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PRKCB protein kinase C, beta [Homo sapiens (human)]

Gene Symbol PRKCB
Entrez Gene ID 5579
Full Name protein kinase C, beta
Synonyms PKC-beta, PKCB, PRKCB1, PRKCB2
General protein information
Preferred Names
protein kinase C beta type
Names
protein kinase C beta type
PKC-B
protein kinase C, beta 1 polypeptide
NP_002729.2
NP_997700.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p11.2

Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

176970

Disorder Html:





The following PRKCB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRKCB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18081 NM_002738 Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector in pcDNA3.1+/C-(K)DYK $379
OHu17455 NM_212535 Homo sapiens protein kinase C, beta (PRKCB), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 Quote Price

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18081
Accession Version NM_002738.6
Sequence Information ORF Nucleotide Sequence (Length: 2022bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein kinase C beta type isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456157.1, BC036472.1 and AC130448.2. This sequence is a reference standard in the RefSeqGene project. On Aug 20, 2008 this sequence version replaced gi:47157320. Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07109.1, BC036472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 
GCCCGCAAAG GCGCCCTCCG GCAGAAGAAC GTGCATGAGG TCAAGAACCA CAAATTCACC
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC
GGGAAGCAGG GATTCCAGTG CCAAGTTTGC TGCTTTGTGG TGCACAAGCG GTGCCATGAA
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGTCCAG CCTCCGATGA CCCCCGCAGC
AAACACAAGT TTAAGATCCA CACGTACTCC AGCCCCACGT TTTGTGACCA CTGTGGGTCA
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAATGTGCAC
AAGCGCTGCG TGATGAATGT TCCCAGCCTG TGTGGCACGG ACCACACGGA GCGCCGCGGC
CGCATCTACA TCCAGGCCCA CATCGACAGG GACGTCCTCA TTGTCCTCGT AAGAGATGCT
AAAAACCTTG TACCTATGGA CCCCAATGGC CTGTCAGATC CCTACGTAAA ACTGAAACTG
ATTCCCGATC CCAAAAGTGA GAGCAAACAG AAGACCAAAA CCATCAAATG CTCCCTCAAC
CCTGAGTGGA ATGAGACATT TAGATTTCAG CTGAAAGAAT CGGACAAAGA CAGAAGACTG
TCAGTAGAGA TTTGGGATTG GGATTTGACC AGCAGGAATG ACTTCATGGG ATCTTTGTCC
TTTGGGATTT CTGAACTTCA GAAAGCCAGT GTTGATGGCT GGTTTAAGTT ACTGAGCCAG
GAGGAAGGCG AGTACTTCAA TGTGCCTGTG CCACCAGAAG GAAGTGAGGC CAATGAAGAA
CTGCGGCAGA AATTTGAGAG GGCCAAGATC AGTCAGGGAA CCAAGGTCCC GGAAGAAAAG
ACGACCAACA CTGTCTCCAA ATTTGACAAC AATGGCAACA GAGACCGGAT GAAACTGACC
GATTTTAACT TCCTAATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA
CGAAAAGGCA CAGATGAGCT CTATGCTGTG AAGATCCTGA AGAAGGACGT TGTGATCCAA
GATGATGACG TGGAGTGCAC TATGGTGGAG AAGCGGGTGT TGGCCCTGCC TGGGAAGCCG
CCCTTCCTGA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTTGTGATG
GAGTACGTGA ATGGGGGCGA CCTCATGTAT CACATCCAGC AAGTCGGCCG GTTCAAGGAG
CCCCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TGTTCTTCTT ACAGAGTAAG
GGCATCATTT ACCGTGACCT AAAACTTGAC AACGTGATGC TCGATTCTGA GGGACACATC
AAGATTGCCG ATTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACCAAGACA
TTCTGTGGCA CTCCAGACTA CATCGCCCCC GAGATAATTG CTTATCAGCC CTATGGGAAG
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG GCAGGCACCC
TTTGAAGGGG AGGATGAAGA TGAACTCTTC CAATCCATCA TGGAACACAA CGTAGCCTAT
CCCAAGTCTA TGTCCAAGGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAACACCCA
GGCAAACGTC TGGGTTGTGG ACCTGAAGGC GAACGTGATA TCAAAGAGCA TGCATTTTTC
