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PKP2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PKP2
Entrez Gene ID 5318
Full Name plakophilin 2
Synonyms ARVD9
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p11

Summary This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602861

Disorder Html: Arrhythmogenic right ventricular dysplasia, familial, 9, 609040 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_004572 NP_004563 plakophilin-2 isoform 2b
NM_001005242 NP_001005242 plakophilin-2 isoform 2a



Homo sapiens (human) PKP2 NP_001005242.2
Pan troglodytes (chimpanzee) PKP2 XP_003954415.1
Canis lupus familiaris (dog) PKP2 XP_543739.2
Bos taurus (cattle) PKP2 NP_001077198.1
Mus musculus (house mouse) Pkp2 NP_080439.1
Rattus norvegicus (Norway rat) Pkp2 NP_001093969.1
Gallus gallus (chicken) PKP2 XP_416362.4
Danio rerio (zebrafish) pkp2 NP_001106904.1
Xenopus (Silurana) tropicalis (western clawed frog) pkp2 NP_001096312.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PKP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PKP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23398 NM_004572 Homo sapiens plakophilin 2 (PKP2), transcript variant 2b, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $622.30
$889.00
OHu23286
NM_001005242 Homo sapiens plakophilin 2 (PKP2), transcript variant 2a, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$339.50-$475.30
$679.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23398
Clone ID Related Accession (Same CDS sequence) NM_004572
Accession Version NM_004572.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2646bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product plakophilin-2 isoform 2b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454360.1, X97675.1, AU125826.1, AC087588.10 and AW439621.1. This sequence is a reference standard in the RefSeqGene project. On Jun 7, 2007 this sequence version replaced gi:52630430. Transcript Variant: This transcript variant (2b) represents the longer transcript variant and encodes the longer isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X97675.1, EU520483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGCAGCCC CCGGCGCCCC AGCTGAGTAC GGCTACATCC GGACCGTCCT GGGCCAGCAG 
