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SERPINA1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SERPINA1
Entrez Gene ID 5265
Full Name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Synonyms A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT
General protein information
Preferred Names
alpha-1-antitrypsin
Names
alpha-1-antitrypsin
serpin A1
alpha-1-antiproteinase
alpha-1-antitrypsin null
alpha-1 protease inhibitor
protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
serine (or cysteine) proteinase inhibitor, clade A, member 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.1

Summary The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

107400

Disorder Html: Emphysema due to AAT deficiency, 613490 (3); Emphysema-cirrhosis, due





The following SERPINA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SERPINA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22141 NM_000295 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001002235 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001002236 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127700 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127701 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127702 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127703 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127704 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127705 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127706 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00
OHu22141 NM_001127707 Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 11, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu22141
Accession Version NM_000295.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-1-antitrypsin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA966896.1, AK026174.1 and AL132708.3. On May 29, 2008 this sequence version replaced gi:50363216. Summary: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) encodes the same protein as the other ten variants of this gene. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC011991.1, AK026174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000286.3
CDS262..1518
Misc Feature(1)100..102(+)
Misc Feature(2)331..333(+)
Misc Feature(3)424..1497(+)
Misc Feature(4)469..471(+)
Misc Feature(5)580..582(+)
Misc Feature(6)1027..1029(+)
Misc Feature(7)1027..1029(+)
Misc Feature(8)1072..1074(+)
Misc Feature(9)1363..1440(+)
Misc Feature(10)1363..1437(+)
Misc Feature(11)1381..1383(+)
Misc Feature(12)1387..1389(+)
Misc Feature(13)1405..1410(+)
Exon (1)1..257
Gene:SERPINA1
Gene Synonym:
Exon (2)258..907
Gene:SERPINA1
Gene Synonym:
Exon (3)908..1178
Gene:SERPINA1
Gene Synonym:
Exon (4)1179..1326
Gene:SERPINA1
Gene Synonym:
Exon (5)1327..3220
Gene:SERPINA1
Gene Synonym:
Translation
Position Chain Variation Link
39 39 a, g dbSNP:55967149
54 54 c, t dbSNP:55973910
57 57 c, t dbSNP:750446620
66 66 a, g dbSNP:535180537
70 70 a, g dbSNP:567862854
72 72 a, g dbSNP:180723265
74 74 a, g dbSNP:55961721
75 75 c, t dbSNP:767135200
82 82 c, g dbSNP:569970622
86 86 c, t dbSNP:756761971
138 138 a, g dbSNP:551649277
139 139 a, g dbSNP:533409962
149 149 a, g dbSNP:559466012
161 161 c, t dbSNP:369574904
162 162 c, t dbSNP:140228762
164 164 -, c dbSNP:202122479
164 164 c, t dbSNP:551681307
165 165 a, g dbSNP:543596928
211 211 -, c dbSNP:568223361
222 222 c, g dbSNP:576413666
236 236 a, c dbSNP:559873401
238 238 c, t dbSNP:558127432
252 252 c, t dbSNP:11558258
255 255 a, g dbSNP:559054925
257 257 c, t dbSNP:762668988
258 258 a, g dbSNP:374417614
259 259 a, g dbSNP:750207710
260 260 a, c dbSNP:767375374
265 265 c, t dbSNP:757174326
266 266 c, t dbSNP:142288916
267 267 a, g dbSNP:200936638
269 269 a, c dbSNP:759598955
274 274 a, g dbSNP:776904334
278 278 c, t dbSNP:140814100
282 282 g, t dbSNP:370038282
284 284 g, t dbSNP:773588978
285 285 c, t dbSNP:772462774
288 288 c, t dbSNP:11558260
291 291 c, t dbSNP:748608984
295 295 a, c dbSNP:377747242
302 302 g, t dbSNP:768352001
304 304 c, t dbSNP:147283849
312 312 c, t dbSNP:143920236
315 315 c, g, t dbSNP:745679666
316 316 a, g dbSNP:780969205
318 318 c, t dbSNP:535608645
321 321 c, t dbSNP:757152220
325 325 a, t dbSNP:751555333
327 327 c, t dbSNP:764012079
331 331 g, t dbSNP:755088914
332 332 c, t dbSNP:753867893
334 334 a, g dbSNP:766542592
337 337 a, g, t dbSNP:750766974
338 338 a, c dbSNP:199422212
340 340 c, t dbSNP:767986567
341 341 c, t dbSNP:190231439
344 344 a, g dbSNP:11558259
348 348 a, t dbSNP:775041289
361 361 a, c dbSNP:769267062
366 366 a, g dbSNP:762920973
369 369 c, t dbSNP:762571838
370 370 a, g dbSNP:11558262
372 372 a, g dbSNP:775022137
373 373 a, t dbSNP:769331986
374 374 c, t dbSNP:745463238
376 376 a, c dbSNP:138070585
380 380 a, g dbSNP:186478039
381 381 c, t dbSNP:368917367
390 390 a, c, t dbSNP:752646694
395 395 c, t dbSNP:758293405
400 400 c, t dbSNP:764792979
419 419 a, g dbSNP:758914650
420 420 -, cct dbSNP:747300627
421 421 c, t dbSNP:374810982
424 424 c, g dbSNP:753921311
432 432 c, t dbSNP:150784949
433 433 a, g, t dbSNP:149319176
434 434 c, g dbSNP:770667932
439 439 a, g dbSNP:767606257
447 447 a, c dbSNP:762321137
448 448 c, t dbSNP:28931570
449 449 a, g dbSNP:764726147
452 452 a, g dbSNP:763483402
455 455 c, t dbSNP:28931569
458 458 c, t dbSNP:769400992
462 462 c, g dbSNP:140744031
467 467 c, t dbSNP:199687431
472 472 a, c dbSNP:11575873
485 485 c, t dbSNP:369966794
488 488 -, tct dbSNP:775982338
491 491 c, t dbSNP:55819880
492 492 c, t dbSNP:746839619
500 500 a, g dbSNP:777478364
505 505 a, g dbSNP:113817720
511 511 a, g dbSNP:111850950
530 530 g, t dbSNP:564267551
533 533 a, g dbSNP:28931568
534 534 c, g dbSNP:756260997
546 546 a, c dbSNP:199962756
547 547 a, g dbSNP:376616935
552 552 c, t dbSNP:781502220
574 574 a, g dbSNP:757510628
583 583 c, g dbSNP:779344345
584 584 g, t dbSNP:137888162
587 587 c, t dbSNP:199422213
588 588 a, g dbSNP:764493280
596 596 c, t dbSNP:758820515
597 597 a, g dbSNP:753313462
598 598 a, g dbSNP:765628480
607 607 a, g dbSNP:769217078
608 608 a, t dbSNP:28931572
609 609 c, g dbSNP:759135389
617 617 c, g dbSNP:749295615
627 627 a, g dbSNP:199725228
634 634 c, t dbSNP:766025736
635 635 a, g dbSNP:709932
639 639 c, t dbSNP:772839968
642 642 c, t dbSNP:372438611
646 646 a, c dbSNP:756311065
653 653 a, c dbSNP:747867823
662 662 c, t dbSNP:774398845
671 671 c, g dbSNP:768432782
675 675 c, t dbSNP:541545839
676 676 a, g dbSNP:11558261
677 677 c, g dbSNP:757562207
681 681 c, t dbSNP:750688252
684 684 c, t dbSNP:368415110
685 685 c, t dbSNP:20546
687 687 a, g dbSNP:758835662
690 690 c, g dbSNP:752979989
691 691 c, t dbSNP:374198121
696 696 a, c dbSNP:11558263
697 697 a, g dbSNP:537285845
708 708 a, g dbSNP:373851357
711 711 a, g dbSNP:146596574
712 712 c, g dbSNP:760175391
716 716 a, g dbSNP:772895093
718 718 a, g dbSNP:369060615
721 721 c, t dbSNP:576575224
724 724 c, t dbSNP:773981008
725 725 -, t dbSNP:772420922
727 727 a, g, t dbSNP:78640395
731 731 a, g dbSNP:749118243
733 733 g, t dbSNP:775552836
738 738 a, g dbSNP:771199057
758 758 a, c dbSNP:142942004
763 763 a, g dbSNP:747053324
771 771 c, g dbSNP:778188056
774 774 c, t dbSNP:190838132
775 775 a, g, t dbSNP:112030253
783 783 c, t dbSNP:72552402
784 784 a, g dbSNP:149770048
786 786 a, g dbSNP:201400592
795 795 a, g dbSNP:573136666
807 807 c, t dbSNP:113813309
