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NOP10 NOP10 ribonucleoprotein [Homo sapiens (human)]

Gene Symbol NOP10
Entrez Gene ID 55505
Full Name NOP10 ribonucleoprotein
Synonyms DKCB1, NOLA3, NOP10P
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q14-q15

Summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606471

Disorder Html: Dyskeratosis congenita, autosomal recessive, 224230 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu19474 NM_018648 Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu19474D
Sequence Information ORF Nucleotide Sequence (Length: 195bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product H/ACA ribonucleoprotein complex subunit 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ218536.1 and BM554889.1. This sequence is a reference standard in the RefSeqGene project. On Oct 18, 2005 this sequence version replaced gi:15011920. Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: BU955288.1, AB043104.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG
CGCCCTGTCC TCTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_061118.1
CDS89..283
Misc Feature(1)80..82(+)
Misc Feature(2)95..247(+)
Misc Feature(3)194..196(+)
Exon (1)1..142
Gene:NOP10
Gene Synonym:
Exon (2)143..535
Gene:NOP10
Gene Synonym:
Translation
Position Chain Variation Link
15 15 c, t dbSNP:561915236
24 24 c, t dbSNP:550497412
30 30 c, g dbSNP:752462785
32 32 c, t dbSNP:775092898
38 38 a, g dbSNP:757349587
39 39 c, t dbSNP:554420284
42 42 c, t dbSNP:753733230
51 51 a, c, t dbSNP:112556317
56 56 a, g dbSNP:370148546
59 59 c, g, t dbSNP:201270793
66 66 a, g, t dbSNP:751282990
67 67 a, c, g dbSNP:762560152
68 68 a, c dbSNP:777218307
70 70 c, t dbSNP:201920207
71 71 a, c, g dbSNP:564679077
73 73 a, t dbSNP:764894891
75 75 a, g dbSNP:373689981
76 76 c, t dbSNP:772371219
79 79 a, g dbSNP:746040045
83 83 c, g dbSNP:779135425
84 84 c, t dbSNP:181783900
87 87 a, t dbSNP:749358405
94 94 -, t dbSNP:756134994
109 109 c, g dbSNP:777783319
112 112 c, t dbSNP:756047969
113 113 a, g dbSNP:752630312
114 114 a, g dbSNP:780995453
115 115 a, g dbSNP:373678744
119 119 a, g dbSNP:370894572
122 122 c, g dbSNP:146261631
126 126 c, g dbSNP:762749739
128 128 g, t dbSNP:749945545
129 129 g, t dbSNP:764689942
139 139 c, g dbSNP:761222362
140 140 a, c dbSNP:560253884
158 158 c, g dbSNP:773341436
163 163 a, t dbSNP:368082745
177 177 c, g dbSNP:748193565
180 180 a, c dbSNP:373843596
182 182 c, g dbSNP:768707296
188 188 c, t dbSNP:121908092
190 190 a, g dbSNP:746979721
200 200 a, g dbSNP:780315311
203 203 a, g dbSNP:779969910
210 210 a, g dbSNP:758289839
216 216 a, g dbSNP:745494123
222 222 a, g, t dbSNP:201604296
228 228 c, t dbSNP:756732260
238 238 a, g dbSNP:562412129
239 239 c, t dbSNP:763635922
240 240 a, g dbSNP:199661222
242 242 c, t dbSNP:752083783
246 246 a, g dbSNP:766693193
251 251 c, t dbSNP:763236137
263 263 a, c dbSNP:750603404
267 267 c, t dbSNP:765367178
274 274 c, t dbSNP:762158306
278 278 c, t dbSNP:776538895
285 285 c, g dbSNP:371001053
294 294 a, c dbSNP:768901406
302 302 a, t dbSNP:201041278
308 308 c, t dbSNP:377680031
313 313 ac, gt dbSNP:386782889
313 313 a, g dbSNP:1045194
314 314 c, t dbSNP:1045204
315 315 c, t dbSNP:370853886
316 316 c, t dbSNP:375648407
317 317 c, g dbSNP:770460479
323 323 c, t dbSNP:749018407
324 324 -, c dbSNP:528879821
326 326 c, t dbSNP:777217218
327 327 a, c, g dbSNP:372176417
328 328 c, g dbSNP:1045238
389 389 c, t dbSNP:146086719
402 402 c, t dbSNP:3062
406 406 c, t dbSNP:554752787
412 412 a, g dbSNP:115413508
419 419 a, c, t dbSNP:3063
432 432 a, g dbSNP:7173
433 433 a, g dbSNP:12818
437 437 g, t dbSNP:184964225
440 440 a, t dbSNP:15117
450 450 a, c dbSNP:753526616
452 452 c, t dbSNP:570903769
467 467 a, g, t dbSNP:113289404
474 474 c, t dbSNP:78931560
477 477 c, t dbSNP:766176686
484 484 c, t dbSNP:567004429
489 489 g, t dbSNP:760223677
499 499 c, t dbSNP:749924715
516 516 a, g, t dbSNP:762234908
522 522 c, g dbSNP:774993334
535 535 c, t dbSNP:548783054

Target ORF information:

RefSeq Version NM_018648
Organism Homo sapiens (human)
Definition Homo sapiens NOP10 ribonucleoprotein (NOP10), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_018648

ORF Insert Sequence:

1
61
121
181
ATGTTTCTCC AGTATTACCT CAACGAGCAG GGAGATCGAG TCTATACGCT GAAGAAATTT 
GACCCGATGG GACAACAGAC CTGCTCAGCC CATCCTGCTC GGTTCTCCCC AGATGACAAA
TACTCTCGAC ACCGAATCAC CATCAAGAAA CGCTTCAAGG TGCTCATGAC CCAGCAACCG
CGCCCTGTCC TCTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.