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATCC AGCCCCCTTA TAAGCCAAAA
GCTTGTGGGC GAAATGCTGA AAACTTCGAC CGATTTTTCA CCCGCCATCC ACCAGTCCTA
ACACCTCCCG ACCAGGAAGT CATCAGGAAT ATTGACCAAT CAGAATTCGA AGGATTTTCC
TTTGTTAACT CTGAATTTTT AAAACCCGAA GTCAAGAGCT AA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_002729.2
CDS198..2219
Misc Feature(1)30..32(+)
Misc Feature(2)243..245(+)
Misc Feature(3)246..248(+)
Misc Feature(4)306..455(+)
Misc Feature(5)306..455(+)
Misc Feature(6)327..386(+)
Misc Feature(7)336..344(+)
Misc Feature(8)501..650(+)
Misc Feature(9)501..650(+)
Misc Feature(10)522..581(+)
Misc Feature(11)531..539(+)
Misc Feature(12)672..1064(+)
Misc Feature(13)756..959(+)
Misc Feature(14)1218..2186(+)
Misc Feature(15)1221..1997(+)
Misc Feature(16)1239..1823(+)
Misc Feature(17)1239..1649(+)
Misc Feature(18)1251..1823(+)
Misc Feature(19)1644..1715(+)
Misc Feature(20)1695..1697(+)
Misc Feature(21)2118..2120(+)
Misc Feature(22)2118..2120(+)
Misc Feature(23)2163..2180(+)
Exon (1)1..370
Gene:PRKCB
Gene Synonym:
Exon (2)371..402
Gene:PRKCB
Gene Synonym:
Exon (3)403..485
Gene:PRKCB
Gene Synonym:
Exon (4)486..597
Gene:PRKCB
Gene Synonym:
Exon (5)598..726
Gene:PRKCB
Gene Synonym:
Exon (6)727..883
Gene:PRKCB
Gene Synonym:
Exon (7)884..1018
Gene:PRKCB
Gene Synonym:
Exon (8)1019..1115
Gene:PRKCB
Gene Synonym:
Exon (9)1116..1262
Gene:PRKCB
Gene Synonym:
Exon (10)1263..1436
Gene:PRKCB
Gene Synonym:
Exon (11)1437..1528
Gene:PRKCB
Gene Synonym:
Exon (12)1529..1591
Gene:PRKCB
Gene Synonym:
Exon (13)1592..1730
Gene:PRKCB
Gene Synonym:
Exon (14)1731..1811
Gene:PRKCB
Gene Synonym:
Exon (15)1812..1919
Gene:PRKCB
Gene Synonym:
Exon (16)1920..2060
Gene:PRKCB
Gene Synonym:
Exon (17)2061..8014
Gene:PRKCB
Gene Synonym:
Translation
Position Chain Variation Link
28 28 a, g dbSNP:371723231
164 164 c, g dbSNP:763455165
165 165 a, g dbSNP:766094053
166 166 c, t dbSNP:751296237
173 173 c, t dbSNP:188342168
174 174 c, g dbSNP:767070226
178 178 a, t dbSNP:535808203
185 185 c, t dbSNP:756077698
188 188 c, g dbSNP:777496943
189 189 a, g dbSNP:374642745
208 208 c, g dbSNP:757085223
211 211 a, c, t dbSNP:201366670
215 215 a, g dbSNP:768549392
220 220 a, c dbSNP:781362818
222 222 c, t dbSNP:575795787
223 223 a, c dbSNP:368093414
232 232 a, t dbSNP:370984906
235 235 a, g dbSNP:749669754
237 237 a, g dbSNP:771388864
247 247 c, t dbSNP:773819749
253 253 a, g dbSNP:759234204
255 255 c, t dbSNP:766899029
262 262 a, g dbSNP:200442462
263 263 c, t dbSNP:775089575
267 267 c, g dbSNP:760228327
269 269 c, t dbSNP:763989321
275 275 c, g dbSNP:753829465
276 276 a, c dbSNP:75964872
284 284 a, g dbSNP:146177740
296 296 a, g dbSNP:751689932
311 311 a, g dbSNP:755247718
326 326 c, t dbSNP:781315165
359 359 c, g, t dbSNP:115667450
383 383 a, g dbSNP:769737298
406 406 g, t dbSNP:370311602
416 416 a, g dbSNP:759454355
428 428 a, g dbSNP:764380918
452 452 a, c dbSNP:754076764
461 461 c, t dbSNP:115750906
462 462 a, g dbSNP:371650623
466 466 a, t dbSNP:750901145
476 476 a, t dbSNP:758927501
482 482 c, g, t dbSNP:371087215
483 483 a, g dbSNP:751886977
484 484 a, g dbSNP:755399339
487 487 a, g dbSNP:777534524
493 493 a, g dbSNP:748776658
496 496 g, t dbSNP:3729895
500 500 a, g dbSNP:756894368
520 520 c, t dbSNP:778983154
521 521 a, g dbSNP:116749372
524 524 c, t dbSNP:771951442
536 536 a, g dbSNP:377143661
554 554 a, g dbSNP:564776408
565 565 a, g dbSNP:769874764
582 582 g, t dbSNP:773546270
603 603 a, g dbSNP:759666193
610 610 a, c dbSNP:772430325