808 808 a, g dbSNP:759578830
813 813 a, c, g, t dbSNP:199422210
813 813 -, c dbSNP:267606950
814 814 a, g dbSNP:147247134
821 821 a, c dbSNP:762801939
823 823 a, g dbSNP:775606044
825 825 a, t dbSNP:769830846
834 834 a, g dbSNP:200414579
848 848 c, t dbSNP:368433503
853 853 a, g dbSNP:766034720
858 858 g, t dbSNP:748377295
861 861 c, t dbSNP:779194062
862 862 a, g dbSNP:760372645
866 866 a, g dbSNP:768943640
874 874 a, g dbSNP:749634278
886 886 c, g dbSNP:780562960
888 888 a, g dbSNP:756577084
895 895 a, g dbSNP:749944428
906 906 a, g dbSNP:780506538
907 907 g, t dbSNP:756773408
909 909 a, c dbSNP:754816836
910 910 a, t dbSNP:387906573
911 911 a, c dbSNP:11558265
920 920 g, t dbSNP:11558257
923 923 a, c dbSNP:368117781
924 924 c, t dbSNP:1140397
934 934 a, c dbSNP:11558264
942 942 c, t dbSNP:766320203
943 943 a, g dbSNP:199422208
945 945 a, g dbSNP:774452372
954 954 a, c dbSNP:145410420
958 958 a, c dbSNP:763108861
960 960 c, t dbSNP:775672099
961 961 a, g dbSNP:374168370
962 962 a, t dbSNP:746197812
966 966 a, c dbSNP:777051992
967 967 a, c dbSNP:771419213
968 968 a, g dbSNP:746531546
971 971 c, t dbSNP:6647
974 974 c, t dbSNP:758136730
978 978 c, t dbSNP:200634040
979 979 a, g dbSNP:72552401
982 982 a, t dbSNP:199422211
986 986 c, t dbSNP:753621457
995 995 c, t dbSNP:766260108
1000 1000 a, c, t dbSNP:28929470
1001 1001 a, g dbSNP:544632177
1006 1006 c, g dbSNP:764220898
1007 1007 c, g dbSNP:577164283
1008 1008 c, t dbSNP:775725332
1009 1009 a, g dbSNP:765419872
1013 1013 g, t dbSNP:759837735
1015 1015 a, t dbSNP:777012321
1018 1018 a, c dbSNP:575123943
1020 1020 c, t dbSNP:761185661
1021 1021 c, t dbSNP:764431473
1023 1023 a, c, g dbSNP:763249215
1029 1029 g, t dbSNP:8350
1030 1030 a, g dbSNP:753068726
1032 1032 g, t dbSNP:376294932
1035 1035 a, g dbSNP:34112109
1043 1043 g, t dbSNP:778732023
1054 1054 c, t dbSNP:768386476
1056 1056 a, g dbSNP:749044003
1058 1058 c, t dbSNP:779843923
1072 1072 a, g dbSNP:755851961
1080 1080 c, g, t dbSNP:2230075
1081 1081 a, g, t dbSNP:752721615
1083 1083 c, t dbSNP:765473272
1096 1096 a, c dbSNP:759736224
1100 1100 a, t dbSNP:121912714
1101 1101 c, t dbSNP:1049800
1102 1102 a, g dbSNP:760917668
1105 1105 a, g dbSNP:370923940
1107 1107 g, t dbSNP:772659184
1111 1111 c, t dbSNP:761442554
1113 1113 a, g dbSNP:771082081
1117 1117 c, t dbSNP:149537225
1124 1124 a, t dbSNP:17580
1126 1126 a, c dbSNP:749030711
1134 1134 c, t dbSNP:779573811
1135 1135 a, g dbSNP:769666780
1136 1136 c, t dbSNP:745624643
1140 1140 a, c, t dbSNP:141095970
1141 1141 a, g dbSNP:772436715
1151 1151 a, c dbSNP:752776707
1156 1156 c, t dbSNP:778905943
1160 1160 c, g, t dbSNP:550592374
1161 1161 a, g dbSNP:538675821
1166 1166 a, t dbSNP:377668175
1168 1168 g, t dbSNP:1802963
1171 1171 a, g dbSNP:749021630
1176 1176 -, aag dbSNP:748777702
1179 1179 a, g dbSNP:759132932
1182 1182 c, t dbSNP:776253560
1183 1183 g, t dbSNP:141620200
1185 1185 c, t dbSNP:138611390
1187 1187 a, g dbSNP:773222881
1192 1192 c, t dbSNP:771862730
1197 1197 a, t dbSNP:749389616
1198 1198 c, t dbSNP:779938258
1207 1207 a, t dbSNP:756246391
1209 1209 -, c dbSNP:35624994
1219 1219 a, g dbSNP:746155701
1223 1223 a, g dbSNP:774775536
1225 1225 g, t dbSNP:55704149
1227 1227 a, c, t dbSNP:190881649
1228 1228 c, t dbSNP:150455534
1230 1230 c, g dbSNP:186393785
1233 1233 a, g dbSNP:375097829
1234 1234 a, t dbSNP:1802962
1236 1236 c, t dbSNP:764238790
1237 1237 a, g dbSNP:139964603
1239 1239 c, t dbSNP:752267053
1244 1244 c, g dbSNP:369788393
1252 1252 a, c, g dbSNP:569455355
1260 1260 c, t dbSNP:181491831
1264 1264 a, g dbSNP:190061930
1275 1275 c, t dbSNP:371761828
1276 1276 g, t dbSNP:765966782
1277 1277 a, g dbSNP:186298255
1282 1282 a, g dbSNP:28929471
1290 1290 c, t dbSNP:760494093
1291 1291 a, g dbSNP:367797069
1292 1292 g, t dbSNP:772059003
1294 1294 g, t dbSNP:761711628
1306 1306 c, g dbSNP:376024688
1309 1309 c, t dbSNP:377739083
1310 1310 c, t dbSNP:770030839
1313 1313 -, t dbSNP:72555374
1322 1322 c, t dbSNP:201788603
1329 1329 c, t dbSNP:9630
1330 1330 a, g dbSNP:373630097
1332 1332 c, g dbSNP:10427
1336 1336 a, g dbSNP:200945035
1339 1339 a, c, g dbSNP:1802959
1340 1340 a, c dbSNP:762930016
1342 1342 -, g dbSNP:72555357
1343 1343 c, g, t dbSNP:1131139
1344 1344 a, g dbSNP:13868
1345 1345 a, c dbSNP:1131154
1347 1347 a, g, t dbSNP:1802961
1350 1350 c, g dbSNP:1050469
1351 1351 a, g dbSNP:201318727
1353 1353 a, c, g, t dbSNP:772289957
1354 1354 a, c, g dbSNP:143370956
1356 1356 c, g, t dbSNP:201774333
1357 1357 a, g dbSNP:28929474
1361 1361 a, c dbSNP:755625134
1362 1362 a, g dbSNP:1050520
1364 1364 a, g dbSNP:551595739
1368 1368 c, t dbSNP:533419579
1369 1369 a, g dbSNP:756871122
1371 1371 -, aaca dbSNP:754737768
1372 1372 -, gctgc dbSNP:751343534
1377 1377 a, t dbSNP:751415975
1378 1378 a, g, t dbSNP:12077
1380 1380 a, g dbSNP:376061125
1381 1381 a, g dbSNP:752723808
1384 1384 a, c dbSNP:765199959
1387 1387 a, t dbSNP:751696406
1391 1391 -, t dbSNP:766291631
1391 1391 -, t dbSNP:763023697
1392 1392 a, t dbSNP:28929473
1395 1395 a, g dbSNP:148362959
1396 1396 a, g dbSNP:773275051
1406 1406 g, t dbSNP:121912713
1407 1407 a, g dbSNP:372140596
1408 1408 g, t dbSNP:762151808
1413 1413 c, t dbSNP:764340766
1416 1416 c, t dbSNP:774551181
1417 1417 a, c, g, t dbSNP:12233
1418 1418 c, t dbSNP:569384943
1419 1419 -, c dbSNP:764325655
1419 1419 -, c dbSNP:776846218
1419 1419 c, t dbSNP:143329723
1420 1420 a, g dbSNP:121912712
1438 1438 c, t dbSNP:61761869
1439 1439 a, c, t dbSNP:199422209
1440 1440 c, t dbSNP:746728426
1449 1449 c, t dbSNP:13170
1456 1456 a, g dbSNP:139972630
1457 1457 c, t dbSNP:777537335
1461 1461 a, c dbSNP:1303
1462 1462 a, c dbSNP:17850837
1467 1467 c, t dbSNP:766128806
1469 1469 c, g dbSNP:778747339
1472 1472 a, g dbSNP:754885222
1477 1477 a, c dbSNP:753705146
1482 1482 c, t dbSNP:767700105
1486 1486 a, g dbSNP:149800596
1498 1498 -, gtg dbSNP:760849035
1507 1507 a, c dbSNP:3191200
1511 1511 a, t dbSNP:200467663
1512 1512 a, g dbSNP:760604419
1517 1517 a, g dbSNP:764249468
1519 1519 c, t dbSNP:72547410
1521 1521 g, t dbSNP:1802960
1522 1522 c, t dbSNP:773192775
1523 1523 -, ctctcgctcc dbSNP:775785700
1525 1525 c, g, t dbSNP:3191219
1527 1527 c, t dbSNP:775768234
1528 1528 a, g dbSNP:747590096
1532 1532 c, t dbSNP:760149475
1536 1536 a, g dbSNP:371674306
1537 1537 c, t dbSNP:770516093
1539 1539 a, c dbSNP:746497525
1552 1552 c, t dbSNP:368409403
1553 1553 c, t dbSNP:771810584
1561 1561 -, c dbSNP:772212056
1561 1561 c, t dbSNP:747969292
1562 1562 c, t dbSNP:778825545
1568 1568 a, g dbSNP:768301490
1595 1595 a, t dbSNP:111611589
1596 1596 a, c dbSNP:113201712
1598 1598 c, t dbSNP:1243163
1694 1694 c, t dbSNP:375619801
1700 1700 a, c dbSNP:138518740
1715 1715 a, t dbSNP:541257510
1719 1719 a, g dbSNP:574176097
1742 1742 a, g dbSNP:2073333
1759 1759 c, g dbSNP:111978668
1781 1781 c, t dbSNP:753776140
1809 1809 g, t dbSNP:770346644
1834 1834 g, t dbSNP:1243164
1844 1844 a, g dbSNP:7144409
1866 1866 c, t dbSNP:112143645
1889 1889 g, t dbSNP:539955367
1931 1931 a, c dbSNP:566212080
1935 1935 a, c dbSNP:547889258
1937 1937 a, c dbSNP:529148469
1938 1938 -, a dbSNP:532237180
1953 1953 c, t dbSNP:568235941
1976 1976 a, t dbSNP:147041519
1997 1997 a, g dbSNP:7142803
1998 1998 a, g dbSNP:147905225
1999 1999 a, g dbSNP:1243165
2000 2000 c, t dbSNP:757874806
