Email to GenScript

Human  Mouse  Rat  Other  

Search Help

Human  Mouse  Rat  Other  

  • THAT   AND
  • THAT   AND


PML promyelocytic leukemia [Homo sapiens (human)]

Gene Symbol PML
Entrez Gene ID 5371
Full Name promyelocytic leukemia
Synonyms MYL, PP8675, RNF71, TRIM19
General protein information
Preferred Names
protein PML
Names
protein PML
RING finger protein 71
promyelocytic leukemia protein
tripartite motif protein TRIM19
probable transcription factor PML
promyelocytic leukemia, inducer of
tripartite motif-containing protein 19
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q22

Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

102578

Disorder Html: Leukemia, acute promyelocytic, PML/RARA type (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu25542 NM_033246 Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu25586 NM_033239 Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA. pcDNA3.1-C-(k)DYK Not in stock -1 Starting from $99.00
OHu25484 NM_002675 Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu25346 NM_033247 Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu25497 NM_033240 Homo sapiens promyelocytic leukemia (PML), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu25441 NM_033250 Homo sapiens promyelocytic leukemia (PML), transcript variant 11, mRNA. pcDNA3.1-C-(k)DYK Not in stock -1 Starting from $99.00
OHu25457 NM_033244 Homo sapiens promyelocytic leukemia (PML), transcript variant 5, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu25455 NM_033238 Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu25540 NM_033249 Homo sapiens promyelocytic leukemia (PML), transcript variant 10, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu25542D
Sequence Information ORF Nucleotide Sequence (Length: 1272bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 7
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BF510860.1. On or before Mar 4, 2006 this sequence version replaced gi:89039089, gi:89039091, gi:89039093, gi:15451774. Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (7) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (7, also known as PML-6B, PML-VIB, TRIM19eta and TRIM19iota) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGAGGAAC
GCGTTGTGGTT GA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_150249.1
CDS141..1412
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..>1394(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1365..1367(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1447
Gene:PML
Gene Synonym:
Exon (6)1448..1835
Gene:PML
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:545412927
44 44 a, c dbSNP:181321458
57 57 c, g dbSNP:569274755
63 63 a, c dbSNP:539800728
65 65 c, t dbSNP:558192870
70 70 c, t dbSNP:566938076
73 73 a, g dbSNP:144576529
80 80 c, t dbSNP:770383081
89 89 c, t dbSNP:553110202
102 102 c, t dbSNP:762187130
116 116 g, t dbSNP:767971085
127 127 c, g dbSNP:752203384
132 132 c, g dbSNP:759066056
133 133 -, g dbSNP:35863954
159 159 a, c dbSNP:574579963
163 163 a, c, t dbSNP:542097036
170 170 a, g dbSNP:763855768
189 189 a, c dbSNP:751354376
203 203 c, t dbSNP:556884444
213 213 a, c dbSNP:376726233
217 217 a, c, g dbSNP:781165510
222 222 a, c dbSNP:28504405
223 223 c, t dbSNP:201524800
225 225 c, t dbSNP:749399804
231 231 a, g dbSNP:768816135
261 261 c, g dbSNP:779135665
264 264 a, g dbSNP:748479176
271 271 a, g dbSNP:761685300
279 279 g, t dbSNP:767279397
283 283 c, t dbSNP:377614337
284 284 a, g dbSNP:545577011
292 292 a, c dbSNP:780062613
306 306 c, t dbSNP:147696900
337 337 -, c dbSNP:34228316
339 339 c, t dbSNP:755088983
341 341 a, g dbSNP:374118853
375 375 c, g dbSNP:28412621
376 376 a, g dbSNP:748429878
378 378 g, t dbSNP:772423497
389 389 a, g dbSNP:572620428
390 390 g, t dbSNP:752972084
391 391 c, t dbSNP:771298279
392 392 a, g dbSNP:369958078
399 399 a, c dbSNP:543332226
413 413 c, t dbSNP:561108241
414 414 c, g dbSNP:762523424
418 418 a, c, g, t dbSNP:531642849
420 420 c, t dbSNP:761487093
425 425 g, t dbSNP:767209117
441 441 a, c dbSNP:772834238
447 447 a, g dbSNP:570405596
454 454 a, c dbSNP:760548118
456 456 a, g dbSNP:372639541
460 460 c, t dbSNP:756707115
483 483 c, t dbSNP:766194468
485 485 c, t dbSNP:753820877
488 488 g, t dbSNP:543417635
491 491 g, t dbSNP:755039717
495 495 c, t dbSNP:765368853
498 498 c, t dbSNP:141544943
505 505 c, t dbSNP:758491320
514 514 c, g dbSNP:77069486
515 515 a, g dbSNP:747300098
518 518 a, g dbSNP:376898295
519 519 a, g dbSNP:764681333
521 521 c, t dbSNP:781759664
527 527 c, t dbSNP:150904456
539 539 a, g dbSNP:770426452
544 544 c, t dbSNP:372931853
548 548 c, t dbSNP:747678613
560 560 c, g dbSNP:771584396
569 569 c, t dbSNP:772957093
578 578 c, t dbSNP:760364748
602 602 a, g dbSNP:375933686
614 614 c, g dbSNP:370861713
617 617 c, t dbSNP:374283665
634 634 c, g dbSNP:759402979
644 644 c, g dbSNP:565000110
649 649 a, g dbSNP:200708179
651 651 a, c dbSNP:758540569
652 652 a, t dbSNP:764195821
659 659 a, g dbSNP:751860822
662 662 a, g dbSNP:112099437
664 664 c, g, t dbSNP:781633419
671 671 c, g dbSNP:368684793
677 677 c, t dbSNP:780737061
680 680 c, t dbSNP:747580265
684 684 c, g, t dbSNP:771660433
692 692 a, c dbSNP:746745053
695 695 c, g dbSNP:200143816
702 702 a, t dbSNP:373742710
709 709 c, t dbSNP:138345086
712 712 a, g dbSNP:759349668
717 717 a, c dbSNP:551261745
718 718 a, g dbSNP:775451143
722 722 c, t dbSNP:367778787
727 727 a, c dbSNP:35291318
728 728 a, c dbSNP:751591785
753 753 a, c dbSNP:762878228
754 754 a, g dbSNP:768489639
759 759 c, t dbSNP:774435967
764 764 c, g dbSNP:761826112
770 770 g, t dbSNP:767815962
781 781 c, t dbSNP:750722602
788 788 a, g dbSNP:371576035
791 791 c, g dbSNP:761106701
800 800 c, t dbSNP:766916406
803 803 c, t dbSNP:754160191
812 812 a, g, t dbSNP:17849258
827 827 c, g dbSNP:779310039
829 829 a, g dbSNP:751040865
848 848 a, g dbSNP:756803454
851 851 c, g dbSNP:780804100
856 856 a, c dbSNP:745581079
860 860 c, g dbSNP:755902214
861 861 g, t dbSNP:779837719
863 863 c, t dbSNP:527374805
871 871 a, c, t dbSNP:548755096
872 872 g, t dbSNP:567362523
874 874 a, g dbSNP:748216366
887 887 a, g dbSNP:772335766
890 890 a, g dbSNP:773561754
891 891 a, c, g dbSNP:769861444
892 892 a, c dbSNP:766524275
893 893 a, t dbSNP:267604312
894 894 -, a dbSNP:771937767
902 902 c, t dbSNP:777008010
904 904 -, g dbSNP:34681920
905 905 c, t dbSNP:759849906
910 910 c, t dbSNP:765744379
914 914 c, t dbSNP:753196785
917 917 g, t dbSNP:756751960
932 932 c, t dbSNP:17849259
934 934 c, t dbSNP:749942852
936 936 c, g dbSNP:755711851
941 941 c, g dbSNP:779600459
950 950 c, t dbSNP:550374192
952 952 c, t dbSNP:369316804
953 953 a, g dbSNP:571588911
959 959 a, c, g dbSNP:112627818
960 960 a, g dbSNP:772139210
979 979 g, t dbSNP:773369332
980 980 c, t dbSNP:777026193
991 991 a, g dbSNP:771145349
995 995 c, g dbSNP:776759306
996 996 a, c, g dbSNP:759926492
999 999 a, g dbSNP:775974503
1007 1007 c, t dbSNP:375794405
1009 1009 g, t dbSNP:763387415
1014 1014 a, g dbSNP:764605006
1018 1018 a, t dbSNP:749893395
1027 1027 a, g dbSNP:755656820
1029 1029 c, t dbSNP:549683798
1031 1031 a, g dbSNP:753491071
1048 1048 c, t dbSNP:754797325
1050 1050 c, g, t dbSNP:778503914
1053 1053 c, t dbSNP:538982599
1059 1059 c, t dbSNP:140050477
1062 1062 a, g dbSNP:747055654
1067 1067 c, t dbSNP:143705203
1068 1068 a, g dbSNP:146344435
1069 1069 a, t dbSNP:377549937
1077 1077 c, g dbSNP:746145846
1084 1084 a, g dbSNP:139917470
1095 1095 c, g dbSNP:775778127
1097 1097 a, g dbSNP:763334625
1098 1098 g, t dbSNP:769118386
1099 1099 a, t dbSNP:774884695
1106 1106 a, g dbSNP:760218638
1113 1113 c, t dbSNP:765869727
1115 1115 c, t dbSNP:142180894
1124 1124 c, g dbSNP:151218142
1131 1131 a, g dbSNP:765004499
1132 1132 c, t dbSNP:752501211
1139 1139 a, g dbSNP:138129034
1154 1154 c, g dbSNP:371084483
1157 1157 c, t dbSNP:749092993
1166 1166 c, t dbSNP:751608431
1173 1173 a, g dbSNP:199516006
1178 1178 g, t dbSNP:781070712
1180 1180 a, g dbSNP:745978140
1182 1182 a, g dbSNP:769864191
1187 1187 c, t dbSNP:780290914
1188 1188 a, g dbSNP:749628246
1205 1205 a, g dbSNP:769063307
1208 1208 c, t dbSNP:774833451
1214 1214 c, g dbSNP:762157300
1219 1219 a, g dbSNP:375594567
1224 1224 c, g dbSNP:775954834
1225 1225 a, g, t dbSNP:74471420
1231 1231 -, ccaa dbSNP:761862912
1243 1243 a, g dbSNP:764951444
1248 1248 a, g dbSNP:752448206
1250 1250 c, g, t dbSNP:762830343
1251 1251 g, t dbSNP:751376158
1254 1254 c, g, t dbSNP:773725664
1257 1257 a, g dbSNP:767515993
1261 1261 a, g dbSNP:545588296
1265 1265 c, g, t dbSNP:750435184
1266 1266 c, t dbSNP:780238004
1271 1271 c, g, t dbSNP:377747936
1272 1272 a, g dbSNP:371413149
1285 1285 a, c, g dbSNP:149871195
1289 1289 a, g dbSNP:556426526
1295 1295 a, c dbSNP:745349363
1300 1300 c, g dbSNP:369148720
1303 1303 c, g dbSNP:769487892
1307 1307 c, t dbSNP:147563445
1314 1314 a, c dbSNP:775280848
1315 1315 a, g dbSNP:762629473
1321 1321 a, c dbSNP:763855841
1331 1331 a, t dbSNP:775074469
1344 1344 c, g dbSNP:768386792
1348 1348 a, g dbSNP:142023780
1356 1356 c, g dbSNP:761496643
1362 1362 a, g dbSNP:767411421
1366 1366 c, g dbSNP:772885645
1385 1385 c, t dbSNP:760545579
1386 1386 a, g dbSNP:766326578
1389 1389 c, g dbSNP:145863996
1401 1401 a, g dbSNP:200546578
1402 1402 c, t dbSNP:139324287
1403 1403 a, g, t dbSNP:746515572
1405 1405 c, t dbSNP:776277079
1423 1423 a, g dbSNP:147120400
1427 1427 a, g dbSNP:375611361
1430 1430 a, t dbSNP:764959569
1432 1432 a, c dbSNP:775464827
1436 1436 a, g dbSNP:762767132
1437 1437 c, g, t dbSNP:371956504
1438 1438 c, t dbSNP:546243501
1442 1442 a, t dbSNP:767645907
1449 1449 c, t dbSNP:765859108
1450 1450 c, g dbSNP:143289477
1453 1453 c, t dbSNP:754660578
1454 1454 c, t dbSNP:778493023
1455 1455 a, g dbSNP:752502722
1459 1459 a, g dbSNP:758123681
1471 1471 c, t dbSNP:777622219
1473 1473 g, t dbSNP:746979292
1477 1477 g, t dbSNP:200104189
1485 1485 a, g dbSNP:148332748
1504 1504 c, t dbSNP:745901797
1510 1510 c, g dbSNP:770162831
1519 1519 c, g, t dbSNP:775792287
1525 1525 a, g, t dbSNP:769207599
1529 1529 a, g, t dbSNP:11272
1531 1531 c, g dbSNP:143616011
1533 1533 a, c dbSNP:371806874
1535 1535 a, c dbSNP:758989714
1537 1537 g, t dbSNP:764875104
1543 1543 a, c dbSNP:368061525
1545 1545 c, g dbSNP:758035628
1552 1552 a, g dbSNP:200895458
1556 1556 a, g dbSNP:751337106
1559 1559 a, g dbSNP:371624259
1563 1563 c, t dbSNP:757172711
1583 1583 a, c dbSNP:781134737
1593 1593 a, g dbSNP:745955110
1594 1594 c, t dbSNP:376784868
1601 1601 a, g dbSNP:193112596
1608 1608 c, t dbSNP:756193172
1611 1611 a, g, t dbSNP:369699833
1614 1614 g, t dbSNP:749576967
1617 1617 a, g dbSNP:768894259
1622 1622 c, t dbSNP:540260798
1623 1623 a, g dbSNP:561752088
1626 1626 c, g dbSNP:748500888
1662 1662 a, g dbSNP:772474621
1664 1664 a, g dbSNP:773642830
1676 1676 c, g dbSNP:761166887
1677 1677 g, t dbSNP:764787231
1679 1679 a, c dbSNP:774960376
1689 1689 c, g dbSNP:762631947
1691 1691 g, t dbSNP:745604382
1697 1697 c, t dbSNP:772168119
1708 1708 c, t dbSNP:116627018
1727 1727 a, g dbSNP:775608365
1740 1740 c, t dbSNP:544478159
1791 1791 c, g, t dbSNP:145373016
1792 1792 a, g dbSNP:533374001
1815 1815 c, t dbSNP:552020355

