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PRF1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PRF1
Entrez Gene ID 5551
Full Name perforin 1 (pore forming protein)
Synonyms FLH2, HPLH2, P1, PFN1, PFP
General protein information
Preferred Names
perforin-1
Names
perforin-1
cytolysin
lymphocyte pore forming protein
lymphocyte pore-forming protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22

Summary The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

170280

Disorder Html: Hemophagocytic lymphohistiocytosis, familial, 2, 603553 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_005041 NP_005032 perforin-1 precursor
NM_001083116 NP_001076585 perforin-1 precursor



Homo sapiens (human) PRF1 NP_001076585.1
Pan troglodytes (chimpanzee) PRF1 XP_507837.2
Macaca mulatta (Rhesus monkey) PRF1 XP_001107909.1
Canis lupus familiaris (dog) PRF1 NP_001184111.1
Bos taurus (cattle) PRF1 NP_001137207.1
Mus musculus (house mouse) Prf1 NP_035203.3
Rattus norvegicus (Norway rat) Prf1 NP_059026.2
Gallus gallus (chicken) LOC101750363 XP_004945747.1
Danio rerio (zebrafish) prf1.7 XP_003200648.1
Danio rerio (zebrafish) LOC100000903 XP_001341008.1
Danio rerio (zebrafish) LOC569443 XP_697920.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100489175 XP_002942088.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100492973 XP_002941527.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC101732838 XP_004919588.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101732506 XP_004918449.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC100489487 XP_002942090.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100489324 XP_002942089.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100491518 XP_002942100.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100493300 XP_002941529.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100493140 XP_002941528.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PRF1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRF1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23295
NM_005041 Homo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
OHu23295
NM_001083116 Homo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23295
Clone ID Related Accession (Same CDS sequence) NM_001083116 , NM_005041
Accession Version NM_005041.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1668bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product perforin-1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA816891.1, X13224.1, BC047695.1 and BQ654088.1. On Mar 21, 2007 this sequence version replaced gi:45935369. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FJ555237.1, AK312754.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2150385, SAMEA2155751 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCAGCCC GTCTGCTCCT CCTGGGCATC CTTCTCCTGC TGCTGCCCCT GCCCGTCCCT 
GCCCCGTGCC ACACAGCCGC ACGCTCAGAG TGCAAGCGCA GCCACAAGTT CGTGCCTGGT
GCATGGCTGG CCGGGGAGGG TGTGGACGTG ACCAGCCTCC GCCGCTCGGG CTCCTTCCCA
GTGGACACAC AAAGGTTCCT GCGGCCCGAC GGCACCTGCA CCCTCTGTGA AAATGCCCTA
CAGGAGGGCA CCCTCCAGCG CCTGCCTCTG GCGCTCACCA ACTGGCGGGC CCAGGGCTCT
GGCTGCCAGC GCCATGTAAC CAGGGCCAAA GTCAGCTCCA CTGAAGCTGT GGCCCGGGAT
GCGGCTCGTA GCATCCGCAA CGACTGGAAG GTCGGGCTGG ACGTGACTCC TAAGCCCACC
AGCAATGTGC ATGTGTCTGT GGCCGGCTCA CACTCACAGG CAGCCAACTT TGCAGCCCAG
AAGACCCACC AGGACCAGTA CAGCTTCAGC ACTGACACGG TGGAGTGCCG CTTCTACAGT
TTCCATGTGG TACACACTCC CCCGCTGCAC CCTGACTTCA AGAGGGCCCT CGGGGACCTG
CCCCACCACT TCAACGCCTC CACCCAGCCC GCCTACCTCA GGCTTATCTC CAACTACGGC
ACCCACTTCA TCCGGGCTGT GGAGCTGGGT GGCCGCATAT CGGCCCTCAC TGCCCTGCGC
ACCTGCGAGC TGGCCCTGGA AGGGCTCACG GACAACGAGG TGGAGGACTG CCTGACTGTC
GAGGCCCAGG TCAACATAGG CATCCACGGC AGCATCTCTG CCGAAGCCAA GGCCTGTGAG
GAGAAGAAGA AGAAGCACAA GATGACGGCC TCCTTCCACC AAACCTACCG GGAGCGCCAC
TCGGAAGTGG TTGGCGGCCA TCACACCTCC ATTAACGACC TGCTGTTCGG GATCCAGGCC
GGGCCCGAGC AGTACTCAGC CTGGGTAAAC TCGCTGCCCG GCAGCCCTGG CCTGGTGGAC
TACACCCTGG AACCCCTGCA CGTGCTGCTG GACAGCCAGG ACCCGCGGCG GGAGGCACTG
AGGAGGGCCC TGAGTCAGTA CCTGACGGAC AGGGCTCGCT GGAGGGACTG CAGCCGGCCG
TGCCCACCAG GGCGGCAGAA GAGCCCCCGA GACCCATGCC AGTGTGTGTG CCATGGCTCA
GCGGTCACCA CCCAGGACTG CTGCCCTCGG CAGAGGGGCC TGGCCCAGCT GGAGGTGACC
TTCATCCAAG CATGGGGCCT GTGGGGGGAC TGGTTCACTG CCACGGATGC CTATGTGAAG
CTCTTCTTTG GTGGCCAGGA GCTGAGGACG AGCACCGTGT GGGACAATAA CAACCCCATC
TGGTCAGTGC GGCTGGATTT TGGGGATGTG CTCCTGGCCA CAGGGGGGCC CCTGAGGTTG
CAGGTCTGGG ATCAGGACTC TGGCAGGGAC GATGACCTCC TTGGCACCTG TGATCAGGCT
CCCAAGTCTG GTTCCCATGA GGTGAGATGC AACCTGAATC ATGGCCACCT AAAATTCCGC
TATCATGCCA GGTGCTTGCC CCACCTGGGA GGAGGCACCT GCCTGGACTA TGTCCCCCAA
ATGCTTCTGG GGGAGCCTCC AGGAAACCGG AGTGGGGCCG TGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005032.2
CDS136..1803
Misc Feature(1)82..84(+)
Misc Feature(2)634..1242(+)
Misc Feature(3)775..777(+)
Misc Feature(4)1165..1167(+)
Misc Feature(5)1297..1677(+)
Misc Feature(6)1423..1611(+)
Misc Feature(7)748..756(+)
Exon (1)1..131
Gene:PRF1
Gene Synonym:
Exon (2)132..674
Gene:PRF1
Gene Synonym:
Exon (3)675..2508
Gene:PRF1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005041
Organism Homo sapiens (human)
Definition Homo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005041