ATCCTGGGAC AACTGGACAG CTCCAGCCTG GCGCTGCCCT CCGAGGCCAA GCTGAAGCTG
GCGGGGAGCA GCGGCCGCGG CGGCCAGACA GTCAAGAGCC TGCGGATCCA GGAGCAGGTG
CAGCAGACCC TCGCCCGGAA GGGCCGCAGC TCCGTGGGCA ACGGAAATCT TCACCGAACC
AGCAGTGTTC CTGAGTATGT CTACAACCTA CACTTGGTTG AAAATGATTT TGTTGGAGGC
CGTTCCCCTG TTCCTAAAAC CTATGACATG CTAAAGGCTG GCACAACTGC CACTTATGAA
GGTCGCTGGG GAAGAGGAAC AGCACAGTAC AGCTCCCAGA AGTCCGTGGA AGAAAGGTCC
TTGAGGCATC CTCTGAGGAG ACTGGAGATT TCTCCTGACA GCAGCCCGGA GAGGGCTCAC
TACACGCACA GCGATTACCA GTACAGCCAG AGAAGCCAGG CTGGGCACAC CCTGCACCAC
CAAGAAAGCA GGCGGGCCGC CCTCCTAGTG CCACCGAGAT ATGCTCGTTC CGAGATCGTG
GGGGTCAGCC GTGCTGGCAC CACAAGCAGG CAGCGCCACT TTGACACATA CCACAGACAG
TACCAGCATG GCTCTGTTAG CGACACCGTT TTTGACAGCA TCCCTGCCAA CCCGGCCCTG
CTCACGTACC CCAGGCCAGG GACCAGCCGC AGCATGGGCA ACCTCTTGGA GAAGGAGAAC
TACCTGACGG CAGGGCTCAC TGTCGGGCAG GTCAGGCCGC TGGTGCCCCT GCAGCCCGTC
ACTCAGAACA GGGCTTCCAG GTCCTCCTGG CATCAGAGCT CCTTCCACAG CACCCGCACG
CTGAGGGAAG CTGGGCCCAG TGTCGCCGTG GATTCCAGCG GGAGGAGAGC GCACTTGACT
GTCGGCCAGG CGGCCGCAGG GGGAAGTGGG AATCTGCTCA CTGAGAGAAG CACTTTCACT
GACTCCCAGC TGGGGAATGC AGACATGGAG ATGACTCTGG AGCGAGCAGT GAGTATGCTC
GAGGCAGACC ACATGCTGCC ATCCAGGATT TCTGCTGCAG CTACTTTCAT ACAGCACGAG
TGCTTCCAGA AATCTGAAGC TCGGAAGAGG GTTAACCAGC TTCGTGGCAT CCTCAAGCTT
CTGCAGCTCC TAAAAGTTCA GAATGAAGAC GTTCAGCGAG CTGTGTGTGG GGCCTTGAGA
AACTTAGTAT TTGAAGACAA TGACAACAAA TTGGAGGTGG CTGAACTAAA TGGGGTACCT
CGGCTGCTCC AGGTGCTGAA GCAAACCAGA GACTTGGAGA CTAAAAAACA AATAACAGAC
CATACAGTCA ATTTAAGAAG TAGGAATGGC TGGCCGGGCG CGGTGGCTCA CGCCTGTAAT
CCCAGCACTT TGGGAGGCCA AGGCGGGCGG ATCACGAGGT CAGGAGTTCG AGACCAGCCT
GACCAACATG GTTTGCTGTG GAATTTGTCA TCTAATGACA AACTCAAGAA TCTCATGATA
ACAGAAGCAT TGCTTACGCT GACGGAGAAT ATCATCATCC CCTTTTCTGG GTGGCCTGAA
GGAGACTACC CAAAAGCAAA TGGTTTGCTC GATTTTGACA TATTCTACAA CGTCACTGGA
TGCCTAAGAA ACATGAGTTC TGCTGGCGCT GATGGGAGAA AAGCGATGAG AAGATGTGAC
GGACTCATTG ACTCACTGGT CCATTATGTC AGAGGAACCA TTGCAGATTA CCAGCCAGAT
GACAAGGCCA CGGAGAATTG TGTGTGCATT CTTCATAACC TCTCCTACCA GCTGGAGGCA
GAGCTCCCAG AGAAATATTC CCAGAATATC TATATTCAAA ACCGGAATAT CCAGACTGAC
AACAACAAAA GTATTGGATG TTTTGGCAGT CGAAGCAGGA AAGTAAAAGA GCAATACCAG
GACGTGCCGA TGCCGGAGGA AAAGAGCAAC CCCAAGGGCG TGGAGTGGCT GTGGCATTCC
