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UGT1A7 cDNA ORF clone, Homo sapiens (human)

Gene Symbol UGT1A7
Entrez Gene ID 54577
Full Name UDP glucuronosyltransferase 1 family, polypeptide A7
Synonyms UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G
General protein information
Preferred Names
UDP-glucuronosyltransferase 1-7
Names
UDP-glucuronosyltransferase 1-7
UDP-glucuronosyltransferase 1-G
UDP-glucuronosyltransferase 1A7
UDP glycosyltransferase 1 family, polypeptide A7
UDP-glucuronosyltransferase 1 family polypeptide A7s
NP_061950.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q37

Summary This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606432


mRNA and Protein(s)

mRNA Protein Name
NM_019077 NP_061950 UDP-glucuronosyltransferase 1-7 precursor



Homo sapiens (human) UGT1A10 NP_061948.1
Homo sapiens (human) UGT1A8 NP_061949.3
Homo sapiens (human) UGT1A7 NP_061950.2
Homo sapiens (human) UGT1A9 NP_066307.1
Mus musculus (house mouse) Ugt1a9 NP_964006.2
Mus musculus (house mouse) Ugt1a10 NP_964003.2
Rattus norvegicus (Norway rat) Ugt1a8 NP_787040.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following UGT1A7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT1A7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu24768 NM_019077 Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24768
Clone ID Related Accession (Same CDS sequence) NM_019077
Accession Version NM_019077.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1593bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product UDP-glucuronosyltransferase 1-7 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY435142.1. This sequence is a reference standard in the RefSeqGene project. On Jan 25, 2004 this sequence version replaced gi:29789083. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY435142.1, U89507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCTCGTG CAGGGTGGAC TGGCCTCCTT CCCCTATATG TGTGTCTACT GCTGACCTGT 
GGCTTTGCCA AGGCAGGGAA GCTGCTGGTA GTGCCCATGG ATGGGAGCCA CTGGTTCACC
ATGCAGTCGG TGGTGGAGAA ACTCATCCTC AGGGGGCATG AGGTGGTCGT AGTCATGCCA
GAGGTGAGTT GGCAACTGGG AAGATCACTG AATTGCACAG TGAAGACTTA CTCAACCTCA
TACACTCTGG AGGATCAGGA CCGGGAGTTC ATGGTTTTTG CCGATGCTCG CTGGACGGCA
CCATTGCGAA GTGCATTTTC TCTATTAACA AGTTCATCCA ATGGTATTTT TGACTTATTT
TTTTCAAATT GCAGGAGTTT GTTTAATGAC CGAAAATTAG TAGAATACTT AAAGGAGAGT
TGTTTTGATG CAGTGTTTCT CGATCCTTTT GATGCCTGTG GCTTAATTGT TGCCAAATAT
TTCTCCCTCC CCTCTGTGGT CTTCGCCAGG GGAATATTTT GCCACTATCT TGAAGAAGGT
GCACAGTGCC CTGCTCCTCT TTCCTATGTC CCCAGACTTC TCTTAGGGTT CTCAGACGCC
ATGACTTTCA AGGAGAGAGT ATGGAACCAC ATCATGCACT TGGAGGAACA TTTATTTTGC
CCCTATTTTT TCAAAAATGT CTTAGAAATA GCCTCTGAAA TTCTCCAAAC CCCTGTCACG
GCATATGATC TCTACAGCCA CACATCAATT TGGTTGTTGC GAACTGACTT TGTTTTGGAG
TATCCCAAAC CCGTGATGCC CAATATGATC TTCATTGGTG GTATCAACTG TCATCAGGGA
AAGCCAGTGC CTATGGAATT TGAAGCCTAC ATTAATGCTT CTGGAGAACA TGGAATTGTG
GTTTTCTCTT TGGGATCAAT GGTCTCAGAA ATTCCAGAGA AGAAAGCTAT GGCAATTGCT
GATGCTTTGG GCAAAATCCC TCAGACAGTC CTGTGGCGGT ACACTGGAAC CCGACCATCG
AATCTTGCGA ACAACACGAT ACTTGTTAAG TGGCTACCCC AAAACGATCT GCTTGGTCAC
CCGATGACCC GTGCCTTTAT CACCCATGCT GGTTCCCATG GTGTTTATGA AAGCATATGC
AATGGCGTTC CCATGGTGAT GATGCCCTTG TTTGGTGATC AGATGGACAA TGCAAAGCGC
ATGGAGACTA AGGGAGCTGG AGTGACCCTG AATGTTCTGG AAATGACTTC TGAAGATTTA
GAAAATGCTC TAAAAGCAGT CATCAATGAC AAAAGTTACA AGGAGAACAT CATGCGCCTC
TCCAGCCTTC ACAAGGACCG CCCGGTGGAG CCGCTGGACC TGGCCGTGTT CTGGGTGGAG
TTTGTGATGA GGCACAAGGG CGCGCCACAC CTGCGCCCCG CAGCCCACGA CCTCACCTGG
TACCAGTACC ATTCCTTGGA CGTGATTGGT TTCCTCTTGG CCGTCGTGCT GACAGTGGCC
TTCATCACCT TTAAATGTTG TGCTTATGGC TACCGGAAAT GCTTGGGGAA AAAAGGGCGA
GTTAAGAAAG CCCACAAATC CAAGACCCAT TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_061950.2
CDS1..1593
Misc Feature(1)76..1563(+)
Misc Feature(2)82..1323(+)
Misc Feature(3)103..1131(+)
Misc Feature(4)103..1122(+)
Misc Feature(5)109..111(+)
Misc Feature(6)1462..1512(+)
Exon (1)1..855
Gene:UGT1A7
Gene Synonym:
Exon (2)856..987
Gene:UGT1A7
Gene Synonym:
Exon (3)988..1075
Gene:UGT1A7
Gene Synonym:
Exon (4)1076..1295
Gene:UGT1A7
Gene Synonym:
Exon (5)1296..2333
Gene:UGT1A7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_019077
Organism Homo sapiens (human)
Definition Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A7 (UGT1A7), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_019077

