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PLN phospholamban [Homo sapiens (human)]

Gene Symbol PLN
Entrez Gene ID 5350
Full Name phospholamban
Synonyms CMD1P, CMH18, PLB
General protein information
Preferred Names
cardiac phospholamban
Names
cardiac phospholamban
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q22.1

Summary The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

172405

Disorder Html: Cardiomyopathy, dilated, 1P, 609909 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu17925 NM_002667 Homo sapiens phospholamban (PLN), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu17925D
Sequence Information ORF Nucleotide Sequence (Length: 159bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cardiac phospholamban
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP259965.1, M63603.1 and BC005269.1. This sequence is a reference standard in the RefSeqGene project. On Jul 18, 2008 this sequence version replaced gi:29171725. Summary: The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005269.1, M63603.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGGAGAAAG TCCAATACCT CACTCGCTCA GCTATAAGAA GAGCCTCAAC CATTGAAATG 
CCTCAACAAG CACGTCAAAA GCTACAGAAT CTATTTATCA ATTTCTGTCT CATCTTAATA
TGTCTCTTGC TGATCTGTAT CATCGTGATG CTTCTCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_002658.1
CDS212..370
Misc Feature(1)98..100(+)
Misc Feature(2)212..367(+)
Misc Feature(3)257..277(+)
Misc Feature(4)257..259(+)
Misc Feature(5)257..259(+)
Misc Feature(6)260..262(+)
Misc Feature(7)260..262(+)
Misc Feature(8)305..367(+)
Exon (1)1..114
Gene:PLN
Gene Synonym:
Exon (2)115..1714
Gene:PLN
Gene Synonym:
Translation
Position Chain Variation Link
59 59 c, t dbSNP:755267827
62 62 a, g dbSNP:9489434
70 70 a, t dbSNP:779232815
75 75 c, t dbSNP:748273819
92 92 c, t dbSNP:150080760
115 115 c, g dbSNP:558554251
126 126 c, g dbSNP:572092385
131 131 c, t dbSNP:541080130
149 149 c, t dbSNP:543790768
151 151 c, g dbSNP:186238926
152 152 c, t dbSNP:529837883
156 156 c, t dbSNP:189611501
161 161 a, t dbSNP:770154758
163 163 a, c, t dbSNP:773520639
168 168 c, t dbSNP:771080303
172 172 a, c, t dbSNP:774271388
173 173 a, c, g dbSNP:375430634
179 179 c, t dbSNP:372647899
184 184 a, t dbSNP:763754683
185 185 c, t dbSNP:753445677
199 199 c, t dbSNP:756839662
201 201 c, t dbSNP:764862475
208 208 c, t dbSNP:749900271
213 213 c, t dbSNP:727503374
215 215 c, g dbSNP:758364608
222 222 -, c dbSNP:774186147
227 227 c, g, t dbSNP:780082801
236 236 c, t dbSNP:111033559
237 237 a, g dbSNP:754782171
238 238 c, t dbSNP:145623013
245 245 a, g dbSNP:749571694
246 246 c, t dbSNP:771044756
247 247 -, aag dbSNP:778096369
247 247 a, g dbSNP:774556120
248 248 -, a dbSNP:727503375
251 251 -, aga dbSNP:397516784
252 252 g, t dbSNP:151112761
254 254 a, g dbSNP:397516785
272 272 a, c dbSNP:397516786
280 280 a, g dbSNP:775923421
284 284 c, t dbSNP:761056344
311 311 a, c dbSNP:745592199
315 315 -, tc dbSNP:747947483
327 327 g, t dbSNP:111033560
328 328 a, g dbSNP:776969887
352 352 c, g dbSNP:552078051
355 355 c, t dbSNP:141114252
356 356 a, g dbSNP:749962743
359 359 a, c dbSNP:757797900
362 362 c, t dbSNP:766452369
363 363 c, t dbSNP:397516783
374 374 a, t dbSNP:397516782
384 384 c, t dbSNP:371507549
390 390 g, t dbSNP:754942529
392 392 c, t dbSNP:781189307
397 397 a, c dbSNP:747890379
398 398 c, g dbSNP:372970382
417 417 a, g dbSNP:778941150
420 420 c, t dbSNP:745978438
421 421 g, t dbSNP:369368451
429 429 a, g dbSNP:544803483
450 450 c, t dbSNP:565692601
459 459 a, g dbSNP:28763979
505 505 c, t dbSNP:780385491
543 543 c, t dbSNP:180799194
583 583 c, t dbSNP:747130253
594 594 a, c dbSNP:35739264
598 598 a, g dbSNP:568262125
599 599 c, t dbSNP:532539997
620 620 c, t dbSNP:79199092
647 647 a, g dbSNP:768837853
673 673 a, g dbSNP:557568289
679 679 a, g dbSNP:570972632
700 700 c, g dbSNP:186663539
753 753 c, t dbSNP:553705193
767 767 a, g, t dbSNP:12198461
785 785 c, t dbSNP:117280667
804 804 -, cac dbSNP:765386927
837 837 a, g dbSNP:760027606
938 938 c, t dbSNP:554698802
939 939 a, t dbSNP:191057969
1059 1059 c, t dbSNP:543235354
1123 1123 a, g dbSNP:748689128
1153 1153 c, t dbSNP:563461651
1165 1165 a, t dbSNP:75600410
1182 1182 c, t dbSNP:537697221
1209 1209 -, tc dbSNP:141447190
1231 1231 g, t dbSNP:371473315
1236 1236 c, t dbSNP:147557787
1279 1279 c, t dbSNP:142301036
1347 1347 a, g dbSNP:113584707
1360 1360 a, t dbSNP:557687689
1368 1368 a, c dbSNP:574434391
1377 1377 a, g, t dbSNP:528466147
1378 1378 a, t dbSNP:548206730
1382 1382 a, t dbSNP:183097878
1395 1395 c, g dbSNP:760850270
1440 1440 a, t dbSNP:562026339
1447 1447 a, c dbSNP:527452464
1468 1468 c, t dbSNP:185945888
1481 1481 c, t dbSNP:550818264
1484 1484 g, t dbSNP:570977086
1506 1506 a, g dbSNP:764978489
1513 1513 c, t dbSNP:775287766
1514 1514 a, g dbSNP:549223893
1532 1532 a, t dbSNP:770271766
1536 1536 c, g dbSNP:762819979
1550 1550 a, g dbSNP:540046916
1613 1613 c, t dbSNP:146145000
1649 1649 a, g dbSNP:537800022
1653 1653 a, t dbSNP:201177617
1655 1655 a, t dbSNP:201951020
1656 1656 a, t dbSNP:200551023
1658 1658 a, t dbSNP:201396273
1677 1677 a, t dbSNP:763768705
1707 1707 a, g dbSNP:41291942
1714 1714 a, g dbSNP:571117883

Target ORF information:

RefSeq Version NM_002667
Organism Homo sapiens (human)
Definition Homo sapiens phospholamban (PLN), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_002667

ORF Insert Sequence:

1
61
121
ATGGAGAAAG TCCAATACCT CACTCGCTCA GCTATAAGAA GAGCCTCAAC CATTGAAATG 
CCTCAACAAG CACGTCAAAA GCTACAGAAT CTATTTATCA ATTTCTGTCT CATCTTAATA
TGTCTCTTGC TGATCTGTAT CATCGTGATG CTTCTCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.