSNP:760608745
426 426 a, g dbSNP:773161274
428 428 a, g dbSNP:771504541
430 430 a, c dbSNP:373572494
437 437 a, c, t dbSNP:352006
437 437 -, c dbSNP:751821210
438 438 c, t dbSNP:768419791
440 440 c, t dbSNP:570398985
444 444 c, t dbSNP:780573464
475 475 c, g dbSNP:180789835
495 495 a, g dbSNP:533881865
518 518 c, t dbSNP:375742261
522 522 a, t dbSNP:566524018

Target ORF information:

RefSeq Version XM_005265696
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens platelet factor 4 (PF4), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005265696

ORF Insert Sequence:

1
61
121
181
241
301
ATGATCACAG CCACACTTAA CGGAGAGCCT GCTGAGTGTC TGGCCACAGT GCCAGGCGCT 
GCACCTGCAC CTCCCACCTG GTTAGAACAA CTTCTGTCTG GGGGAGGTGT GATTTATGCT
GAAGCTGAAG AAGATGGGGA CCTGCAGTGC CTGTGTGTGA AGACCACCTC CCAGGTCCGT
CCCAGGCACA TCACCAGCCT GGAGGTGATC AAGGCCGGAC CCCACTGCCC CACTGCCCAA
CTGATAGCCA CGCTGAAGAA TGGAAGGAAA ATTTGCTTGG ACCTGCAAGC CCCGCTGTAC
AAGAAAATAA TTAAGAAACT TTTGGAGAGT TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21626
Accession Version NM_002619.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 306bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product platelet factor 4 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097709.3, M25897.1 and GD143506.1. This sequence is a reference standard in the RefSeqGene project. On Mar 14, 2012 this sequence version replaced gi:194097423. Summary: This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23245326 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: H82497.1, AJ705588.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2146236, SAMEA2149004 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGAGCTCCG CAGCCGGGTT CTGCGCCTCA CGCCCCGGGC TGCTGTTCCT GGGGTTGCTG 
CTCCTGCCAC TTGTGGTCGC CTTCGCCAGC GCTGAAGCTG AAGAAGATGG GGACCTGCAG
TGCCTGTGTG TGAAGACCAC CTCCCAGGTC CGTCCCAGGC ACATCACCAG CCTGGAGGTG
ATCAAGGCCG GACCCCACTG CCCCACTGCC CAACTGATAG CCACGCTGAA GAATGGAAGG
AAAATTTGCT TGGACCTGCA AGCCCCGCTG TACAAGAAAA TAATTAAGAA ACTTTTGGAG
AGTTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002610.1
CDS172..477
Misc Feature(1)136..138(+)
Misc Feature(2)283..471(+)
Misc Feature(3)283..450(+)
Misc Feature(4)283..291(+)
Misc Feature(5)286..468(+)
Misc Feature(6)286..414(+)
Misc Feature(7)289..300(+)
Misc Feature(8)292..372(+)
Misc Feature(9)295..336(+)
Misc Feature(10)298..420(+)
Misc Feature(11)301..417(+)
Misc Feature(12)322..471(+)
Misc Feature(13)328..414(+)
Misc Feature(14)334..468(+)
Misc Feature(15)361..369(+)
Misc Feature(16)361..369(+)
Misc Feature(17)400..408(+)
Misc Feature(18)445..465(+)
Exon (1)1..262
Gene:PF4
Gene Synonym:
Exon (2)263..389
Gene:PF4
Gene Synonym:
Exon (3)390..856
Gene:PF4
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:13151226
30 30 g, t dbSNP:13128069
46 46 c, t dbSNP:552765329
52 52 c, t dbSNP:182327392
77 77 a, t dbSNP:116253707
81 81 g, t dbSNP:774022989
82 82 a, g dbSNP:371436633
95 95 a, g dbSNP:143069856
103 103 c, t dbSNP:1050933
105 105 a, t dbSNP:527865572
114 114 c, t dbSNP:753363168
132 132 c, g dbSNP:758089839
135 135 a, c dbSNP:752703711
141 141 -, ac dbSNP:748797747
141 141 a, c dbSNP:765313215
144 144 c, g dbSNP:553937127
151 151 c, t dbSNP:367691357
159 159 c, g dbSNP:1050934
166 166 c, t dbSNP:753463492
171 171 c, g dbSNP:190601797
176 176 c, g dbSNP:765791891
177 177 -, c dbSNP:777627477
182 182 c, t dbSNP:566602689
188 188 g, t dbSNP:760313465