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCTCGTG CAGGGTGGAC TGGCCTCCTT CCCCTATATG TGTGTCTACT GCTGACCTGT 
GGCTTTGCCA AGGCAGGGAA GCTGCTGGTA GTGCCCATGG ATGGGAGCCA CTGGTTCACC
ATGCAGTCGG TGGTGGAGAA ACTCATCCTC AGGGGGCATG AGGTGGTCGT AGTCATGCCA
GAGGTGAGTT GGCAACTGGG AAGATCACTG AATTGCACAG TGAAGACTTA CTCAACCTCA
TACACTCTGG AGGATCAGGA CCGGGAGTTC ATGGTTTTTG CCGATGCTCG CTGGACGGCA
CCATTGCGAA GTGCATTTTC TCTATTAACA AGTTCATCCA ATGGTATTTT TGACTTATTT
TTTTCAAATT GCAGGAGTTT GTTTAATGAC CGAAAATTAG TAGAATACTT AAAGGAGAGT
TGTTTTGATG CAGTGTTTCT CGATCCTTTT GATGCCTGTG GCTTAATTGT TGCCAAATAT
TTCTCCCTCC CCTCTGTGGT CTTCGCCAGG GGAATATTTT GCCACTATCT TGAAGAAGGT
GCACAGTGCC CTGCTCCTCT TTCCTATGTC CCCAGACTTC TCTTAGGGTT CTCAGACGCC
ATGACTTTCA AGGAGAGAGT ATGGAACCAC ATCATGCACT TGGAGGAACA TTTATTTTGC
CCCTATTTTT TCAAAAATGT CTTAGAAATA GCCTCTGAAA TTCTCCAAAC CCCTGTCACG
GCATATGATC TCTACAGCCA CACATCAATT TGGTTGTTGC GAACTGACTT TGTTTTGGAG
TATCCCAAAC CCGTGATGCC CAATATGATC TTCATTGGTG GTATCAACTG TCATCAGGGA
AAGCCAGTGC CTATGGAATT TGAAGCCTAC ATTAATGCTT CTGGAGAACA TGGAATTGTG
GTTTTCTCTT TGGGATCAAT GGTCTCAGAA ATTCCAGAGA AGAAAGCTAT GGCAATTGCT
GATGCTTTGG GCAAAATCCC TCAGACAGTC CTGTGGCGGT ACACTGGAAC CCGACCATCG
AATCTTGCGA ACAACACGAT ACTTGTTAAG TGGCTACCCC AAAACGATCT GCTTGGTCAC
CCGATGACCC GTGCCTTTAT CACCCATGCT GGTTCCCATG GTGTTTATGA AAGCATATGC
AATGGCGTTC CCATGGTGAT GATGCCCTTG TTTGGTGATC AGATGGACAA TGCAAAGCGC
ATGGAGACTA AGGGAGCTGG AGTGACCCTG AATGTTCTGG AAATGACTTC TGAAGATTTA
GAAAATGCTC TAAAAGCAGT CATCAATGAC AAAAGTTACA AGGAGAACAT CATGCGCCTC
TCCAGCCTTC ACAAGGACCG CCCGGTGGAG CCGCTGGACC TGGCCGTGTT CTGGGTGGAG
TTTGTGATGA GGCACAAGGG CGCGCCACAC CTGCGCCCCG CAGCCCACGA CCTCACCTGG
TACCAGTACC ATTCCTTGGA CGTGATTGGT TTCCTCTTGG CCGTCGTGCT GACAGTGGCC
TTCATCACCT TTAAATGTTG TGCTTATGGC TACCGGAAAT GCTTGGGGAA AAAAGGGCGA
GTTAAGAAAG CCCACAAATC CAAGACCCAT TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Discovery and refinement of loci associated with lipid levels
Nat. Genet. 45 (11), 1274-1283 (2013)
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Doring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR.