622 622 a, g dbSNP:550043137
626 626 c, t dbSNP:760934314
627 627 a, g dbSNP:764534677
638 638 a, t dbSNP:753475682
647 647 a, g dbSNP:761578978
655 655 c, t dbSNP:765028943
656 656 c, g dbSNP:372836893
665 665 a, g dbSNP:757992423
669 669 c, t dbSNP:779838345
670 670 a, g dbSNP:751524971
672 672 c, t dbSNP:754659392
674 674 c, t dbSNP:573327064
683 683 c, t dbSNP:749465077
690 690 c, g dbSNP:199648786
692 692 a, g dbSNP:556028547
695 695 c, t dbSNP:576008026
710 710 c, t dbSNP:115645964
711 711 a, g dbSNP:200811816
717 717 a, g dbSNP:775803818
719 719 c, t dbSNP:116345778
725 725 c, t dbSNP:540341676
732 732 g, t dbSNP:779094238
746 746 c, t dbSNP:746115990
747 747 c, g dbSNP:573366163
768 768 c, t dbSNP:758345369
782 782 c, t dbSNP:543897172
783 783 a, g dbSNP:747105951
785 785 a, g dbSNP:769253047
791 791 a, g dbSNP:777343122
798 798 a, t dbSNP:748510627
799 799 c, t dbSNP:770291872
803 803 c, t dbSNP:3729896
833 833 a, c, t dbSNP:762695587
837 837 a, g dbSNP:773891890
885 885 c, g dbSNP:200005518
898 898 c, t dbSNP:770589472
899 899 a, c, g dbSNP:114093019
902 902 c, t dbSNP:771584055
911 911 a, g dbSNP:17847891
935 935 c, t dbSNP:760639179
947 947 c, t dbSNP:763829980
953 953 a, g dbSNP:753635581
993 993 c, g dbSNP:777404333
995 995 c, t dbSNP:766610202
1002 1002 a, g dbSNP:756684442
1009 1009 c, t dbSNP:751743022
1013 1013 c, t dbSNP:755036948
1016 1016 a, c dbSNP:781448514
1024 1024 a, g dbSNP:745475837
1046 1046 c, t dbSNP:17847884
1061 1061 c, g dbSNP:779746680
1067 1067 a, g dbSNP:746506850
1070 1070 a, g dbSNP:568306326
1078 1078 a, g dbSNP:199901715
1085 1085 a, g dbSNP:748062707
1090 1090 a, g dbSNP:147975795
1101 1101 a, c dbSNP:536939564
1102 1102 a, g dbSNP:762879227
1103 1103 a, g dbSNP:115598469
1117 1117 c, g dbSNP:141851225
1120 1120 a, c dbSNP:760838283
1125 1125 a, g dbSNP:764189258
1127 1127 c, t dbSNP:201781724
1142 1142 a, g dbSNP:146104501
1143 1143 a, g dbSNP:749777388
1147 1147 c, t dbSNP:202044032
1148 1148 a, g dbSNP:750938251
1159 1159 c, t dbSNP:139055681
1160 1160 a, g dbSNP:766756709
1161 1161 a, g dbSNP:751175487
1162 1162 c, t dbSNP:754563290
1169 1169 c, t dbSNP:780936454
1172 1172 c, g dbSNP:374744056
1174 1174 c, t dbSNP:755710261
1175 1175 c, t dbSNP:777796805
1177 1177 a, g dbSNP:749243156
1178 1178 a, g dbSNP:114856527
1187 1187 c, g dbSNP:778877195
1192 1192 c, g dbSNP:149128755
1203 1203 c, t dbSNP:768732945
1205 1205 a, g dbSNP:539838175
1215 1215 a, c dbSNP:776981512
1217 1217 c, t dbSNP:116346810
1226 1226 c, t dbSNP:56041613
1233 1233 a, g dbSNP:773665394
1235 1235 a, g dbSNP:763468825
1236 1236 g, t dbSNP:766920124
1259 1259 a, c, g dbSNP:556610239
1278 1278 a, c dbSNP:750377270
1282 1282 a, g dbSNP:758085883
1286 1286 a, c dbSNP:779917484
1288 1288 c, g dbSNP:148312044
1295 1295 a, g dbSNP:756297068
1301 1301 c, t dbSNP:202161442
1302 1302 a, g dbSNP:141758720
1325 1325 c, t dbSNP:749354695
1346 1346 c, t dbSNP:543064850
1347 1347 a, g dbSNP:200238437
1352 1352 a, g dbSNP:774656581
1359 1359 a, c dbSNP:746420133
1365 1365 a, g dbSNP:267604474
1369 1369 a, g dbSNP:772277246
1372 1372 a, g dbSNP:775901586
1374 1374 g, t dbSNP:761166216
1380 1380 a, g dbSNP:763837460
1382 1382 a, c dbSNP:776487939
1388 1388 c, t dbSNP:432998
1396 1396 c, t dbSNP:764831474
1397 1397 a, g, t dbSNP:141827066
1418 1418 a, c dbSNP:766266252
1434 1434 a, t dbSNP:369508594
1435 1435 g, t dbSNP:201855972
1460 1460 c, g dbSNP:754699676
1463 1463 c, t dbSNP:55942437
