The following PGK1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGK1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1254bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||phosphoglycerate kinase 1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC336483.1, BC103752.1 and
This sequence is a reference standard in the RefSeqGene project.
On Apr 18, 2008 this sequence version replaced gi:22095338.
Summary: The protein encoded by this gene is a glycolytic enzyme
that catalyzes the conversion of 1,3-diphosphoglycerate to
3-phosphoglycerate. The encoded protein may also act as a cofactor
for polymerase alpha. Additionally, this protein is secreted by
tumor cells where it participates in angiogenesis by functioning to
reduce disulfide bonds in the serine protease, plasmin, which
consequently leads to the release of the tumor blood vessel
inhibitor angiostatin. The encoded protein has been identified as a
moonlighting protein based on its ability to perform
mechanistically distinct functions. Deficiency of the enzyme is
associated with a wide range of clinical phenotypes hemolytic
anemia and neurological impairment. Pseudogenes of this gene have
been defined on chromosomes 19, 21 and the X chromosome. [provided
by RefSeq, Jan 2014].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
multifunctional gene product(s) :: PMID: 2324090, 11130727
Transcript exon combination :: AB062432.1, BC113568.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.