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PPIB peptidylprolyl isomerase B (cyclophilin B) [Homo sapiens (human)]

Gene Symbol PPIB
Entrez Gene ID 5479
Full Name peptidylprolyl isomerase B (cyclophilin B)
Synonyms CYP-S1, CYPB, HEL-S-39, OI9, SCYLP
General protein information
Preferred Names
peptidyl-prolyl cis-trans isomerase B
Names
peptidyl-prolyl cis-trans isomerase B
PPIase B
rotamase B
S-cyclophilin
cyclophilin-like protein
NP_000933.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q21-q22

Summary The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

123841

Disorder Html: Osteogenesis imperfecta, type IX, 259440 (3)





The following PPIB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPIB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19649 NM_000942 Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$199

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu19649
Accession Version NM_000942.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 651bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear Document: OHu19649D_COA.pdf (pdf)
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product peptidyl-prolyl cis-trans isomerase B precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ931949.1, BC008848.2 and BC001125.2. This sequence is a reference standard in the RefSeqGene project. On Mar 2, 2004 this sequence version replaced gi:34147592. Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001125.2, BC008848.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
ATGCTGCGCC TCTCCGAACG CAACATGAAG GTGCTCCTTG CCGCCGCCCT CATCGCGGGG 
TCCGTCTTCT TCCTGCTGCT GCCGGGACCT TCTGCGGCCG ATGAGAAGAA GAAGGGGCCC
AAAGTCACCG TCAAGGTGTA TTTTGACCTA CGAATTGGAG ATGAAGATGT AGGCCGGGTG
ATCTTTGGTC TCTTCGGAAA GACTGTTCCA AAAACAGTGG ATAATTTTGT GGCCTTAGCT
ACAGGAGAGA AAGGATTTGG CTACAAAAAC AGCAAATTCC ATCGTGTAAT CAAGGACTTC
ATGATCCAGG GCGGAGACTT CACCAGGGGA GATGGCACAG GAGGAAAGAG CATCTACGGT
GAGCGCTTCC CCGATGAGAA CTTCAAACTG AAGCACTACG GGCCTGGCTG GGTGAGCATG
GCCAACGCAG GCAAAGACAC CAACGGCTCC CAGTTCTTCA TCACGACAGT CAAGACAGCC
TGGCTAGATG GCAAGCATGT GGTGTTTGGC AAAGTTCTAG AGGGCATGGA GGTGGTGCGG
AAGGTGGAGA GCACCAAGAC AGACAGCCGG GATAAACCCC TGAAGGATGT GATCATCGCA
GACTGCGGCA AGATCGAGGT GGAGAAGCCC TTTGCCATCG CCAAGGAGTA G
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000933.1
CDS170..820
Misc Feature(1)302..778(+)
Misc Feature(2)449..652(+)
Misc Feature(3)773..775(+)
Misc Feature(4)806..817(+)
Exon (1)1..304
Gene:PPIB
Gene Synonym:
Exon (2)305..418
Gene:PPIB
Gene Synonym:
Exon (3)419..512
Gene:PPIB
Gene Synonym:
Exon (4)513..697
Gene:PPIB
Gene Synonym:
Exon (5)698..1028
Gene:PPIB
Gene Synonym:
Translation
Position Chain Variation Link
23 23 a, g dbSNP:552008482
35 35 -, gc dbSNP:34392166
46 46 g, t dbSNP:764156938
72 72 a, c dbSNP:527689470
76 76 c, g dbSNP:369957382
78 78 a, c, g, t dbSNP:376643972
79 79 a, g dbSNP:544474028
90 90 g, t dbSNP:191528507
92 92 c, g dbSNP:372547970
119 119 a, c dbSNP:751128796
120 120 c, t dbSNP:766196275
123 123 c, t dbSNP:762904496
128 128 g, t dbSNP:773042414
134 134 c, t dbSNP:559300402
139 139 a, c, t dbSNP:776824072
140 140 a, t dbSNP:768918215
143 143 c, g dbSNP:747032527
144 144 c, g dbSNP:775604794
145 145 c, g dbSNP:772067068
150 150 a, g dbSNP:188404221
154 154 g, t dbSNP:779568765
158 158 c, g, t dbSNP:572092561
160 160 a, c dbSNP:375998912
161 161 c, g, t dbSNP:367616150
162 162 c, g, t dbSNP:757856817
165 165 -, ccgcct, t dbSNP:761203848
169 169 a, g dbSNP:750290728
170 170 a, g dbSNP:201472818
173 173 c, g dbSNP:761575765
178 178 c, t dbSNP:141504929
188 188 a, c, t dbSNP:760906683
193 193 c, t dbSNP:148644836
195 195 g, t dbSNP:137853864
199 199 a, g dbSNP:772124759
201 201 c, t dbSNP:759602757
202 202 c, g dbSNP:568054483
203 203 a, c dbSNP:771613998
205 205 a, c dbSNP:556370363
211 211 c, t dbSNP:532229131
212 212 a, g dbSNP:367853445
214 214 c, t dbSNP:746610540
217 217 c, t dbSNP:779574130
218 218 c, g dbSNP:757918812
220 220 c, t dbSNP:749987416
225 225 c, t dbSNP:537654261
232 232 a, c, t dbSNP:4904
239 239 -, ttc dbSNP:775722308
253 253 c, g dbSNP:763891853
254 254 a, g dbSNP:200307684
273 273 a, g dbSNP:752960312
277 277 g, t dbSNP:767692265
281 281 -, aag dbSNP:772423240
284 284 g, t dbSNP:759664826
287 287 c, g dbSNP:774612111