Target ORF information:

RefSeq Version NM_033246
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_033246

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGAGGAAC
GCGTTGTGGTT GA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25586D
Sequence Information ORF Nucleotide Sequence (Length: 2490bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 9
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BC034251.1. On or before Jun 24, 2006 this sequence version replaced gi:67089161, gi:15451764. Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (9) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (9, also known as PML-II and TRIM19kappa) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230403.1, AF230410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TGCATGGAGC CCATGGAGAC CGCCGAGCCA
CAGTCCTCGC CAGCCCACTC CTCGCCAGCC CACTCCTCGC CAGCCCACTC CTCGCCAGTC
CAGTCTCTGC TGAGAGCACA AGGAGCCTCC AGCCTGCCCT GTGGCACATA CCACCCCCCA
GCTTGGCCTC CCCACCAGCC CGCTGAGCAG GCTGCCACCC CCGATGCTGA GCCTCACAGC
GAGCCTCCTG ATCACCAGGA GCGCCCTGCC GTCCACCGTG GGATCCGCTA CCTGTTGTAC
AGAGCACAGA GAGCCATCCG CCTTCGCCAT GCCCTCCGCT TGCACCCTCA ATTGCATCGG
GCCCCTATTC GGACTTGGTC TCCCCATGTG GTCCAAGCCA GCACTCCTGC CATCACAGGG
CCCCTCAACC ATCCTGCCAA TGCCCAGGAA CATCCTGCCC AGCTGCAAAG GGGCATCAGC
CCACCCCACC GGATACGAGG GGCTGTGCGA TCCCGCAGCC GCTCCCTCCG GGGCTCCTCC
CATTTATCCC AGTGGCTCAA CAACTTTTTT GCCCTCCCCT TCTCCTCCAT GGCTTCCCAG
CTTGACATGT CTTCCGTGGT GGGGGCAGGG GAAAGCAGAG CCCAGACTCT TGGAGCAGGT
GTTCCCCCTG GGGACTCTGT CAGAGGCTCC ATGGAGGCCT CTCAAGTCCA AGTGCCTCTG
GAAGCCTCTC CAATTACATT CCCACCACCC TGTGCCCCAG AAAGGCCCCC CATCAGCCCA
GTCCCAGGCG CCCGTCAAGC AGGCCTCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_150242.1
CDS141..2630
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1850(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1656..>1937(+)
Misc Feature(27)1677..1679(+)
Misc Feature(28)1683..1685(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1692..1694(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1719..1721(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1728..1730(+)
Misc Feature(35)1743..1745(+)
Misc Feature(36)1794..1799(+)
Misc Feature(37)1806..1826(+)
Misc Feature(38)1833..1835(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..1850
Gene:PML
Gene Synonym:
Exon (8)1851..3073
Gene:PML
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:545412927
44 44 a, c dbSNP:181321458
57 57 c, g dbSNP:569274755
63 63 a, c dbSNP:539800728
65 65 c, t dbSNP:558192870
70 70 c, t dbSNP:566938076
73 73 a, g dbSNP:144576529
80 80 c, t dbSNP:770383081
89 89 c, t dbSNP:553110202
102 102 c, t dbSNP:762187130
116 116 g, t dbSNP:767971085
127 127 c, g dbSNP:752203384
132 132 c, g dbSNP:759066056
133 133 -, g dbSNP:35863954
159 159 a, c dbSNP:574579963
163 163 a, c, t dbSNP:542097036
170 170 a, g dbSNP:763855768
189 189 a, c dbSNP:751354376
203 203 c, t dbSNP:556884444
213 213 a, c dbSNP:376726233
217 217 a, c, g dbSNP:781165510
222 222 a, c dbSNP:28504405
223 223 c, t dbSNP:201524800
225 225 c, t dbSNP:749399804
231 231 a, g dbSNP:768816135
261 261 c, g dbSNP:779135665
264 264 a, g dbSNP:748479176
271 271 a, g dbSNP:761685300
279 279 g, t dbSNP:767279397
283 283 c, t dbSNP:377614337
284 284 a, g dbSNP:545577011
292 292 a, c dbSNP:780062613
306 306 c, t dbSNP:147696900
337 337 -, c dbSNP:34228316
339 339 c, t dbSNP:755088983
341 341 a, g dbSNP:374118853
375 375 c, g dbSNP:28412621
376 376 a, g dbSNP:748429878
378 378 g, t dbSNP:772423497
389 389 a, g dbSNP:572620428
390 390 g, t dbSNP:752972084
391 391 c, t dbSNP:771298279
392 392 a, g dbSNP:369958078
399 399 a, c dbSNP:543332226
413 413 c, t dbSNP:561108241
414 414 c, g dbSNP:762523424
418 418 a, c, g, t dbSNP:531642849
420 420 c, t dbSNP:761487093
425 425 g, t dbSNP:767209117
441 441 a, c dbSNP:772834238
447 447 a, g dbSNP:570405596
454 454 a, c dbSNP:760548118
456 456 a, g dbSNP:372639541
460 460 c, t dbSNP:756707115
483 483 c, t dbSNP:766194468
485 485 c, t dbSNP:753820877
488 488 g, t dbSNP:543417635
491 491 g, t dbSNP:755039717
495 495 c, t dbSNP:765368853
498 498 c, t dbSNP:141544943
505 505 c, t dbSNP:758491320
514 514 c, g dbSNP:77069486
515 515 a, g dbSNP:747300098
518 518 a, g dbSNP:376898295
519 519 a, g dbSNP:764681333
521 521 c, t dbSNP:781759664
527 527 c, t dbSNP:150904456
539 539 a, g dbSNP:770426452
544 544 c, t dbSNP:372931853
548 548 c, t dbSNP:747678613
560 560 c, g dbSNP:771584396
569 569 c, t dbSNP:772957093
578 578 c, t dbSNP:760364748
602 602 a, g dbSNP:375933686
614 614 c, g dbSNP:370861713
617 617 c, t dbSNP:374283665
634 634 c, g dbSNP:759402979
644 644 c, g dbSNP:565000110
649 649 a, g dbSNP:200708179
651 651 a, c dbSNP:758540569
652 652 a, t dbSNP:764195821
659 659 a, g dbSNP:751860822
662 662 a, g dbSNP:112099437
664 664 c, g, t dbSNP:781633419
671 671 c, g dbSNP:368684793
677 677 c, t dbSNP:780737061
680 680 c, t dbSNP:747580265
684 684 c, g, t dbSNP:771660433
692 692 a, c dbSNP:746745053
695 695 c, g dbSNP:200143816
702 702 a, t dbSNP:373742710
709 709 c, t dbSNP:138345086
712 712 a, g dbSNP:759349668
717 717 a, c dbSNP:551261745
718 718 a, g dbSNP:775451143
722 722 c, t dbSNP:367778787
727 727 a, c dbSNP:35291318
728 728 a, c dbSNP:751591785
753 753 a, c dbSNP:762878228
754 754 a, g dbSNP:768489639
759 759 c, t dbSNP:774435967
764 764 c, g dbSNP:761826112
770 770 g, t dbSNP:767815962
781 781 c, t dbSNP:750722602
788 788 a, g dbSNP:371576035
791 791 c, g dbSNP:761106701
800 800 c, t dbSNP:766916406
803 803 c, t dbSNP:754160191
812 812 a, g, t dbSNP:17849258
827 827 c, g dbSNP:779310039
829 829 a, g dbSNP:751040865
848 848 a, g dbSNP:756803454
851 851 c, g dbSNP:780804100
856 856 a, c dbSNP:745581079
860 860 c, g dbSNP:755902214
861 861 g, t dbSNP:779837719
863 863 c, t dbSNP:527374805
871 871 a, c, t dbSNP:548755096
872 872 g, t dbSNP:567362523
874 874 a, g dbSNP:748216366
887 887 a, g dbSNP:772335766
890 890 a, g dbSNP:773561754
891 891 a, c, g dbSNP:769861444
892 892 a, c dbSNP:766524275
893 893 a, t dbSNP:267604312
894 894 -, a dbSNP:771937767
902 902 c, t dbSNP:777008010
904 904 -, g dbSNP:34681920
905 905 c, t dbSNP:759849906
910 910 c, t dbSNP:765744379
914 914 c, t dbSNP:753196785
917 917 g, t dbSNP:756751960
932 932 c, t dbSNP:17849259
934 934 c, t dbSNP:749942852
936 936 c, g dbSNP:755711851
941 941 c, g dbSNP:779600459
950 950 c, t dbSNP:550374192
952 952 c, t dbSNP:369316804
953 953 a, g dbSNP:571588911
959 959 a, c, g dbSNP:112627818
960 960 a, g dbSNP:772139210
979 979 g, t dbSNP:773369332
980 980 c, t dbSNP:777026193
991 991 a, g dbSNP:771145349
995 995 c, g dbSNP:776759306
996 996 a, c, g dbSNP:759926492
999 999 a, g dbSNP:775974503
1007 1007 c, t dbSNP:375794405
1009 1009 g, t dbSNP:763387415
1014 1014 a, g dbSNP:764605006
1018 1018 a, t dbSNP:749893395
1027 1027 a, g dbSNP:755656820
1029 1029 c, t dbSNP:549683798
1031 1031 a, g dbSNP:753491071
1048 1048 c, t dbSNP:754797325
1050 1050 c, g, t dbSNP:778503914
1053 1053 c, t dbSNP:538982599
1059 1059 c, t dbSNP:140050477
1062 1062 a, g dbSNP:747055654
1067 1067 c, t dbSNP:143705203
1068 1068 a, g dbSNP:146344435
1069 1069 a, t dbSNP:377549937
1077 1077 c, g dbSNP:746145846
1084 1084 a, g dbSNP:139917470
1095 1095 c, g dbSNP:775778127
1097 1097 a, g dbSNP:763334625
1098 1098 g, t dbSNP:769118386
1099 1099 a, t dbSNP:774884695
1106 1106 a, g dbSNP:760218638
1113 1113 c, t dbSNP:765869727
1115 1115 c, t dbSNP:142180894
1124 1124 c, g dbSNP:151218142
1131 1131 a, g dbSNP:765004499
1132 1132 c, t dbSNP:752501211
1139 1139 a, g dbSNP:138129034
1154 1154 c, g dbSNP:371084483
1157 1157 c, t dbSNP:749092993
1166 1166 c, t dbSNP:751608431
1173 1173 a, g dbSNP:199516006
1178 1178 g, t dbSNP:781070712
1180 1180 a, g dbSNP:745978140
1182 1182 a, g dbSNP:769864191
1187 1187 c, t dbSNP:780290914
1188 1188 a, g dbSNP:749628246
1205 1205 a, g dbSNP:769063307
1208 1208 c, t dbSNP:774833451
1214 1214 c, g dbSNP:762157300
1219 1219 a, g dbSNP:375594567
1224 1224 c, g dbSNP:775954834
1225 1225 a, g, t dbSNP:74471420
1231 1231 -, ccaa dbSNP:761862912
1243 1243 a, g dbSNP:764951444
1248 1248 a, g dbSNP:752448206
1250 1250 c, g, t dbSNP:762830343
1251 1251 g, t dbSNP:751376158
1254 1254 c, g, t dbSNP:773725664
1257 1257 a, g dbSNP:767515993
1261 1261 a, g dbSNP:545588296
1265 1265 c, g, t dbSNP:750435184
1266 1266 c, t dbSNP:780238004
1271 1271 c, g, t dbSNP:377747936
1272 1272 a, g dbSNP:371413149
1285 1285 a, c, g dbSNP:149871195
1289 1289 a, g dbSNP:556426526
1295 1295 a, c dbSNP:745349363
1300 1300 c, g dbSNP:369148720
1303 1303 c, g dbSNP:769487892
1307 1307 c, t dbSNP:147563445
1314 1314 a, c dbSNP:775280848
1315 1315 a, g dbSNP:762629473
1321 1321 a, c dbSNP:763855841
1331 1331 a, t dbSNP:775074469
1344 1344 c, g dbSNP:768386792
1348 1348 a, g dbSNP:142023780
1356 1356 c, g dbSNP:761496643
1362 1362 a, g dbSNP:767411421
1366 1366 c, g dbSNP:772885645
1385 1385 c, t dbSNP:760545579
1386 1386 a, g dbSNP:766326578
1389 1389 c, g dbSNP:145863996
1397 1397 c, g, t dbSNP:543631733
1398 1398 a, g dbSNP:565219584
1399 1399 a, c dbSNP:763180010
1404 1404 a, g dbSNP:764247291
1412 1412 a, t dbSNP:751936860
1415 1415 a, g dbSNP:532878240
1419 1419 a, g dbSNP:746160914
1427 1427 g, t dbSNP:781760131
1431 1431 g, t dbSNP:751033700
1434 1434 c, t dbSNP:756580480
1438 1438 a, g dbSNP:778426636
1440 1440 a, c dbSNP:758611701
1450 1450 c, t dbSNP:747633287
1453 1453 a, g dbSNP:771715585
1458 1458 a, g dbSNP:772181249
1482 1482 a, g dbSNP:777441794
1486 1486 c, t dbSNP:746784735
1490 1490 c, t dbSNP:138775462
1493 1493 c, t dbSNP:776546547
1494 1494 a, g dbSNP:759404689