2018 2018 a, g dbSNP:111349695
2023 2023 a, g dbSNP:559864059
2084 2084 c, t dbSNP:45538932
2085 2085 c, t dbSNP:541516970
2086 2086 a, g dbSNP:140980287
2087 2087 a, c dbSNP:574344564
2171 2171 c, t dbSNP:370477090
2174 2174 c, t dbSNP:370359507
2176 2176 g, t dbSNP:550067693
2196 2196 c, t dbSNP:151205402
2210 2210 -, c dbSNP:113934719
2211 2211 -, c dbSNP:538852248
2214 2214 c, t dbSNP:777765085
2215 2215 a, g dbSNP:554660748
2238 2238 c, t dbSNP:543782194
2259 2259 c, t dbSNP:142149216
2282 2282 a, g dbSNP:558473967
2297 2297 c, t dbSNP:539869030
2302 2302 a, g dbSNP:566075265
2307 2307 c, t dbSNP:193052802
2310 2310 c, t dbSNP:139984116
2343 2343 a, g dbSNP:752931014
2371 2371 c, t dbSNP:188391982
2372 2372 c, t dbSNP:1051052
2412 2412 c, t dbSNP:531520334
2435 2435 a, g dbSNP:560007661
2457 2457 c, t dbSNP:556761230
2464 2464 c, t dbSNP:184719827
2465 2465 c, g dbSNP:527388016
2466 2466 a, g dbSNP:192683802
2486 2486 c, t dbSNP:1243166
2496 2496 a, g dbSNP:761761325
2499 2499 a, t dbSNP:541533553
2513 2513 a, g dbSNP:559680950
2537 2537 c, t dbSNP:146502831
2540 2540 c, t dbSNP:571151263
2560 2560 c, t dbSNP:529769859
2565 2565 c, t dbSNP:376326793
2572 2572 a, g dbSNP:562161103
2574 2574 c, t dbSNP:143994738
2584 2584 c, g dbSNP:576539120
2585 2585 a, g dbSNP:11628917
2627 2627 a, t dbSNP:773885714
2659 2659 a, g dbSNP:139136785
2689 2689 a, g dbSNP:572480272
2690 2690 c, g dbSNP:777299970
2691 2691 c, t dbSNP:554160611
2712 2712 a, c dbSNP:377711852
2723 2723 a, g dbSNP:574840088
2735 2735 c, t dbSNP:568321968
2739 2739 a, g dbSNP:11832
2747 2747 c, t dbSNP:538093703
2749 2749 c, t dbSNP:570305752
2805 2805 a, g dbSNP:9944155
2810 2810 c, t dbSNP:78367974
2849 2849 a, c, g dbSNP:11568814
2862 2862 a, g dbSNP:372207184
2864 2864 c, t dbSNP:149278583
2905 2905 a, g dbSNP:746198853
2932 2932 a, g dbSNP:139506803
2958 2958 a, c dbSNP:369233057
2973 2973 a, g dbSNP:550400230
3012 3012 a, t dbSNP:781709902
3057 3057 c, t dbSNP:771546663
3058 3058 a, t dbSNP:747510751
3073 3073 c, t dbSNP:56325294
3082 3082 c, t dbSNP:777905452
3085 3085 c, g, t dbSNP:79555504
3086 3086 g, t dbSNP:555062772
3094 3094 a, g dbSNP:758466620
3134 3134 a, g dbSNP:187187152
3146 3146 a, g dbSNP:746099389
3150 3150 a, g dbSNP:752837451
3167 3167 a, g dbSNP:182137190
3182 3182 c, t dbSNP:560493769
3201 3201 a, g dbSNP:779038848
3219 3219 c, t dbSNP:755223577

Target ORF information:

RefSeq Version NM_000295
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000295

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22141
Accession Version NM_001002235.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-1-antitrypsin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA428299.1, BX161449.1 and AL132708.3. On May 29, 2008 this sequence version replaced gi:50363220. Summary: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All eleven variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX161449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001002235.1
CDS241..1497
Misc Feature(1)220..222(+)
Misc Feature(2)310..312(+)
Misc Feature(3)403..1476(+)
Misc Feature(4)448..450(+)
Misc Feature(5)559..561(+)
Misc Feature(6)1006..1008(+)
Misc Feature(7)1006..1008(+)
Misc Feature(8)1051..1053(+)
Misc Feature(9)1342..1419(+)
Misc Feature(10)1342..1416(+)
Misc Feature(11)1366..1368(+)
Misc Feature(12)1384..1389(+)
Exon (1)1..236
Gene:SERPINA1
Gene Synonym:
Exon (2)237..886
Gene:SERPINA1
Gene Synonym:
Exon (3)887..1157
Gene:SERPINA1
Gene Synonym:
Exon (4)1158..1305
Gene:SERPINA1
Gene Synonym:
Exon (5)1306..3199
Gene:SERPINA1
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, g dbSNP:8008743
46 46 a, g dbSNP:372703551
47 47 c, t dbSNP:571103038
80 80 a, g dbSNP:74500081
115 115 cc, tt dbSNP:386780186
115 115 c, t dbSNP:546604090
116 116 c, t dbSNP:8004738
146 146 a, g dbSNP:56367058
194 194 a, g dbSNP:548934735
232 232 a, g dbSNP:78070723
237 237 a, g dbSNP:374417614
238 238 a, g dbSNP:750207710
239 239 a, c dbSNP:767375374
244 244 c, t dbSNP:757174326
245 245 c, t dbSNP:142288916
246 246 a, g dbSNP:200936638
248 248 a, c dbSNP:759598955
253 253 a, g dbSNP:776904334
257 257 c, t dbSNP:140814100
261 261 g, t dbSNP:370038282
263 263 g, t dbSNP:773588978
264 264 c, t dbSNP:772462774
267 267 c, t dbSNP:11558260
270 270 c, t dbSNP:748608984
274 274 a, c dbSNP:377747242
281 281 g, t dbSNP:768352001
283 283 c, t dbSNP:147283849
291 291 c, t dbSNP:143920236
294 294 c, g, t dbSNP:745679666
295 295 a, g dbSNP:780969205
297 297 c, t dbSNP:535608645
300 300 c, t dbSNP:757152220
304 304 a, t dbSNP:751555333
306 306 c, t dbSNP:764012079
310 310 g, t dbSNP:755088914
311 311 c, t dbSNP:753867893
313 313 a, g dbSNP:766542592
316 316 a, g, t dbSNP:750766974
317 317 a, c dbSNP:199422212
319 319 c, t dbSNP:767986567
320 320 c, t dbSNP:190231439
323 323 a, g dbSNP:11558259
327 327 a, t dbSNP:775041289
340 340 a, c dbSNP:769267062
345 345 a, g dbSNP:762920973
348 348 c, t dbSNP:762571838
349 349 a, g dbSNP:11558262
351 351 a, g dbSNP:775022137
352 352 a, t dbSNP:769331986
353 353 c, t dbSNP:745463238
355 355 a, c dbSNP:138070585
359 359 a, g dbSNP:186478039
360 360 c, t dbSNP:368917367
369 369 a, c, t dbSNP:752646694
374 374 c, t dbSNP:758293405
379 379 c, t dbSNP:764792979
398 398 a, g dbSNP:758914650
399 399 -, cct dbSNP:747300627
400 400 c, t dbSNP:374810982
403 403 c, g dbSNP:753921311
411 411 c, t dbSNP:150784949
412 412 a, g, t dbSNP:149319176
413 413 c, g dbSNP:770667932
418 418 a, g dbSNP:767606257
426 426 a, c dbSNP:762321137
427 427 c, t dbSNP:28931570
428 428 a, g dbSNP:764726147
431 431 a, g dbSNP:763483402
434 434 c, t dbSNP:28931569
437 437 c, t dbSNP:769400992
441 441 c, g dbSNP:140744031
446 446 c, t dbSNP:199687431
451 451 a, c dbSNP:11575873
464 464 c, t dbSNP:369966794
467 467 -, tct dbSNP:775982338
470 470 c, t dbSNP:55819880
471 471 c, t dbSNP:746839619
479 479 a, g dbSNP:777478364
484 484 a, g dbSNP:113817720
490 490 a, g dbSNP:111850950
509 509 g, t dbSNP:564267551
512 512 a, g dbSNP:28931568
513 513 c, g dbSNP:756260997
525 525 a, c dbSNP:199962756
526 526 a, g dbSNP:376616935
531 531 c, t dbSNP:781502220
553 553 a, g dbSNP:757510628
562 562 c, g dbSNP:779344345
563 563 g, t dbSNP:137888162
566 566 c, t dbSNP:199422213
567 567 a, g dbSNP:764493280
575 575 c, t dbSNP:758820515
576 576 a, g dbSNP:753313462
577 577 a, g dbSNP:765628480
586 586 a, g dbSNP:769217078
587 587 a, t dbSNP:28931572
588 588 c, g dbSNP:759135389
596 596 c, g dbSNP:749295615
606 606 a, g dbSNP:199725228
613 613 c, t dbSNP:766025736
614 614 a, g dbSNP:709932
618 618 c, t dbSNP:772839968
621 621 c, t dbSNP:372438611
625 625 a, c dbSNP:756311065
632 632 a, c dbSNP:747867823
641 641 c, t dbSNP:774398845
650 650 c, g dbSNP:768432782
654 654 c, t dbSNP:541545839
655 655 a, g dbSNP:11558261
656 656 c, g dbSNP:757562207
660 660 c, t dbSNP:750688252
663 663 c, t dbSNP:368415110
664 664 c, t dbSNP:20546
666 666 a, g dbSNP:758835662
669 669 c, g dbSNP:752979989
670 670 c, t dbSNP:374198121
675 675 a, c dbSNP:11558263
676 676 a, g dbSNP:537285845
687 687 a, g dbSNP:373851357
690 690 a, g dbSNP:146596574
691 691 c, g dbSNP:760175391
695 695 a, g dbSNP:772895093
697 697 a, g dbSNP:369060615
700 700 c, t dbSNP:576575224
703 703 c, t dbSNP:773981008
704 704 -, t dbSNP:772420922
706 706 a, g, t dbSNP:78640395
710 710 a, g dbSNP:749118243