book

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study
Atherosclerosis 229 (1), 155-160 (2013)
Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC and Bowden DW.


book

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population
Genet. Epidemiol. 37 (3), 293-300 (2013)
Dai X, Wu C, He Y, Gui L, Zhou L, Guo H, Yuan J, Yang B, Li J, Deng Q, Huang S, Guan L, Hu D, Zhu J, Min X, Lang M, Li D, Yang H, Hu FB, Lin D, Wu T and He M.


book

A genome-wide assessment of variability in human serum metabolism
Hum. Mutat. 34 (3), 515-524 (2013)
Hong MG, Karlsson R, Magnusson PK, Lewis MR, Isaacs W, Zheng LS, Xu J, Gronberg H, Ingelsson E, Pawitan Y, Broeckling C, Prenni JE, Wiklund F and Prince JA.


book

Association between polymorphisms in UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk
Asian Pac. J. Cancer Prev. 13 (5), 2311-2314 (2012)
Osawa K, Nakarai C, Akiyama M, Hashimoto R, Tsutou A, Takahashi J, Takaoka Y, Kawamura S, Shimada E, Tanaka K, Kozuka M, Yamamoto M and Kido Y.


book

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene
Pharmacogenetics 10 (7), 629-644 (2000)
Guillemette C, Ritter JK, Auyeung DJ, Kessler FK and Housman DE.


book

Human UDP-glucuronosyltransferases: metabolism, expression, and disease
Annu. Rev. Pharmacol. Toxicol. 40, 581-616 (2000)
Tukey RH and Strassburg CP.


book

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence
Pharmacogenetics 7 (4), 255-269 (1997)
Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF and Nebert DW.


book

Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
Mol. Pharmacol. 52 (2), 212-220 (1997)
Strassburg CP, Oldhafer K, Manns MP and Tukey RH.


book

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37
Cytogenet. Cell Genet. 63 (2), 114-116 (1993)
van Es HH, Bout A, Liu J, Anderson L, Duncan AM, Bosma P, Oude Elferink R, Jansen PL, Chowdhury JR and Schurr E.


 
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