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCAGCCC GTCTGCTCCT CCTGGGCATC CTTCTCCTGC TGCTGCCCCT GCCCGTCCCT 
GCCCCGTGCC ACACAGCCGC ACGCTCAGAG TGCAAGCGCA GCCACAAGTT CGTGCCTGGT
GCATGGCTGG CCGGGGAGGG TGTGGACGTG ACCAGCCTCC GCCGCTCGGG CTCCTTCCCA
GTGGACACAC AAAGGTTCCT GCGGCCCGAC GGCACCTGCA CCCTCTGTGA AAATGCCCTA
CAGGAGGGCA CCCTCCAGCG CCTGCCTCTG GCGCTCACCA ACTGGCGGGC CCAGGGCTCT
GGCTGCCAGC GCCATGTAAC CAGGGCCAAA GTCAGCTCCA CTGAAGCTGT GGCCCGGGAT
GCGGCTCGTA GCATCCGCAA CGACTGGAAG GTCGGGCTGG ACGTGACTCC TAAGCCCACC
AGCAATGTGC ATGTGTCTGT GGCCGGCTCA CACTCACAGG CAGCCAACTT TGCAGCCCAG
AAGACCCACC AGGACCAGTA CAGCTTCAGC ACTGACACGG TGGAGTGCCG CTTCTACAGT
TTCCATGTGG TACACACTCC CCCGCTGCAC CCTGACTTCA AGAGGGCCCT CGGGGACCTG
CCCCACCACT TCAACGCCTC CACCCAGCCC GCCTACCTCA GGCTTATCTC CAACTACGGC
ACCCACTTCA TCCGGGCTGT GGAGCTGGGT GGCCGCATAT CGGCCCTCAC TGCCCTGCGC
ACCTGCGAGC TGGCCCTGGA AGGGCTCACG GACAACGAGG TGGAGGACTG CCTGACTGTC
GAGGCCCAGG TCAACATAGG CATCCACGGC AGCATCTCTG CCGAAGCCAA GGCCTGTGAG
GAGAAGAAGA AGAAGCACAA GATGACGGCC TCCTTCCACC AAACCTACCG GGAGCGCCAC
TCGGAAGTGG TTGGCGGCCA TCACACCTCC ATTAACGACC TGCTGTTCGG GATCCAGGCC
GGGCCCGAGC AGTACTCAGC CTGGGTAAAC TCGCTGCCCG GCAGCCCTGG CCTGGTGGAC
TACACCCTGG AACCCCTGCA CGTGCTGCTG GACAGCCAGG ACCCGCGGCG GGAGGCACTG
AGGAGGGCCC TGAGTCAGTA CCTGACGGAC AGGGCTCGCT GGAGGGACTG CAGCCGGCCG
TGCCCACCAG GGCGGCAGAA GAGCCCCCGA GACCCATGCC AGTGTGTGTG CCATGGCTCA
GCGGTCACCA CCCAGGACTG CTGCCCTCGG CAGAGGGGCC TGGCCCAGCT GGAGGTGACC
TTCATCCAAG CATGGGGCCT GTGGGGGGAC TGGTTCACTG CCACGGATGC CTATGTGAAG
CTCTTCTTTG GTGGCCAGGA GCTGAGGACG AGCACCGTGT GGGACAATAA CAACCCCATC
TGGTCAGTGC GGCTGGATTT TGGGGATGTG CTCCTGGCCA CAGGGGGGCC CCTGAGGTTG
CAGGTCTGGG ATCAGGACTC TGGCAGGGAC GATGACCTCC TTGGCACCTG TGATCAGGCT
CCCAAGTCTG GTTCCCATGA GGTGAGATGC AACCTGAATC ATGGCCACCT AAAATTCCGC
TATCATGCCA GGTGCTTGCC CCACCTGGGA GGAGGCACCT GCCTGGACTA TGTCCCCCAA
ATGCTTCTGG GGGAGCCTCC AGGAAACCGG AGTGGGGCCG TGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23295
Clone ID Related Accession (Same CDS sequence) NM_001083116 , NM_005041
Accession Version NM_001083116.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1668bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product perforin-1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA941244.1, X13224.1, BC047695.1 and BQ654088.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: FJ555237.1, AK312754.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2155751 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCAGCCC GTCTGCTCCT CCTGGGCATC CTTCTCCTGC TGCTGCCCCT GCCCGTCCCT 