712 712 g, t dbSNP:775552836
717 717 a, g dbSNP:771199057
737 737 a, c dbSNP:142942004
742 742 a, g dbSNP:747053324
750 750 c, g dbSNP:778188056
753 753 c, t dbSNP:190838132
754 754 a, g, t dbSNP:112030253
762 762 c, t dbSNP:72552402
763 763 a, g dbSNP:149770048
765 765 a, g dbSNP:201400592
774 774 a, g dbSNP:573136666
786 786 c, t dbSNP:113813309
787 787 a, g dbSNP:759578830
792 792 a, c, g, t dbSNP:199422210
792 792 -, c dbSNP:267606950
793 793 a, g dbSNP:147247134
800 800 a, c dbSNP:762801939
802 802 a, g dbSNP:775606044
804 804 a, t dbSNP:769830846
813 813 a, g dbSNP:200414579
827 827 c, t dbSNP:368433503
832 832 a, g dbSNP:766034720
837 837 g, t dbSNP:748377295
840 840 c, t dbSNP:779194062
841 841 a, g dbSNP:760372645
845 845 a, g dbSNP:768943640
853 853 a, g dbSNP:749634278
865 865 c, g dbSNP:780562960
867 867 a, g dbSNP:756577084
874 874 a, g dbSNP:749944428
885 885 a, g dbSNP:780506538
886 886 g, t dbSNP:756773408
888 888 a, c dbSNP:754816836
889 889 a, t dbSNP:387906573
890 890 a, c dbSNP:11558265
899 899 g, t dbSNP:11558257
902 902 a, c dbSNP:368117781
903 903 c, t dbSNP:1140397
913 913 a, c dbSNP:11558264
921 921 c, t dbSNP:766320203
922 922 a, g dbSNP:199422208
924 924 a, g dbSNP:774452372
933 933 a, c dbSNP:145410420
937 937 a, c dbSNP:763108861
939 939 c, t dbSNP:775672099
940 940 a, g dbSNP:374168370
941 941 a, t dbSNP:746197812
945 945 a, c dbSNP:777051992
946 946 a, c dbSNP:771419213
947 947 a, g dbSNP:746531546
950 950 c, t dbSNP:6647
953 953 c, t dbSNP:758136730
957 957 c, t dbSNP:200634040
958 958 a, g dbSNP:72552401
961 961 a, t dbSNP:199422211
965 965 c, t dbSNP:753621457
974 974 c, t dbSNP:766260108
979 979 a, c, t dbSNP:28929470
980 980 a, g dbSNP:544632177
985 985 c, g dbSNP:764220898
986 986 c, g dbSNP:577164283
987 987 c, t dbSNP:775725332
988 988 a, g dbSNP:765419872
992 992 g, t dbSNP:759837735
994 994 a, t dbSNP:777012321
997 997 a, c dbSNP:575123943
999 999 c, t dbSNP:761185661
1000 1000 c, t dbSNP:764431473
1002 1002 a, c, g dbSNP:763249215
1008 1008 g, t dbSNP:8350
1009 1009 a, g dbSNP:753068726
1011 1011 g, t dbSNP:376294932
1014 1014 a, g dbSNP:34112109
1022 1022 g, t dbSNP:778732023
1033 1033 c, t dbSNP:768386476
1035 1035 a, g dbSNP:749044003
1037 1037 c, t dbSNP:779843923
1051 1051 a, g dbSNP:755851961
1059 1059 c, g, t dbSNP:2230075
1060 1060 a, g, t dbSNP:752721615
1062 1062 c, t dbSNP:765473272
1075 1075 a, c dbSNP:759736224
1079 1079 a, t dbSNP:121912714
1080 1080 c, t dbSNP:1049800
1081 1081 a, g dbSNP:760917668
1084 1084 a, g dbSNP:370923940
1086 1086 g, t dbSNP:772659184
1090 1090 c, t dbSNP:761442554
1092 1092 a, g dbSNP:771082081
1096 1096 c, t dbSNP:149537225
1103 1103 a, t dbSNP:17580
1105 1105 a, c dbSNP:749030711
1113 1113 c, t dbSNP:779573811
1114 1114 a, g dbSNP:769666780
1115 1115 c, t dbSNP:745624643
1119 1119 a, c, t dbSNP:141095970
1120 1120 a, g dbSNP:772436715
1130 1130 a, c dbSNP:752776707
1135 1135 c, t dbSNP:778905943
1139 1139 c, g, t dbSNP:550592374
1140 1140 a, g dbSNP:538675821
1145 1145 a, t dbSNP:377668175
1147 1147 g, t dbSNP:1802963
1150 1150 a, g dbSNP:749021630
1155 1155 -, aag dbSNP:748777702
1158 1158 a, g dbSNP:759132932
1161 1161 c, t dbSNP:776253560
1162 1162 g, t dbSNP:141620200
1164 1164 c, t dbSNP:138611390
1166 1166 a, g dbSNP:773222881
1171 1171 c, t dbSNP:771862730
1176 1176 a, t dbSNP:749389616
1177 1177 c, t dbSNP:779938258
1186 1186 a, t dbSNP:756246391
1188 1188 -, c dbSNP:35624994
1198 1198 a, g dbSNP:746155701
1202 1202 a, g dbSNP:774775536
1204 1204 g, t dbSNP:55704149
1206 1206 a, c, t dbSNP:190881649
1207 1207 c, t dbSNP:150455534
1209 1209 c, g dbSNP:186393785
1212 1212 a, g dbSNP:375097829
1213 1213 a, t dbSNP:1802962
1215 1215 c, t dbSNP:764238790
1216 1216 a, g dbSNP:139964603
1218 1218 c, t dbSNP:752267053
1223 1223 c, g dbSNP:369788393
1231 1231 a, c, g dbSNP:569455355
1239 1239 c, t dbSNP:181491831
1243 1243 a, g dbSNP:190061930
1254 1254 c, t dbSNP:371761828
1255 1255 g, t dbSNP:765966782
1256 1256 a, g dbSNP:186298255
1261 1261 a, g dbSNP:28929471
1269 1269 c, t dbSNP:760494093
1270 1270 a, g dbSNP:367797069
1271 1271 g, t dbSNP:772059003
1273 1273 g, t dbSNP:761711628
1285 1285 c, g dbSNP:376024688
1288 1288 c, t dbSNP:377739083
1289 1289 c, t dbSNP:770030839
1292 1292 -, t dbSNP:72555374
1301 1301 c, t dbSNP:201788603
1308 1308 c, t dbSNP:9630
1309 1309 a, g dbSNP:373630097
1311 1311 c, g dbSNP:10427
1315 1315 a, g dbSNP:200945035
1318 1318 a, c, g dbSNP:1802959
1319 1319 a, c dbSNP:762930016
1321 1321 -, g dbSNP:72555357
1322 1322 c, g, t dbSNP:1131139
1323 1323 a, g dbSNP:13868
1324 1324 a, c dbSNP:1131154
1326 1326 a, g, t dbSNP:1802961
1329 1329 c, g dbSNP:1050469
1330 1330 a, g dbSNP:201318727
1332 1332 a, c, g, t dbSNP:772289957
1333 1333 a, c, g dbSNP:143370956
1335 1335 c, g, t dbSNP:201774333
1336 1336 a, g dbSNP:28929474
1340 1340 a, c dbSNP:755625134
1341 1341 a, g dbSNP:1050520
1343 1343 a, g dbSNP:551595739
1347 1347 c, t dbSNP:533419579
1348 1348 a, g dbSNP:756871122
1350 1350 -, aaca dbSNP:754737768
1351 1351 -, gctgc dbSNP:751343534
1356 1356 a, t dbSNP:751415975
1357 1357 a, g, t dbSNP:12077
1359 1359 a, g dbSNP:376061125
1360 1360 a, g dbSNP:752723808
1363 1363 a, c dbSNP:765199959
1366 1366 a, t dbSNP:751696406
1370 1370 -, t dbSNP:766291631
1370 1370 -, t dbSNP:763023697
1371 1371 a, t dbSNP:28929473
1374 1374 a, g dbSNP:148362959
1375 1375 a, g dbSNP:773275051
1385 1385 g, t dbSNP:121912713
1386 1386 a, g dbSNP:372140596
1387 1387 g, t dbSNP:762151808
1392 1392 c, t dbSNP:764340766
1395 1395 c, t dbSNP:774551181
1396 1396 a, c, g, t dbSNP:12233
1397 1397 c, t dbSNP:569384943
1398 1398 -, c dbSNP:764325655
1398 1398 -, c dbSNP:776846218
1398 1398 c, t dbSNP:143329723
1399 1399 a, g dbSNP:121912712
1417 1417 c, t dbSNP:61761869
1418 1418 a, c, t dbSNP:199422209
1419 1419 c, t dbSNP:746728426
1428 1428 c, t dbSNP:13170
1435 1435 a, g dbSNP:139972630
1436 1436 c, t dbSNP:777537335
1440 1440 a, c dbSNP:1303
1441 1441 a, c dbSNP:17850837
1446 1446 c, t dbSNP:766128806
1448 1448 c, g dbSNP:778747339
1451 1451 a, g dbSNP:754885222
1456 1456 a, c dbSNP:753705146
1461 1461 c, t dbSNP:767700105
1465 1465 a, g dbSNP:149800596
1477 1477 -, gtg dbSNP:760849035
1486 1486 a, c dbSNP:3191200
1490 1490 a, t dbSNP:200467663
1491 1491 a, g dbSNP:760604419
1496 1496 a, g dbSNP:764249468
1498 1498 c, t dbSNP:72547410
1500 1500 g, t dbSNP:1802960
1501 1501 c, t dbSNP:773192775
1502 1502 -, ctctcgctcc dbSNP:775785700
1504 1504 c, g, t dbSNP:3191219
1506 1506 c, t dbSNP:775768234
1507 1507 a, g dbSNP:747590096
1511 1511 c, t dbSNP:760149475
1515 1515 a, g dbSNP:371674306
1516 1516 c, t dbSNP:770516093
1518 1518 a, c dbSNP:746497525
1531 1531 c, t dbSNP:368409403
1532 1532 c, t dbSNP:771810584
1540 1540 -, c dbSNP:772212056
1540 1540 c, t dbSNP:747969292
1541 1541 c, t dbSNP:778825545
1547 1547 a, g dbSNP:768301490
1574 1574 a, t dbSNP:111611589
1575 1575 a, c dbSNP:113201712
1577 1577 c, t dbSNP:1243163
1673 1673 c, t dbSNP:375619801
1679 1679 a, c dbSNP:138518740
1694 1694 a, t dbSNP:541257510
1698 1698 a, g dbSNP:574176097
1721 1721 a, g dbSNP:2073333
1738 1738 c, g dbSNP:111978668
1760 1760 c, t dbSNP:753776140
1788 1788 g, t dbSNP:770346644
1813 1813 g, t dbSNP:1243164
1823 1823 a, g dbSNP:7144409
1845 1845 c, t dbSNP:112143645
1868 1868 g, t dbSNP:539955367