ATTGTTATAA GGATGTATCT GTCCTTGATC GCCAAAAGTG TCCGCAACTA CACACAAGAA
GCATCCTTAG GAGCTCTGCA GAACCTCACG GCCGGAAGTG GACCAATGCC GACATCAGTG
GCTCAGACAG TTGTCCAGAA GGAAAGTGGC CTGCAGCACA CCCGAAAGAT GCTGCATGTT
GGTGACCCAA GTGTGAAAAA GACAGCCATC TCGCTGCTGA GGAATCTGTC CCGGAATCTT
TCTCTGCAGA ATGAAATTGC CAAAGAAACT CTCCCTGATT TGGTTTCCAT CATTCCTGAC
ACAGTCCCGA GTACTGACCT TCTCATTGAA ACTACAGCCT CTGCCTGTTA CACATTGAAC
AACATAATCC AAAACAGTTA CCAGAATGCA CGCGACCTTC TAAACACCGG GGGCATCCAG
AAAATTATGG CCATTAGTGC AGGCGATGCC TATGCCTCCA ACAAAGCAAG TAAAGCTGCT
TCCGTCCTTC TGTATTCTCT GTGGGCACAC ACGGAACTGC ATCATGCCTA CAAGAAGGCT
CAGTTTAAGA AGACAGATTT TGTCAACAGC CGGACTGCCA AAGCCTACCA CTCCCTTAAA
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004563.2
CDS116..2761
Misc Feature(1)245..247(+)
Misc Feature(2)509..511(+)
Misc Feature(3)509..511(+)
Misc Feature(4)566..568(+)
Misc Feature(5)575..577(+)
Misc Feature(6)578..580(+)
Misc Feature(7)620..622(+)
Misc Feature(8)620..622(+)
Misc Feature(9)704..706(+)
Misc Feature(10)866..868(+)
Misc Feature(11)1100..1102(+)
Misc Feature(12)1136..1264(+)
Misc Feature(13)1163..1516(+)
Misc Feature(14)1226..1516(+)
Misc Feature(15)1268..1387(+)
Misc Feature(16)1394..1516(+)
Misc Feature(17)1826..1963(+)
Misc Feature(18)2126..2248(+)
Misc Feature(19)2138..2527(+)
Misc Feature(20)2213..2527(+)
Misc Feature(21)2270..2389(+)
Misc Feature(22)2402..2527(+)
Misc Feature(23)2534..2662(+)
Exon (1)1..338
Gene:PKP2
Gene Synonym:
Exon (2)339..451
Gene:PKP2
Gene Synonym:
Exon (3)452..1149
Gene:PKP2
Gene Synonym:
Exon (4)1150..1285
Gene:PKP2
Gene Synonym:
Exon (5)1286..1493
Gene:PKP2
Gene Synonym:
Exon (6)1494..1625
Gene:PKP2
Gene Synonym:
Exon (7)1626..1803
Gene:PKP2
Gene Synonym:
Exon (8)1804..1921
Gene:PKP2
Gene Synonym:
Exon (9)1922..2086
Gene:PKP2
Gene Synonym:
Exon (10)2087..2260
Gene:PKP2
Gene Synonym:
Exon (11)2261..2414
Gene:PKP2
Gene Synonym:
Exon (12)2415..2604
Gene:PKP2
Gene Synonym:
Exon (13)2605..2692
Gene:PKP2
Gene Synonym:
Exon (14)2693..4439
Gene:PKP2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004572
Organism Homo sapiens (human)
Definition Homo sapiens plakophilin 2 (PKP2), transcript variant 2b, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004572

