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PITX1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PITX1
Entrez Gene ID 5307
Full Name paired-like homeodomain 1
Synonyms BFT, CCF, LBNBG, POTX, PTX1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31.1

Summary This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602149

Disorder Html: Clubfoot, congenital, 119800 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_002653 NP_002644 pituitary homeobox 1


Homo sapiens (human) PITX1 NP_002644.4
Pan troglodytes (chimpanzee) PITX1 XP_001168135.1
Macaca mulatta (Rhesus monkey) PITX1 XP_002804564.1
Canis lupus familiaris (dog) PITX1 XP_005626613.1
Bos taurus (cattle) PITX1 NP_001192229.1
Mus musculus (house mouse) Pitx1 NP_035227.1
Rattus norvegicus (Norway rat) Pitx1 NP_446076.1
Gallus gallus (chicken) PITX1 NP_001161158.1
Danio rerio (zebrafish) pitx1 NP_001035436.3
Xenopus (Silurana) tropicalis (western clawed frog) pitx1 NP_001007500.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PITX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PITX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18454
NM_002653 Homo sapiens paired-like homeodomain 1 (PITX1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18454
Clone ID Related Accession (Same CDS sequence) NM_002653
Accession Version NM_002653.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 945bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product pituitary homeobox 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX362641.2, BC009412.1 and AC008406.7. This sequence is a reference standard in the RefSeqGene project. On Jul 24, 2007 this sequence version replaced gi:24234701. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX362641.2, U70370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGACGCCT TCAAGGGGGG CATGAGCCTG GAGCGGCTGC CGGAGGGGCT CCGGCCGCCG 
CCGCCGCCAC CCCATGACAT GGGGCCCGCC TTCCACCTGG CCCGGCCCGC CGACCCCCGC
GAGCCGCTCG AGAACTCCGC CAGCGAGTCG TCTGACACGG AGCTGCCAGA GAAGGAGCGC
GGCGGGGAAC CCAAGGGGCC CGAGGACAGT GGTGCGGGAG GCACGGGCTG CGGCGGCGCA
GACGACCCAG CCAAGAAGAA GAAGCAGCGG CGGCAACGTA CGCACTTCAC AAGCCAGCAG
TTGCAAGAGC TAGAGGCCAC GTTCCAGAGG AACCGCTACC CCGACATGAG CATGAGGGAG
GAGATCGCCG TGTGGACCAA CCTCACCGAG CCGCGCGTGC GGGTCTGGTT CAAGAACCGG
CGAGCCAAGT GGCGTAAGCG CGAGCGTAAC CAGCAGCTGG ACCTGTGCAA GGGTGGCTAC
GTGCCGCAGT TCAGCGGCCT AGTGCAGCCC TACGAGGACG TGTACGCCGC CGGCTACTCC
TACAACAACT GGGCCGCCAA GAGCCTGGCG CCAGCGCCGC TCTCCACCAA GAGCTTCACC
TTCTTCAACT CCATGAGCCC GCTGTCGTCG CAGTCCATGT TCTCAGCACC CAGCTCCATC
TCCTCCATGA CCATGCCGTC CAGCATGGGC CCAGGCGCCG TGCCTGGCAT GCCCAACTCG
GGCCTCAACA ACATCAACAA CCTCACCGGC TCCTCGCTCA ACTCGGCCAT GTCGCCGGGC
GCTTGCCCGT ACGGCACTCC CGCCTCGCCC TACAGCGTCT ACCGGGACAC GTGCAACTCG
AGCCTAGCCA GCCTGCGGCT CAAGTCCAAA CAGCACTCGT CGTTTGGCTA CGGCGGCCTG
CAGGGCCCGG CCTCGGGCCT CAACGCGTGC CAGTACAACA GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002644.4
CDS394..1338
Misc Feature(1)175..177(+)
Misc Feature(2)394..396(+)
Misc Feature(3)529..531(+)
Misc Feature(4)535..537(+)
Misc Feature(5)661..837(+)
Misc Feature(6)661..831(+)
Misc Feature(7)667..819(+)
Misc Feature(8)832..1230(+)
Misc Feature(9)1000..>1215(+)
Misc Feature(10)1216..1272(+)
Misc Feature(11)1231..1272(+)
Misc Feature(12)1249..1263(+)
Exon (1)1..562
Gene:PITX1
Gene Synonym:
Exon (2)563..795
Gene:PITX1
Gene Synonym:
Exon (3)796..2383
Gene:PITX1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_002653
Organism Homo sapiens (human)
Definition Homo sapiens paired-like homeodomain 1 (PITX1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002653