1910 1910 a, c dbSNP:566212080
1914 1914 a, c dbSNP:547889258
1916 1916 a, c dbSNP:529148469
1917 1917 -, a dbSNP:532237180
1932 1932 c, t dbSNP:568235941
1955 1955 a, t dbSNP:147041519
1976 1976 a, g dbSNP:7142803
1977 1977 a, g dbSNP:147905225
1978 1978 a, g dbSNP:1243165
1979 1979 c, t dbSNP:757874806
1997 1997 a, g dbSNP:111349695
2002 2002 a, g dbSNP:559864059
2063 2063 c, t dbSNP:45538932
2064 2064 c, t dbSNP:541516970
2065 2065 a, g dbSNP:140980287
2066 2066 a, c dbSNP:574344564
2150 2150 c, t dbSNP:370477090
2153 2153 c, t dbSNP:370359507
2155 2155 g, t dbSNP:550067693
2175 2175 c, t dbSNP:151205402
2189 2189 -, c dbSNP:113934719
2190 2190 -, c dbSNP:538852248
2193 2193 c, t dbSNP:777765085
2194 2194 a, g dbSNP:554660748
2217 2217 c, t dbSNP:543782194
2238 2238 c, t dbSNP:142149216
2261 2261 a, g dbSNP:558473967
2276 2276 c, t dbSNP:539869030
2281 2281 a, g dbSNP:566075265
2286 2286 c, t dbSNP:193052802
2289 2289 c, t dbSNP:139984116
2322 2322 a, g dbSNP:752931014
2350 2350 c, t dbSNP:188391982
2351 2351 c, t dbSNP:1051052
2391 2391 c, t dbSNP:531520334
2414 2414 a, g dbSNP:560007661
2436 2436 c, t dbSNP:556761230
2443 2443 c, t dbSNP:184719827
2444 2444 c, g dbSNP:527388016
2445 2445 a, g dbSNP:192683802
2465 2465 c, t dbSNP:1243166
2475 2475 a, g dbSNP:761761325
2478 2478 a, t dbSNP:541533553
2492 2492 a, g dbSNP:559680950
2516 2516 c, t dbSNP:146502831
2519 2519 c, t dbSNP:571151263
2539 2539 c, t dbSNP:529769859
2544 2544 c, t dbSNP:376326793
2551 2551 a, g dbSNP:562161103
2553 2553 c, t dbSNP:143994738
2563 2563 c, g dbSNP:576539120
2564 2564 a, g dbSNP:11628917
2606 2606 a, t dbSNP:773885714
2638 2638 a, g dbSNP:139136785
2668 2668 a, g dbSNP:572480272
2669 2669 c, g dbSNP:777299970
2670 2670 c, t dbSNP:554160611
2691 2691 a, c dbSNP:377711852
2702 2702 a, g dbSNP:574840088
2714 2714 c, t dbSNP:568321968
2718 2718 a, g dbSNP:11832
2726 2726 c, t dbSNP:538093703
2728 2728 c, t dbSNP:570305752
2784 2784 a, g dbSNP:9944155
2789 2789 c, t dbSNP:78367974
2828 2828 a, c, g dbSNP:11568814
2841 2841 a, g dbSNP:372207184
2843 2843 c, t dbSNP:149278583
2884 2884 a, g dbSNP:746198853
2911 2911 a, g dbSNP:139506803
2937 2937 a, c dbSNP:369233057
2952 2952 a, g dbSNP:550400230
2991 2991 a, t dbSNP:781709902
3036 3036 c, t dbSNP:771546663
3037 3037 a, t dbSNP:747510751
3052 3052 c, t dbSNP:56325294
3061 3061 c, t dbSNP:777905452
3064 3064 c, g, t dbSNP:79555504
3065 3065 g, t dbSNP:555062772
3073 3073 a, g dbSNP:758466620
3113 3113 a, g dbSNP:187187152
3125 3125 a, g dbSNP:746099389
3129 3129 a, g dbSNP:752837451
3146 3146 a, g dbSNP:182137190
3161 3161 c, t dbSNP:560493769
3180 3180 a, g dbSNP:779038848
3198 3198 c, t dbSNP:755223577

Target ORF information:

RefSeq Version NM_001002235
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001002235

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22141
Accession Version NM_001002236.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-1-antitrypsin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA428299.1, BX247968.1 and AL132708.3. On May 29, 2008 this sequence version replaced gi:50363218. Summary: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All eleven variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX247968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001002236.1
CDS555..1811
Misc Feature(1)435..437(+)
Misc Feature(2)624..626(+)
Misc Feature(3)717..1790(+)
Misc Feature(4)762..764(+)
Misc Feature(5)873..875(+)
Misc Feature(6)1320..1322(+)
Misc Feature(7)1320..1322(+)
Misc Feature(8)1365..1367(+)
Misc Feature(9)1656..1733(+)
Misc Feature(10)1656..1730(+)
Misc Feature(11)1680..1682(+)
Misc Feature(12)1698..1703(+)
Exon (1)1..236
Gene:SERPINA1
Gene Synonym:
Exon (2)237..446
Gene:SERPINA1
Gene Synonym:
Exon (3)447..550
Gene:SERPINA1
Gene Synonym:
Exon (4)551..1200
Gene:SERPINA1
Gene Synonym:
Exon (5)1201..1471
Gene:SERPINA1
Gene Synonym:
Exon (6)1472..1619
Gene:SERPINA1
Gene Synonym:
Exon (7)1620..3513
Gene:SERPINA1
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, g dbSNP:8008743
46 46 a, g dbSNP:372703551
47 47 c, t dbSNP:571103038
80 80 a, g dbSNP:74500081
115 115 cc, tt dbSNP:386780186
115 115 c, t dbSNP:546604090
116 116 c, t dbSNP:8004738
146 146 a, g dbSNP:56367058
194 194 a, g dbSNP:548934735
232 232 a, g dbSNP:78070723
240 240 a, g dbSNP:111323063
309 309 -, cccc dbSNP:150271298
372 372 -, tctg dbSNP:761880516
373 373 c, g dbSNP:2070609
381 381 c, t dbSNP:758670032
382 382 a, g dbSNP:748998639
422 422 a, g dbSNP:557789873
424 424 a, g dbSNP:539401561
454 454 c, t dbSNP:369574904
455 455 c, t dbSNP:140228762
457 457 -, c dbSNP:202122479
457 457 c, t dbSNP:551681307
458 458 a, g dbSNP:543596928
504 504 -, c dbSNP:568223361
515 515 c, g dbSNP:576413666
529 529 a, c dbSNP:559873401
531 531 c, t dbSNP:558127432
545 545 c, t dbSNP:11558258
548 548 a, g dbSNP:559054925
550 550 c, t dbSNP:762668988
551 551 a, g dbSNP:374417614
552 552 a, g dbSNP:750207710
553 553 a, c dbSNP:767375374
558 558 c, t dbSNP:757174326
559 559 c, t dbSNP:142288916
560 560 a, g dbSNP:200936638
562 562 a, c dbSNP:759598955
567 567 a, g dbSNP:776904334
571 571 c, t dbSNP:140814100
575 575 g, t dbSNP:370038282
577 577 g, t dbSNP:773588978
578 578 c, t dbSNP:772462774
581 581 c, t dbSNP:11558260
584 584 c, t dbSNP:748608984
588 588 a, c dbSNP:377747242
595 595 g, t dbSNP:768352001
597 597 c, t dbSNP:147283849
605 605 c, t dbSNP:143920236
608 608 c, g, t dbSNP:745679666
609 609 a, g dbSNP:780969205
611 611 c, t dbSNP:535608645
614 614 c, t dbSNP:757152220
618 618 a, t dbSNP:751555333
620 620 c, t dbSNP:764012079
624 624 g, t dbSNP:755088914
625 625 c, t dbSNP:753867893
627 627 a, g dbSNP:766542592
630 630 a, g, t dbSNP:750766974
631 631 a, c dbSNP:199422212
633 633 c, t dbSNP:767986567
634 634 c, t dbSNP:190231439
637 637 a, g dbSNP:11558259
641 641 a, t dbSNP:775041289
654 654 a, c dbSNP:769267062
659 659 a, g dbSNP:762920973
662 662 c, t dbSNP:762571838
663 663 a, g dbSNP:11558262
665 665 a, g dbSNP:775022137
666 666 a, t dbSNP:769331986
667 667 c, t dbSNP:745463238
669 669 a, c dbSNP:138070585
673 673 a, g dbSNP:186478039
674 674 c, t dbSNP:368917367
683 683 a, c, t dbSNP:752646694
688 688 c, t dbSNP:758293405
693 693 c, t dbSNP:764792979
712 712 a, g dbSNP:758914650
713 713 -, cct dbSNP:747300627
714 714 c, t dbSNP:374810982
717 717 c, g dbSNP:753921311
725 725 c, t dbSNP:150784949
726 726 a, g, t dbSNP:149319176
727 727 c, g dbSNP:770667932
732 732 a, g dbSNP:767606257
740 740 a, c dbSNP:762321137
741 741 c, t dbSNP:28931570
742 742 a, g dbSNP:764726147
745 745 a, g dbSNP:763483402
748 748 c, t dbSNP:28931569
751 751 c, t dbSNP:769400992
755 755 c, g dbSNP:140744031
760 760 c, t dbSNP:199687431
765 765 a, c dbSNP:11575873
778 778 c, t dbSNP:369966794
781 781 -, tct dbSNP:775982338
784 784 c, t dbSNP:55819880
785 785 c, t dbSNP:746839619
793 793 a, g dbSNP:777478364
798 798 a, g dbSNP:113817720
804 804 a, g dbSNP:111850950
823 823 g, t dbSNP:564267551
826 826 a, g dbSNP:28931568
827 827 c, g dbSNP:756260997
839 839 a, c dbSNP:199962756
840 840 a, g dbSNP:376616935
845 845 c, t dbSNP:781502220
867 867 a, g dbSNP:757510628
876 876 c, g dbSNP:779344345
877 877 g, t dbSNP:137888162
880 880 c, t dbSNP:199422213
881 881 a, g dbSNP:764493280
889 889 c, t dbSNP:758820515
890 890 a, g dbSNP:753313462