1503 1503 a, t dbSNP:769635059
1505 1505 c, t dbSNP:376333996
1506 1506 a, g dbSNP:11555843
1513 1513 c, t dbSNP:143771296
1522 1522 c, g dbSNP:148158604
1538 1538 g, t dbSNP:774767661
1549 1549 a, g dbSNP:769734938
1553 1553 a, g dbSNP:775333596
1555 1555 c, t dbSNP:200123201
1556 1556 a, g dbSNP:142009914
1573 1573 a, g dbSNP:774573419
1575 1575 a, t dbSNP:762065759
1577 1577 c, t dbSNP:767871709
1580 1580 a, c dbSNP:773669860
1589 1589 c, g dbSNP:760985638
1594 1594 c, t dbSNP:766886570
1595 1595 c, t dbSNP:754360816
1638 1638 a, c dbSNP:757922767
1647 1647 c, t dbSNP:763529879
1648 1648 a, g dbSNP:751085157
1654 1654 c, t dbSNP:756856518
1657 1657 c, t dbSNP:202019975
1658 1658 a, c, g dbSNP:377287687
1676 1676 c, t dbSNP:780031954
1684 1684 a, g dbSNP:749109993
1689 1689 a, g dbSNP:768725303
1694 1694 a, g dbSNP:774520402
1698 1698 c, t dbSNP:748267579
1699 1699 c, t dbSNP:772391650
1714 1714 c, t dbSNP:370723883
1715 1715 a, g dbSNP:375629289
1717 1717 c, t dbSNP:771267596
1721 1721 c, t dbSNP:777059436
1729 1729 g, t dbSNP:759979414
1734 1734 a, g dbSNP:146047180
1736 1736 c, t dbSNP:751032145
1747 1747 a, c dbSNP:761356725
1749 1749 a, g dbSNP:767138681
1751 1751 c, t dbSNP:750106015
1757 1757 a, g dbSNP:138807296
1769 1769 c, g dbSNP:779652279
1772 1772 c, t dbSNP:753687495
1775 1775 a, g dbSNP:754924275
1785 1785 a, g dbSNP:11855663
1787 1787 c, t dbSNP:748216241
1788 1788 a, g dbSNP:374199653
1789 1789 a, g dbSNP:146326362
1790 1790 a, g dbSNP:747134619
1794 1794 a, g dbSNP:771198810
1804 1804 a, g dbSNP:200546578
1805 1805 c, t dbSNP:139324287
1806 1806 a, g, t dbSNP:746515572
1808 1808 c, t dbSNP:776277079
1826 1826 a, g dbSNP:147120400
1830 1830 a, g dbSNP:375611361
1833 1833 a, t dbSNP:764959569
1835 1835 a, c dbSNP:775464827
1839 1839 a, g dbSNP:762767132
1840 1840 c, g, t dbSNP:371956504
1841 1841 c, t dbSNP:546243501
1845 1845 a, t dbSNP:767645907
1855 1855 c, t dbSNP:149710270
1864 1864 c, t dbSNP:370195590
1872 1872 a, g dbSNP:144559886
1874 1874 c, t dbSNP:779853709
1875 1875 a, g dbSNP:749032616
1885 1885 a, c dbSNP:768176990
1888 1888 c, t dbSNP:372539605
1889 1889 a, g dbSNP:761477583
1894 1894 c, t dbSNP:78340702
1903 1903 c, t dbSNP:374669015
1905 1905 c, t dbSNP:760751573
1913 1913 c, g, t dbSNP:766513520
1915 1915 c, t dbSNP:147652568
1918 1918 c, t dbSNP:765346623
1919 1919 a, g dbSNP:557907134
1922 1922 a, t dbSNP:758784141
1926 1926 c, t dbSNP:778435415
1928 1928 c, t dbSNP:752043168
1930 1930 c, t dbSNP:757831781
1931 1931 c, t dbSNP:141958169
1933 1933 c, t dbSNP:779668164
1939 1939 a, c, t dbSNP:373088243
1942 1942 a, c dbSNP:778383459
1944 1944 -, c, tc dbSNP:745595474
1945 1945 c, g dbSNP:747953604
1948 1948 g, t dbSNP:771790286
1949 1949 c, g dbSNP:772988267
1952 1952 a, g dbSNP:747007010
1957 1957 a, c dbSNP:770833935
1963 1963 g, t dbSNP:199513809
1972 1972 a, g dbSNP:144234369
1983 1983 a, g dbSNP:765516841
1990 1990 a, c, g dbSNP:775515717
1996 1996 c, g dbSNP:780250401
1998 1998 c, g dbSNP:201804134
1999 1999 -, c dbSNP:140797024
1999 1999 c, t dbSNP:369292960
2008 2008 c, t dbSNP:751955342
2010 2010 c, t dbSNP:757884929
2021 2021 c, t dbSNP:201226688
2022 2022 a, g dbSNP:112272650
2031 2031 g, t dbSNP:754391223
2032 2032 c, t dbSNP:778635203
2037 2037 -, c dbSNP:779911916
2039 2039 c, t dbSNP:369911359
2042 2042 c, g, t dbSNP:140216915
2043 2043 a, g dbSNP:746776339
2048 2048 c, t dbSNP:770931063
2049 2049 a, g dbSNP:776383657
2057 2057 c, g dbSNP:745972252
2060 2060 c, t dbSNP:769694101
2061 2061 a, g dbSNP:200905984
2064 2064 c, g dbSNP:200094687
2073 2073 -, ca dbSNP:746939556
2078 2078 -, ggagcgc dbSNP:769801328
2078 2078 a, g dbSNP:202182247
2082 2082 c, t dbSNP:200988291
2083 2083 a, g dbSNP:377501404
2084 2084 c, t dbSNP:768084783
2090 2090 c, t dbSNP:150442989
2091 2091 a, g dbSNP:756641826
2092 2092 a, t dbSNP:764714500
2096 2096 a, c dbSNP:752181739
2097 2097 c, t dbSNP:138276205
2100 2100 a, g dbSNP:777364305
2106 2106 c, t dbSNP:371144013
2107 2107 a, g dbSNP:149202279
2109 2109 c, t dbSNP:781192354
2117 2117 -, g dbSNP:773299181
2129 2129 a, g dbSNP:377354460
2138 2138 -, c dbSNP:763286510
2139 2139 c, t dbSNP:145160033
2146 2146 a, g, t dbSNP:570306547
2149 2149 a, g dbSNP:139031068
2157 2157 c, t dbSNP:75056290
2158 2158 a, g dbSNP:145646904
2166 2166 c, g dbSNP:546342488
2169 2169 c, g dbSNP:368679910
2175 2175 c, t dbSNP:772387700
2176 2176 a, g, t dbSNP:148106218
2178 2178 c, t dbSNP:761137155
2179 2179 a, g dbSNP:141894268
2184 2184 c, t dbSNP:752236847
2186 2186 c, t dbSNP:150761242
2187 2187 a, c dbSNP:763750133
2191 2191 a, g dbSNP:751144387
2192 2192 c, g dbSNP:528725581
2194 2194 c, t dbSNP:756926576
2199 2199 c, t dbSNP:200400610
2202 2202 a, c dbSNP:139143471
2213 2213 c, t dbSNP:756042432
2225 2225 c, t dbSNP:780094996
2226 2226 c, g dbSNP:369036000
2232 2232 a, g dbSNP:369253046
2238 2238 a, g dbSNP:148636537
2239 2239 a, g dbSNP:748377564
2240 2240 g, t dbSNP:772317014
2243 2243 c, t dbSNP:569562998
2250 2250 c, t dbSNP:568065544
2252 2252 c, t dbSNP:761061019
2256 2256 a, g dbSNP:771449149
2258 2258 c, t dbSNP:147213990
2260 2260 a, g dbSNP:762452812
2262 2262 a, g dbSNP:763658568
2263 2263 a, c dbSNP:751063469
2279 2279 c, g dbSNP:761419093
2287 2287 a, c, g dbSNP:140648301
2295 2295 -, tcagc dbSNP:774865430
2295 2295 a, g dbSNP:755884869
2299 2299 a, g dbSNP:766428057
2301 2301 c, t dbSNP:770399088
2304 2304 c, g dbSNP:754956837
2310 2310 -, cggata dbSNP:760047613
2310 2310 c, t dbSNP:377295816
2311 2311 a, g dbSNP:144170102
2314 2314 a, t dbSNP:145461366
2315 2315 a, t dbSNP:201456778
2316 2316 c, t dbSNP:778003774
2317 2317 a, g, t dbSNP:148418079
2320 2320 a, g dbSNP:200633780
2321 2321 c, g dbSNP:746431068
2322 2322 g, t dbSNP:770261381
2325 2325 c, g dbSNP:773770329
2328 2328 c, t dbSNP:115552704
2334 2334 c, t dbSNP:767093256
2335 2335 a, g dbSNP:573828634
2337 2337 a, g dbSNP:377619576
2340 2340 c, t dbSNP:760401435
2341 2341 a, g dbSNP:766337991
2344 2344 c, t dbSNP:753664781
2348 2348 c, t dbSNP:755006151
2349 2349 c, t dbSNP:765228989
2350 2350 a, g dbSNP:752743066
2367 2367 c, t dbSNP:369142690
2393 2393 c, t dbSNP:777860927
2402 2402 -, ctc dbSNP:767914773
2407 2407 c, t dbSNP:541612791
2411 2411 a, g dbSNP:757456806
2414 2414 c, t dbSNP:781582190
2421 2421 c, t dbSNP:746195982
2425 2425 a, c dbSNP:190536709
2427 2427 a, g dbSNP:142557214
2432 2432 c, t dbSNP:747619129
2435 2435 c, t dbSNP:550995360
2436 2436 a, g dbSNP:150969738
2439 2439 g, t dbSNP:760456533
2442 2442 c, g dbSNP:770677767
2445 2445 g, t dbSNP:776599019
2449 2449 a, g dbSNP:759358156
2454 2454 a, c, g dbSNP:743580
2457 2457 a, c dbSNP:752612389
2460 2460 g, t dbSNP:564420390
2462 2462 c, t dbSNP:145127312
2463 2463 a, c, g, t dbSNP:146867846
2468 2468 g, t dbSNP:750806582
2473 2473 a, g dbSNP:762036261
2474 2474 a, g dbSNP:756407264
2478 2478 c, g dbSNP:780279843
2479 2479 a, g, t dbSNP:743581
2492 2492 a, g dbSNP:769025379
2493 2493 c, g dbSNP:777383825
2498 2498 c, t dbSNP:746478828
2501 2501 a, c dbSNP:770731332
2518 2518 a, c dbSNP:546604386
2519 2519 a, c dbSNP:759409184
2528 2528 c, t dbSNP:769695419
2535 2535 c, t dbSNP:775134797
2540 2540 a, g dbSNP:568147640
2543 2543 a, t dbSNP:763903277
2544 2544 a, c, g dbSNP:743582
2557 2557 c, t dbSNP:767737457
2563 2563 c, t dbSNP:750714511
2565 2565 a, c, t dbSNP:756279904
2569 2569 c, g, t dbSNP:754125548
2573 2573 c, t dbSNP:779240182
2574 2574 a, g dbSNP:746534010
2578 2578 c, t dbSNP:551193666
2585 2585 -, c dbSNP:753194759
2587 2587 c, t dbSNP:373658022
2591 2591 a, c dbSNP:370009213
2592 2592 a, g dbSNP:745572445
2599 2599 a, c dbSNP:763492413
2605 2605 c, t dbSNP:769309342
2606 2606 a, g dbSNP:377715350
2608 2608 a, g dbSNP:748992721
2609 2609 c, t dbSNP:370446869
2610 2610 a, g dbSNP:774212743
2611 2611 c, g dbSNP:761737205
2612 2612 a, c dbSNP:767643856
2613 2613 c, t dbSNP:773258021
2614 2614 a, g dbSNP:76608781
2633 2633 a, g dbSNP:766472006
2641 2641 c, g, t dbSNP:754251974
2643 2643 c, t dbSNP:765845760
2661 2661 -, ccaacacc dbSNP:761216136
2661 2661 c, g dbSNP:753322191
2664 2664 a, g dbSNP:758958596
2669 2669 c, g dbSNP:780898373
2671 2671 g, t dbSNP:551754840
2673 2673 c, t dbSNP:755818610
2674 2674 c, t dbSNP:201691315
2675 2675 c, t dbSNP:200958951
2676 2676 a, c, g dbSNP:111658103
2677 2677 g, t dbSNP:768265290
2680 2680 c, g, t dbSNP:199725271
2684 2684 a, g dbSNP:771970407
2690 2690 c, t dbSNP:555380806
2705 2705 c, t dbSNP:370389300
2707 2707 a, c dbSNP:759232644
2711 2711 a, c, t dbSNP:200028634
2714 2714 -, c dbSNP:763544092
2715 2715 c, t dbSNP:759801761
2719 2719 a, g dbSNP:765753935
2727 2727 a, g, t dbSNP:149573441
2730 2730 c, t dbSNP:764655064
2731 2731 a, g dbSNP:749968529
2738 2738 a, g dbSNP:755517240
2742 2742 a, c dbSNP:779759818
2747 2747 -, t dbSNP:753297773
2754 2754 a, g dbSNP:748953974
2755 2755 c, t dbSNP:754605423
2759 2759 c, t dbSNP:537901535
2763 2763 c, t dbSNP:747902260
2764 2764 a, g dbSNP:375250698
2773 2773 g, t dbSNP:777515480
2774 2774 c, t dbSNP:368406946
2777 2777 c, t dbSNP:770985567
2778 2778 c, g dbSNP:776756524
2780 2780 a, g dbSNP:759724691
2782 2782 a, g dbSNP:770109605
2784 2784 -, c dbSNP:756907429
2790 2790 c, g dbSNP:141224194
2792 2792 g, t dbSNP:762592
2826 2826 a, g dbSNP:188723955
2829 2829 a, g dbSNP:370140201
2897 2897 c, t dbSNP:764436102
2914 2914 a, g dbSNP:9479
2917 2917 c, t dbSNP:1051697
2935 2935 a, g dbSNP:553424812
2954 2954 a, g dbSNP:568754580
2972 2972 c, t dbSNP:1051700
2985 2985 c, t dbSNP:1051702
2992 2992 g, t dbSNP:573127760
2995 2995 c, t dbSNP:1051703
3072 3072 c, t dbSNP:192800282