1470 1470 -, g dbSNP:767358252
1472 1472 g, t dbSNP:754012268
1493 1493 c, t dbSNP:536103282
1502 1502 c, t dbSNP:369762663
1507 1507 a, g dbSNP:750515509
1521 1521 c, t dbSNP:758468877
1523 1523 c, t dbSNP:780652979
1529 1529 a, t dbSNP:751735254
1535 1535 c, t dbSNP:755505988
1536 1536 a, g dbSNP:781780434
1545 1545 a, g dbSNP:748531840
1550 1550 c, t dbSNP:770067840
1553 1553 c, t dbSNP:777415569
1554 1554 a, g dbSNP:748923188
1556 1556 c, t dbSNP:770380229
1568 1568 a, g dbSNP:376961976
1579 1579 a, g dbSNP:370646498
1589 1589 c, t dbSNP:200457901
1610 1610 c, t dbSNP:745373140
1619 1619 c, t dbSNP:771588066
1628 1628 c, g dbSNP:775433458
1646 1646 c, t dbSNP:746954626
1660 1660 g, t dbSNP:768685403
1667 1667 a, g dbSNP:776256139
1670 1670 c, t dbSNP:752583432
1681 1681 c, g dbSNP:761763038
1696 1696 a, c dbSNP:111341519
1704 1704 a, g dbSNP:766692518
1712 1712 a, c dbSNP:774726787
1721 1721 c, t dbSNP:17847876
1727 1727 c, t dbSNP:367690547
1738 1738 c, t dbSNP:751018138
1745 1745 a, g dbSNP:376039132
1781 1781 a, g dbSNP:780923538
1784 1784 c, t dbSNP:748126363
1807 1807 g, t dbSNP:769663948
1832 1832 c, t dbSNP:777925353
1854 1854 a, g dbSNP:749084012
1856 1856 c, t dbSNP:770775429
1862 1862 a, g dbSNP:571472508
1867 1867 a, c dbSNP:780076694
1868 1868 c, t dbSNP:747289504
1869 1869 a, g dbSNP:368238909
1884 1884 c, t dbSNP:17847879
1899 1899 a, g dbSNP:761943712
1902 1902 a, g dbSNP:770267855
1907 1907 c, t dbSNP:773720305
1919 1919 c, g dbSNP:763157141
1920 1920 a, c dbSNP:201555288
1933 1933 a, t dbSNP:769865916
1945 1945 a, g dbSNP:773667135
1960 1960 a, c, g dbSNP:35631544
1967 1967 c, t dbSNP:3729904
1968 1968 a, g dbSNP:774746011
1971 1971 c, t dbSNP:767640161
1972 1972 a, g dbSNP:767265943
1975 1975 a, g dbSNP:775297421
1976 1976 c, t dbSNP:574612696
1989 1989 a, g dbSNP:114846751
1998 1998 c, t dbSNP:753672328
1999 1999 a, g dbSNP:757200847
2006 2006 c, t dbSNP:765130298
2009 2009 c, t dbSNP:750215960
2019 2019 a, c dbSNP:758199138
2025 2025 c, t dbSNP:781322629
2026 2026 a, g dbSNP:563116744
2036 2036 c, t dbSNP:756137300
2047 2047 a, t dbSNP:371799088
2058 2058 a, g dbSNP:777885939
2062 2062 a, g dbSNP:776865411
2068 2068 a, g dbSNP:374654582
2084 2084 c, t dbSNP:369345275
2088 2088 a, c dbSNP:750530322
2096 2096 c, t dbSNP:758612506
2099 2099 c, t dbSNP:531903837
2100 2100 c, t dbSNP:752139446
2107 2107 c, t dbSNP:755317392
2108 2108 a, t dbSNP:149446950
2124 2124 c, g dbSNP:748583092
2126 2126 c, t dbSNP:755715113
2144 2144 a, g dbSNP:777459805
2146 2146 a, g dbSNP:561468141
2148 2148 a, g dbSNP:748738611
2153 2153 a, c dbSNP:770433090
2165 2165 c, t dbSNP:143953612
2166 2166 a, g dbSNP:745816864
2204 2204 c, t dbSNP:772098050
2205 2205 a, g dbSNP:775118763
2224 2224 -, a dbSNP:760572231
2226 2226 -, gtgta dbSNP:763821320
2228 2228 a, g dbSNP:199871261
2235 2235 a, t dbSNP:765546616
2237 2237 c, t dbSNP:773586102
2238 2238 a, g dbSNP:369724465
2246 2246 c, t dbSNP:766584611
2250 2250 c, t dbSNP:751735189
2265 2265 a, g dbSNP:755406243
2266 2266 c, t dbSNP:373045947
2267 2267 g, t dbSNP:752990001
2285 2285 c, t dbSNP:749807722
2296 2296 c, t dbSNP:554207643
2297 2297 a, g dbSNP:567706096
2347 2347 a, t dbSNP:3380
2366 2366 c, g dbSNP:146020925
2382 2382 a, g dbSNP:751061416
2383 2383 a, c dbSNP:757766956
2397 2397 a, g dbSNP:41280844
2401 2401 c, t dbSNP:544361894
2433 2433 a, g dbSNP:4787872
2474 2474 c, t dbSNP:149339486
2475 2475 a, g, t dbSNP:540175940
