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FEV FEV (ETS oncogene family) [Homo sapiens (human)]

Gene Symbol FEV
Entrez Gene ID 54738
Full Name FEV (ETS oncogene family)
Synonyms HSRNAFEV, PET-1
General protein information
Preferred Names
protein FEV
Names
protein FEV
fifth Ewing variant protein
PC12 ETS domain-containing transcription factor 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q36

Summary This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607150

Disorder Html:





The following FEV gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FEV gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19395 NM_017521 Homo sapiens FEV (ETS oncogene family) (FEV), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$188.3
$269

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19395
Accession Version NM_017521.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein FEV
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Y08976.1 and BC023511.2. This sequence is a reference standard in the RefSeqGene project. On Dec 10, 2004 this sequence version replaced gi:8923788. Summary: This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y08976.1, CA867675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_059991.1
CDS583..1299
Misc Feature(1)313..315(+)
Misc Feature(2)634..639(+)
Misc Feature(3)718..966(+)
Misc Feature(4)967..1296(+)
Exon (1)1..634
Gene:FEV
Gene Synonym:
Exon (2)635..709
Gene:FEV
Gene Synonym:
Exon (3)710..1879
Gene:FEV
Gene Synonym:
Translation
Position Chain Variation Link
41 41 a, g dbSNP:543223524
55 55 a, g dbSNP:572585201
93 93 -, c dbSNP:111614832
171 171 a, c dbSNP:540842214
200 200 c, t dbSNP:554423666
402 402 c, t dbSNP:545424427
428 428 g, t dbSNP:373374254
482 482 c, t dbSNP:558136164
534 534 -, c dbSNP:397841107
539 539 -, c dbSNP:3835980
543 543 c, t dbSNP:536698351
553 553 c, g, t dbSNP:575751546
554 554 a, c dbSNP:749524651
559 559 c, t dbSNP:780483757
563 563 c, g dbSNP:756420197
564 564 c, g dbSNP:750775328
574 574 c, g dbSNP:768012694
575 575 c, g dbSNP:757757180
576 576 g, t dbSNP:752041950
581 581 c, t dbSNP:763655673
583 583 a, g dbSNP:762428733
594 594 a, c dbSNP:774992873
607 607 c, t dbSNP:764801662
612 612 a, g dbSNP:554306880
613 613 c, t dbSNP:202121405
623 623 c, t dbSNP:776364152
628 628 c, t dbSNP:377762045
637 637 c, g dbSNP:752161359
640 640 g, t dbSNP:764750038
652 652 c, t dbSNP:759167857
657 657 c, t dbSNP:753529334
664 664 g, t dbSNP:766193353
672 672 a, c dbSNP:760448801
675 675 c, g dbSNP:532473906
676 676 a, g dbSNP:553689168
682 682 g, t dbSNP:372143346
719 719 a, g dbSNP:759630260
722 722 a, t dbSNP:776776811
730 730 c, t dbSNP:573116414
765 765 a, c, g, t dbSNP:772468410
768 768 c, t dbSNP:748650671
770 770 c, g dbSNP:779455782
771 771 c, t dbSNP:755493413
774 774 c, t dbSNP:748683998
813 813 a, c dbSNP:779649452
816 816 c, g, t dbSNP:750128101
825 825 c, t dbSNP:376714840
828 828 c, g dbSNP:767207801
831 831 a, g dbSNP:757171963
836 836 a, g dbSNP:751411997
846 846 a, c dbSNP:373955525
847 847 g, t dbSNP:201649508
848 848 a, g dbSNP:200750890
867 867 c, t dbSNP:776522408
887 887 a, g dbSNP:766530727
904 904 c, t dbSNP:760778914
905 905 a, g dbSNP:773550327
909 909 c, t dbSNP:772413346
919 919 a, g dbSNP:748458463
935 935 a, c dbSNP:373765480
939 939 c, t dbSNP:860573
949 949 a, g dbSNP:749827919
963 963 c, t dbSNP:779397610
964 964 c, t dbSNP:755714367
970 970 c, g dbSNP:745489853
976 976 a, g dbSNP:780931047
977 977 c, t dbSNP:756973980
978 978 c, g dbSNP:751360431
983 983 c, t dbSNP:439880
991 991 c, t dbSNP:764000948
992 992 c, g dbSNP:758386421
995 995 c, g, t dbSNP:766366402
996 996 g, t dbSNP:145426408
999 999 c, t dbSNP:750483793
1000 1000 a, g dbSNP:767664032
1005 1005 a, c dbSNP:762057968
1033 1033 a, g dbSNP:774651715
1040 1040 c, t dbSNP:575351845
1071 1071 a, g dbSNP:777406156
1085 1085 a, c dbSNP:375436
1128 1128 c, t dbSNP:557070541
1146 1146 a, g dbSNP:427890
1151 1151 a, c dbSNP:434331
1170 1170 c, g dbSNP:535653522
1175 1175 c, g dbSNP:568685841
1251 1251 c, t dbSNP:763362080
1256 1256 c, g dbSNP:113930604
1272 1272 a, c dbSNP:546967536
1280 1280 -, g dbSNP:141171754
1285 1285 a, g dbSNP:776082147
1307 1307 g, t dbSNP:770213076
1308 1308 a, g dbSNP:772278665
1331 1331 a, g dbSNP:745308464
1360 1360 g, t dbSNP:2301296
1369 1369 g, t dbSNP:435910
1377 1377 a, c dbSNP:443017
1380 1380 a, g dbSNP:190949414
1388 1388 c, t dbSNP:79354023
1430 1430 c, t dbSNP:548843046
1470 1470 a, c dbSNP:13025223
1499 1499 c, t dbSNP:149868566
1500 1500 a, g dbSNP:139049927
1519 1519 a, c, g dbSNP:376093959
1523 1523 c, t dbSNP:112376740
1529 1529 a, c dbSNP:13025054
1536 1536 a, t dbSNP:6749120
1544 1544 -, t dbSNP:146554227
1613 1613 c, t dbSNP:749177947
1614 1614 c, t dbSNP:451253
1615 1615 c, t dbSNP:147418810
1627 1627 a, g dbSNP:777420471
1633 1633 c, g dbSNP:374633301
1690 1690 c, g dbSNP:540109197
1722 1722 a, g dbSNP:755885043
1792 1792 a, g dbSNP:752635825
1820 1820 c, g dbSNP:767402546
1865 1865 a, g dbSNP:754508742