Target ORF information:

RefSeq Version NM_033239
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 9, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_033239

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TGCATGGAGC CCATGGAGAC CGCCGAGCCA
CAGTCCTCGC CAGCCCACTC CTCGCCAGCC CACTCCTCGC CAGCCCACTC CTCGCCAGTC
CAGTCTCTGC TGAGAGCACA AGGAGCCTCC AGCCTGCCCT GTGGCACATA CCACCCCCCA
GCTTGGCCTC CCCACCAGCC CGCTGAGCAG GCTGCCACCC CCGATGCTGA GCCTCACAGC
GAGCCTCCTG ATCACCAGGA GCGCCCTGCC GTCCACCGTG GGATCCGCTA CCTGTTGTAC
AGAGCACAGA GAGCCATCCG CCTTCGCCAT GCCCTCCGCT TGCACCCTCA ATTGCATCGG
GCCCCTATTC GGACTTGGTC TCCCCATGTG GTCCAAGCCA GCACTCCTGC CATCACAGGG
CCCCTCAACC ATCCTGCCAA TGCCCAGGAA CATCCTGCCC AGCTGCAAAG GGGCATCAGC
CCACCCCACC GGATACGAGG GGCTGTGCGA TCCCGCAGCC GCTCCCTCCG GGGCTCCTCC
CATTTATCCC AGTGGCTCAA CAACTTTTTT GCCCTCCCCT TCTCCTCCAT GGCTTCCCAG
CTTGACATGT CTTCCGTGGT GGGGGCAGGG GAAAGCAGAG CCCAGACTCT TGGAGCAGGT
GTTCCCCCTG GGGACTCTGT CAGAGGCTCC ATGGAGGCCT CTCAAGTCCA AGTGCCTCTG
GAAGCCTCTC CAATTACATT CCCACCACCC TGTGCCCCAG AAAGGCCCCC CATCAGCCCA
GTCCCAGGCG CCCGTCAAGC AGGCCTCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25484D
Sequence Information ORF Nucleotide Sequence (Length: 1902bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 6
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BF510860.1. On or before Sep 20, 2006 this sequence version replaced gi:113425704, gi:15451782. Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (6, also known as PML-IV, PML-X and TRIM19zeta) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X63131.1, AF230406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
AGTGGGTTCT CCTGGGGCTA CCCCCACCCC TTTCTAATTTT AG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_002666.1
CDS141..2042
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1853(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1677..1679(+)
Misc Feature(27)1683..1685(+)
Misc Feature(28)1692..1694(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1719..1721(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1728..1730(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1743..1745(+)
Misc Feature(35)1794..1799(+)
Misc Feature(36)1806..1826(+)
Misc Feature(37)1818..1820(+)
Misc Feature(38)1821..1823(+)
Misc Feature(39)1824..1826(+)
Misc Feature(40)1833..1835(+)
Misc Feature(41)1833..1835(+)
Misc Feature(42)1872..1874(+)
Misc Feature(43)1875..1877(+)
Misc Feature(44)1878..1880(+)
Misc Feature(45)1884..1886(+)
Misc Feature(46)1887..1889(+)
Misc Feature(47)1986..1988(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..1850
Gene:PML
Gene Synonym:
Exon (8)1851..2238
Gene:PML
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:545412927
44 44 a, c dbSNP:181321458
57 57 c, g dbSNP:569274755
63 63 a, c dbSNP:539800728
65 65 c, t dbSNP:558192870
70 70 c, t dbSNP:566938076
73 73 a, g dbSNP:144576529
80 80 c, t dbSNP:770383081
89 89 c, t dbSNP:553110202
102 102 c, t dbSNP:762187130
116 116 g, t dbSNP:767971085
127 127 c, g dbSNP:752203384
132 132 c, g dbSNP:759066056
133 133 -, g dbSNP:35863954
159 159 a, c dbSNP:574579963
163 163 a, c, t dbSNP:542097036
170 170 a, g dbSNP:763855768
189 189 a, c dbSNP:751354376
203 203 c, t dbSNP:556884444
213 213 a, c dbSNP:376726233
217 217 a, c, g dbSNP:781165510
222 222 a, c dbSNP:28504405
223 223 c, t dbSNP:201524800
225 225 c, t dbSNP:749399804
231 231 a, g dbSNP:768816135
261 261 c, g dbSNP:779135665
264 264 a, g dbSNP:748479176
271 271 a, g dbSNP:761685300
279 279 g, t dbSNP:767279397
283 283 c, t dbSNP:377614337
284 284 a, g dbSNP:545577011
292 292 a, c dbSNP:780062613
306 306 c, t dbSNP:147696900
337 337 -, c dbSNP:34228316
339 339 c, t dbSNP:755088983
341 341 a, g dbSNP:374118853
375 375 c, g dbSNP:28412621
376 376 a, g dbSNP:748429878
378 378 g, t dbSNP:772423497
389 389 a, g dbSNP:572620428
390 390 g, t dbSNP:752972084
391 391 c, t dbSNP:771298279
392 392 a, g dbSNP:369958078
399 399 a, c dbSNP:543332226
413 413 c, t dbSNP:561108241
414 414 c, g dbSNP:762523424
418 418 a, c, g, t dbSNP:531642849
420 420 c, t dbSNP:761487093
425 425 g, t dbSNP:767209117
441 441 a, c dbSNP:772834238
447 447 a, g dbSNP:570405596
454 454 a, c dbSNP:760548118
456 456 a, g dbSNP:372639541
460 460 c, t dbSNP:756707115
483 483 c, t dbSNP:766194468
485 485 c, t dbSNP:753820877
488 488 g, t dbSNP:543417635
491 491 g, t dbSNP:755039717
495 495 c, t dbSNP:765368853
498 498 c, t dbSNP:141544943
505 505 c, t dbSNP:758491320
514 514 c, g dbSNP:77069486
515 515 a, g dbSNP:747300098
518 518 a, g dbSNP:376898295
519 519 a, g dbSNP:764681333
521 521 c, t dbSNP:781759664
527 527 c, t dbSNP:150904456
539 539 a, g dbSNP:770426452
544 544 c, t dbSNP:372931853
548 548 c, t dbSNP:747678613
560 560 c, g dbSNP:771584396
569 569 c, t dbSNP:772957093
578 578 c, t dbSNP:760364748
602 602 a, g dbSNP:375933686
614 614 c, g dbSNP:370861713
617 617 c, t dbSNP:374283665
634 634 c, g dbSNP:759402979
644 644 c, g dbSNP:565000110
649 649 a, g dbSNP:200708179
651 651 a, c dbSNP:758540569
652 652 a, t dbSNP:764195821
659 659 a, g dbSNP:751860822
662 662 a, g dbSNP:112099437
664 664 c, g, t dbSNP:781633419
671 671 c, g dbSNP:368684793
677 677 c, t dbSNP:780737061
680 680 c, t dbSNP:747580265
684 684 c, g, t dbSNP:771660433
692 692 a, c dbSNP:746745053
695 695 c, g dbSNP:200143816
702 702 a, t dbSNP:373742710
709 709 c, t dbSNP:138345086
712 712 a, g dbSNP:759349668
717 717 a, c dbSNP:551261745
718 718 a, g dbSNP:775451143
722 722 c, t dbSNP:367778787
727 727 a, c dbSNP:35291318
728 728 a, c dbSNP:751591785
753 753 a, c dbSNP:762878228
754 754 a, g dbSNP:768489639
759 759 c, t dbSNP:774435967
764 764 c, g dbSNP:761826112
770 770 g, t dbSNP:767815962
781 781 c, t dbSNP:750722602
788 788 a, g dbSNP:371576035
791 791 c, g dbSNP:761106701
800 800 c, t dbSNP:766916406
803 803 c, t dbSNP:754160191
812 812 a, g, t dbSNP:17849258
827 827 c, g dbSNP:779310039
829 829 a, g dbSNP:751040865
848 848 a, g dbSNP:756803454
851 851 c, g dbSNP:780804100
856 856 a, c dbSNP:745581079
860 860 c, g dbSNP:755902214
861 861 g, t dbSNP:779837719
863 863 c, t dbSNP:527374805
871 871 a, c, t dbSNP:548755096
872 872 g, t dbSNP:567362523
874 874 a, g dbSNP:748216366
887 887 a, g dbSNP:772335766
890 890 a, g dbSNP:773561754
891 891 a, c, g dbSNP:769861444
892 892 a, c dbSNP:766524275
893 893 a, t dbSNP:267604312
894 894 -, a dbSNP:771937767
902 902 c, t dbSNP:777008010
904 904 -, g dbSNP:34681920
905 905 c, t dbSNP:759849906
910 910 c, t dbSNP:765744379
914 914 c, t dbSNP:753196785
917 917 g, t dbSNP:756751960
932 932 c, t dbSNP:17849259
934 934 c, t dbSNP:749942852
936 936 c, g dbSNP:755711851
941 941 c, g dbSNP:779600459
950 950 c, t dbSNP:550374192
952 952 c, t dbSNP:369316804
953 953 a, g dbSNP:571588911
