×

POU3F2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol POU3F2
Entrez Gene ID 5454
Full Name POU class 3 homeobox 2
Synonyms BRN2, N-Oct3, OCT7, OTF-7, OTF7, POUF3, brn-2, oct-7
General protein information
Preferred Names
POU domain, class 3, transcription factor 2
Names
POU domain, class 3, transcription factor 2
brain-2
octamer-binding protein 7
octamer-binding transcription factor 7
brain-specific homeobox/POU domain protein 2
nervous system-specific octamer-binding transcription factor N-Oct-3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q16

Summary This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]. lac of sum
Disorder MIM:

600494


mRNA and Protein(s)

mRNA Protein Name
NM_005604 NP_005595 POU domain, class 3, transcription factor 2



Homo sapiens (human) POU3F2 NP_005595.2
Pan troglodytes (chimpanzee) POU3F2 XP_003950948.1
Macaca mulatta (Rhesus monkey) LOC694524 XP_001083202.1
Canis lupus familiaris (dog) LOC481931 XP_539052.3
Bos taurus (cattle) POU3F2 NP_001073817.1
Mus musculus (house mouse) Pou3f2 NP_032925.1
Rattus norvegicus (Norway rat) Pou3f2 NP_742082.1
Danio rerio (zebrafish) pou3f2b NP_571235.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100486226 NP_001263306.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following POU3F2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU3F2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu10724 NM_005604 Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu10724
Clone ID Related Accession (Same CDS sequence) NM_005604
Accession Version NM_005604.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1332bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 16-MAR-2014
Organism Homo sapiens (human)
Product POU domain, class 3, transcription factor 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA491157.1, BC051699.1 and AL022395.2. On Mar 14, 2012 this sequence version replaced gi:51702520. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC051699.1 [ECO:0000345] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGACCG CAGCGTCTAA CCACTACAGC CTGCTCACCT CCAGCGCCTC CATCGTGCAC 
GCCGAGCCGC CCGGCGGCAT GCAGCAGGGC GCGGGGGGCT ACCGCGAAGC GCAGAGCCTG
GTGCAGGGCG ACTACGGCGC TCTGCAGAGC AACGGACACC CGCTCAGCCA CGCTCACCAG
TGGATCACCG CGCTGTCCCA CGGCGGCGGC GGCGGGGGCG GTGGCGGCGG CGGGGGGGGC
GGGGGCGGCG GCGGGGGCGG CGGCGACGGC TCCCCGTGGT CCACCAGCCC CCTGGGCCAG
CCGGACATCA AGCCCTCGGT GGTGGTGCAG CAGGGCGGCC GCGGAGACGA GCTGCACGGG
CCAGGCGCCC TGCAGCAGCA GCATCAGCAG CAGCAACAGC AACAGCAGCA GCAACAGCAG
CAACAGCAGC AGCAGCAGCA GCAACAGCGG CCGCCGCATC TGGTGCACCA CGCCGCTAAC
CACCACCCGG GACCCGGGGC ATGGCGGAGC GCGGCGGCTG CAGCGCACCT CCCACCCTCC
ATGGGAGCGT CCAACGGCGG CTTGCTCTAC TCGCAGCCCA GCTTCACGGT GAACGGCATG
CTGGGCGCCG GCGGGCAGCC GGCCGGTCTG CACCACCACG GCCTGCGGGA CGCGCACGAC
GAGCCACACC ATGCCGACCA CCACCCGCAC CCGCACTCGC ACCCACACCA GCAGCCGCCG
CCCCCGCCGC CCCCGCAGGG TCCGCCTGGC CACCCAGGCG CGCACCACGA CCCGCACTCG
GACGAGGACA CGCCGACCTC GGACGACCTG GAGCAGTTCG CCAAGCAGTT CAAGCAGCGG
CGGATCAAAC TGGGATTTAC CCAAGCGGAC GTGGGGCTGG CTCTGGGCAC CCTGTATGGC
AACGTGTTCT CGCAGACCAC CATCTGCAGG TTTGAGGCCC TGCAGCTGAG CTTCAAGAAC
ATGTGCAAGC TGAAGCCTTT GTTGAACAAG TGGTTGGAGG AGGCGGACTC GTCCTCGGGC
AGCCCCACGA GCATAGACAA GATCGCAGCG CAAGGGCGCA AGCGGAAAAA GCGGACCTCC
ATCGAGGTGA GCGTCAAGGG GGCTCTGGAG AGCCATTTCC TCAAATGCCC CAAGCCCTCG
GCCCAGGAGA TCACCTCCCT CGCGGACAGC TTACAGCTGG AGAAGGAGGT GGTGAGAGTT
TGGTTTTGTA ACAGGAGACA GAAAGAGAAA AGGATGACCC CTCCCGGAGG GACTCTGCCG
GGCGCCGAGG ATGTGTACGG GGGGAGTAGG GACACTCCAC CACACCACGG GGTGCAGACG
CCCGTCCAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005595.2
CDS171..1502
Misc Feature(1)6..8(+)
Misc Feature(2)954..1178(+)
Misc Feature(3)1191..1193(+)
Misc Feature(4)1233..1406(+)
Misc Feature(5)1233..1403(+)
Misc Feature(6)1239..1391(+)
Exon (1)1..4087
Gene:POU3F2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005604
Organism Homo sapiens (human)
Definition Homo sapiens POU class 3 homeobox 2 (POU3F2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005604