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGCAGCCC CCGGCGCCCC AGCTGAGTAC GGCTACATCC GGACCGTCCT GGGCCAGCAG 
ATCCTGGGAC AACTGGACAG CTCCAGCCTG GCGCTGCCCT CCGAGGCCAA GCTGAAGCTG
GCGGGGAGCA GCGGCCGCGG CGGCCAGACA GTCAAGAGCC TGCGGATCCA GGAGCAGGTG
CAGCAGACCC TCGCCCGGAA GGGCCGCAGC TCCGTGGGCA ACGGAAATCT TCACCGAACC
AGCAGTGTTC CTGAGTATGT CTACAACCTA CACTTGGTTG AAAATGATTT TGTTGGAGGC
CGTTCCCCTG TTCCTAAAAC CTATGACATG CTAAAGGCTG GCACAACTGC CACTTATGAA
GGTCGCTGGG GAAGAGGAAC AGCACAGTAC AGCTCCCAGA AGTCCGTGGA AGAAAGGTCC
TTGAGGCATC CTCTGAGGAG ACTGGAGATT TCTCCTGACA GCAGCCCGGA GAGGGCTCAC
TACACGCACA GCGATTACCA GTACAGCCAG AGAAGCCAGG CTGGGCACAC CCTGCACCAC
CAAGAAAGCA GGCGGGCCGC CCTCCTAGTG CCACCGAGAT ATGCTCGTTC CGAGATCGTG
GGGGTCAGCC GTGCTGGCAC CACAAGCAGG CAGCGCCACT TTGACACATA CCACAGACAG
TACCAGCATG GCTCTGTTAG CGACACCGTT TTTGACAGCA TCCCTGCCAA CCCGGCCCTG
CTCACGTACC CCAGGCCAGG GACCAGCCGC AGCATGGGCA ACCTCTTGGA GAAGGAGAAC
TACCTGACGG CAGGGCTCAC TGTCGGGCAG GTCAGGCCGC TGGTGCCCCT GCAGCCCGTC
ACTCAGAACA GGGCTTCCAG GTCCTCCTGG CATCAGAGCT CCTTCCACAG CACCCGCACG
CTGAGGGAAG CTGGGCCCAG TGTCGCCGTG GATTCCAGCG GGAGGAGAGC GCACTTGACT
GTCGGCCAGG CGGCCGCAGG GGGAAGTGGG AATCTGCTCA CTGAGAGAAG CACTTTCACT
GACTCCCAGC TGGGGAATGC AGACATGGAG ATGACTCTGG AGCGAGCAGT GAGTATGCTC
GAGGCAGACC ACATGCTGCC ATCCAGGATT TCTGCTGCAG CTACTTTCAT ACAGCACGAG
TGCTTCCAGA AATCTGAAGC TCGGAAGAGG GTTAACCAGC TTCGTGGCAT CCTCAAGCTT
CTGCAGCTCC TAAAAGTTCA GAATGAAGAC GTTCAGCGAG CTGTGTGTGG GGCCTTGAGA
AACTTAGTAT TTGAAGACAA TGACAACAAA TTGGAGGTGG CTGAACTAAA TGGGGTACCT
CGGCTGCTCC AGGTGCTGAA GCAAACCAGA GACTTGGAGA CTAAAAAACA AATAACAGAC
CATACAGTCA ATTTAAGAAG TAGGAATGGC TGGCCGGGCG CGGTGGCTCA CGCCTGTAAT
CCCAGCACTT TGGGAGGCCA AGGCGGGCGG ATCACGAGGT CAGGAGTTCG AGACCAGCCT
GACCAACATG GTTTGCTGTG GAATTTGTCA TCTAATGACA AACTCAAGAA TCTCATGATA
ACAGAAGCAT TGCTTACGCT GACGGAGAAT ATCATCATCC CCTTTTCTGG GTGGCCTGAA
GGAGACTACC CAAAAGCAAA TGGTTTGCTC GATTTTGACA TATTCTACAA CGTCACTGGA
TGCCTAAGAA ACATGAGTTC TGCTGGCGCT GATGGGAGAA AAGCGATGAG AAGATGTGAC
GGACTCATTG ACTCACTGGT CCATTATGTC AGAGGAACCA TTGCAGATTA CCAGCCAGAT
GACAAGGCCA CGGAGAATTG TGTGTGCATT CTTCATAACC TCTCCTACCA GCTGGAGGCA
GAGCTCCCAG AGAAATATTC CCAGAATATC TATATTCAAA ACCGGAATAT CCAGACTGAC
AACAACAAAA GTATTGGATG TTTTGGCAGT CGAAGCAGGA AAGTAAAAGA GCAATACCAG
GACGTGCCGA TGCCGGAGGA AAAGAGCAAC CCCAAGGGCG TGGAGTGGCT GTGGCATTCC
ATTGTTATAA GGATGTATCT GTCCTTGATC GCCAAAAGTG TCCGCAACTA CACACAAGAA
GCATCCTTAG GAGCTCTGCA GAACCTCACG GCCGGAAGTG GACCAATGCC GACATCAGTG
GCTCAGACAG TTGTCCAGAA GGAAAGTGGC CTGCAGCACA CCCGAAAGAT GCTGCATGTT
