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PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G [Homo sapiens (human)]

Gene Symbol PPM1G
Entrez Gene ID 5496
Full Name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Synonyms PP2CG, PP2CGAMMA, PPP2CG
General protein information
Preferred Names
protein phosphatase 1G
Names
protein phosphatase 1G
PP2C-gamma
PP2C, gamma
protein phosphatase 1C
protein phosphatase 2C gamma isoform
protein phosphatase 2C isoform gamma
protein phosphatase magnesium-dependent 1 gamma
protein phosphatase 2, catalytic subunit, gamma isoform
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
NP_817092.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p23.3

Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]. lac of sum
Disorder MIM:

605119

Disorder Html:





The following PPM1G gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPM1G gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27573 NM_177983 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27573
Accession Version NM_177983.2
Sequence Information ORF Nucleotide Sequence (Length: 1641bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein phosphatase 1G
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA520893.1 and BC000057.2. On May 10, 2012 this sequence version replaced gi:29826281. Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000057.2, Y13936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG
AAGAAGGCCA AGCGAGACTA G
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_817092.1
CDS262..1902
Misc Feature(1)238..240(+)
Misc Feature(2)340..>618(+)
Misc Feature(3)367..447(+)
Misc Feature(4)808..810(+)
Misc Feature(5)808..810(+)
Misc Feature(6)1231..1776(+)
Misc Feature(7)1408..1410(+)
Misc Feature(8)1840..1842(+)
Exon (1)1..381
Gene:PPM1G
Gene Synonym:
Exon (2)382..451
Gene:PPM1G
Gene Synonym:
Exon (3)452..537
Gene:PPM1G
Gene Synonym:
Exon (4)538..670
Gene:PPM1G
Gene Synonym:
Exon (5)671..1086
Gene:PPM1G
Gene Synonym:
Exon (6)1087..1227
Gene:PPM1G
Gene Synonym:
Exon (7)1228..1462
Gene:PPM1G
Gene Synonym:
Exon (8)1463..1592
Gene:PPM1G
Gene Synonym:
Exon (9)1593..1695
Gene:PPM1G
Gene Synonym:
Exon (10)1696..2302
Gene:PPM1G
Gene Synonym:
Translation
Position Chain Variation Link
9 9 a, c dbSNP:367650195
28 28 a, c dbSNP:530330554
39 39 c, g dbSNP:4007174
91 91 c, t dbSNP:183754658
99 99 c, g dbSNP:541458967
132 132 a, g dbSNP:191443726
154 154 c, t dbSNP:756259625
160 160 c, t dbSNP:770624327
187 187 c, t dbSNP:558974402
192 192 a, c dbSNP:543592351
205 205 a, t dbSNP:185804071
217 217 c, t dbSNP:556878062
220 220 a, g dbSNP:535593074
236 236 c, t dbSNP:759372320
238 238 c, t dbSNP:568033045
241 241 -, g dbSNP:34350409
246 246 c, t dbSNP:552822343
248 248 a, g dbSNP:552096761
253 253 a, g dbSNP:763089412
255 255 c, t dbSNP:534585613
300 300 c, t dbSNP:773425646
322 322 c, t dbSNP:769784930
332 332 c, g dbSNP:746588751
348 348 c, t dbSNP:570150546
369 369 c, t dbSNP:777326754
396 396 -, tgt dbSNP:749128166
413 413 a, g dbSNP:768790936
438 438 c, t dbSNP:143551387
453 453 a, g dbSNP:749102731