891 891 a, g dbSNP:765628480
900 900 a, g dbSNP:769217078
901 901 a, t dbSNP:28931572
902 902 c, g dbSNP:759135389
910 910 c, g dbSNP:749295615
920 920 a, g dbSNP:199725228
927 927 c, t dbSNP:766025736
928 928 a, g dbSNP:709932
932 932 c, t dbSNP:772839968
935 935 c, t dbSNP:372438611
939 939 a, c dbSNP:756311065
946 946 a, c dbSNP:747867823
955 955 c, t dbSNP:774398845
964 964 c, g dbSNP:768432782
968 968 c, t dbSNP:541545839
969 969 a, g dbSNP:11558261
970 970 c, g dbSNP:757562207
974 974 c, t dbSNP:750688252
977 977 c, t dbSNP:368415110
978 978 c, t dbSNP:20546
980 980 a, g dbSNP:758835662
983 983 c, g dbSNP:752979989
984 984 c, t dbSNP:374198121
989 989 a, c dbSNP:11558263
990 990 a, g dbSNP:537285845
1001 1001 a, g dbSNP:373851357
1004 1004 a, g dbSNP:146596574
1005 1005 c, g dbSNP:760175391
1009 1009 a, g dbSNP:772895093
1011 1011 a, g dbSNP:369060615
1014 1014 c, t dbSNP:576575224
1017 1017 c, t dbSNP:773981008
1018 1018 -, t dbSNP:772420922
1020 1020 a, g, t dbSNP:78640395
1024 1024 a, g dbSNP:749118243
1026 1026 g, t dbSNP:775552836
1031 1031 a, g dbSNP:771199057
1051 1051 a, c dbSNP:142942004
1056 1056 a, g dbSNP:747053324
1064 1064 c, g dbSNP:778188056
1067 1067 c, t dbSNP:190838132
1068 1068 a, g, t dbSNP:112030253
1076 1076 c, t dbSNP:72552402
1077 1077 a, g dbSNP:149770048
1079 1079 a, g dbSNP:201400592
1088 1088 a, g dbSNP:573136666
1100 1100 c, t dbSNP:113813309
1101 1101 a, g dbSNP:759578830
1106 1106 a, c, g, t dbSNP:199422210
1106 1106 -, c dbSNP:267606950
1107 1107 a, g dbSNP:147247134
1114 1114 a, c dbSNP:762801939
1116 1116 a, g dbSNP:775606044
1118 1118 a, t dbSNP:769830846
1127 1127 a, g dbSNP:200414579
1141 1141 c, t dbSNP:368433503
1146 1146 a, g dbSNP:766034720
1151 1151 g, t dbSNP:748377295
1154 1154 c, t dbSNP:779194062
1155 1155 a, g dbSNP:760372645
1159 1159 a, g dbSNP:768943640
1167 1167 a, g dbSNP:749634278
1179 1179 c, g dbSNP:780562960
1181 1181 a, g dbSNP:756577084
1188 1188 a, g dbSNP:749944428
1199 1199 a, g dbSNP:780506538
1200 1200 g, t dbSNP:756773408
1202 1202 a, c dbSNP:754816836
1203 1203 a, t dbSNP:387906573
1204 1204 a, c dbSNP:11558265
1213 1213 g, t dbSNP:11558257
1216 1216 a, c dbSNP:368117781
1217 1217 c, t dbSNP:1140397
1227 1227 a, c dbSNP:11558264
1235 1235 c, t dbSNP:766320203
1236 1236 a, g dbSNP:199422208
1238 1238 a, g dbSNP:774452372
1247 1247 a, c dbSNP:145410420
1251 1251 a, c dbSNP:763108861
1253 1253 c, t dbSNP:775672099
1254 1254 a, g dbSNP:374168370
1255 1255 a, t dbSNP:746197812
1259 1259 a, c dbSNP:777051992
1260 1260 a, c dbSNP:771419213
1261 1261 a, g dbSNP:746531546
1264 1264 c, t dbSNP:6647
1267 1267 c, t dbSNP:758136730
1271 1271 c, t dbSNP:200634040
1272 1272 a, g dbSNP:72552401
1275 1275 a, t dbSNP:199422211
1279 1279 c, t dbSNP:753621457
1288 1288 c, t dbSNP:766260108
1293 1293 a, c, t dbSNP:28929470
1294 1294 a, g dbSNP:544632177
1299 1299 c, g dbSNP:764220898
1300 1300 c, g dbSNP:577164283
1301 1301 c, t dbSNP:775725332
1302 1302 a, g dbSNP:765419872
1306 1306 g, t dbSNP:759837735
1308 1308 a, t dbSNP:777012321
1311 1311 a, c dbSNP:575123943
1313 1313 c, t dbSNP:761185661
1314 1314 c, t dbSNP:764431473
1316 1316 a, c, g dbSNP:763249215
1322 1322 g, t dbSNP:8350
1323 1323 a, g dbSNP:753068726
1325 1325 g, t dbSNP:376294932
1328 1328 a, g dbSNP:34112109
1336 1336 g, t dbSNP:778732023
1347 1347 c, t dbSNP:768386476
1349 1349 a, g dbSNP:749044003
1351 1351 c, t dbSNP:779843923
1365 1365 a, g dbSNP:755851961
1373 1373 c, g, t dbSNP:2230075
1374 1374 a, g, t dbSNP:752721615
1376 1376 c, t dbSNP:765473272
1389 1389 a, c dbSNP:759736224
1393 1393 a, t dbSNP:121912714
1394 1394 c, t dbSNP:1049800
1395 1395 a, g dbSNP:760917668
1398 1398 a, g dbSNP:370923940
1400 1400 g, t dbSNP:772659184
1404 1404 c, t dbSNP:761442554
1406 1406 a, g dbSNP:771082081
1410 1410 c, t dbSNP:149537225
1417 1417 a, t dbSNP:17580
1419 1419 a, c dbSNP:749030711
1427 1427 c, t dbSNP:779573811
1428 1428 a, g dbSNP:769666780
1429 1429 c, t dbSNP:745624643
1433 1433 a, c, t dbSNP:141095970
1434 1434 a, g dbSNP:772436715
1444 1444 a, c dbSNP:752776707
1449 1449 c, t dbSNP:778905943
1453 1453 c, g, t dbSNP:550592374
1454 1454 a, g dbSNP:538675821
1459 1459 a, t dbSNP:377668175
1461 1461 g, t dbSNP:1802963
1464 1464 a, g dbSNP:749021630
1469 1469 -, aag dbSNP:748777702
1472 1472 a, g dbSNP:759132932
1475 1475 c, t dbSNP:776253560
1476 1476 g, t dbSNP:141620200
1478 1478 c, t dbSNP:138611390
1480 1480 a, g dbSNP:773222881
1485 1485 c, t dbSNP:771862730
1490 1490 a, t dbSNP:749389616
1491 1491 c, t dbSNP:779938258
1500 1500 a, t dbSNP:756246391
1502 1502 -, c dbSNP:35624994
1512 1512 a, g dbSNP:746155701
1516 1516 a, g dbSNP:774775536
1518 1518 g, t dbSNP:55704149
1520 1520 a, c, t dbSNP:190881649
1521 1521 c, t dbSNP:150455534
1523 1523 c, g dbSNP:186393785
1526 1526 a, g dbSNP:375097829
1527 1527 a, t dbSNP:1802962
1529 1529 c, t dbSNP:764238790
1530 1530 a, g dbSNP:139964603
1532 1532 c, t dbSNP:752267053
1537 1537 c, g dbSNP:369788393
1545 1545 a, c, g dbSNP:569455355
1553 1553 c, t dbSNP:181491831
1557 1557 a, g dbSNP:190061930
1568 1568 c, t dbSNP:371761828
1569 1569 g, t dbSNP:765966782
1570 1570 a, g dbSNP:186298255
1575 1575 a, g dbSNP:28929471
1583 1583 c, t dbSNP:760494093
1584 1584 a, g dbSNP:367797069
1585 1585 g, t dbSNP:772059003
1587 1587 g, t dbSNP:761711628
1599 1599 c, g dbSNP:376024688
1602 1602 c, t dbSNP:377739083
1603 1603 c, t dbSNP:770030839
1606 1606 -, t dbSNP:72555374
1615 1615 c, t dbSNP:201788603
1622 1622 c, t dbSNP:9630
1623 1623 a, g dbSNP:373630097
1625 1625 c, g dbSNP:10427
1629 1629 a, g dbSNP:200945035
1632 1632 a, c, g dbSNP:1802959
1633 1633 a, c dbSNP:762930016
1635 1635 -, g dbSNP:72555357
1636 1636 c, g, t dbSNP:1131139
1637 1637 a, g dbSNP:13868
1638 1638 a, c dbSNP:1131154
1640 1640 a, g, t dbSNP:1802961
1643 1643 c, g dbSNP:1050469
1644 1644 a, g dbSNP:201318727
1646 1646 a, c, g, t dbSNP:772289957
1647 1647 a, c, g dbSNP:143370956
1649 1649 c, g, t dbSNP:201774333
1650 1650 a, g dbSNP:28929474
1654 1654 a, c dbSNP:755625134
1655 1655 a, g dbSNP:1050520
1657 1657 a, g dbSNP:551595739
1661 1661 c, t dbSNP:533419579
1662 1662 a, g dbSNP:756871122
1664 1664 -, aaca dbSNP:754737768
1665 1665 -, gctgc dbSNP:751343534
1670 1670 a, t dbSNP:751415975
1671 1671 a, g, t dbSNP:12077
1673 1673 a, g dbSNP:376061125
1674 1674 a, g dbSNP:752723808
1677 1677 a, c dbSNP:765199959
1680 1680 a, t dbSNP:751696406
1684 1684 -, t dbSNP:766291631
1684 1684 -, t dbSNP:763023697
1685 1685 a, t dbSNP:28929473
1688 1688 a, g dbSNP:148362959
1689 1689 a, g dbSNP:773275051
1699 1699 g, t dbSNP:121912713
1700 1700 a, g dbSNP:372140596
1701 1701 g, t dbSNP:762151808
1706 1706 c, t dbSNP:764340766
1709 1709 c, t dbSNP:774551181
1710 1710 a, c, g, t dbSNP:12233
1711 1711 c, t dbSNP:569384943
1712 1712 -, c dbSNP:764325655
1712 1712 -, c dbSNP:776846218
1712 1712 c, t dbSNP:143329723
1713 1713 a, g dbSNP:121912712
1731 1731 c, t dbSNP:61761869
1732 1732 a, c, t dbSNP:199422209
1733 1733 c, t dbSNP:746728426
1742 1742 c, t dbSNP:13170
1749 1749 a, g dbSNP:139972630
1750 1750 c, t dbSNP:777537335
1754 1754 a, c dbSNP:1303
1755 1755 a, c dbSNP:17850837
1760 1760 c, t dbSNP:766128806
1762 1762 c, g dbSNP:778747339
1765 1765 a, g dbSNP:754885222
1770 1770 a, c dbSNP:753705146
1775 1775 c, t dbSNP:767700105