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGACGCCT TCAAGGGGGG CATGAGCCTG GAGCGGCTGC CGGAGGGGCT CCGGCCGCCG 
CCGCCGCCAC CCCATGACAT GGGGCCCGCC TTCCACCTGG CCCGGCCCGC CGACCCCCGC
GAGCCGCTCG AGAACTCCGC CAGCGAGTCG TCTGACACGG AGCTGCCAGA GAAGGAGCGC
GGCGGGGAAC CCAAGGGGCC CGAGGACAGT GGTGCGGGAG GCACGGGCTG CGGCGGCGCA
GACGACCCAG CCAAGAAGAA GAAGCAGCGG CGGCAACGTA CGCACTTCAC AAGCCAGCAG
TTGCAAGAGC TAGAGGCCAC GTTCCAGAGG AACCGCTACC CCGACATGAG CATGAGGGAG
GAGATCGCCG TGTGGACCAA CCTCACCGAG CCGCGCGTGC GGGTCTGGTT CAAGAACCGG
CGAGCCAAGT GGCGTAAGCG CGAGCGTAAC CAGCAGCTGG ACCTGTGCAA GGGTGGCTAC
GTGCCGCAGT TCAGCGGCCT AGTGCAGCCC TACGAGGACG TGTACGCCGC CGGCTACTCC
TACAACAACT GGGCCGCCAA GAGCCTGGCG CCAGCGCCGC TCTCCACCAA GAGCTTCACC
TTCTTCAACT CCATGAGCCC GCTGTCGTCG CAGTCCATGT TCTCAGCACC CAGCTCCATC
TCCTCCATGA CCATGCCGTC CAGCATGGGC CCAGGCGCCG TGCCTGGCAT GCCCAACTCG
GGCCTCAACA ACATCAACAA CCTCACCGGC TCCTCGCTCA ACTCGGCCAT GTCGCCGGGC
GCTTGCCCGT ACGGCACTCC CGCCTCGCCC TACAGCGTCT ACCGGGACAC GTGCAACTCG
AGCCTAGCCA GCCTGCGGCT CAAGTCCAAA CAGCACTCGT CGTTTGGCTA CGGCGGCCTG
CAGGGCCCGG CCTCGGGCCT CAACGCGTGC CAGTACAACA GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
Nat Commun 5, 3650 (2014)
Corominas R, Yang X, Lin GN, Kang S, Shen Y, Ghamsari L, Broly M, Rodriguez M, Tam S, Trigg SA, Fan C, Yi S, Tasan M, Lemmens I, Kuang X, Zhao N, Malhotra D, Michaelson JJ, Vacic V, Calderwood MA, Roth FP, Tavernier J, Horvath S, Salehi-Ashtiani K, Korkin D, Sebat J, Hill DE, Hao T, Vidal M and Iakoucheva LM.


book

Genetic variants associated with disordered eating
Int J Eat Disord 46 (6), 594-608 (2013)
Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW and Martin NG.


book

Liebenberg syndrome is caused by a deletion upstream to the PITX1 gene resulting in transformation of the upper limbs to reflect lower limb characteristics
Gene 524 (1), 65-71 (2013)
Al-Qattan MM, Al-Thunayan A, Alabdulkareem I and Al Balwi M.


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Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Nat. Genet. 45 (6), 686-689 (2013)
Ruark E, Seal S, McDonald H, Zhang F, Elliot A, Lau K, Perdeaux E, Rapley E, Eeles R, Peto J, Kote-Jarai Z, Muir K, Nsengimana J, Shipley J, Bishop DT, Stratton MR, Easton DF, Huddart RA, Rahman N and Turnbull C.