456 456 a, g dbSNP:561065684
466 466 g, t dbSNP:375124641
468 468 a, g dbSNP:138207162
471 471 c, t dbSNP:548787975
479 479 a, g dbSNP:527921079
480 480 a, g dbSNP:757071656
493 493 a, g dbSNP:754148586
498 498 c, t dbSNP:764384903
513 513 c, g dbSNP:376435628
561 561 c, t dbSNP:147074123
562 562 a, g dbSNP:369944692
567 567 c, t dbSNP:189542345
568 568 a, g dbSNP:773561298
571 571 a, c dbSNP:765520326
574 574 c, t dbSNP:760390481
577 577 a, g dbSNP:774959084
595 595 a, g dbSNP:771646355
606 606 a, g dbSNP:147885777
622 622 c, t dbSNP:745342915
647 647 -, aaaaag dbSNP:746383480
649 649 a, g dbSNP:774483402
650 650 a, g dbSNP:200581342
665 665 a, g dbSNP:770974463
667 667 a, g dbSNP:749157963
675 675 c, t dbSNP:770495893
677 677 a, g dbSNP:556461965
696 696 g, t dbSNP:368602227
710 710 a, c dbSNP:769664441
718 718 a, g dbSNP:747865877
726 726 a, g dbSNP:781526558
737 737 a, g dbSNP:768747491
745 745 a, c dbSNP:151079105
750 750 c, t dbSNP:780120254
755 755 a, g dbSNP:758422602
756 756 c, t dbSNP:773935463
760 760 a, g dbSNP:750957890
764 764 c, t dbSNP:537746727
775 775 a, g dbSNP:757685868
789 789 c, g dbSNP:754135745
796 796 a, g dbSNP:142918816
804 804 a, g dbSNP:759270434
807 807 g, t dbSNP:751203077
810 810 c, t dbSNP:766012472
821 821 a, c, g dbSNP:773243184
825 825 a, g dbSNP:143307663
826 826 a, g dbSNP:769598071
846 846 a, c dbSNP:761727055
857 857 c, t dbSNP:776294831
858 858 c, t dbSNP:768440109
862 862 c, t dbSNP:139796030
875 875 a, g dbSNP:780207713
876 876 a, c, t dbSNP:372242443
877 877 a, c dbSNP:779528558
889 889 a, g dbSNP:779237800
894 894 c, t dbSNP:757697346
897 897 -, acaa dbSNP:779348619
897 897 a, g dbSNP:367693259
898 898 a, g dbSNP:533658521
899 899 -, gctt dbSNP:757622317
899 899 c, g dbSNP:566204099
900 900 a, c dbSNP:373757292
901 901 a, t dbSNP:533384037
902 902 g, t dbSNP:569344054
911 911 a, t dbSNP:551307055
914 914 c, t dbSNP:139203531
915 915 a, g dbSNP:751291063
919 919 c, t dbSNP:766100053
921 921 c, t dbSNP:529518084
925 925 a, g dbSNP:749888056
926 926 c, t dbSNP:370931792
940 940 a, g dbSNP:765285925
994 994 g, t dbSNP:200481644
995 995 c, g dbSNP:776581979
1003 1003 c, g dbSNP:768469871
1007 1007 c, t dbSNP:760428968
1009 1009 a, c dbSNP:775735484
1010 1010 a, g dbSNP:772264870
1012 1012 a, g, t dbSNP:200231742
1019 1019 a, g dbSNP:774295705
1023 1023 c, t dbSNP:770988405
1061 1061 c, t dbSNP:150808424
1095 1095 c, t dbSNP:372867701
1102 1102 c, g dbSNP:775256762
1109 1109 a, g dbSNP:374394013
1118 1118 c, g dbSNP:76364491
1136 1136 a, g dbSNP:147058083
1137 1137 a, g dbSNP:759694629
1146 1146 -, gga dbSNP:759023688
1146 1146 a, g dbSNP:774588427
1148 1148 a, g dbSNP:770950792
1155 1155 c, t dbSNP:749359140
1173 1173 c, t dbSNP:138986348
1188 1188 -, agaaga dbSNP:751490485
1191 1191 -, aga dbSNP:371928915
1193 1193 -, aga dbSNP:766266042
1206 1206 a, g dbSNP:376953572
1226 1226 a, t dbSNP:770412416
1241 1241 g, t dbSNP:11551138
1254 1254 a, g dbSNP:149149429
1260 1260 a, g dbSNP:764083279
1296 1296 c, t dbSNP:756047326
1328 1328 c, t dbSNP:145406652
1352 1352 a, g dbSNP:377329230
1380 1380 a, g dbSNP:759338427