1779 1779 a, g dbSNP:149800596
1791 1791 -, gtg dbSNP:760849035
1800 1800 a, c dbSNP:3191200
1804 1804 a, t dbSNP:200467663
1805 1805 a, g dbSNP:760604419
1810 1810 a, g dbSNP:764249468
1812 1812 c, t dbSNP:72547410
1814 1814 g, t dbSNP:1802960
1815 1815 c, t dbSNP:773192775
1816 1816 -, ctctcgctcc dbSNP:775785700
1818 1818 c, g, t dbSNP:3191219
1820 1820 c, t dbSNP:775768234
1821 1821 a, g dbSNP:747590096
1825 1825 c, t dbSNP:760149475
1829 1829 a, g dbSNP:371674306
1830 1830 c, t dbSNP:770516093
1832 1832 a, c dbSNP:746497525
1845 1845 c, t dbSNP:368409403
1846 1846 c, t dbSNP:771810584
1854 1854 -, c dbSNP:772212056
1854 1854 c, t dbSNP:747969292
1855 1855 c, t dbSNP:778825545
1861 1861 a, g dbSNP:768301490
1888 1888 a, t dbSNP:111611589
1889 1889 a, c dbSNP:113201712
1891 1891 c, t dbSNP:1243163
1987 1987 c, t dbSNP:375619801
1993 1993 a, c dbSNP:138518740
2008 2008 a, t dbSNP:541257510
2012 2012 a, g dbSNP:574176097
2035 2035 a, g dbSNP:2073333
2052 2052 c, g dbSNP:111978668
2074 2074 c, t dbSNP:753776140
2102 2102 g, t dbSNP:770346644
2127 2127 g, t dbSNP:1243164
2137 2137 a, g dbSNP:7144409
2159 2159 c, t dbSNP:112143645
2182 2182 g, t dbSNP:539955367
2224 2224 a, c dbSNP:566212080
2228 2228 a, c dbSNP:547889258
2230 2230 a, c dbSNP:529148469
2231 2231 -, a dbSNP:532237180
2246 2246 c, t dbSNP:568235941
2269 2269 a, t dbSNP:147041519
2290 2290 a, g dbSNP:7142803
2291 2291 a, g dbSNP:147905225
2292 2292 a, g dbSNP:1243165
2293 2293 c, t dbSNP:757874806
2311 2311 a, g dbSNP:111349695
2316 2316 a, g dbSNP:559864059
2377 2377 c, t dbSNP:45538932
2378 2378 c, t dbSNP:541516970
2379 2379 a, g dbSNP:140980287
2380 2380 a, c dbSNP:574344564
2464 2464 c, t dbSNP:370477090
2467 2467 c, t dbSNP:370359507
2469 2469 g, t dbSNP:550067693
2489 2489 c, t dbSNP:151205402
2503 2503 -, c dbSNP:113934719
2504 2504 -, c dbSNP:538852248
2507 2507 c, t dbSNP:777765085
2508 2508 a, g dbSNP:554660748
2531 2531 c, t dbSNP:543782194
2552 2552 c, t dbSNP:142149216
2575 2575 a, g dbSNP:558473967
2590 2590 c, t dbSNP:539869030
2595 2595 a, g dbSNP:566075265
2600 2600 c, t dbSNP:193052802
2603 2603 c, t dbSNP:139984116
2636 2636 a, g dbSNP:752931014
2664 2664 c, t dbSNP:188391982
2665 2665 c, t dbSNP:1051052
2705 2705 c, t dbSNP:531520334
2728 2728 a, g dbSNP:560007661
2750 2750 c, t dbSNP:556761230
2757 2757 c, t dbSNP:184719827
2758 2758 c, g dbSNP:527388016
2759 2759 a, g dbSNP:192683802
2779 2779 c, t dbSNP:1243166
2789 2789 a, g dbSNP:761761325
2792 2792 a, t dbSNP:541533553
2806 2806 a, g dbSNP:559680950
2830 2830 c, t dbSNP:146502831
2833 2833 c, t dbSNP:571151263
2853 2853 c, t dbSNP:529769859
2858 2858 c, t dbSNP:376326793
2865 2865 a, g dbSNP:562161103
2867 2867 c, t dbSNP:143994738
2877 2877 c, g dbSNP:576539120
2878 2878 a, g dbSNP:11628917
2920 2920 a, t dbSNP:773885714
2952 2952 a, g dbSNP:139136785
2982 2982 a, g dbSNP:572480272
2983 2983 c, g dbSNP:777299970
2984 2984 c, t dbSNP:554160611
3005 3005 a, c dbSNP:377711852
3016 3016 a, g dbSNP:574840088
3028 3028 c, t dbSNP:568321968
3032 3032 a, g dbSNP:11832
3040 3040 c, t dbSNP:538093703
3042 3042 c, t dbSNP:570305752
3098 3098 a, g dbSNP:9944155
3103 3103 c, t dbSNP:78367974
3142 3142 a, c, g dbSNP:11568814
3155 3155 a, g dbSNP:372207184
3157 3157 c, t dbSNP:149278583
3198 3198 a, g dbSNP:746198853
3225 3225 a, g dbSNP:139506803
3251 3251 a, c dbSNP:369233057
3266 3266 a, g dbSNP:550400230
3305 3305 a, t dbSNP:781709902
3350 3350 c, t dbSNP:771546663
3351 3351 a, t dbSNP:747510751
3366 3366 c, t dbSNP:56325294
3375 3375 c, t dbSNP:777905452
3378 3378 c, g, t dbSNP:79555504
3379 3379 g, t dbSNP:555062772
3387 3387 a, g dbSNP:758466620
3427 3427 a, g dbSNP:187187152
3439 3439 a, g dbSNP:746099389
3443 3443 a, g dbSNP:752837451
3460 3460 a, g dbSNP:182137190
3475 3475 c, t dbSNP:560493769
3494 3494 a, g dbSNP:779038848
3512 3512 c, t dbSNP:755223577

Target ORF information:

RefSeq Version NM_001002236
Organism Homo sapiens (human)
Definition Homo sapiens serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (SERPINA1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001002236

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu22141
Accession Version NM_001127700.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1257bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-1-antitrypsin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA428299.1, DA427262.1, BX247968.1 and AL132708.3. Summary: The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All eleven variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC015642.2, GU727620.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGCCGTCTT CTGTCTCGTG GGGCATCCTC CTGCTGGCAG GCCTGTGCTG CCTGGTCCCT 
GTCTCCCTGG CTGAGGATCC CCAGGGAGAT GCTGCCCAGA AGACAGATAC ATCCCACCAT
GATCAGGATC ACCCAACCTT CAACAAGATC ACCCCCAACC TGGCTGAGTT CGCCTTCAGC
CTATACCGCC AGCTGGCACA CCAGTCCAAC AGCACCAATA TCTTCTTCTC CCCAGTGAGC
ATCGCTACAG CCTTTGCAAT GCTCTCCCTG GGGACCAAGG CTGACACTCA CGATGAAATC
CTGGAGGGCC TGAATTTCAA CCTCACGGAG ATTCCGGAGG CTCAGATCCA TGAAGGCTTC
CAGGAACTCC TCCGTACCCT CAACCAGCCA GACAGCCAGC TCCAGCTGAC CACCGGCAAT
GGCCTGTTCC TCAGCGAGGG CCTGAAGCTA GTGGATAAGT TTTTGGAGGA TGTTAAAAAG
TTGTACCACT CAGAAGCCTT CACTGTCAAC TTCGGGGACA CCGAAGAGGC CAAGAAACAG
ATCAACGATT ACGTGGAGAA GGGTACTCAA GGGAAAATTG TGGATTTGGT CAAGGAGCTT
GACAGAGACA CAGTTTTTGC TCTGGTGAAT TACATCTTCT TTAAAGGCAA ATGGGAGAGA
CCCTTTGAAG TCAAGGACAC CGAGGAAGAG GACTTCCACG TGGACCAGGT GACCACCGTG
AAGGTGCCTA TGATGAAGCG TTTAGGCATG TTTAACATCC AGCACTGTAA GAAGCTGTCC
AGCTGGGTGC TGCTGATGAA ATACCTGGGC AATGCCACCG CCATCTTCTT CCTGCCTGAT
GAGGGGAAAC TACAGCACCT GGAAAATGAA CTCACCCACG ATATCATCAC CAAGTTCCTG
GAAAATGAAG ACAGAAGGTC TGCCAGCTTA CATTTACCCA AACTGTCCAT TACTGGAACC
TATGATCTGA AGAGCGTCCT GGGTCAACTG GGCATCACTA AGGTCTTCAG CAATGGGGCT
GACCTCTCCG GGGTCACAGA GGAGGCACCC CTGAAGCTCT CCAAGGCCGT GCATAAGGCT
GTGCTGACCA TCGACGAGAA AGGGACTGAA GCTGCTGGGG CCATGTTTTT AGAGGCCATA
CCCATGTCTA TCCCCCCCGA GGTCAAGTTC AACAAACCCT TTGTCTTCTT AATGATTGAA
CAAAATACCA AGTCTCCCCT CTTCATGGGA AAAGTGGTGA ATCCCACCCA AAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001121172.1
CDS278..1534
Misc Feature(1)209..211(+)
Misc Feature(2)440..1513(+)
Misc Feature(3)1043..1045(+)
Misc Feature(4)1379..1456(+)
Misc Feature(5)1379..1453(+)
Misc Feature(6)1421..1426(+)
Exon (1)1..273
Gene:SERPINA1
Gene Synonym:
Exon (2)274..923
Gene:SERPINA1
Gene Synonym:
Exon (3)924..1194
Gene:SERPINA1
Gene Synonym:
Exon (4)1195..1342
Gene:SERPINA1
Gene Synonym:
Exon (5)1343..3236
Gene:SERPINA1
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, g dbSNP:8008743
46 46 a, g dbSNP:372703551
47 47 c, t dbSNP:571103038
80 80 a, g dbSNP:74500081
115 115 cc, tt dbSNP:386780186
115 115 c, t dbSNP:546604090
116 116 c, t dbSNP:8004738
146 146 a, g dbSNP:56367058
194 194 a, g dbSNP:548934735
232 232 a, g dbSNP:78070723
241 241 a, g dbSNP:2753929
274 274 a, g dbSNP:374417614
275 275 a, g dbSNP:750207710
276 276 a, c dbSNP:767375374
281 281 c, t dbSNP:757174326
282 282 c, t dbSNP:142288916
283 283 a, g dbSNP:200936638
285 285 a, c dbSNP:759598955
290 290 a, g dbSNP:776904334
294 294 c, t dbSNP:140814100
298 298 g, t dbSNP:370038282
300 300 g, t dbSNP:773588978
301 301 c, t dbSNP:772462774
304 304 c, t dbSNP:11558260
307 307 c, t dbSNP:748608984
311 311 a, c dbSNP:377747242
318 318 g, t dbSNP:768352001
320 320 c, t dbSNP:147283849