959 959 a, c, g dbSNP:112627818
960 960 a, g dbSNP:772139210
979 979 g, t dbSNP:773369332
980 980 c, t dbSNP:777026193
991 991 a, g dbSNP:771145349
995 995 c, g dbSNP:776759306
996 996 a, c, g dbSNP:759926492
999 999 a, g dbSNP:775974503
1007 1007 c, t dbSNP:375794405
1009 1009 g, t dbSNP:763387415
1014 1014 a, g dbSNP:764605006
1018 1018 a, t dbSNP:749893395
1027 1027 a, g dbSNP:755656820
1029 1029 c, t dbSNP:549683798
1031 1031 a, g dbSNP:753491071
1048 1048 c, t dbSNP:754797325
1050 1050 c, g, t dbSNP:778503914
1053 1053 c, t dbSNP:538982599
1059 1059 c, t dbSNP:140050477
1062 1062 a, g dbSNP:747055654
1067 1067 c, t dbSNP:143705203
1068 1068 a, g dbSNP:146344435
1069 1069 a, t dbSNP:377549937
1077 1077 c, g dbSNP:746145846
1084 1084 a, g dbSNP:139917470
1095 1095 c, g dbSNP:775778127
1097 1097 a, g dbSNP:763334625
1098 1098 g, t dbSNP:769118386
1099 1099 a, t dbSNP:774884695
1106 1106 a, g dbSNP:760218638
1113 1113 c, t dbSNP:765869727
1115 1115 c, t dbSNP:142180894
1124 1124 c, g dbSNP:151218142
1131 1131 a, g dbSNP:765004499
1132 1132 c, t dbSNP:752501211
1139 1139 a, g dbSNP:138129034
1154 1154 c, g dbSNP:371084483
1157 1157 c, t dbSNP:749092993
1166 1166 c, t dbSNP:751608431
1173 1173 a, g dbSNP:199516006
1178 1178 g, t dbSNP:781070712
1180 1180 a, g dbSNP:745978140
1182 1182 a, g dbSNP:769864191
1187 1187 c, t dbSNP:780290914
1188 1188 a, g dbSNP:749628246
1205 1205 a, g dbSNP:769063307
1208 1208 c, t dbSNP:774833451
1214 1214 c, g dbSNP:762157300
1219 1219 a, g dbSNP:375594567
1224 1224 c, g dbSNP:775954834
1225 1225 a, g, t dbSNP:74471420
1231 1231 -, ccaa dbSNP:761862912
1243 1243 a, g dbSNP:764951444
1248 1248 a, g dbSNP:752448206
1250 1250 c, g, t dbSNP:762830343
1251 1251 g, t dbSNP:751376158
1254 1254 c, g, t dbSNP:773725664
1257 1257 a, g dbSNP:767515993
1261 1261 a, g dbSNP:545588296
1265 1265 c, g, t dbSNP:750435184
1266 1266 c, t dbSNP:780238004
1271 1271 c, g, t dbSNP:377747936
1272 1272 a, g dbSNP:371413149
1285 1285 a, c, g dbSNP:149871195
1289 1289 a, g dbSNP:556426526
1295 1295 a, c dbSNP:745349363
1300 1300 c, g dbSNP:369148720
1303 1303 c, g dbSNP:769487892
1307 1307 c, t dbSNP:147563445
1314 1314 a, c dbSNP:775280848
1315 1315 a, g dbSNP:762629473
1321 1321 a, c dbSNP:763855841
1331 1331 a, t dbSNP:775074469
1344 1344 c, g dbSNP:768386792
1348 1348 a, g dbSNP:142023780
1356 1356 c, g dbSNP:761496643
1362 1362 a, g dbSNP:767411421
1366 1366 c, g dbSNP:772885645
1385 1385 c, t dbSNP:760545579
1386 1386 a, g dbSNP:766326578
1389 1389 c, g dbSNP:145863996
1397 1397 c, g, t dbSNP:543631733
1398 1398 a, g dbSNP:565219584
1399 1399 a, c dbSNP:763180010
1404 1404 a, g dbSNP:764247291
1412 1412 a, t dbSNP:751936860
1415 1415 a, g dbSNP:532878240
1419 1419 a, g dbSNP:746160914
1427 1427 g, t dbSNP:781760131
1431 1431 g, t dbSNP:751033700
1434 1434 c, t dbSNP:756580480
1438 1438 a, g dbSNP:778426636
1440 1440 a, c dbSNP:758611701
1450 1450 c, t dbSNP:747633287
1453 1453 a, g dbSNP:771715585
1458 1458 a, g dbSNP:772181249
1482 1482 a, g dbSNP:777441794
1486 1486 c, t dbSNP:746784735
1490 1490 c, t dbSNP:138775462
1493 1493 c, t dbSNP:776546547
1494 1494 a, g dbSNP:759404689
1503 1503 a, t dbSNP:769635059
1505 1505 c, t dbSNP:376333996
1506 1506 a, g dbSNP:11555843
1513 1513 c, t dbSNP:143771296
1522 1522 c, g dbSNP:148158604
1538 1538 g, t dbSNP:774767661
1549 1549 a, g dbSNP:769734938
1553 1553 a, g dbSNP:775333596
1555 1555 c, t dbSNP:200123201
1556 1556 a, g dbSNP:142009914
1573 1573 a, g dbSNP:774573419
1575 1575 a, t dbSNP:762065759
1577 1577 c, t dbSNP:767871709
1580 1580 a, c dbSNP:773669860
1589 1589 c, g dbSNP:760985638
1594 1594 c, t dbSNP:766886570
1595 1595 c, t dbSNP:754360816
1638 1638 a, c dbSNP:757922767
1647 1647 c, t dbSNP:763529879
1648 1648 a, g dbSNP:751085157
1654 1654 c, t dbSNP:756856518
1657 1657 c, t dbSNP:202019975
1658 1658 a, c, g dbSNP:377287687
1676 1676 c, t dbSNP:780031954
1684 1684 a, g dbSNP:749109993
1689 1689 a, g dbSNP:768725303
1694 1694 a, g dbSNP:774520402
1698 1698 c, t dbSNP:748267579
1699 1699 c, t dbSNP:772391650
1714 1714 c, t dbSNP:370723883
1715 1715 a, g dbSNP:375629289
1717 1717 c, t dbSNP:771267596
1721 1721 c, t dbSNP:777059436
1729 1729 g, t dbSNP:759979414
1734 1734 a, g dbSNP:146047180
1736 1736 c, t dbSNP:751032145
1747 1747 a, c dbSNP:761356725
1749 1749 a, g dbSNP:767138681
1751 1751 c, t dbSNP:750106015
1757 1757 a, g dbSNP:138807296
1769 1769 c, g dbSNP:779652279
1772 1772 c, t dbSNP:753687495
1775 1775 a, g dbSNP:754924275
1785 1785 a, g dbSNP:11855663
1787 1787 c, t dbSNP:748216241
1788 1788 a, g dbSNP:374199653
1789 1789 a, g dbSNP:146326362
1790 1790 a, g dbSNP:747134619
1794 1794 a, g dbSNP:771198810
1804 1804 a, g dbSNP:200546578
1805 1805 c, t dbSNP:139324287
1806 1806 a, g, t dbSNP:746515572
1808 1808 c, t dbSNP:776277079
1826 1826 a, g dbSNP:147120400
1830 1830 a, g dbSNP:375611361
1833 1833 a, t dbSNP:764959569
1835 1835 a, c dbSNP:775464827
1839 1839 a, g dbSNP:762767132
1840 1840 c, g, t dbSNP:371956504
1841 1841 c, t dbSNP:546243501
1845 1845 a, t dbSNP:767645907
1852 1852 c, t dbSNP:765859108
1853 1853 c, g dbSNP:143289477
1856 1856 c, t dbSNP:754660578
1857 1857 c, t dbSNP:778493023
1858 1858 a, g dbSNP:752502722
1862 1862 a, g dbSNP:758123681
1874 1874 c, t dbSNP:777622219
1876 1876 g, t dbSNP:746979292
1880 1880 g, t dbSNP:200104189
1888 1888 a, g dbSNP:148332748
1907 1907 c, t dbSNP:745901797
1913 1913 c, g dbSNP:770162831
1922 1922 c, g, t dbSNP:775792287
1928 1928 a, g, t dbSNP:769207599
1932 1932 a, g, t dbSNP:11272
1934 1934 c, g dbSNP:143616011
1936 1936 a, c dbSNP:371806874
1938 1938 a, c dbSNP:758989714
1940 1940 g, t dbSNP:764875104
1946 1946 a, c dbSNP:368061525
1948 1948 c, g dbSNP:758035628
1955 1955 a, g dbSNP:200895458
1959 1959 a, g dbSNP:751337106
1962 1962 a, g dbSNP:371624259
1966 1966 c, t dbSNP:757172711
1986 1986 a, c dbSNP:781134737
1996 1996 a, g dbSNP:745955110
1997 1997 c, t dbSNP:376784868
2004 2004 a, g dbSNP:193112596
2011 2011 c, t dbSNP:756193172
2014 2014 a, g, t dbSNP:369699833
2017 2017 g, t dbSNP:749576967
2020 2020 a, g dbSNP:768894259
2025 2025 c, t dbSNP:540260798
2026 2026 a, g dbSNP:561752088
2029 2029 c, g dbSNP:748500888
2065 2065 a, g dbSNP:772474621
2067 2067 a, g dbSNP:773642830
2079 2079 c, g dbSNP:761166887
2080 2080 g, t dbSNP:764787231
2082 2082 a, c dbSNP:774960376
2092 2092 c, g dbSNP:762631947
2094 2094 g, t dbSNP:745604382
2100 2100 c, t dbSNP:772168119
2111 2111 c, t dbSNP:116627018
2130 2130 a, g dbSNP:775608365
2143 2143 c, t dbSNP:544478159
2194 2194 c, g, t dbSNP:145373016
2195 2195 a, g dbSNP:533374001
2218 2218 c, t dbSNP:552020355

Target ORF information:

RefSeq Version NM_002675
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_002675