2476 2476 c, t dbSNP:189252078
2510 2510 a, g dbSNP:780448620
2563 2563 c, t dbSNP:565600588
2586 2586 g, t dbSNP:528811260
2587 2587 a, g, t dbSNP:776451620
2603 2603 c, t dbSNP:144672987
2605 2605 c, t dbSNP:148546127
2610 2610 a, g dbSNP:114644570
2636 2636 c, g dbSNP:765135135
2688 2688 a, g dbSNP:78674142
2697 2697 a, c dbSNP:370678030
2757 2757 g, t dbSNP:768890246
2770 2770 c, g dbSNP:778908629
2786 2786 a, g dbSNP:748243670
2795 2795 a, g dbSNP:142859099
2798 2798 a, g dbSNP:571918517
2799 2799 a, g dbSNP:770838606
2806 2806 a, t dbSNP:776482253
2822 2822 a, g dbSNP:3785380
2888 2888 c, t dbSNP:548071065
2923 2923 g, t dbSNP:567965059
2929 2929 c, t dbSNP:536622842
2946 2946 a, g dbSNP:549923790
2955 2955 a, c dbSNP:570120401
2976 2976 c, t dbSNP:538802980
3000 3000 c, t dbSNP:182199378
3016 3016 a, g, t dbSNP:3785379
3027 3027 a, g dbSNP:147723634
3043 3043 -, aaaaaaaaga dbSNP:3837785
3052 3052 a, g dbSNP:79376982
3059 3059 a, g dbSNP:769525237
3062 3062 -, aaaaaaaaag dbSNP:72271620
3107 3107 a, g dbSNP:3785378
3113 3113 a, g dbSNP:374468788
3132 3132 c, t dbSNP:570027537
3139 3139 c, t dbSNP:56687328
3165 3165 c, g dbSNP:562369315
3167 3167 a, g dbSNP:185582992
3230 3230 g, t dbSNP:116093872
3237 3237 c, g dbSNP:371790470
3264 3264 a, c dbSNP:544820250
3265 3265 a, g dbSNP:564984055
3307 3307 g, t dbSNP:527842503
3339 3339 a, g dbSNP:548034449
3379 3379 c, t dbSNP:140893375
3385 3385 a, c dbSNP:71379853
3389 3389 a, t dbSNP:371807314
3390 3390 -, a dbSNP:59543980
3390 3390 a, t dbSNP:768153480
3391 3391 a, t dbSNP:79997806
3400 3400 a, g dbSNP:549111342
3401 3401 a, g dbSNP:116357421
3403 3403 a, g dbSNP:76359194
3444 3444 g, t dbSNP:78750834
3515 3515 a, g dbSNP:8059889
3518 3518 a, g dbSNP:113196567
3558 3558 a, g dbSNP:190191882
3621 3621 a, g dbSNP:374319540
3656 3656 a, g dbSNP:552204624
3670 3670 a, g dbSNP:755212283
3672 3672 a, g dbSNP:781200953
3735 3735 c, t dbSNP:147946613
3750 3750 c, t dbSNP:567326312
3757 3757 a, g dbSNP:181718271
3780 3780 -, c dbSNP:35860232
3784 3784 a, g dbSNP:185391750
3810 3810 a, g dbSNP:41303765
3837 3837 a, c dbSNP:536202910
3843 3843 c, g dbSNP:368007255
3844 3844 a, g dbSNP:75859222
3850 3850 c, t dbSNP:112729951
3857 3857 a, t dbSNP:545026936
3858 3858 c, g dbSNP:140599804
3932 3932 a, t dbSNP:572188065
3933 3933 a, g dbSNP:541622767
3941 3941 a, g dbSNP:561351683
3971 3971 c, t dbSNP:113823327
3983 3983 c, t dbSNP:190250028
4007 4007 c, t dbSNP:545670795
4021 4021 c, t dbSNP:114738789
4046 4046 a, c dbSNP:181254533
4047 4047 c, t dbSNP:532374362
4055 4055 -, c dbSNP:138855260
4056 4056 c, t dbSNP:185977261
4081 4081 c, t dbSNP:565817695
4089 4089 c, t dbSNP:528588769
4150 4150 a, t dbSNP:371761150
4178 4178 a, t dbSNP:114136375
4180 4180 c, t dbSNP:575981430
4213 4213 a, g dbSNP:536459323
4274 4274 g, t dbSNP:556139661
4290 4290 c, g dbSNP:114638203
4319 4319 a, g dbSNP:150101137
4327 4327 c, t dbSNP:558621953
4399 4399 a, c dbSNP:73550432
4405 4405 a, g dbSNP:145450586
4442 4442 a, c, t dbSNP:554658577
4446 4446 c, t dbSNP:554303989
4469 4469 c, t dbSNP:762806678
4475 4475 a, g dbSNP:41309270
4478 4478 a, g dbSNP:774000910
4487 4487 -, agagaaagaaag dbSNP:577607333
4495 4495 g, t dbSNP:761251780
4497 4497 a, t dbSNP:41311262
4504 4504 a, g dbSNP:3209801
4508 4508 a, g dbSNP:1131276
4511 4511 a, g dbSNP:1131277
4512 4512 a, t dbSNP:190798839
4525 4525 -, gaaa dbSNP:539877257
4534 4534 a, g dbSNP:532699839
4543 4543 a, g dbSNP:545768247
