The following UGT1A7 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UGT1A7 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1593bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||UDP-glucuronosyltransferase 1-7 precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY435142.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 25, 2004 this sequence version replaced gi:29789083.
Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme
of the glucuronidation pathway that transforms small lipophilic
molecules, such as steroids, bilirubin, hormones, and drugs, into
water-soluble, excretable metabolites. This gene is part of a
complex locus that encodes several UDP-glucuronosyltransferases.
The locus includes thirteen unique alternate first exons followed
by four common exons. Four of the alternate first exons are
considered pseudogenes. Each of the remaining nine 5' exons may be
spliced to the four common exons, resulting in nine proteins with
different N-termini and identical C-termini. Each first exon
encodes the substrate binding site, and is regulated by its own
promoter. The enzyme encoded by this gene has moderate
glucuronidase activity with phenols. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AY435142.1, U89507.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.