GCCCCGTGCC ACACAGCCGC ACGCTCAGAG TGCAAGCGCA GCCACAAGTT CGTGCCTGGT
GCATGGCTGG CCGGGGAGGG TGTGGACGTG ACCAGCCTCC GCCGCTCGGG CTCCTTCCCA
GTGGACACAC AAAGGTTCCT GCGGCCCGAC GGCACCTGCA CCCTCTGTGA AAATGCCCTA
CAGGAGGGCA CCCTCCAGCG CCTGCCTCTG GCGCTCACCA ACTGGCGGGC CCAGGGCTCT
GGCTGCCAGC GCCATGTAAC CAGGGCCAAA GTCAGCTCCA CTGAAGCTGT GGCCCGGGAT
GCGGCTCGTA GCATCCGCAA CGACTGGAAG GTCGGGCTGG ACGTGACTCC TAAGCCCACC
AGCAATGTGC ATGTGTCTGT GGCCGGCTCA CACTCACAGG CAGCCAACTT TGCAGCCCAG
AAGACCCACC AGGACCAGTA CAGCTTCAGC ACTGACACGG TGGAGTGCCG CTTCTACAGT
TTCCATGTGG TACACACTCC CCCGCTGCAC CCTGACTTCA AGAGGGCCCT CGGGGACCTG
CCCCACCACT TCAACGCCTC CACCCAGCCC GCCTACCTCA GGCTTATCTC CAACTACGGC
ACCCACTTCA TCCGGGCTGT GGAGCTGGGT GGCCGCATAT CGGCCCTCAC TGCCCTGCGC
ACCTGCGAGC TGGCCCTGGA AGGGCTCACG GACAACGAGG TGGAGGACTG CCTGACTGTC
GAGGCCCAGG TCAACATAGG CATCCACGGC AGCATCTCTG CCGAAGCCAA GGCCTGTGAG
GAGAAGAAGA AGAAGCACAA GATGACGGCC TCCTTCCACC AAACCTACCG GGAGCGCCAC
TCGGAAGTGG TTGGCGGCCA TCACACCTCC ATTAACGACC TGCTGTTCGG GATCCAGGCC
GGGCCCGAGC AGTACTCAGC CTGGGTAAAC TCGCTGCCCG GCAGCCCTGG CCTGGTGGAC
TACACCCTGG AACCCCTGCA CGTGCTGCTG GACAGCCAGG ACCCGCGGCG GGAGGCACTG
AGGAGGGCCC TGAGTCAGTA CCTGACGGAC AGGGCTCGCT GGAGGGACTG CAGCCGGCCG
TGCCCACCAG GGCGGCAGAA GAGCCCCCGA GACCCATGCC AGTGTGTGTG CCATGGCTCA
GCGGTCACCA CCCAGGACTG CTGCCCTCGG CAGAGGGGCC TGGCCCAGCT GGAGGTGACC
TTCATCCAAG CATGGGGCCT GTGGGGGGAC TGGTTCACTG CCACGGATGC CTATGTGAAG
CTCTTCTTTG GTGGCCAGGA GCTGAGGACG AGCACCGTGT GGGACAATAA CAACCCCATC
TGGTCAGTGC GGCTGGATTT TGGGGATGTG CTCCTGGCCA CAGGGGGGCC CCTGAGGTTG
CAGGTCTGGG ATCAGGACTC TGGCAGGGAC GATGACCTCC TTGGCACCTG TGATCAGGCT
CCCAAGTCTG GTTCCCATGA GGTGAGATGC AACCTGAATC ATGGCCACCT AAAATTCCGC
TATCATGCCA GGTGCTTGCC CCACCTGGGA GGAGGCACCT GCCTGGACTA TGTCCCCCAA
ATGCTTCTGG GGGAGCCTCC AGGAAACCGG AGTGGGGCCG TGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001076585.1
CDS162..1829
Misc Feature(1)105..107(+)
Misc Feature(2)660..1268(+)
Misc Feature(3)801..803(+)
Misc Feature(4)1191..1193(+)
Misc Feature(5)1323..1703(+)
Misc Feature(6)1449..1637(+)
Misc Feature(7)774..782(+)
Exon (1)1..131
Gene:PRF1
Gene Synonym:
Exon (2)132..700
Gene:PRF1
Gene Synonym:
Exon (3)701..2534
Gene:PRF1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001083116
Organism Homo sapiens (human)
Definition Homo sapiens perforin 1 (pore forming protein) (PRF1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001083116