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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Nat. Genet. 45 (5), 501-512 (2013)
Berndt SI, Gustafsson S, Magi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson A, Johnson T, Kanoni S, Kleber ME, Konig IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Muller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg M, Campbell H, Chasman DI, Chines PS, Collins FS, Connell JM, Cookson WO, de Faire U, de Vegt F, Dei M, Dimitriou M, Edkins S, Estrada K, Evans DM, Farrall M, Ferrario MM, Ferrieres J, Franke L, Frau F, Gejman PV, Grallert H, Gronberg H, Gudnason V, Hall AS, Hall P, Hartikainen AL, Hayward C, Heard-Costa NL, Heath AC, Hebebrand J, Homuth G, Hu FB, Hunt SE, Hypponen E, Iribarren C, Jacobs KB, Jansson JO, Jula A, Kahonen M, Kathiresan S, Kee F, Khaw KT, Kivimaki M, Koenig W, Kraja AT, Kumari M, Kuulasmaa K, Kuusisto J, Laitinen JH, Lakka TA, Langenberg C, Launer LJ, Lind L, Lindstrom J, Liu J, Liuzzi A, Lokki ML, Lorentzon M, Madden PA, Magnusson PK, Manunta P, Marek D, Marz W, Mateo Leach I, McKnight B, Medland SE, Mihailov E, Milani L, Montgomery GW, Mooser V, Muhleisen TW, Munroe PB, Musk AW, Narisu N, Navis G, Nicholson G, Nohr EA, Ong KK, Oostra BA, Palmer CN, Palotie A, Peden JF, Pedersen N, Peters A, Polasek O, Pouta A, Pramstaller PP, Prokopenko I, Putter C, Radhakrishnan A, Raitakari O, Rendon A, Rivadeneira F, Rudan I, Saaristo TE, Sambrook JG, Sanders AR, Sanna S, Saramies J, Schipf S, Schreiber S, Schunkert H, Shin SY, Signorini S, Sinisalo J, Skrobek B, Soranzo N, Stancakova A, Stark K, Stephens JC, Stirrups K, Stolk RP, Stumvoll M, Swift AJ, Theodoraki EV, Thorand B, Tregouet DA, Tremoli E, Van der Klauw MM, van Meurs JB, Vermeulen SH, Viikari J, Virtamo J, Vitart V, Waeber G, Wang Z, Widen E, Wild SH, Willemsen G, Winkelmann BR, Witteman JC, Wolffenbuttel BH, Wong A, Wright AF, Zillikens MC, Amouyel P, Boehm BO, Boerwinkle E, Boomsma DI, Caulfield MJ, Chanock SJ, Cupples LA, Cusi D, Dedoussis GV, Erdmann J, Eriksson JG, Franks PW, Froguel P, Gieger C, Gyllensten U, Hamsten A, Harris TB, Hengstenberg C, Hicks AA, Hingorani A, Hinney A, Hofman A, Hovingh KG, Hveem K, Illig T, Jarvelin MR, Jockel KH, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kuh D, Laakso M, Lehtimaki T, Levinson DF, Martin NG, Metspalu A, Morris AD, Nieminen MS, Njolstad I, Ohlsson C, Oldehinkel AJ, Ouwehand WH, Palmer LJ, Penninx B, Power C, Province MA, Psaty BM, Qi L, Rauramaa R, Ridker PM, Ripatti S, Salomaa V, Samani NJ, Snieder H, Sorensen TI, Spector TD, Stefansson K, Tonjes A, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Vollenweider P, Wallaschofski H, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Abecasis GR, Assimes TL, Barroso I, Boehnke M, Borecki IB, Deloukas P, Fox CS, Frayling T, Groop LC, Haritunian T, Heid IM, Hunter D, Kaplan RC, Karpe F, Moffatt MF, Mohlke KL, O'Connell JR, Pawitan Y, Schadt EE, Schlessinger D, Steinthorsdottir V, Strachan DP, Thorsteinsdottir U, van Duijn CM, Visscher PM, Di Blasio AM, Hirschhorn JN, Lindgren CM, Morris AP, Meyre D, Scherag A, McCarthy MI, Speliotes EK, North KE, Loos RJ and Ingelsson E.


book

NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene
Mol. Cell. Biol. 17 (11), 6673-6682 (1997)
Poulin G, Turgeon B and Drouin J.


book

Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb
Dev. Dyn. 209 (2), 242-253 (1997)
Shang J, Luo Y and Clayton DA.


book

Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)
Genomics 40 (1), 108-113 (1997)
Shang J, Li X, Ring HZ, Clayton DA and Francke U.


book

Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome
Mamm. Genome 8 (11), 841-845 (1997)
Crawford MJ, Lanctot C, Tremblay JJ, Jenkins N, Gilbert D, Copeland N, Beatty B and Drouin J.


book

P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development
Proc. Natl. Acad. Sci. U.S.A. 93 (15), 7706-7710 (1996)
Szeto DP, Ryan AK, O'Connell SM and Rosenfeld MG.


 
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