GGTGACCCAA GTGTGAAAAA GACAGCCATC TCGCTGCTGA GGAATCTGTC CCGGAATCTT
TCTCTGCAGA ATGAAATTGC CAAAGAAACT CTCCCTGATT TGGTTTCCAT CATTCCTGAC
ACAGTCCCGA GTACTGACCT TCTCATTGAA ACTACAGCCT CTGCCTGTTA CACATTGAAC
AACATAATCC AAAACAGTTA CCAGAATGCA CGCGACCTTC TAAACACCGG GGGCATCCAG
AAAATTATGG CCATTAGTGC AGGCGATGCC TATGCCTCCA ACAAAGCAAG TAAAGCTGCT
TCCGTCCTTC TGTATTCTCT GTGGGCACAC ACGGAACTGC ATCATGCCTA CAAGAAGGCT
CAGTTTAAGA AGACAGATTT TGTCAACAGC CGGACTGCCA AAGCCTACCA CTCCCTTAAA
GACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23286
Clone ID Related Accession (Same CDS sequence) NM_001005242
Accession Version NM_001005242.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2514bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product plakophilin-2 isoform 2a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB454360.1, BC126199.1, AC087588.10 and AW439621.1. On Jun 7, 2007 this sequence version replaced gi:52630431. Transcript Variant: This transcript variant (2a) lacks an alternate exon as compared to transcript variant 2b and encodes the shorter isoform (2a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962346 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGCAGCCC CCGGCGCCCC AGCTGAGTAC GGCTACATCC GGACCGTCCT GGGCCAGCAG 
ATCCTGGGAC AACTGGACAG CTCCAGCCTG GCGCTGCCCT CCGAGGCCAA GCTGAAGCTG
GCGGGGAGCA GCGGCCGCGG CGGCCAGACA GTCAAGAGCC TGCGGATCCA GGAGCAGGTG
CAGCAGACCC TCGCCCGGAA GGGCCGCAGC TCCGTGGGCA ACGGAAATCT TCACCGAACC
AGCAGTGTTC CTGAGTATGT CTACAACCTA CACTTGGTTG AAAATGATTT TGTTGGAGGC
CGTTCCCCTG TTCCTAAAAC CTATGACATG CTAAAGGCTG GCACAACTGC CACTTATGAA
GGTCGCTGGG GAAGAGGAAC AGCACAGTAC AGCTCCCAGA AGTCCGTGGA AGAAAGGTCC
TTGAGGCATC CTCTGAGGAG ACTGGAGATT TCTCCTGACA GCAGCCCGGA GAGGGCTCAC
TACACGCACA GCGATTACCA GTACAGCCAG AGAAGCCAGG CTGGGCACAC CCTGCACCAC
CAAGAAAGCA GGCGGGCCGC CCTCCTAGTG CCACCGAGAT ATGCTCGTTC CGAGATCGTG
GGGGTCAGCC GTGCTGGCAC CACAAGCAGG CAGCGCCACT TTGACACATA CCACAGACAG
TACCAGCATG GCTCTGTTAG CGACACCGTT TTTGACAGCA TCCCTGCCAA CCCGGCCCTG
CTCACGTACC CCAGGCCAGG GACCAGCCGC AGCATGGGCA ACCTCTTGGA GAAGGAGAAC
TACCTGACGG CAGGGCTCAC TGTCGGGCAG GTCAGGCCGC TGGTGCCCCT GCAGCCCGTC
ACTCAGAACA GGGCTTCCAG GTCCTCCTGG CATCAGAGCT CCTTCCACAG CACCCGCACG
CTGAGGGAAG CTGGGCCCAG TGTCGCCGTG GATTCCAGCG GGAGGAGAGC GCACTTGACT
GTCGGCCAGG CGGCCGCAGG GGGAAGTGGG AATCTGCTCA CTGAGAGAAG CACTTTCACT
GACTCCCAGC TGGGGAATGC AGACATGGAG ATGACTCTGG AGCGAGCAGT GAGTATGCTC
GAGGCAGACC ACATGCTGCC ATCCAGGATT TCTGCTGCAG CTACTTTCAT ACAGCACGAG
TGCTTCCAGA AATCTGAAGC TCGGAAGAGG GTTAACCAGC TTCGTGGCAT CCTCAAGCTT