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG TCCTCCCGAG AGCTGGATGA CAGCAGCAGT
GAGTCCAGTG ACCTCCAGCT GGAAGGCCCC AGCACCCTCA GGGTCCTGGA CGAGAACCTT
GCTGACCCCC AAGCAGAAGA CAGACCTCTG GTTTTCTTTG ACCTCAAGAT TGACAATGAA
AGTGGGTTCT CCTGGGGCTA CCCCCACCCC TTTCTAATTTT AG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25346D
Sequence Information ORF Nucleotide Sequence (Length: 1308bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 8
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BC034251.1. On Jun 9, 2005 this sequence version replaced gi:15451776. Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (8) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (8, also known as PML-VII and TRIM19theta) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230408.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCTGCCT
CCTCCAGCCC ATGCTCTTAC AGGCCCTGCA CAGAGTAGCA CTCATTAA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_150250.2
CDS141..1448
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..>1394(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1365..1367(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1782
Gene:PML
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:545412927
44 44 a, c dbSNP:181321458
57 57 c, g dbSNP:569274755
63 63 a, c dbSNP:539800728
65 65 c, t dbSNP:558192870
70 70 c, t dbSNP:566938076
73 73 a, g dbSNP:144576529
80 80 c, t dbSNP:770383081
89 89 c, t dbSNP:553110202
102 102 c, t dbSNP:762187130
116 116 g, t dbSNP:767971085
127 127 c, g dbSNP:752203384
132 132 c, g dbSNP:759066056
133 133 -, g dbSNP:35863954
159 159 a, c dbSNP:574579963
163 163 a, c, t dbSNP:542097036
170 170 a, g dbSNP:763855768
189 189 a, c dbSNP:751354376
203 203 c, t dbSNP:556884444
213 213 a, c dbSNP:376726233
217 217 a, c, g dbSNP:781165510
222 222 a, c dbSNP:28504405
223 223 c, t dbSNP:201524800
225 225 c, t dbSNP:749399804
231 231 a, g dbSNP:768816135
261 261 c, g dbSNP:779135665
264 264 a, g dbSNP:748479176
271 271 a, g dbSNP:761685300
279 279 g, t dbSNP:767279397
283 283 c, t dbSNP:377614337
284 284 a, g dbSNP:545577011
292 292 a, c dbSNP:780062613
306 306 c, t dbSNP:147696900
337 337 -, c dbSNP:34228316
339 339 c, t dbSNP:755088983
341 341 a, g dbSNP:374118853
375 375 c, g dbSNP:28412621
376 376 a, g dbSNP:748429878
378 378 g, t dbSNP:772423497
389 389 a, g dbSNP:572620428
390 390 g, t dbSNP:752972084
391 391 c, t dbSNP:771298279
392 392 a, g dbSNP:369958078
399 399 a, c dbSNP:543332226
413 413 c, t dbSNP:561108241
414 414 c, g dbSNP:762523424
418 418 a, c, g, t dbSNP:531642849
420 420 c, t dbSNP:761487093
425 425 g, t dbSNP:767209117
441 441 a, c dbSNP:772834238
447 447 a, g dbSNP:570405596
454 454 a, c dbSNP:760548118
456 456 a, g dbSNP:372639541
460 460 c, t dbSNP:756707115
483 483 c, t dbSNP:766194468
485 485 c, t dbSNP:753820877
488 488 g, t dbSNP:543417635
491 491 g, t dbSNP:755039717
495 495 c, t dbSNP:765368853
498 498 c, t dbSNP:141544943
505 505 c, t dbSNP:758491320
514 514 c, g dbSNP:77069486
515 515 a, g dbSNP:747300098
518 518 a, g dbSNP:376898295
519 519 a, g dbSNP:764681333
521 521 c, t dbSNP:781759664
527 527 c, t dbSNP:150904456
539 539 a, g dbSNP:770426452
544 544 c, t dbSNP:372931853
548 548 c, t dbSNP:747678613
560 560 c, g dbSNP:771584396
569 569 c, t dbSNP:772957093
578 578 c, t dbSNP:760364748
602 602 a, g dbSNP:375933686
614 614 c, g dbSNP:370861713
617 617 c, t dbSNP:374283665
634 634 c, g dbSNP:759402979
644 644 c, g dbSNP:565000110
649 649 a, g dbSNP:200708179
651 651 a, c dbSNP:758540569
652 652 a, t dbSNP:764195821
659 659 a, g dbSNP:751860822
662 662 a, g dbSNP:112099437
664 664 c, g, t dbSNP:781633419
671 671 c, g dbSNP:368684793
677 677 c, t dbSNP:780737061
680 680 c, t dbSNP:747580265
684 684 c, g, t dbSNP:771660433
692 692 a, c dbSNP:746745053
695 695 c, g dbSNP:200143816
702 702 a, t dbSNP:373742710
709 709 c, t dbSNP:138345086
712 712 a, g dbSNP:759349668
717 717 a, c dbSNP:551261745
718 718 a, g dbSNP:775451143
722 722 c, t dbSNP:367778787
727 727 a, c dbSNP:35291318
728 728 a, c dbSNP:751591785
753 753 a, c dbSNP:762878228
754 754 a, g dbSNP:768489639
759 759 c, t dbSNP:774435967
764 764 c, g dbSNP:761826112
770 770 g, t dbSNP:767815962
781 781 c, t dbSNP:750722602
788 788 a, g dbSNP:371576035
791 791 c, g dbSNP:761106701
800 800 c, t dbSNP:766916406
803 803 c, t dbSNP:754160191
812 812 a, g, t dbSNP:17849258
827 827 c, g dbSNP:779310039
829 829 a, g dbSNP:751040865
848 848 a, g dbSNP:756803454
851 851 c, g dbSNP:780804100
856 856 a, c dbSNP:745581079
860 860 c, g dbSNP:755902214
861 861 g, t dbSNP:779837719
863 863 c, t dbSNP:527374805
871 871 a, c, t dbSNP:548755096
872 872 g, t dbSNP:567362523
874 874 a, g dbSNP:748216366
887 887 a, g dbSNP:772335766
890 890 a, g dbSNP:773561754
891 891 a, c, g dbSNP:769861444
892 892 a, c dbSNP:766524275
893 893 a, t dbSNP:267604312
894 894 -, a dbSNP:771937767
902 902 c, t dbSNP:777008010
904 904 -, g dbSNP:34681920
905 905 c, t dbSNP:759849906
910 910 c, t dbSNP:765744379
914 914 c, t dbSNP:753196785
917 917 g, t dbSNP:756751960
932 932 c, t dbSNP:17849259
934 934 c, t dbSNP:749942852
936 936 c, g dbSNP:755711851
941 941 c, g dbSNP:779600459
950 950 c, t dbSNP:550374192
952 952 c, t dbSNP:369316804
953 953 a, g dbSNP:571588911
959 959 a, c, g dbSNP:112627818
960 960 a, g dbSNP:772139210
979 979 g, t dbSNP:773369332
980 980 c, t dbSNP:777026193
991 991 a, g dbSNP:771145349
995 995 c, g dbSNP:776759306
996 996 a, c, g dbSNP:759926492
999 999 a, g dbSNP:775974503
1007 1007 c, t dbSNP:375794405
1009 1009 g, t dbSNP:763387415
1014 1014 a, g dbSNP:764605006
1018 1018 a, t dbSNP:749893395
1027 1027 a, g dbSNP:755656820
1029 1029 c, t dbSNP:549683798
1031 1031 a, g dbSNP:753491071
1048 1048 c, t dbSNP:754797325
1050 1050 c, g, t dbSNP:778503914
1053 1053 c, t dbSNP:538982599
1059 1059 c, t dbSNP:140050477
1062 1062 a, g dbSNP:747055654
1067 1067 c, t dbSNP:143705203
1068 1068 a, g dbSNP:146344435
1069 1069 a, t dbSNP:377549937
1077 1077 c, g dbSNP:746145846
1084 1084 a, g dbSNP:139917470
1095 1095 c, g dbSNP:775778127
1097 1097 a, g dbSNP:763334625
1098 1098 g, t dbSNP:769118386
1099 1099 a, t dbSNP:774884695
1106 1106 a, g dbSNP:760218638
1113 1113 c, t dbSNP:765869727
1115 1115 c, t dbSNP:142180894
1124 1124 c, g dbSNP:151218142
1131 1131 a, g dbSNP:765004499
1132 1132 c, t dbSNP:752501211
1139 1139 a, g dbSNP:138129034
1154 1154 c, g dbSNP:371084483
1157 1157 c, t dbSNP:749092993
1166 1166 c, t dbSNP:751608431
1173 1173 a, g dbSNP:199516006
1178 1178 g, t dbSNP:781070712
1180 1180 a, g dbSNP:745978140
1182 1182 a, g dbSNP:769864191
1187 1187 c, t dbSNP:780290914
1188 1188 a, g dbSNP:749628246
1205 1205 a, g dbSNP:769063307
1208 1208 c, t dbSNP:774833451
1214 1214 c, g dbSNP:762157300
1219 1219 a, g dbSNP:375594567
1224 1224 c, g dbSNP:775954834
1225 1225 a, g, t dbSNP:74471420
1231 1231 -, ccaa dbSNP:761862912
1243 1243 a, g dbSNP:764951444
1248 1248 a, g dbSNP:752448206
1250 1250 c, g, t dbSNP:762830343
1251 1251 g, t dbSNP:751376158
1254 1254 c, g, t dbSNP:773725664
1257 1257 a, g dbSNP:767515993
1261 1261 a, g dbSNP:545588296
1265 1265 c, g, t dbSNP:750435184
1266 1266 c, t dbSNP:780238004
1271 1271 c, g, t dbSNP:377747936
1272 1272 a, g dbSNP:371413149
1285 1285 a, c, g dbSNP:149871195
1289 1289 a, g dbSNP:556426526
1295 1295 a, c dbSNP:745349363
1300 1300 c, g dbSNP:369148720
1303 1303 c, g dbSNP:769487892
1307 1307 c, t dbSNP:147563445
1314 1314 a, c dbSNP:775280848
1315 1315 a, g dbSNP:762629473
1321 1321 a, c dbSNP:763855841
1331 1331 a, t dbSNP:775074469
1344 1344 c, g dbSNP:768386792
1348 1348 a, g dbSNP:142023780
1356 1356 c, g dbSNP:761496643
1362 1362 a, g dbSNP:767411421
1366 1366 c, g dbSNP:772885645
1385 1385 c, t dbSNP:760545579
1386 1386 a, g dbSNP:766326578
1389 1389 c, g dbSNP:145863996
1399 1399 c, t dbSNP:555380806
1414 1414 c, t dbSNP:370389300
1416 1416 a, c dbSNP:759232644
1420 1420 a, c, t dbSNP:200028634
1423 1423 -, c dbSNP:763544092
1424 1424 c, t dbSNP:759801761
1428 1428 a, g dbSNP:765753935
1436 1436 a, g, t dbSNP:149573441
1439 1439 c, t dbSNP:764655064
1440 1440 a, g dbSNP:749968529
1447 1447 a, g dbSNP:755517240
1451 1451 a, c dbSNP:779759818
1456 1456 -, t dbSNP:753297773
1463 1463 a, g dbSNP:748953974
1464 1464 c, t dbSNP:754605423
1468 1468 c, t dbSNP:537901535
1472 1472 c, t dbSNP:747902260
1473 1473 a, g dbSNP:375250698
1482 1482 g, t dbSNP:777515480
1483 1483 c, t dbSNP:368406946
1486 1486 c, t dbSNP:770985567
1487 1487 c, g dbSNP:776756524
1489 1489 a, g dbSNP:759724691
1491 1491 a, g dbSNP:770109605
1493 1493 -, c dbSNP:756907429
1499 1499 c, g dbSNP:141224194
1501 1501 g, t dbSNP:762592
1535 1535 a, g dbSNP:188723955
1538 1538 a, g dbSNP:370140201
1606 1606 c, t dbSNP:764436102
1623 1623 a, g dbSNP:9479
1626 1626 c, t dbSNP:1051697
1644 1644 a, g dbSNP:553424812
1663 1663 a, g dbSNP:568754580
1681 1681 c, t dbSNP:1051700
1694 1694 c, t dbSNP:1051702
1701 1701 g, t dbSNP:573127760
1704 1704 c, t dbSNP:1051703
1781 1781 c, t dbSNP:192800282

Target ORF information:

RefSeq Version NM_033247
Organism Homo sapiens (human)
Definition Homo sapiens promyelocytic leukemia (PML), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_033247