289 289 -, c dbSNP:137853865
290 290 a, g dbSNP:771164709
293 293 a, g dbSNP:137883097
299 299 a, g dbSNP:773864288
301 301 c, g dbSNP:770125730
305 305 a, g, t dbSNP:570335950
308 308 c, t dbSNP:373715158
321 321 -, g dbSNP:774594521
321 321 g, t dbSNP:754829389
322 322 a, t dbSNP:751764020
336 336 a, c dbSNP:766774244
339 339 c, t dbSNP:758537632
344 344 a, c dbSNP:750516270
345 345 a, g dbSNP:765392059
347 347 g, t dbSNP:11558595
356 356 c, g dbSNP:527678792
367 367 a, c dbSNP:370565028
369 369 a, g dbSNP:777208720
373 373 c, t dbSNP:764376245
374 374 -, gt dbSNP:771118063
383 383 a, t dbSNP:761099119
385 385 a, t dbSNP:773982357
390 390 a, g dbSNP:766543270
393 393 a, g dbSNP:202087362
396 396 c, t dbSNP:772554369
402 402 a, c, g dbSNP:747974523
403 403 c, g, t dbSNP:370932084
407 407 a, g dbSNP:746857197
409 409 a, t dbSNP:772980857
410 410 a, g dbSNP:200786931
416 416 c, g dbSNP:750682454
435 435 a, g dbSNP:779947681
440 440 a, g dbSNP:368454186
441 441 -, g dbSNP:777787222
444 444 a, c, g dbSNP:112988616
452 452 a, c, t dbSNP:757275030
453 453 a, g dbSNP:771584197
460 460 c, t dbSNP:778225397
463 463 a, g dbSNP:756576726
480 480 -, g dbSNP:768479552
481 481 c, t dbSNP:753222182
482 482 a, g dbSNP:137853866
493 493 c, t dbSNP:2307247
496 496 a, g dbSNP:545257277
503 503 a, g dbSNP:11558596
507 507 c, t dbSNP:199971446
526 526 c, t dbSNP:138741187
527 527 a, g dbSNP:755547351
528 528 a, g dbSNP:568378169
534 534 a, g dbSNP:780409157
541 541 c, t dbSNP:11558597
542 542 a, g dbSNP:753537023
547 547 a, g, t dbSNP:755666526
555 555 a, t dbSNP:752300639
556 556 a, g dbSNP:771047010
567 567 a, g dbSNP:766970513
568 568 c, t dbSNP:373618000
572 572 c, t dbSNP:774166877
574 574 c, t dbSNP:749436404
583 583 -, gagcatggcc dbSNP:137853868
585 585 g, t dbSNP:150146348
595 595 c, t dbSNP:766129397
596 596 a, g dbSNP:762799337
603 603 a, g dbSNP:773405777
607 607 c, t dbSNP:770049169
612 612 a, g dbSNP:761849545
613 613 c, t dbSNP:549542551
614 614 a, g dbSNP:768639196
620 620 c, t dbSNP:121434559
622 622 g, t dbSNP:747485022
631 631 c, t dbSNP:780494412
633 633 c, t dbSNP:772552633
634 634 a, c, g dbSNP:369334476
635 635 a, g dbSNP:140817860
640 640 c, g dbSNP:755792823
645 645 c, t dbSNP:752317657
651 651 a, g dbSNP:780698990
657 657 a, g dbSNP:200990246
659 659 c, g dbSNP:777799513
661 661 c, g dbSNP:28720193
662 662 a, g dbSNP:201926681
666 666 a, t dbSNP:754448469
667 667 c, t dbSNP:751507032
671 671 g, t dbSNP:766357669
672 672 c, t dbSNP:762713590
678 678 a, g dbSNP:199606428
688 688 a, g dbSNP:151284742
698 698 g, t dbSNP:760777976
705 705 c, t dbSNP:775675512
707 707 c, t dbSNP:767732148
708 708 a, g dbSNP:760065852
712 712 a, g dbSNP:775006610
717 717 a, c dbSNP:369952028
725 725 -, aaga dbSNP:137853869
732 732 -, acag dbSNP:398122834
735 735 g, t dbSNP:749670269
737 737 c, t dbSNP:776320521
738 738 a, g dbSNP:200864554
743 743 a, g dbSNP:746706260
748 748 a, c dbSNP:779488612
749 749 c, t dbSNP:530126062
766 766 c, t dbSNP:369889089
775 775 c, t dbSNP:143287832
776 776 a, g dbSNP:757054086
783 783 a, t dbSNP:753616327
785 785 a, g dbSNP:763983999
789 789 c, t dbSNP:1804427
794 794 a, g dbSNP:775716090
795 795 a, g dbSNP:756245364
797 797 c, t dbSNP:200904948
803 803 a, g dbSNP:752983598
808 808 c, t dbSNP:767641975
809 809 a, g dbSNP:759753798
819 819 a, g dbSNP:774983936
821 821 c, g dbSNP:142381852
822 822 g, t dbSNP:766839875
832 832 a, g dbSNP:763342854
834 834 a, c dbSNP:201974607
837 837 c, t dbSNP:770217370
841 841 -, agt dbSNP:753313770
841 841 a, t dbSNP:2307248
849 849 c, t dbSNP:532903614
850 850 a, g dbSNP:771559275
854 854 a, g dbSNP:367916633
871 871 c, t dbSNP:373762582
872 872 a, g dbSNP:201075610
883 883 c, t dbSNP:9091
885 885 c, g dbSNP:2230223
899 899 c, t dbSNP:1804426
900 900 c, t dbSNP:540855873
901 901 a, g dbSNP:202116920
907 907 a, g dbSNP:572025913
912 912 c, g, t dbSNP:1043001
925 925 a, c dbSNP:1803362
928 928 a, c dbSNP:1043016
934 934 c, t dbSNP:776274131
938 938 c, t dbSNP:541426098
965 965 -, t dbSNP:34628002
974 974 c, t dbSNP:574102477
985 985 a, c dbSNP:1043082
1003 1003 -, a dbSNP:376202696
1007 1007 g, t dbSNP:62024249
1009 1009 -, t dbSNP:397748288
1010 1010 a, t dbSNP:113626158
1022 1022 -, t, tt dbSNP:5813282
1024 1024 -, a dbSNP:202080377