CTGCAGCTCC TAAAAGTTCA GAATGAAGAC GTTCAGCGAG CTGTGTGTGG GGCCTTGAGA
AACTTAGTAT TTGAAGACAA TGACAACAAA TTGGAGGTGG CTGAACTAAA TGGGGTACCT
CGGCTGCTCC AGGTGCTGAA GCAAACCAGA GACTTGGAGA CTAAAAAACA AATAACAGGT
TTGCTGTGGA ATTTGTCATC TAATGACAAA CTCAAGAATC TCATGATAAC AGAAGCATTG
CTTACGCTGA CGGAGAATAT CATCATCCCC TTTTCTGGGT GGCCTGAAGG AGACTACCCA
AAAGCAAATG GTTTGCTCGA TTTTGACATA TTCTACAACG TCACTGGATG CCTAAGAAAC
ATGAGTTCTG CTGGCGCTGA TGGGAGAAAA GCGATGAGAA GATGTGACGG ACTCATTGAC
TCACTGGTCC ATTATGTCAG AGGAACCATT GCAGATTACC AGCCAGATGA CAAGGCCACG
GAGAATTGTG TGTGCATTCT TCATAACCTC TCCTACCAGC TGGAGGCAGA GCTCCCAGAG
AAATATTCCC AGAATATCTA TATTCAAAAC CGGAATATCC AGACTGACAA CAACAAAAGT
ATTGGATGTT TTGGCAGTCG AAGCAGGAAA GTAAAAGAGC AATACCAGGA CGTGCCGATG
CCGGAGGAAA AGAGCAACCC CAAGGGCGTG GAGTGGCTGT GGCATTCCAT TGTTATAAGG
ATGTATCTGT CCTTGATCGC CAAAAGTGTC CGCAACTACA CACAAGAAGC ATCCTTAGGA
GCTCTGCAGA ACCTCACGGC CGGAAGTGGA CCAATGCCGA CATCAGTGGC TCAGACAGTT
GTCCAGAAGG AAAGTGGCCT GCAGCACACC CGAAAGATGC TGCATGTTGG TGACCCAAGT
GTGAAAAAGA CAGCCATCTC GCTGCTGAGG AATCTGTCCC GGAATCTTTC TCTGCAGAAT
GAAATTGCCA AAGAAACTCT CCCTGATTTG GTTTCCATCA TTCCTGACAC AGTCCCGAGT
ACTGACCTTC TCATTGAAAC TACAGCCTCT GCCTGTTACA CATTGAACAA CATAATCCAA
AACAGTTACC AGAATGCACG CGACCTTCTA AACACCGGGG GCATCCAGAA AATTATGGCC
ATTAGTGCAG GCGATGCCTA TGCCTCCAAC AAAGCAAGTA AAGCTGCTTC CGTCCTTCTG
TATTCTCTGT GGGCACACAC GGAACTGCAT CATGCCTACA AGAAGGCTCA GTTTAAGAAG
ACAGATTTTG TCAACAGCCG GACTGCCAAA GCCTACCACT CCCTTAAAGA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001005242.2
CDS116..2629
Misc Feature(1)509..511(+)
Misc Feature(2)620..622(+)
Misc Feature(3)1163..1516(+)
Misc Feature(4)1226..1516(+)
Misc Feature(5)2006..2395(+)
Misc Feature(6)2081..2395(+)
Exon (1)1..338
Gene:PKP2
Gene Synonym:
Exon (2)339..451
Gene:PKP2
Gene Synonym:
Exon (3)452..1149
Gene:PKP2
Gene Synonym:
Exon (4)1150..1285
Gene:PKP2
Gene Synonym:
Exon (5)1286..1493
Gene:PKP2
Gene Synonym:
Exon (6)1494..1671
Gene:PKP2
Gene Synonym:
Exon (7)1672..1789
Gene:PKP2
Gene Synonym:
Exon (8)1790..1954
Gene:PKP2
Gene Synonym:
Exon (9)1955..2128
Gene:PKP2
Gene Synonym:
Exon (10)2129..2282
Gene:PKP2
Gene Synonym:
Exon (11)2283..2472
Gene:PKP2
Gene Synonym:
Exon (12)2473..2560
Gene:PKP2
Gene Synonym:
Exon (13)2561..4307
Gene:PKP2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001005242
Organism Homo sapiens (human)
Definition Homo sapiens plakophilin 2 (PKP2), transcript variant 2a, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001005242