4561 4561 -, a dbSNP:145016072
4569 4569 -, gaag dbSNP:777160320
4585 4585 c, g dbSNP:2021847
4587 4587 a, g dbSNP:761311608
4661 4661 a, g dbSNP:148858748
4684 4684 g, t dbSNP:548239016
4691 4691 a, t dbSNP:371842506
4705 4705 a, g dbSNP:145309658
4706 4706 c, t dbSNP:779328021
4752 4752 a, g, t dbSNP:41313541
4809 4809 a, g dbSNP:369926841
4810 4810 a, g dbSNP:765387696
4828 4828 a, c dbSNP:569836009
4858 4858 -, c dbSNP:34197974
4882 4882 c, t dbSNP:551260838
4927 4927 g, t dbSNP:752911153
4952 4952 c, t dbSNP:538963779
4969 4969 a, g dbSNP:777868595
4984 4984 a, c dbSNP:747080767
4993 4993 g, t dbSNP:558583777
5028 5028 a, g dbSNP:756113104
5040 5040 a, g dbSNP:565638706
5055 5055 a, c dbSNP:34097947
5065 5065 c, g dbSNP:534604535
5069 5069 c, t dbSNP:559624580
5070 5070 a, g dbSNP:574489646
5073 5073 g, t dbSNP:779978881
5140 5140 c, t dbSNP:749054030
5154 5154 c, t dbSNP:543636928
5185 5185 c, t dbSNP:138047682
5206 5206 a, g dbSNP:569980136
5268 5268 c, t dbSNP:140957380
5275 5275 g, t dbSNP:41311260
5283 5283 a, c dbSNP:41311258
5322 5322 c, t dbSNP:528424781
5376 5376 a, c, t dbSNP:747845818
5377 5377 a, g dbSNP:183896121
5382 5382 a, c dbSNP:569989375
5424 5424 c, t dbSNP:144891284
5429 5429 c, t dbSNP:772913310
5473 5473 a, g dbSNP:776688940
5493 5493 a, t dbSNP:188939352
5539 5539 g, t dbSNP:766800125
5604 5604 a, c dbSNP:777137115
5715 5715 c, g dbSNP:77825011
5716 5716 a, g dbSNP:530928600
5734 5734 a, g dbSNP:138780084
5740 5740 a, g dbSNP:28552982
5769 5769 g, t dbSNP:566000584
5781 5781 c, t dbSNP:41303763
5797 5797 a, g dbSNP:150831990
5812 5812 a, g dbSNP:752970001
5884 5884 c, t dbSNP:568040108
5891 5891 a, g dbSNP:2239338
5924 5924 a, c dbSNP:73550434
5946 5946 -, g dbSNP:34630014
5967 5967 c, g dbSNP:2239339
5989 5989 a, g dbSNP:539651319
6022 6022 g, t dbSNP:138123553
6030 6030 c, g dbSNP:573218817
6039 6039 g, t dbSNP:757273576
6044 6044 a, c dbSNP:537870579
6052 6052 -, ga dbSNP:34045233
6059 6059 a, t dbSNP:541844279
6082 6082 c, g, t dbSNP:147259878
6085 6085 c, g dbSNP:140931038
6093 6093 c, g dbSNP:544733927
6099 6099 c, t dbSNP:191748340
6120 6120 c, t dbSNP:749210728
6121 6121 a, g dbSNP:754840890
6139 6139 c, g dbSNP:35434839
6145 6145 c, g dbSNP:778819280
6147 6147 a, g dbSNP:747944600
6190 6190 a, g dbSNP:369641483
6226 6226 c, t dbSNP:41311256
6257 6257 c, g dbSNP:374358833
6264 6264 c, t dbSNP:376874115
6276 6276 a, g dbSNP:528413110
6280 6280 c, g dbSNP:772933373
6285 6285 a, t dbSNP:411103
6296 6296 a, g dbSNP:568086068
6319 6319 a, g dbSNP:11865035
6322 6322 a, g dbSNP:550605744
6328 6328 a, g dbSNP:570237636
6332 6332 c, t dbSNP:8056058
6347 6347 c, g dbSNP:3087957
6373 6373 c, t dbSNP:777031701
6400 6400 a, g dbSNP:148593800
6405 6405 c, g dbSNP:543418871
6412 6412 a, t dbSNP:760126877
6417 6417 c, t dbSNP:536192410
6455 6455 -, a dbSNP:781761202
6496 6496 c, g dbSNP:113354788
6517 6517 a, g dbSNP:183148409
6542 6542 g, t dbSNP:575554627
6567 6567 g, t dbSNP:544301722
6591 6591 -, a dbSNP:139806286
6648 6648 -, ttttg, ttttgttttgttttg, ttttgttttgttttgttttg dbSNP:10639027
6648 6648 c, g dbSNP:199618218
6649 6649 -, ttttgttttg dbSNP:560058397
6658 6658 -, ttttgttttg dbSNP:532257453
6677 6677 -, gttttgttttgtttt dbSNP:10657133
6680 6680 c, g dbSNP:564537414
6691 6691 c, g dbSNP:578168356
6733 6733 -, tagat dbSNP:138369749
6734 6734 -, gatta dbSNP:201843272
6734 6734 a, t dbSNP:111528401
6737 6737 -, tagat dbSNP:3216342
6737 6737 c, t dbSNP:77746351