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCGACCG CAGCGTCTAA CCACTACAGC CTGCTCACCT CCAGCGCCTC CATCGTGCAC 
GCCGAGCCGC CCGGCGGCAT GCAGCAGGGC GCGGGGGGCT ACCGCGAAGC GCAGAGCCTG
GTGCAGGGCG ACTACGGCGC TCTGCAGAGC AACGGACACC CGCTCAGCCA CGCTCACCAG
TGGATCACCG CGCTGTCCCA CGGCGGCGGC GGCGGGGGCG GTGGCGGCGG CGGGGGGGGC
GGGGGCGGCG GCGGGGGCGG CGGCGACGGC TCCCCGTGGT CCACCAGCCC CCTGGGCCAG
CCGGACATCA AGCCCTCGGT GGTGGTGCAG CAGGGCGGCC GCGGAGACGA GCTGCACGGG
CCAGGCGCCC TGCAGCAGCA GCATCAGCAG CAGCAACAGC AACAGCAGCA GCAACAGCAG
CAACAGCAGC AGCAGCAGCA GCAACAGCGG CCGCCGCATC TGGTGCACCA CGCCGCTAAC
CACCACCCGG GACCCGGGGC ATGGCGGAGC GCGGCGGCTG CAGCGCACCT CCCACCCTCC
ATGGGAGCGT CCAACGGCGG CTTGCTCTAC TCGCAGCCCA GCTTCACGGT GAACGGCATG
CTGGGCGCCG GCGGGCAGCC GGCCGGTCTG CACCACCACG GCCTGCGGGA CGCGCACGAC
GAGCCACACC ATGCCGACCA CCACCCGCAC CCGCACTCGC ACCCACACCA GCAGCCGCCG
CCCCCGCCGC CCCCGCAGGG TCCGCCTGGC CACCCAGGCG CGCACCACGA CCCGCACTCG
GACGAGGACA CGCCGACCTC GGACGACCTG GAGCAGTTCG CCAAGCAGTT CAAGCAGCGG
CGGATCAAAC TGGGATTTAC CCAAGCGGAC GTGGGGCTGG CTCTGGGCAC CCTGTATGGC
AACGTGTTCT CGCAGACCAC CATCTGCAGG TTTGAGGCCC TGCAGCTGAG CTTCAAGAAC
ATGTGCAAGC TGAAGCCTTT GTTGAACAAG TGGTTGGAGG AGGCGGACTC GTCCTCGGGC
AGCCCCACGA GCATAGACAA GATCGCAGCG CAAGGGCGCA AGCGGAAAAA GCGGACCTCC
ATCGAGGTGA GCGTCAAGGG GGCTCTGGAG AGCCATTTCC TCAAATGCCC CAAGCCCTCG
GCCCAGGAGA TCACCTCCCT CGCGGACAGC TTACAGCTGG AGAAGGAGGT GGTGAGAGTT
TGGTTTTGTA ACAGGAGACA GAAAGAGAAA AGGATGACCC CTCCCGGAGG GACTCTGCCG
GGCGCCGAGG ATGTGTACGG GGGGAGTAGG GACACTCCAC CACACCACGG GGTGCAGACG
CCCGTCCAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
Pharmacogenomics J. 14 (1), 6-13 (2014)
Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Ida Chen YD, de Craen AJ, Eijgelsheim M, Enquobahrie D, Evans DS, Ford I, Garcia ME, Gudnason V, Harris TB, Heckbert SR, Hochner H, Hofman A, Hsueh WC, Isaacs A, Jukema JW, Knekt P, Kors JA, Krijthe BP, Kristiansson K, Laaksonen M, Liu Y, Li X, Macfarlane PW, Newton-Cheh C, Nieminen MS, Oostra BA, Peloso GM, Porthan K, Rice K, Rivadeneira FF, Rotter JI, Salomaa V, Sattar N, Siscovick DS, Slagboom PE, Smith AV, Sotoodehnia N, Stott DJ, Stricker BH, Sturmer T, Trompet S, Uitterlinden AG, van Duijn C, Westendorp RG, Witteman JC, Whitsel EA and Psaty BM.


book

Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer
Lab. Invest. 93 (4), 408-421 (2013)
Sakaeda M, Sato H, Ishii J, Miyata C, Kamma H, Shishido-Hara Y, Shimoyamada H, Fujiwara M, Endo T, Tanaka R, Kondo H, Goya T, Aoki I and Yazawa T.


book

POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer
Pathol. Int. 63 (3), 158-168 (2013)
Ishii J, Sato H, Sakaeda M, Shishido-Hara Y, Hiramatsu C, Kamma H, Shimoyamada H, Fujiwara M, Endo T, Aoki I and Yazawa T.


book

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population
PLoS ONE 7 (12), E51954 (2012)
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA and Butte NF.


book

The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression
Oncogene 11 (10), 2157-2164 (1995)
Eisen T, Easty DJ, Bennett DC and Goding CR.


book

Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16
Genomics 26 (2), 272-280 (1995)
Atanasoski S, Toldo SS, Malipiero U, Schreiber E, Fries R and Fontana A.


book

cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif
Nucleic Acids Res. 21 (2), 253-258 (1993)
Schreiber E, Tobler A, Malipiero U, Schaffner W and Fontana A.


book

Structure and evolution of four POU domain genes expressed in mouse brain
Proc. Natl. Acad. Sci. U.S.A. 89 (8), 3280-3284 (1992)
Hara Y, Rovescalli AC, Kim Y and Nirenberg M.


book

Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins
Nucleic Acids Res. 18 (18), 5495-5503 (1990)
Schreiber E, Harshman K, Kemler I, Malipiero U, Schaffner W and Fontana A.


book

Expression of a large family of POU-domain regulatory genes in mammalian brain development
Nature 340 (6228), 35-41 (1989)
He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW and Rosenfeld MG.


 
*
*
*
*