Target ORF information:

RefSeq Version NM_000942
Organism Homo sapiens (human)
Definition Homo sapiens peptidylprolyl isomerase B (cyclophilin B) (PPIB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000942

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGCTGCGCC TCTCCGAACG CAACATGAAG GTGCTCCTTG CCGCCGCCCT CATCGCGGGG 
TCCGTCTTCT TCCTGCTGCT GCCGGGACCT TCTGCGGCCG ATGAGAAGAA GAAGGGGCCC
AAAGTCACCG TCAAGGTGTA TTTTGACCTA CGAATTGGAG ATGAAGATGT AGGCCGGGTG
ATCTTTGGTC TCTTCGGAAA GACTGTTCCA AAAACAGTGG ATAATTTTGT GGCCTTAGCT
ACAGGAGAGA AAGGATTTGG CTACAAAAAC AGCAAATTCC ATCGTGTAAT CAAGGACTTC
ATGATCCAGG GCGGAGACTT CACCAGGGGA GATGGCACAG GAGGAAAGAG CATCTACGGT
GAGCGCTTCC CCGATGAGAA CTTCAAACTG AAGCACTACG GGCCTGGCTG GGTGAGCATG
GCCAACGCAG GCAAAGACAC CAACGGCTCC CAGTTCTTCA TCACGACAGT CAAGACAGCC
TGGCTAGATG GCAAGCATGT GGTGTTTGGC AAAGTTCTAG AGGGCATGGA GGTGGTGCGG
AAGGTGGAGA GCACCAAGAC AGACAGCCGG GATAAACCCC TGAAGGATGT GATCATCGCA
GACTGCGGCA AGATCGAGGT GGAGAAGCCC TTTGCCATCG CCAAGGAGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.