6762 6762 a, g dbSNP:2239340
6769 6769 c, t dbSNP:559631819
6773 6773 g, t dbSNP:187559261
6818 6818 a, g dbSNP:765636612
6834 6834 c, g dbSNP:576504109
6861 6861 a, g dbSNP:555032800
6884 6884 a, g dbSNP:542064232
6896 6896 a, g dbSNP:191675978
6915 6915 a, g dbSNP:184182024
6969 6969 c, t dbSNP:549479707
6970 6970 a, g dbSNP:78946887
6985 6985 c, t dbSNP:397299
7058 7058 -, aacaca dbSNP:770917537
7058 7058 -, aaca dbSNP:779726774
7058 7058 -, a dbSNP:200055220
7059 7059 -, acacacacacacacaca dbSNP:368430381
7059 7059 -, aca dbSNP:571047917
7059 7059 -, a dbSNP:371994904
7059 7059 a, c, g dbSNP:28605861
7063 7063 -, a dbSNP:34377767
7077 7077 -, gcac dbSNP:377077346
7114 7114 -, gg dbSNP:201572518
7173 7173 c, t dbSNP:546788400
7192 7192 a, g dbSNP:567094475
7261 7261 g, t dbSNP:761912918
7287 7287 a, c dbSNP:755328611
7293 7293 a, g dbSNP:535681290
7315 7315 a, g dbSNP:756514512
7317 7317 a, g dbSNP:377532181
7330 7330 c, t dbSNP:3729908
7331 7331 a, g dbSNP:569466338
7334 7334 a, c, g dbSNP:41278144
7339 7339 a, g dbSNP:771901529
7344 7344 a, g dbSNP:200017388
7360 7360 c, g, t dbSNP:202022036
7385 7385 a, c dbSNP:773514796
7386 7386 a, g dbSNP:763241619
7387 7387 c, t dbSNP:771315885
7390 7390 c, t dbSNP:778710250
7406 7406 a, g dbSNP:759718537
7420 7420 a, g dbSNP:767852403
7426 7426 c, t dbSNP:148637931
7428 7428 a, c dbSNP:760907855
7436 7436 a, c dbSNP:764466114
7439 7439 c, t dbSNP:554313951
7447 7447 c, g dbSNP:756874692
7453 7453 c, t dbSNP:778605803
7462 7462 a, c, g dbSNP:749890233
7487 7487 a, g dbSNP:779793250
7493 7493 c, g dbSNP:747003127
7494 7494 c, t dbSNP:142427207
7505 7505 a, g dbSNP:781115157
7518 7518 c, t dbSNP:748016236
7530 7530 c, g dbSNP:771275086
7531 7531 c, t dbSNP:424741
7532 7532 a, g dbSNP:367894275
7534 7534 c, g, t dbSNP:140062455
7535 7535 a, g dbSNP:374831115
7536 7536 c, t dbSNP:530749955
7540 7540 a, c, g dbSNP:764633636
7562 7562 c, g dbSNP:543785816
7567 7567 c, t dbSNP:764726776
7568 7568 a, g dbSNP:777590273
7607 7607 a, g dbSNP:187700395
7630 7630 a, g dbSNP:113336763
7634 7634 c, t dbSNP:563551037
7651 7651 c, t dbSNP:532856714
7669 7669 c, t dbSNP:192474372
7700 7700 c, g dbSNP:185685652
7712 7712 c, t dbSNP:368074978
7713 7713 a, g dbSNP:190510502
7717 7717 c, t dbSNP:530936284
7718 7718 a, g dbSNP:746616204
7731 7731 c, g dbSNP:569510913
7789 7789 c, t dbSNP:181492069
7818 7818 c, t dbSNP:563616555
7819 7819 g, t dbSNP:558172407
7851 7851 a, g dbSNP:770455975
7903 7903 a, g dbSNP:552569497
7904 7904 c, t dbSNP:144042856
7921 7921 g, t dbSNP:564592733
7933 7933 -, t dbSNP:34526646
7942 7942 c, t dbSNP:1063471
7955 7955 c, t dbSNP:146441057
7986 7986 a, t dbSNP:775921208
7988 7988 a, g dbSNP:574068314

Target ORF information:

RefSeq Version NM_002738
Organism Homo sapiens (human)
Definition Homo sapiens protein kinase C, beta (PRKCB), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002738

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 
GCCCGCAAAG GCGCCCTCCG GCAGAAGAAC GTGCATGAGG TCAAGAACCA CAAATTCACC
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC
GGGAAGCAGG GATTCCAGTG CCAAGTTTGC TGCTTTGTGG TGCACAAGCG GTGCCATGAA
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGTCCAG CCTCCGATGA CCCCCGCAGC
AAACACAAGT TTAAGATCCA CACGTACTCC AGCCCCACGT TTTGTGACCA CTGTGGGTCA
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAATGTGCAC
AAGCGCTGCG TGATGAATGT TCCCAGCCTG TGTGGCACGG ACCACACGGA GCGCCGCGGC
CGCATCTACA TCCAGGCCCA CATCGACAGG GACGTCCTCA TTGTCCTCGT AAGAGATGCT