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGCAGCCC CCGGCGCCCC AGCTGAGTAC GGCTACATCC GGACCGTCCT GGGCCAGCAG 
ATCCTGGGAC AACTGGACAG CTCCAGCCTG GCGCTGCCCT CCGAGGCCAA GCTGAAGCTG
GCGGGGAGCA GCGGCCGCGG CGGCCAGACA GTCAAGAGCC TGCGGATCCA GGAGCAGGTG
CAGCAGACCC TCGCCCGGAA GGGCCGCAGC TCCGTGGGCA ACGGAAATCT TCACCGAACC
AGCAGTGTTC CTGAGTATGT CTACAACCTA CACTTGGTTG AAAATGATTT TGTTGGAGGC
CGTTCCCCTG TTCCTAAAAC CTATGACATG CTAAAGGCTG GCACAACTGC CACTTATGAA
GGTCGCTGGG GAAGAGGAAC AGCACAGTAC AGCTCCCAGA AGTCCGTGGA AGAAAGGTCC
TTGAGGCATC CTCTGAGGAG ACTGGAGATT TCTCCTGACA GCAGCCCGGA GAGGGCTCAC
TACACGCACA GCGATTACCA GTACAGCCAG AGAAGCCAGG CTGGGCACAC CCTGCACCAC
CAAGAAAGCA GGCGGGCCGC CCTCCTAGTG CCACCGAGAT ATGCTCGTTC CGAGATCGTG
GGGGTCAGCC GTGCTGGCAC CACAAGCAGG CAGCGCCACT TTGACACATA CCACAGACAG
TACCAGCATG GCTCTGTTAG CGACACCGTT TTTGACAGCA TCCCTGCCAA CCCGGCCCTG
CTCACGTACC CCAGGCCAGG GACCAGCCGC AGCATGGGCA ACCTCTTGGA GAAGGAGAAC
TACCTGACGG CAGGGCTCAC TGTCGGGCAG GTCAGGCCGC TGGTGCCCCT GCAGCCCGTC
ACTCAGAACA GGGCTTCCAG GTCCTCCTGG CATCAGAGCT CCTTCCACAG CACCCGCACG
CTGAGGGAAG CTGGGCCCAG TGTCGCCGTG GATTCCAGCG GGAGGAGAGC GCACTTGACT
GTCGGCCAGG CGGCCGCAGG GGGAAGTGGG AATCTGCTCA CTGAGAGAAG CACTTTCACT
GACTCCCAGC TGGGGAATGC AGACATGGAG ATGACTCTGG AGCGAGCAGT GAGTATGCTC
GAGGCAGACC ACATGCTGCC ATCCAGGATT TCTGCTGCAG CTACTTTCAT ACAGCACGAG
TGCTTCCAGA AATCTGAAGC TCGGAAGAGG GTTAACCAGC TTCGTGGCAT CCTCAAGCTT
CTGCAGCTCC TAAAAGTTCA GAATGAAGAC GTTCAGCGAG CTGTGTGTGG GGCCTTGAGA
AACTTAGTAT TTGAAGACAA TGACAACAAA TTGGAGGTGG CTGAACTAAA TGGGGTACCT
CGGCTGCTCC AGGTGCTGAA GCAAACCAGA GACTTGGAGA CTAAAAAACA AATAACAGGT
TTGCTGTGGA ATTTGTCATC TAATGACAAA CTCAAGAATC TCATGATAAC AGAAGCATTG
CTTACGCTGA CGGAGAATAT CATCATCCCC TTTTCTGGGT GGCCTGAAGG AGACTACCCA
AAAGCAAATG GTTTGCTCGA TTTTGACATA TTCTACAACG TCACTGGATG CCTAAGAAAC
ATGAGTTCTG CTGGCGCTGA TGGGAGAAAA GCGATGAGAA GATGTGACGG ACTCATTGAC
TCACTGGTCC ATTATGTCAG AGGAACCATT GCAGATTACC AGCCAGATGA CAAGGCCACG
GAGAATTGTG TGTGCATTCT TCATAACCTC TCCTACCAGC TGGAGGCAGA GCTCCCAGAG
AAATATTCCC AGAATATCTA TATTCAAAAC CGGAATATCC AGACTGACAA CAACAAAAGT
ATTGGATGTT TTGGCAGTCG AAGCAGGAAA GTAAAAGAGC AATACCAGGA CGTGCCGATG
CCGGAGGAAA AGAGCAACCC CAAGGGCGTG GAGTGGCTGT GGCATTCCAT TGTTATAAGG
ATGTATCTGT CCTTGATCGC CAAAAGTGTC CGCAACTACA CACAAGAAGC ATCCTTAGGA
GCTCTGCAGA ACCTCACGGC CGGAAGTGGA CCAATGCCGA CATCAGTGGC TCAGACAGTT
GTCCAGAAGG AAAGTGGCCT GCAGCACACC CGAAAGATGC TGCATGTTGG TGACCCAAGT
GTGAAAAAGA CAGCCATCTC GCTGCTGAGG AATCTGTCCC GGAATCTTTC TCTGCAGAAT
GAAATTGCCA AAGAAACTCT CCCTGATTTG GTTTCCATCA TTCCTGACAC AGTCCCGAGT
ACTGACCTTC TCATTGAAAC TACAGCCTCT GCCTGTTACA CATTGAACAA CATAATCCAA
AACAGTTACC AGAATGCACG CGACCTTCTA AACACCGGGG GCATCCAGAA AATTATGGCC
ATTAGTGCAG GCGATGCCTA TGCCTCCAAC AAAGCAAGTA AAGCTGCTTC CGTCCTTCTG
TATTCTCTGT GGGCACACAC GGAACTGCAT CATGCCTACA AGAAGGCTCA GTTTAAGAAG
ACAGATTTTG TCAACAGCCG GACTGCCAAA GCCTACCACT CCCTTAAAGA CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy
Circ. Res. 114 (3), 454-468 (2014)
Chen SN, Gurha P, Lombardi R, Ruggiero A, Willerson JT and Marian AJ.


