||ORF Nucleotide Sequence (Length: 159bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP259965.1, M63603.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jul 18, 2008 this sequence version replaced gi:29171725.
Summary: The protein encoded by this gene is found as a pentamer
and is a major substrate for the cAMP-dependent protein kinase in
cardiac muscle. The encoded protein is an inhibitor of cardiac
muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated
state, but inhibition is relieved upon phosphorylation of the
protein. The subsequent activation of the Ca(2+) pump leads to
enhanced muscle relaxation rates, thereby contributing to the
inotropic response elicited in heart by beta-agonists. The encoded
protein is a key regulator of cardiac diastolic function. Mutations
in this gene are a cause of inherited human dilated cardiomyopathy
with refractory congestive heart failure. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC005269.1, M63603.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.