Target ORF information:

RefSeq Version NM_017521
Organism Homo sapiens (human)
Definition Homo sapiens FEV (ETS oncogene family) (FEV), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_017521

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGAGACAGA GCGGCGCCTC CCAGCCCCTG CTGATCAACA TGTACCTGCC AGATCCCGTC 
GGAGACGGTC TCTTCAAGGA CGGGAAGAAC CCGAGCTGGG GGCCGCTGAG CCCCGCGGTT
CAGAAAGGCA GCGGACAGAT CCAGCTGTGG CAGTTTCTGC TGGAGCTGCT GGCTGACCGC
GCGAACGCCG GCTGCATCGC GTGGGAGGGC GGTCACGGCG AGTTCAAGCT CACGGACCCG
GACGAGGTGG CGCGGCGGTG GGGCGAGCGC AAGAGCAAGC CCAACATGAA CTACGACAAG
CTGAGCCGCG CCCTGCGCTA CTACTACGAC AAGAACATCA TGAGCAAGGT GCATGGCAAG
CGCTACGCCT ACCGCTTCGA CTTCCAGGGC CTGGCGCAGG CCTGCCAGCC GCCGCCCGCG
CACGCTCATG CCGCCGCCGC AGCTGCTGCC GCCGCCGCGG CCGCCCAGGA CGGCGCGCTC
TACAAGCTGC CCGCCGGCCT CGCCCCGCTG CCCTTCCCCG GCCTCTCCAA ACTCAACCTC
ATGGCCGCCT CGGCCGGGGT CGCGCCCGCC GGCTTCTCCT ACTGGCCGGG CCCGGGCCCC
GCCGCCACCG CTGCCGCCGC CACCGCCGCG CTCTACCCCA GTCCCAGCTT GCAGCCCCCG
CCCGGGCCCT TCGGGGCCGT GGCCGCAGCC TCGCACTTGG GGGGCCATTA CCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.