328 328 c, t dbSNP:143920236
331 331 c, g, t dbSNP:745679666
332 332 a, g dbSNP:780969205
334 334 c, t dbSNP:535608645
337 337 c, t dbSNP:757152220
341 341 a, t dbSNP:751555333
343 343 c, t dbSNP:764012079
347 347 g, t dbSNP:755088914
348 348 c, t dbSNP:753867893
350 350 a, g dbSNP:766542592
353 353 a, g, t dbSNP:750766974
354 354 a, c dbSNP:199422212
356 356 c, t dbSNP:767986567
357 357 c, t dbSNP:190231439
360 360 a, g dbSNP:11558259
364 364 a, t dbSNP:775041289
377 377 a, c dbSNP:769267062
382 382 a, g dbSNP:762920973
385 385 c, t dbSNP:762571838
386 386 a, g dbSNP:11558262
388 388 a, g dbSNP:775022137
389 389 a, t dbSNP:769331986
390 390 c, t dbSNP:745463238
392 392 a, c dbSNP:138070585
396 396 a, g dbSNP:186478039
397 397 c, t dbSNP:368917367
406 406 a, c, t dbSNP:752646694
411 411 c, t dbSNP:758293405
416 416 c, t dbSNP:764792979
435 435 a, g dbSNP:758914650
436 436 -, cct dbSNP:747300627
437 437 c, t dbSNP:374810982
440 440 c, g dbSNP:753921311
448 448 c, t dbSNP:150784949
449 449 a, g, t dbSNP:149319176
450 450 c, g dbSNP:770667932
455 455 a, g dbSNP:767606257
463 463 a, c dbSNP:762321137
464 464 c, t dbSNP:28931570
465 465 a, g dbSNP:764726147
468 468 a, g dbSNP:763483402
471 471 c, t dbSNP:28931569
474 474 c, t dbSNP:769400992
478 478 c, g dbSNP:140744031
483 483 c, t dbSNP:199687431
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978 978 a, t dbSNP:746197812
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1022 1022 c, g dbSNP:764220898
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1024 1024 c, t dbSNP:775725332
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1029 1029 g, t dbSNP:759837735
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1034 1034 a, c dbSNP:575123943
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1046 1046 a, g dbSNP:753068726
1048 1048 g, t dbSNP:376294932
1051 1051 a, g dbSNP:34112109
1059 1059 g, t dbSNP:778732023
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1117 1117 c, t dbSNP:1049800
1118 1118 a, g dbSNP:760917668
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1123 1123 g, t dbSNP:772659184
1127 1127 c, t dbSNP:761442554
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1140 1140 a, t dbSNP:17580
1142 1142 a, c dbSNP:749030711
1150 1150 c, t dbSNP:779573811
1151 1151 a, g dbSNP:769666780
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1203 1203 a, g dbSNP:773222881
1208 1208 c, t dbSNP:771862730
1213 1213 a, t dbSNP:749389616
1214 1214 c, t dbSNP:779938258
1223 1223 a, t dbSNP:756246391
1225 1225 -, c dbSNP:35624994
1235 1235 a, g dbSNP:746155701
1239 1239 a, g dbSNP:774775536
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1243 1243 a, c, t dbSNP:190881649
1244 1244 c, t dbSNP:150455534
1246 1246 c, g dbSNP:186393785
1249 1249 a, g dbSNP:375097829
1250 1250 a, t dbSNP:1802962
1252 1252 c, t dbSNP:764238790
1253 1253 a, g dbSNP:139964603
1255 1255 c, t dbSNP:752267053
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1268 1268 a, c, g dbSNP:569455355
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1292 1292 g, t dbSNP:765966782
1293 1293 a, g dbSNP:186298255
1298 1298 a, g dbSNP:28929471
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1307 1307 a, g dbSNP:367797069
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1322 1322 c, g dbSNP:376024688
1325 1325 c, t dbSNP:377739083
1326 1326 c, t dbSNP:770030839
1329 1329 -, t dbSNP:72555374
1338 1338 c, t dbSNP:201788603
1345 1345 c, t dbSNP:9630
1346 1346 a, g dbSNP:373630097
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1352 1352 a, g dbSNP:200945035
1355 1355 a, c, g dbSNP:1802959
1356 1356 a, c dbSNP:762930016
1358 1358 -, g dbSNP:72555357
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1361 1361 a, c dbSNP:1131154
1363 1363 a, g, t dbSNP:1802961
1366 1366 c, g dbSNP:1050469
1367 1367 a, g dbSNP:201318727
1369 1369 a, c, g, t dbSNP:772289957
1370 1370 a, c, g dbSNP:143370956
1372 1372 c, g, t dbSNP:201774333
1373 1373 a, g dbSNP:28929474
1377 1377 a, c dbSNP:755625134
1378 1378 a, g dbSNP:1050520
1380 1380 a, g dbSNP:551595739
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1385 1385 a, g dbSNP:756871122
1387 1387 -, aaca dbSNP:754737768
1388 1388 -, gctgc dbSNP:751343534
1393 1393 a, t dbSNP:751415975
1394 1394 a, g, t dbSNP:12077
1396 1396 a, g dbSNP:376061125
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1400 1400 a, c dbSNP:765199959
1403 1403 a, t dbSNP:751696406
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1412 1412 a, g dbSNP:773275051
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1424 1424 g, t dbSNP:762151808
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1433 1433 a, c, g, t dbSNP:12233
1434 1434 c, t dbSNP:569384943
1435 1435 -, c dbSNP:764325655
1435 1435 -, c dbSNP:776846218
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1514 1514 -, gtg dbSNP:760849035
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1538 1538 c, t dbSNP:773192775
1539 1539 -, ctctcgctcc dbSNP:775785700
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1548 1548 c, t dbSNP:760149475
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1553 1553 c, t dbSNP:770516093
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1568 1568 c, t dbSNP:368409403
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1577 1577 -, c dbSNP:772212056
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1612 1612 a, c dbSNP:113201712
1614 1614 c, t dbSNP:1243163
1710 1710 c, t dbSNP:375619801
1716 1716 a, c dbSNP:138518740
1731 1731 a, t dbSNP:541257510
1735 1735 a, g dbSNP:574176097
1758 1758 a, g dbSNP:2073333
1775 1775 c, g dbSNP:111978668
1797 1797 c, t dbSNP:753776140
1825 1825 g, t dbSNP:770346644
1850 1850 g, t dbSNP:1243164
1860 1860 a, g dbSNP:7144409
1882 1882 c, t dbSNP:112143645
1905 1905 g, t dbSNP:539955367
1947 1947 a, c dbSNP:566212080
1951 1951 a, c dbSNP:547889258
1953 1953 a, c dbSNP:529148469
1954 1954 -, a dbSNP:532237180
1969 1969 c, t dbSNP:568235941
1992 1992 a, t dbSNP:147041519
2013 2013 a, g dbSNP:7142803
2014 2014 a, g dbSNP:147905225
2015 2015 a, g dbSNP:1243165
2016 2016 c, t dbSNP:757874806
2034 2034 a, g dbSNP:111349695
2039 2039 a, g dbSNP:559864059
2100 2100 c, t dbSNP:45538932
2101 2101 c, t dbSNP:541516970
2102 2102 a, g dbSNP:140980287
2103 2103 a, c dbSNP:574344564
2187 2187 c, t dbSNP:370477090
2190 2190 c, t dbSNP:370359507
2192 2192 g, t dbSNP:550067693
2212 2212 c, t dbSNP:151205402
2226 2226 -, c dbSNP:113934719
2227 2227 -, c dbSNP:538852248
2230 2230 c, t dbSNP:777765085
2231 2231 a, g dbSNP:554660748
2254 2254 c, t dbSNP:543782194
2275 2275 c, t dbSNP:142149216
2298 2298 a, g dbSNP:558473967
2313 2313 c, t dbSNP:539869030
2318 2318 a, g dbSNP:566075265
2323 2323 c, t dbSNP:193052802
2326 2326 c, t dbSNP:139984116
2359 2359 a, g dbSNP:752931014
2387 2387 c, t dbSNP:188391982
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2515 2515 a, t dbSNP:541533553
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2553 2553 c, t dbSNP:146502831
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2588 2588 a, g dbSNP:562161103
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2600 2600 c, g dbSNP:576539120
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2643 2643 a, t dbSNP:773885714
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3101 3101