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCAGCCC GTCTGCTCCT CCTGGGCATC CTTCTCCTGC TGCTGCCCCT GCCCGTCCCT 
GCCCCGTGCC ACACAGCCGC ACGCTCAGAG TGCAAGCGCA GCCACAAGTT CGTGCCTGGT
GCATGGCTGG CCGGGGAGGG TGTGGACGTG ACCAGCCTCC GCCGCTCGGG CTCCTTCCCA
GTGGACACAC AAAGGTTCCT GCGGCCCGAC GGCACCTGCA CCCTCTGTGA AAATGCCCTA
CAGGAGGGCA CCCTCCAGCG CCTGCCTCTG GCGCTCACCA ACTGGCGGGC CCAGGGCTCT
GGCTGCCAGC GCCATGTAAC CAGGGCCAAA GTCAGCTCCA CTGAAGCTGT GGCCCGGGAT
GCGGCTCGTA GCATCCGCAA CGACTGGAAG GTCGGGCTGG ACGTGACTCC TAAGCCCACC
AGCAATGTGC ATGTGTCTGT GGCCGGCTCA CACTCACAGG CAGCCAACTT TGCAGCCCAG
AAGACCCACC AGGACCAGTA CAGCTTCAGC ACTGACACGG TGGAGTGCCG CTTCTACAGT
TTCCATGTGG TACACACTCC CCCGCTGCAC CCTGACTTCA AGAGGGCCCT CGGGGACCTG
CCCCACCACT TCAACGCCTC CACCCAGCCC GCCTACCTCA GGCTTATCTC CAACTACGGC
ACCCACTTCA TCCGGGCTGT GGAGCTGGGT GGCCGCATAT CGGCCCTCAC TGCCCTGCGC
ACCTGCGAGC TGGCCCTGGA AGGGCTCACG GACAACGAGG TGGAGGACTG CCTGACTGTC
GAGGCCCAGG TCAACATAGG CATCCACGGC AGCATCTCTG CCGAAGCCAA GGCCTGTGAG
GAGAAGAAGA AGAAGCACAA GATGACGGCC TCCTTCCACC AAACCTACCG GGAGCGCCAC
TCGGAAGTGG TTGGCGGCCA TCACACCTCC ATTAACGACC TGCTGTTCGG GATCCAGGCC
GGGCCCGAGC AGTACTCAGC CTGGGTAAAC TCGCTGCCCG GCAGCCCTGG CCTGGTGGAC
TACACCCTGG AACCCCTGCA CGTGCTGCTG GACAGCCAGG ACCCGCGGCG GGAGGCACTG
AGGAGGGCCC TGAGTCAGTA CCTGACGGAC AGGGCTCGCT GGAGGGACTG CAGCCGGCCG
TGCCCACCAG GGCGGCAGAA GAGCCCCCGA GACCCATGCC AGTGTGTGTG CCATGGCTCA
GCGGTCACCA CCCAGGACTG CTGCCCTCGG CAGAGGGGCC TGGCCCAGCT GGAGGTGACC
TTCATCCAAG CATGGGGCCT GTGGGGGGAC TGGTTCACTG CCACGGATGC CTATGTGAAG
CTCTTCTTTG GTGGCCAGGA GCTGAGGACG AGCACCGTGT GGGACAATAA CAACCCCATC
TGGTCAGTGC GGCTGGATTT TGGGGATGTG CTCCTGGCCA CAGGGGGGCC CCTGAGGTTG
CAGGTCTGGG ATCAGGACTC TGGCAGGGAC GATGACCTCC TTGGCACCTG TGATCAGGCT
CCCAAGTCTG GTTCCCATGA GGTGAGATGC AACCTGAATC ATGGCCACCT AAAATTCCGC
TATCATGCCA GGTGCTTGCC CCACCTGGGA GGAGGCACCT GCCTGGACTA TGTCCCCCAA
ATGCTTCTGG GGGAGCCTCC AGGAAACCGG AGTGGGGCCG TGTGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Circulating CD56dim NK cells expressing perforin are increased in progressive multiple sclerosis
J. Neuroimmunol. 265 (1-2), 124-127 (2013)
Plantone D, Marti A, Frisullo G, Iorio R, Damato V, Nociti V, Patanella AK, Bianco A, Mirabella M and Batocchi AP.