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCTGCCT
CCTCCAGCCC ATGCTCTTAC AGGCCCTGCA CAGAGTAGCA CTCATTAA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu25497D
Sequence Information ORF Nucleotide Sequence (Length: 1836bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product protein PML isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X63131.1 and BX647287.1. On or before Jun 24, 2006 this sequence version replaced gi:67089158, gi:15451766. Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230402.1, M79463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGGAGCCTG CACCCGCCCG ATCTCCGAGG CCCCAGCAGG ACCCCGCCCG GCCCCAGGAG 
CCCACCATGC CTCCCCCCGA GACCCCCTCT GAAGGCCGCC AGCCCAGCCC CAGCCCCAGC
CCTACAGAGC GAGCCCCCGC TTCGGAGGAG GAGTTCCAGT TTCTGCGCTG CCAGCAATGC
CAGGCGGAAG CCAAGTGCCC GAAGCTGCTG CCTTGTCTGC ACACGCTGTG CTCAGGATGC
CTGGAGGCGT CGGGCATGCA GTGCCCCATC TGCCAGGCGC CCTGGCCCCT AGGTGCAGAC
ACACCCGCCC TGGATAACGT CTTTTTCGAG AGTCTGCAGC GGCGCCTGTC GGTGTACCGG
CAGATTGTGG ATGCGCAGGC TGTGTGCACC CGCTGCAAAG AGTCGGCCGA CTTCTGGTGC
TTTGAGTGCG AGCAGCTCCT CTGCGCCAAG TGCTTCGAGG CACACCAGTG GTTCCTCAAG
CACGAGGCCC GGCCCCTAGC AGAGCTGCGC AACCAGTCGG TGCGTGAGTT CCTGGACGGC
ACCCGCAAGA CCAACAACAT CTTCTGCTCC AACCCCAACC ACCGCACCCC TACGCTGACC
AGCATCTACT GCCGAGGATG TTCCAAGCCG CTGTGCTGCT CGTGCGCGCT CCTTGACAGC
AGCCACAGTG AGCTCAAGTG CGACATCAGC GCAGAGATCC AGCAGCGACA GGAGGAGCTG
GACGCCATGA CGCAGGCGCT GCAGGAGCAG GATAGTGCCT TTGGCGCGGT TCACGCGCAG
ATGCACGCGG CCGTCGGCCA GCTGGGCCGC GCGCGTGCCG AGACCGAGGA GCTGATCCGC
GAGCGCGTGC GCCAGGTGGT AGCTCACGTG CGGGCTCAGG AGCGCGAGCT GCTGGAGGCT
GTGGACGCGC GGTACCAGCG CGACTACGAG GAGATGGCCA GTCGGCTGGG CCGCCTGGAT
GCTGTGCTGC AGCGCATCCG CACGGGCAGC GCGCTGGTGC AGAGGATGAA GTGCTACGCC
TCGGACCAGG AGGTGCTGGA CATGCACGGT TTCCTGCGCC AGGCGCTCTG CCGCCTGCGC
CAGGAGGAGC CCCAGAGCCT GCAAGCTGCC GTGCGCACCG ATGGCTTCGA CGAGTTCAAG
GTGCGCCTGC AGGACCTCAG CTCTTGCATC ACCCAGGGGA AAGATGCAGC TGTATCCAAG
AAAGCCAGCC CAGAGGCTGC CAGCACTCCC AGGGACCCTA TTGACGTTGA CCTGCCCGAG
GAGGCAGAGA GAGTGAAGGC CCAGGTTCAG GCCCTGGGGC TGGCTGAAGC CCAGCCTATG
GCTGTGGTAC AGTCAGTGCC CGGGGCACAC CCCGTGCCAG TGTACGCCTT CTCCATCAAA
GGCCCTTCCT ATGGAGAGGA TGTCTCCAAT ACAACGACAG CCCAGAAGAG GAAGTGCAGC
CAGACCCAGT GCCCCAGGAA GGTCATCAAG ATGGAGTCTG AGGAGGGGAA GGAGGCAAGG
TTGGCTCGGA GCTCCCCGGA GCAGCCCAGG CCCAGCACCT CCAAGGCAGT CTCACCACCC
CACCTGGATG GACCGCCTAG CCCCAGGAGC CCCGTCATAG GAAGTGAGGT CTTCCTGCCC
AACAGCAACC ACGTGGCCAG TGGCGCCGGG GAGGCAGAGG AACGCGTTGT GGTGATCAGC
AGCTCGGAAG ACTCAGATGC CGAAAACTCG GTGAGTGGCC CAGAAGTTCA GCCCAGGACT
CCTGCCTCCC CCCATTTCAG GTCCCAGGGG GCACAGCCAC AGCAGGTGAC TCTCAGACTT
GCCTTGCGCC TGGGGAATTT TCCAGTGAGG CATTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_150243.2
CDS141..1976
Misc Feature(1)162..164(+)
Misc Feature(2)222..224(+)
Misc Feature(3)246..248(+)
Misc Feature(4)252..254(+)
Misc Feature(5)258..260(+)
Misc Feature(6)264..266(+)
Misc Feature(7)309..425(+)
Misc Feature(8)309..413(+)
Misc Feature(9)333..335(+)
Misc Feature(10)489..491(+)
Misc Feature(11)510..638(+)
Misc Feature(12)618..620(+)
Misc Feature(13)816..818(+)
Misc Feature(14)858..1850(+)
Misc Feature(15)1320..1325(+)
Misc Feature(16)1347..1349(+)
Misc Feature(17)1347..1349(+)
Misc Feature(18)1365..1367(+)
Misc Feature(19)1482..1805(+)
Misc Feature(20)1566..1610(+)
Misc Feature(21)1599..1601(+)
Misc Feature(22)1608..1610(+)
Misc Feature(23)1650..1652(+)
Misc Feature(24)1653..1655(+)
Misc Feature(25)1653..1655(+)
Misc Feature(26)1677..1679(+)
Misc Feature(27)1683..1685(+)
Misc Feature(28)1692..1694(+)
Misc Feature(29)1692..1694(+)
Misc Feature(30)1719..1721(+)
Misc Feature(31)1719..1721(+)
Misc Feature(32)1728..1730(+)
Misc Feature(33)1728..1730(+)
Misc Feature(34)1743..1745(+)
Misc Feature(35)1794..1799(+)
Misc Feature(36)1806..1826(+)
Misc Feature(37)1833..1835(+)
Exon (1)1..269
Gene:PML
Gene Synonym:
Exon (2)270..742
Gene:PML
Gene Synonym:
Exon (3)743..1323
Gene:PML
Gene Synonym:
Exon (4)1324..1394
Gene:PML
Gene Synonym:
Exon (5)1395..1538
Gene:PML
Gene Synonym:
Exon (6)1539..1797
Gene:PML
Gene Synonym:
Exon (7)1798..3714
Gene:PML
Gene Synonym:
Translation
Position Chain Variation Link
26 26 c, g dbSNP:545412927
44 44 a, c dbSNP:181321458
57 57 c, g dbSNP:569274755
63 63 a, c dbSNP:539800728
65 65 c, t dbSNP:558192870
70 70 c, t dbSNP:566938076
73 73 a, g dbSNP:144576529
80 80 c, t dbSNP:770383081
89 89 c, t dbSNP:553110202
102 102 c, t dbSNP:762187130
116 116 g, t dbSNP:767971085
127 127 c, g dbSNP:752203384
132 132 c, g dbSNP:759066056
133 133 -, g dbSNP:35863954
159 159 a, c dbSNP:574579963
163 163 a, c, t dbSNP:542097036
170 170 a, g dbSNP:763855768
189 189 a, c dbSNP:751354376
203 203 c, t dbSNP:556884444
213 213 a, c dbSNP:376726233
217 217 a, c, g dbSNP:781165510
222 222 a, c dbSNP:28504405
223 223 c, t dbSNP:201524800
225 225 c, t dbSNP:749399804
231 231 a, g dbSNP:768816135
261 261 c, g dbSNP:779135665
264 264 a, g dbSNP:748479176
271 271 a, g dbSNP:761685300
279 279 g, t dbSNP:767279397
283 283 c, t dbSNP:377614337
284 284 a, g dbSNP:545577011
292 292 a, c dbSNP:780062613
306 306 c, t dbSNP:147696900
337 337 -, c dbSNP:34228316
339 339 c, t dbSNP:755088983
341 341 a, g dbSNP:374118853
375 375 c, g dbSNP:28412621
376 376 a, g dbSNP:748429878
378 378 g, t dbSNP:772423497
389 389 a, g dbSNP:572620428
390 390 g, t dbSNP:752972084
391 391 c, t dbSNP:771298279
392 392 a, g dbSNP:369958078
399 399 a, c dbSNP:543332226
413 413 c, t dbSNP:561108241
414 414 c, g dbSNP:762523424
418 418 a, c, g, t dbSNP:531642849
420 420 c, t dbSNP:761487093
425 425 g, t dbSNP:767209117
441 441 a, c dbSNP:772834238
447 447 a, g dbSNP:570405596
454 454 a, c dbSNP:760548118
456 456 a, g dbSNP:372639541
460 460 c, t dbSNP:756707115
483 483 c, t dbSNP:766194468
485 485 c, t dbSNP:753820877
488 488 g, t dbSNP:543417635
491 491 g, t dbSNP:755039717
495 495 c, t dbSNP:765368853
498 498 c, t dbSNP:141544943
505 505 c, t dbSNP:758491320
514 514 c, g dbSNP:77069486
515 515 a, g dbSNP:747300098
518 518 a, g dbSNP:376898295
519 519 a, g dbSNP:764681333
521 521 c, t dbSNP:781759664
527 527 c, t dbSNP:150904456
539 539 a, g dbSNP:770426452
544 544 c, t dbSNP:372931853
548 548 c, t dbSNP:747678613
560 560 c, g dbSNP:771584396
569 569 c, t dbSNP:772957093
578 578 c, t dbSNP:760364748
602 602 a, g dbSNP:375933686
614 614 c, g dbSNP:370861713
617 617 c, t dbSNP:374283665
634 634 c, g dbSNP:759402979
644 644 c, g dbSNP:565000110
649 649 a, g dbSNP:200708179
651 651 a, c dbSNP:758540569
652 652 a, t dbSNP:764195821
659 659 a, g dbSNP:751860822
662 662 a, g dbSNP:112099437
664 664 c, g, t dbSNP:781633419
671 671 c, g dbSNP:368684793
677 677 c, t dbSNP:780737061
680 680 c, t dbSNP:747580265
684 684 c, g, t dbSNP:771660433
692 692 a, c dbSNP:746745053
695 695 c, g dbSNP:200143816
702 702 a, t dbSNP:373742710
709 709 c, t dbSNP:138345086
712 712 a, g dbSNP:759349668
717 717 a, c dbSNP:551261745
718 718 a, g dbSNP:775451143
722 722 c, t dbSNP:367778787
727 727 a, c dbSNP:35291318
728 728 a, c dbSNP:751591785
753 753 a, c dbSNP:762878228
754 754 a, g dbSNP:768489639
759 759 c, t dbSNP:774435967
764 764 c, g dbSNP:761826112
770 770 g, t dbSNP:767815962
781 781 c, t dbSNP:750722602
788 788 a, g dbSNP:371576035
791 791 c, g dbSNP:761106701
800 800 c, t dbSNP:766916406
803 803 c, t dbSNP:754160191
812 812 a, g, t dbSNP:17849258
827 827 c, g dbSNP:779310039
829 829 a, g dbSNP:751040865
848 848 a, g dbSNP:756803454
851 851 c, g dbSNP:780804100
856 856 a, c dbSNP:745581079
860 860 c, g dbSNP:755902214
861 861 g, t dbSNP:779837719
863 863 c, t dbSNP:527374805
871 871 a, c, t dbSNP:548755096
872 872 g, t dbSNP:567362523
874 874 a, g dbSNP:748216366
887 887 a, g dbSNP:772335766
890 890 a, g dbSNP:773561754
891 891 a, c, g dbSNP:769861444
892 892 a, c dbSNP:766524275
893 893 a, t dbSNP:267604312
894 894 -, a dbSNP:771937767
902 902 c, t dbSNP:777008010
904 904 -, g dbSNP:34681920
905 905 c, t dbSNP:759849906
910 910 c, t dbSNP:765744379
914 914 c, t dbSNP:753196785
917 917 g, t dbSNP:756751960
932 932 c, t dbSNP:17849259
934 934 c, t dbSNP:749942852
936 936 c, g dbSNP:755711851
941 941 c, g dbSNP:779600459
950 950 c, t dbSNP:550374192
952 952 c, t dbSNP:369316804
953 953 a, g dbSNP:571588911
959 959 a, c, g dbSNP:112627818
960 960 a, g dbSNP:772139210
979 979 g, t dbSNP:773369332
980 980 c, t dbSNP:777026193
991 991 a, g dbSNP:771145349
995 995 c, g dbSNP:776759306
996 996 a, c, g dbSNP:759926492
999 999 a, g dbSNP:775974503
1007 1007 c, t dbSNP:375794405
1009 1009 g, t dbSNP:763387415
1014 1014 a, g dbSNP:764605006
1018 1018 a, t dbSNP:749893395
1027 1027 a, g dbSNP:755656820
1029 1029 c, t dbSNP:549683798
1031 1031 a, g dbSNP:753491071
1048 1048 c, t dbSNP:754797325
1050 1050 c, g, t dbSNP:778503914
1053 1053 c, t dbSNP:538982599
1059 1059 c, t dbSNP:140050477
1062 1062 a, g dbSNP:747055654
1067 1067 c, t dbSNP:143705203
1068 1068 a, g dbSNP:146344435
1069 1069 a, t dbSNP:377549937
1077 1077 c, g dbSNP:746145846
1084 1084 a, g dbSNP:139917470
1095 1095 c, g dbSNP:775778127
1097 1097 a, g dbSNP:763334625
1098 1098 g, t dbSNP:769118386
1099 1099 a, t dbSNP:774884695
1106 1106 a, g dbSNP:760218638
1113 1113 c, t dbSNP:765869727
1115 1115 c, t dbSNP:142180894
1124 1124 c, g dbSNP:151218142
1131 1131 a, g dbSNP:765004499
1132 1132 c, t dbSNP:752501211
1139 1139 a, g dbSNP:138129034
1154 1154 c, g dbSNP:371084483
1157 1157 c, t dbSNP:749092993
1166 1166 c, t dbSNP:751608431
1173 1173 a, g dbSNP:199516006
1178 1178 g, t dbSNP:781070712
1180 1180 a, g dbSNP:745978140
1182 1182 a, g dbSNP:769864191
1187 1187 c, t dbSNP:780290914
1188 1188 a, g dbSNP:749628246
1205 1205 a, g dbSNP:769063307
1208 1208 c, t dbSNP:774833451
1214 1214 c, g dbSNP:762157300