1383 1383 a, c dbSNP:774478534
1416 1416 c, t dbSNP:766604066
1418 1418 c, t dbSNP:146853264
1441 1441 c, t dbSNP:773422459
1458 1458 c, t dbSNP:769928748
1461 1461 c, t dbSNP:762431623
1481 1481 a, g dbSNP:750616199
1494 1494 g, t dbSNP:765437403
1527 1527 c, t dbSNP:761953110
1535 1535 a, g dbSNP:777324615
1538 1538 c, t dbSNP:769190699
1549 1549 -, a dbSNP:769591401
1550 1550 c, t dbSNP:761008440
1554 1554 c, t dbSNP:746316815
1587 1587 a, c dbSNP:772263118
1615 1615 a, g dbSNP:761254916
1634 1634 c, t dbSNP:370746610
1639 1639 a, c dbSNP:559680086
1648 1648 a, c dbSNP:767959962
1651 1651 a, g dbSNP:759866921
1655 1655 a, t dbSNP:772902911
1666 1666 a, c dbSNP:769426819
1669 1669 c, t dbSNP:747724484
1670 1670 a, g dbSNP:776211882
1699 1699 c, t dbSNP:761468712
1718 1718 c, g dbSNP:776100043
1720 1720 g, t dbSNP:768252204
1722 1722 c, t dbSNP:746478590
1743 1743 a, g dbSNP:775553914
1758 1758 a, c dbSNP:772129314
1779 1779 a, g dbSNP:114495106
1782 1782 c, t dbSNP:374563765
1784 1784 a, g dbSNP:371650198
1789 1789 a, g dbSNP:749551429
1793 1793 c, t dbSNP:777830450
1798 1798 c, t dbSNP:569991722
1800 1800 a, c, t dbSNP:768081772
1809 1809 a, g dbSNP:755481511
1811 1811 c, g dbSNP:752007624
1812 1812 a, t dbSNP:766752573
1825 1825 c, g dbSNP:763187934
1832 1832 -, agg dbSNP:745986073
1832 1832 a, c dbSNP:753576114
1837 1837 c, t dbSNP:763640846
1838 1838 c, t dbSNP:760296752
1840 1840 c, t dbSNP:774865320
1843 1843 a, g dbSNP:11551140
1850 1850 a, g dbSNP:771647065
1853 1853 c, g dbSNP:759566696
1856 1856 a, g dbSNP:201337102
1872 1872 c, t dbSNP:774387308
1873 1873 a, g dbSNP:770886509
1876 1876 a, g dbSNP:771161165
1877 1877 a, g dbSNP:749018998
1885 1885 -, aag dbSNP:756332441
1885 1885 a, g dbSNP:142505060
1886 1886 a, c dbSNP:144588722
1887 1887 -, aag dbSNP:779446858
1888 1888 g, t dbSNP:748339394
1894 1894 a, c, t dbSNP:375191761
1896 1896 a, g dbSNP:752092055
1897 1897 g, t dbSNP:750398276
1914 1914 a, c dbSNP:1062922
1915 1915 c, t dbSNP:777658215
1921 1921 c, t dbSNP:758855772
1926 1926 a, c dbSNP:370518447
1937 1937 c, t dbSNP:750746567
1938 1938 c, t dbSNP:1045325
1939 1939 c, t dbSNP:760254759
1945 1945 c, t dbSNP:752345939
1946 1946 c, t dbSNP:767162046
1948 1948 c, t dbSNP:377582896
1952 1952 c, g dbSNP:759083140
2024 2024 c, t dbSNP:561584823
2035 2035 c, t dbSNP:374808606
2042 2042 a, c dbSNP:11551139
2043 2043 a, g dbSNP:114078642
2050 2050 c, t dbSNP:528245778
2056 2056 c, g dbSNP:371846172
2061 2061 c, t dbSNP:564057545
2088 2088 a, t dbSNP:546040537
2089 2089 c, t dbSNP:4582
2093 2093 a, g dbSNP:780172546
2116 2116 a, g dbSNP:756297756
2163 2163 a, c, g dbSNP:183380289
2166 2166 -, ggggggg dbSNP:144324155
2210 2210 -, t dbSNP:200885263
2211 2211 -, t dbSNP:552850836
2217 2217 c, t dbSNP:753582920
2224 2224 a, g dbSNP:763768691
2233 2233 a, g dbSNP:529495251
2274 2274 a, g dbSNP:541601639

Target ORF information:

RefSeq Version NM_177983
Organism Homo sapiens (human)
Definition Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_177983

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.