book

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation
Eur. J. Hum. Genet. 21 (11), 1232-1239 (2013)
Dias C, McDonald A, Sincan M, Rupps R, Markello T, Salvarinova R, Santos RF, Menghrajani K, Ahaghotu C, Sutherland DP, Fortuno ES 3rd, Kollmann TR, Demos M, Friedman JM, Speert DP, Gahl WA and Boerkoel CF.


book

Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients
Protein Sci. 22 (6), 823-839 (2013)
An O, Gursoy A, Gurgey A and Keskin O.


book

Association between granzyme B and perforin I polymorphisms and allograft outcomes in Hispanic kidney transplant recipients
Clin Transplant 27 (3), E308-E315 (2013)
Corrales-Tellez E, Vu D, Shah T, Hutchinson I and Min DI.


book

An acidic microenvironment increases NK cell killing of Cryptococcus neoformans and Cryptococcus gattii by enhancing perforin degranulation
PLoS Pathog. 9 (7), E1003439 (2013)
Islam A, Li SS, Oykhman P, Timm-McCann M, Huston SM, Stack D, Xiang RF, Kelly MM and Mody CH.


book

Hemophagocytic Lymphohistiocytosis, Familial
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Zhang,K., Filipovich,A.H., Johnson,J., Marsh,R.A. and Villanueva,J.


book

Human perforin (PRF1) maps to 10q22, a region that is syntenic with mouse chromosome 10
Genomics 13 (4), 1300-1302 (1992)
Fink TM, Zimmer M, Weitz S, Tschopp J, Jenne DE and Lichter P.


book

Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin
Mol. Immunol. 27 (7), 589-602 (1990)
Peitsch MC, Amiguet P, Guy R, Brunner J, Maizel JV Jr and Tschopp J.


book

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities
Science 233 (4760), 184-190 (1986)
Young,J.D., Cohn,Z.A. and Podack,E.R.


book

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity
Cell 44 (6), 849-859 (1986)
Young,J.D., Hengartner,H., Podack,E.R. and Cohn,Z.A.


 
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