1219 1219 a, g dbSNP:375594567
1224 1224 c, g dbSNP:775954834
1225 1225 a, g, t dbSNP:74471420
1231 1231 -, ccaa dbSNP:761862912
1243 1243 a, g dbSNP:764951444
1248 1248 a, g dbSNP:752448206
1250 1250 c, g, t dbSNP:762830343
1251 1251 g, t dbSNP:751376158
1254 1254 c, g, t dbSNP:773725664
1257 1257 a, g dbSNP:767515993
1261 1261 a, g dbSNP:545588296
1265 1265 c, g, t dbSNP:750435184
1266 1266 c, t dbSNP:780238004
1271 1271 c, g, t dbSNP:377747936
1272 1272 a, g dbSNP:371413149
1285 1285 a, c, g dbSNP:149871195
1289 1289 a, g dbSNP:556426526
1295 1295 a, c dbSNP:745349363
1300 1300 c, g dbSNP:369148720
1303 1303 c, g dbSNP:769487892
1307 1307 c, t dbSNP:147563445
1314 1314 a, c dbSNP:775280848
1315 1315 a, g dbSNP:762629473
1321 1321 a, c dbSNP:763855841
1331 1331 a, t dbSNP:775074469
1344 1344 c, g dbSNP:768386792
1348 1348 a, g dbSNP:142023780
1356 1356 c, g dbSNP:761496643
1362 1362 a, g dbSNP:767411421
1366 1366 c, g dbSNP:772885645
1385 1385 c, t dbSNP:760545579
1386 1386 a, g dbSNP:766326578
1389 1389 c, g dbSNP:145863996
1397 1397 c, g, t dbSNP:543631733
1398 1398 a, g dbSNP:565219584
1399 1399 a, c dbSNP:763180010
1404 1404 a, g dbSNP:764247291
1412 1412 a, t dbSNP:751936860
1415 1415 a, g dbSNP:532878240
1419 1419 a, g dbSNP:746160914
1427 1427 g, t dbSNP:781760131
1431 1431 g, t dbSNP:751033700
1434 1434 c, t dbSNP:756580480
1438 1438 a, g dbSNP:778426636
1440 1440 a, c dbSNP:758611701
1450 1450 c, t dbSNP:747633287
1453 1453 a, g dbSNP:771715585
1458 1458 a, g dbSNP:772181249
1482 1482 a, g dbSNP:777441794
1486 1486 c, t dbSNP:746784735
1490 1490 c, t dbSNP:138775462
1493 1493 c, t dbSNP:776546547
1494 1494 a, g dbSNP:759404689
1503 1503 a, t dbSNP:769635059
1505 1505 c, t dbSNP:376333996
1506 1506 a, g dbSNP:11555843
1513 1513 c, t dbSNP:143771296
1522 1522 c, g dbSNP:148158604
1538 1538 g, t dbSNP:774767661
1549 1549 a, g dbSNP:769734938
1553 1553 a, g dbSNP:775333596
1555 1555 c, t dbSNP:200123201
1556 1556 a, g dbSNP:142009914
1573 1573 a, g dbSNP:774573419
1575 1575 a, t dbSNP:762065759
1577 1577 c, t dbSNP:767871709
1580 1580 a, c dbSNP:773669860
1589 1589 c, g dbSNP:760985638
1594 1594 c, t dbSNP:766886570
1595 1595 c, t dbSNP:754360816
1638 1638 a, c dbSNP:757922767
1647 1647 c, t dbSNP:763529879
1648 1648 a, g dbSNP:751085157
1654 1654 c, t dbSNP:756856518
1657 1657 c, t dbSNP:202019975
1658 1658 a, c, g dbSNP:377287687
1676 1676 c, t dbSNP:780031954
1684 1684 a, g dbSNP:749109993
1689 1689 a, g dbSNP:768725303
1694 1694 a, g dbSNP:774520402
1698 1698 c, t dbSNP:748267579
1699 1699 c, t dbSNP:772391650
1714 1714 c, t dbSNP:370723883
1715 1715 a, g dbSNP:375629289
1717 1717 c, t dbSNP:771267596
1721 1721 c, t dbSNP:777059436
1729 1729 g, t dbSNP:759979414
1734 1734 a, g dbSNP:146047180
1736 1736 c, t dbSNP:751032145
1747 1747 a, c dbSNP:761356725
1749 1749 a, g dbSNP:767138681
1751 1751 c, t dbSNP:750106015
1757 1757 a, g dbSNP:138807296
1769 1769 c, g dbSNP:779652279
1772 1772 c, t dbSNP:753687495
1775 1775 a, g dbSNP:754924275
1785 1785 a, g dbSNP:11855663
1787 1787 c, t dbSNP:748216241
1788 1788 a, g dbSNP:374199653
1789 1789 a, g dbSNP:146326362
1790 1790 a, g dbSNP:747134619
1794 1794 a, g dbSNP:771198810
1804 1804 a, g dbSNP:200546578
1805 1805 c, t dbSNP:139324287
1806 1806 a, g, t dbSNP:746515572
1808 1808 c, t dbSNP:776277079
1826 1826 a, g dbSNP:147120400
1830 1830 a, g dbSNP:375611361
1833 1833 a, t dbSNP:764959569
1835 1835 a, c dbSNP:775464827
1839 1839 a, g dbSNP:762767132
1840 1840 c, g, t dbSNP:371956504
1841 1841 c, t dbSNP:546243501
1845 1845 a, t dbSNP:767645907
1858 1858 g, t dbSNP:750484230
1866 1866 a, g dbSNP:199650015
1889 1889 c, t dbSNP:528613508
1892 1892 c, g dbSNP:749639984
1901 1901 c, g dbSNP:748073857
1904 1904 c, t dbSNP:547562643
1906 1906 -, a dbSNP:755639247
1909 1909 a, g dbSNP:755313454
1911 1911 -, c dbSNP:144919564
1913 1913 a, c dbSNP:779293548
1922 1922 a, g dbSNP:201277938
1935 1935 a, c dbSNP:772444669
1947 1947 a, c, t dbSNP:137870675
1948 1948 a, g dbSNP:769598989
1954 1954 g, t dbSNP:775231611
1973 1973 c, t dbSNP:762665741
1987 1987 a, g dbSNP:768427910
1992 1992 a, g dbSNP:774007862
2014 2014 c, g dbSNP:149460862
2033 2033 c, t dbSNP:569633755
2047 2047 c, t dbSNP:774036129
2089 2089 -, ccagagc dbSNP:570519460
2096 2096 a, c dbSNP:143915845
2185 2185 c, g dbSNP:186758195
2197 2197 c, t dbSNP:190263815
2277 2277 a, g dbSNP:182535198
2312 2312 c, t dbSNP:762388865
2334 2334 c, g dbSNP:780535513
2338 2338 a, g dbSNP:553035041
2349 2349 c, t dbSNP:765606610
2413 2413 a, t dbSNP:767414766
2421 2421 c, g dbSNP:750535595
2424 2424 c, t dbSNP:187580906
2431 2431 a, t dbSNP:766603231
2455 2455 c, t dbSNP:754026923
2460 2460 c, t dbSNP:755150965
2468 2468 a, g dbSNP:779392545
2470 2470 c, t dbSNP:536070251
2484 2484 c, t dbSNP:369839253
2496 2496 c, t dbSNP:149710270
2505 2505 c, t dbSNP:370195590
2513 2513 a, g dbSNP:144559886
2515 2515 c, t dbSNP:779853709
2516 2516 a, g dbSNP:749032616
2526 2526 a, c dbSNP:768176990
2529 2529 c, t dbSNP:372539605
2530 2530 a, g dbSNP:761477583
2535 2535 c, t dbSNP:78340702
2544 2544 c, t dbSNP:374669015
2546 2546 c, t dbSNP:760751573
2554 2554 c, g, t dbSNP:766513520
2556 2556 c, t dbSNP:147652568
2559 2559 c, t dbSNP:765346623
2560 2560 a, g dbSNP:557907134
2563 2563 a, t dbSNP:758784141
2567 2567 c, t dbSNP:778435415
2569 2569 c, t dbSNP:752043168
2571 2571 c, t dbSNP:757831781
2572 2572 c, t dbSNP:141958169
2574 2574 c, t dbSNP:779668164
2580 2580 a, c, t dbSNP:373088243
2583 2583 a, c dbSNP:778383459
2585 2585 -, c, tc dbSNP:745595474
2586 2586 c, g dbSNP:747953604
2589 2589 g, t dbSNP:771790286
2590 2590 c, g dbSNP:772988267
2593 2593 a, g dbSNP:747007010
2598 2598 a, c dbSNP:770833935
2604 2604 g, t dbSNP:199513809
2613 2613 a, g dbSNP:144234369
2624 2624 a, g dbSNP:765516841
2631 2631 a, c, g dbSNP:775515717
2637 2637 c, g dbSNP:780250401
2639 2639 c, g dbSNP:201804134
2640 2640 -, c dbSNP:140797024
2640 2640 c, t dbSNP:369292960
2649 2649 c, t dbSNP:751955342
2651 2651 c, t dbSNP:757884929
2662 2662 c, t dbSNP:201226688
2663 2663 a, g dbSNP:112272650
2672 2672 g, t dbSNP:754391223
2673 2673 c, t dbSNP:778635203
2678 2678 -, c dbSNP:779911916
2680 2680 c, t dbSNP:369911359
2683 2683 c, g, t dbSNP:140216915
2684 2684 a, g dbSNP:746776339
2689 2689 c, t dbSNP:770931063
2690 2690 a, g dbSNP:776383657
2698 2698 c, g dbSNP:745972252
2701 2701 c, t dbSNP:769694101
2702 2702 a, g dbSNP:200905984
2705 2705 c, g dbSNP:200094687
2714 2714 -, ca dbSNP:746939556
2719 2719 -, ggagcgc dbSNP:769801328
2719 2719 a, g dbSNP:202182247
2723 2723 c, t dbSNP:200988291
2724 2724 a, g dbSNP:377501404
2725 2725 c, t dbSNP:768084783
2731 2731 c, t dbSNP:150442989
2732 2732 a, g dbSNP:756641826
2733 2733 a, t dbSNP:764714500
2737 2737 a, c dbSNP:752181739
2738 2738 c, t dbSNP:138276205
2741 2741 a, g dbSNP:777364305
2747 2747 c, t dbSNP:371144013
2748 2748 a, g dbSNP:149202279
2750 2750 c, t dbSNP:781192354
2758 2758 -, g dbSNP:773299181
2770 2770 a, g dbSNP:377354460
2779 2779 -, c dbSNP:763286510
2780 2780 c, t dbSNP:145160033
2787 2787 a, g, t dbSNP:570306547
2790 2790 a, g dbSNP:139031068
2798 2798 c, t dbSNP:75056290
2799 2799 a, g dbSNP:145646904
2807 2807 c, g dbSNP:546342488
2810 2810 c, g dbSNP:368679910
2816 2816 c, t dbSNP:772387700
2817 2817 a, g, t dbSNP:148106218
2819 2819 c, t dbSNP:761137155
2820 2820 a, g dbSNP:141894268
2825 2825 c, t dbSNP:752236847
2827 2827 c, t dbSNP:150761242
2828 2828 a, c dbSNP:763750133
2832 2832 a, g dbSNP:751144387
2833 2833 c, g dbSNP:528725581
2835 2835 c, t dbSNP:756926576
2840 2840 c, t dbSNP:200400610
2843 2843 a, c dbSNP:139143471
2854 2854 c, t dbSNP:756042432
2866 2866 c, t dbSNP:780094996
2867 2867 c, g dbSNP:369036000
2873 2873 a, g dbSNP:369253046
2879 2879 a, g dbSNP:148636537
2880 2880 a, g dbSNP:748377564
2881 2881 g, t dbSNP:772317014
2884 2884 c, t dbSNP:569562998
2891 2891 c, t dbSNP:568065544
2893 2893 c, t dbSNP:761061019
2897 2897 a, g dbSNP:771449149
2899 2899 c, t dbSNP:147213990
2901 2901 a, g dbSNP:762452812
2903 2903 a, g dbSNP:763658568
2904 2904 a, c dbSNP:751063469
2920 2920 c, g dbSNP:761419093
2928 2928 a, c, g dbSNP:140648301
2936 2936 -, tcagc dbSNP:774865430
2936 2936 a, g dbSNP:755884869
2940 2940 a, g dbSNP:766428057
2942 2942 c, t dbSNP:770399088
2945 2945 c, g dbSNP:754956837
2951 2951 -, cggata dbSNP:760047613
2951 2951 c, t dbSNP:377295816
2952 2952 a, g dbSNP:144170102
2955 2955 a, t dbSNP:145461366
2956 2956 a, t dbSNP:201456778
2957 2957 c, t dbSNP:778003774
2958 2958 a, g, t dbSNP:148418079
2961 2961 a, g dbSNP:200633780
2962 2962 c, g dbSNP:746431068
2963 2963 g, t dbSNP:770261381
2966 2966 c, g dbSNP:773770329
2969 2969 c, t dbSNP:115552704
2975 2975 c, t dbSNP:767093256
2976 2976 a, g dbSNP:573828634
2978 2978 a, g dbSNP:377619576
2981 2981 c, t dbSNP:760401435
2982 2982 a, g dbSNP:766337991
2985 2985 c, t dbSNP:753664781
2989 2989 c, t dbSNP:755006151
2990 2990 c, t dbSNP:765228989
2991 2991 a, g dbSNP:752743066
3008 3008 c, t dbSNP:369142690
3034 3034 c, t dbSNP:777860927
3043 3043 -, ctc dbSNP:767914773
3048 3048 c, t dbSNP:541612791
3052 3052 a, g dbSNP:757456806
3055 3055 c, t dbSNP:781582190
3062 3062 c, t dbSNP:746195982
3066 3066 a, c dbSNP:190536709
3068 3068 a, g dbSNP:142557214
3073 3073 c, t dbSNP:747619129
3076 3076 c, t dbSNP:550995360
3077 3077 a, g dbSNP:150969738
3080 3080 g, t dbSNP:760456533
3083 3083 c, g dbSNP:770677767
3086 3086 g, t dbSNP:776599019
3090 3090 a, g dbSNP:759358156
3095 3095 a, c, g dbSNP:743580
3098 3098 a, c dbSNP:752612389
3101 3101 g, t dbSNP:564420390
3103 3103 c, t dbSNP:145127312
3104 3104 a, c, g, t dbSNP:146867846