book

Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression
J. Invest. Dermatol. 134 (1), 112-122 (2014)
Koetsier JL, Amargo EV, Todorovic V, Green KJ and Godsel LM.


book

Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy
Eur. J. Hum. Genet. 21 (11), 1226-1231 (2013)
Li Mura IE, Bauce B, Nava A, Fanciulli M, Vazza G, Mazzotti E, Rigato I, De Bortoli M, Beffagna G, Lorenzon A, Calore M, Dazzo E, Nobile C, Mostacciuolo ML, Corrado D, Basso C, Daliento L, Thiene G and Rampazzo A.


book

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population
Ann. Med. 45 (4), 328-335 (2013)
Lahtinen AM, Havulinna AS, Noseworthy PA, Jula A, Karhunen PJ, Perola M, Newton-Cheh C, Salomaa V and Kontula K.


book

Left-dominant arrhythmogenic cardiomyopathy in a large family: associated desmosomal or nondesmosomal genotype?
Heart Rhythm 10 (4), 548-559 (2013)
Groeneweg JA, van der Zwaag PA, Jongbloed JD, Cox MG, Vreeker A, de Boer RA, van der Heijden JF, van Veen TA, McKenna WJ, van Tintelen JP, Dooijes D and Hauer RN.


book

Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
Differentiation 64 (5), 291-306 (1999)
Schmidt A, Langbein L, Pratzel S, Rode M, Rackwitz HR and Franke WW.


book

Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues
Differentiation 64 (5), 277-290 (1999)
Mertens C, Kuhn C, Moll R, Schwetlick I and Franke WW.


book

Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily
Genomics 51 (3), 452-454 (1998)
Bonne S, van Hengel J and van Roy F.


book

Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque
J. Cell Biol. 135 (4), 1009-1025 (1996)
Mertens C, Kuhn C and Franke WW.


book

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
McNally,E., MacLeod,H. and Dellefave-Castillo,L.


 
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