The following PLN gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLN gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 159bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP259965.1, M63603.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jul 18, 2008 this sequence version replaced gi:29171725.
Summary: The protein encoded by this gene is found as a pentamer
and is a major substrate for the cAMP-dependent protein kinase in
cardiac muscle. The encoded protein is an inhibitor of cardiac
muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated
state, but inhibition is relieved upon phosphorylation of the
protein. The subsequent activation of the Ca(2+) pump leads to
enhanced muscle relaxation rates, thereby contributing to the
inotropic response elicited in heart by beta-agonists. The encoded
protein is a key regulator of cardiac diastolic function. Mutations
in this gene are a cause of inherited human dilated cardiomyopathy
with refractory congestive heart failure. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC005269.1, M63603.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.