189 189 g, t dbSNP:760386282
228 228 a, g dbSNP:772670974
233 233 c, t dbSNP:772514338
235 235 c, t dbSNP:1804152
244 244 a, g dbSNP:116796864
247 247 -, g dbSNP:534064919
247 247 g, t dbSNP:1801572
251 251 c, t dbSNP:774670149
256 256 a, g dbSNP:542589815
261 261 a, c dbSNP:749785500
266 266 a, t dbSNP:763456646
288 288 -, g dbSNP:752500140
289 289 c, t dbSNP:371761255
294 294 c, t dbSNP:769939662
297 297 c, g dbSNP:745985720
298 298 c, t dbSNP:781299844
299 299 a, g dbSNP:771346319
312 312 c, t dbSNP:747219092
313 313 c, t dbSNP:570410040
315 315 a, c dbSNP:778862826
316 316 c, t dbSNP:552013857
331 331 c, t dbSNP:753842279
333 333 c, t dbSNP:779803294
335 335 c, t dbSNP:756052383
336 336 c, g dbSNP:749971685
338 338 a, c dbSNP:367951530
342 342 a, c dbSNP:756919582
343 343 c, t dbSNP:751148599
346 346 c, g dbSNP:764474600
359 359 a, c dbSNP:763257073
360 360 c, t dbSNP:144253863
361 361 a, g dbSNP:765704070
365 365 c, t dbSNP:374382692
373 373 c, t dbSNP:776632658
376 376 a, g dbSNP:370792656
380 380 a, c, t dbSNP:139635008
384 384 a, g dbSNP:747237488
385 385 c, g dbSNP:773524830
387 387 c, g dbSNP:2233648
389 389 g, t dbSNP:749081610
393 393 c, g dbSNP:755329363
395 395 a, c, t dbSNP:142397385
397 397 -, ct dbSNP:767187533
408 408 a, g dbSNP:116188786
410 410 a, g dbSNP:750593879
411 411 a, g dbSNP:4694
416 416 a, t dbSNP:767579474
419 419 g, t dbSNP:114655702
421 421 c, g, t dbSNP:201899718
422 422 -, t dbSNP:754856155
423 423 a, c, g dbSNP:199976537
426 426 c, t dbSNP:62313967
429 429 a, g dbSNP:759426259
434 434 c, g dbSNP:776380939
437 437 c, t dbSNP:753905048
445 445 a, c dbSNP:746934074
453 453 a, c dbSNP:778270423
468 468 a, g dbSNP:771544036
470 470 a, g dbSNP:200691269
473 473 c, g, t dbSNP:111283987
480 480 a, g dbSNP:778575894
482 482 c, t dbSNP:754560965
483 483 a, g, t dbSNP:780559042
485 485 c, t dbSNP:770725817
492 492 c, t dbSNP:201608869
493 493 a, c, g dbSNP:556219221
495 495 a, g dbSNP:751569874
499 499 a, g, t dbSNP:763159986
501 501 a, g dbSNP:776469211
504 504 c, t dbSNP:770653921
508 508 a, g dbSNP:760608745
510 510 a, g dbSNP:773161274
512 512 a, g dbSNP:771504541
514 514 a, c dbSNP:373572494
521 521 a, c, t dbSNP:352006
521 521 -, c dbSNP:751821210
522 522 c, t dbSNP:768419791
524 524 c, t dbSNP:570398985
528 528 c, t dbSNP:780573464
559 559 c, g dbSNP:180789835
579 579 a, g dbSNP:533881865
602 602 c, t dbSNP:375742261
606 606 a, t dbSNP:566524018
611 611 g, t dbSNP:568941777
616 616 c, g dbSNP:11574451
623 623 a, t dbSNP:530284824
639 639 a, t dbSNP:563084152
662 662 a, g dbSNP:551020582
692 692 c, t dbSNP:759798519
737 737 g, t dbSNP:11574452
768 768 a, c dbSNP:41265667
770 770 c, t dbSNP:352005
798 798 g, t dbSNP:144889653
828 828 c, t dbSNP:352004
852 852 a, g dbSNP:561011636

Target ORF information:

RefSeq Version NM_002619
Organism Homo sapiens (human)
Definition Homo sapiens platelet factor 4 (PF4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002619

ORF Insert Sequence:

1
61
121
181
241
301
ATGAGCTCCG CAGCCGGGTT CTGCGCCTCA CGCCCCGGGC TGCTGTTCCT GGGGTTGCTG 
CTCCTGCCAC TTGTGGTCGC CTTCGCCAGC GCTGAAGCTG AAGAAGATGG GGACCTGCAG
TGCCTGTGTG TGAAGACCAC CTCCCAGGTC CGTCCCAGGC ACATCACCAG CCTGGAGGTG
ATCAAGGCCG GACCCCACTG CCCCACTGCC CAACTGATAG CCACGCTGAA GAATGGAAGG
AAAATTTGCT TGGACCTGCA AGCCCCGCTG TACAAGAAAA TAATTAAGAA ACTTTTGGAG
AGTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.