AAAAACCTTG TACCTATGGA CCCCAATGGC CTGTCAGATC CCTACGTAAA ACTGAAACTG
ATTCCCGATC CCAAAAGTGA GAGCAAACAG AAGACCAAAA CCATCAAATG CTCCCTCAAC
CCTGAGTGGA ATGAGACATT TAGATTTCAG CTGAAAGAAT CGGACAAAGA CAGAAGACTG
TCAGTAGAGA TTTGGGATTG GGATTTGACC AGCAGGAATG ACTTCATGGG ATCTTTGTCC
TTTGGGATTT CTGAACTTCA GAAAGCCAGT GTTGATGGCT GGTTTAAGTT ACTGAGCCAG
GAGGAAGGCG AGTACTTCAA TGTGCCTGTG CCACCAGAAG GAAGTGAGGC CAATGAAGAA
CTGCGGCAGA AATTTGAGAG GGCCAAGATC AGTCAGGGAA CCAAGGTCCC GGAAGAAAAG
ACGACCAACA CTGTCTCCAA ATTTGACAAC AATGGCAACA GAGACCGGAT GAAACTGACC
GATTTTAACT TCCTAATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA
CGAAAAGGCA CAGATGAGCT CTATGCTGTG AAGATCCTGA AGAAGGACGT TGTGATCCAA
GATGATGACG TGGAGTGCAC TATGGTGGAG AAGCGGGTGT TGGCCCTGCC TGGGAAGCCG
CCCTTCCTGA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTTGTGATG
GAGTACGTGA ATGGGGGCGA CCTCATGTAT CACATCCAGC AAGTCGGCCG GTTCAAGGAG
CCCCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TGTTCTTCTT ACAGAGTAAG
GGCATCATTT ACCGTGACCT AAAACTTGAC AACGTGATGC TCGATTCTGA GGGACACATC
AAGATTGCCG ATTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACCAAGACA
TTCTGTGGCA CTCCAGACTA CATCGCCCCC GAGATAATTG CTTATCAGCC CTATGGGAAG
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG GCAGGCACCC
TTTGAAGGGG AGGATGAAGA TGAACTCTTC CAATCCATCA TGGAACACAA CGTAGCCTAT
CCCAAGTCTA TGTCCAAGGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAACACCCA
GGCAAACGTC TGGGTTGTGG ACCTGAAGGC GAACGTGATA TCAAAGAGCA TGCATTTTTC
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATCC AGCCCCCTTA TAAGCCAAAA
GCTTGTGGGC GAAATGCTGA AAACTTCGAC CGATTTTTCA CCCGCCATCC ACCAGTCCTA
ACACCTCCCG ACCAGGAAGT CATCAGGAAT ATTGACCAAT CAGAATTCGA AGGATTTTCC
TTTGTTAACT CTGAATTTTT AAAACCCGAA GTCAAGAGCT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17455
Accession Version NM_212535.2
Sequence Information ORF Nucleotide Sequence (Length: 2016bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein kinase C beta type isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB456157.1, X06318.1, BC036472.1 and AC130448.2. On Aug 20, 2008 this sequence version replaced gi:47157321. Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) uses an alternate splice junction at the 5' end of the last exon compared to variant 2. The resulting isoform (1) has a distinct and shorter C-terminus compared to isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X06318.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 
GCCCGCAAAG GCGCCCTCCG GCAGAAGAAC GTGCATGAGG TCAAGAACCA CAAATTCACC
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC
GGGAAGCAGG GATTCCAGTG CCAAGTTTGC TGCTTTGTGG TGCACAAGCG GTGCCATGAA
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGTCCAG CCTCCGATGA CCCCCGCAGC
AAACACAAGT TTAAGATCCA CACGTACTCC AGCCCCACGT TTTGTGACCA CTGTGGGTCA
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAATGTGCAC
AAGCGCTGCG TGATGAATGT TCCCAGCCTG TGTGGCACGG ACCACACGGA GCGCCGCGGC
CGCATCTACA TCCAGGCCCA CATCGACAGG GACGTCCTCA TTGTCCTCGT AAGAGATGCT
AAAAACCTTG TACCTATGGA CCCCAATGGC CTGTCAGATC CCTACGTAAA ACTGAAACTG
ATTCCCGATC CCAAAAGTGA GAGCAAACAG AAGACCAAAA CCATCAAATG CTCCCTCAAC
CCTGAGTGGA ATGAGACATT TAGATTTCAG CTGAAAGAAT CGGACAAAGA CAGAAGACTG
TCAGTAGAGA TTTGGGATTG GGATTTGACC AGCAGGAATG ACTTCATGGG ATCTTTGTCC
TTTGGGATTT CTGAACTTCA GAAAGCCAGT GTTGATGGCT GGTTTAAGTT ACTGAGCCAG
GAGGAAGGCG AGTACTTCAA TGTGCCTGTG CCACCAGAAG GAAGTGAGGC CAATGAAGAA
CTGCGGCAGA AATTTGAGAG GGCCAAGATC AGTCAGGGAA CCAAGGTCCC GGAAGAAAAG
ACGACCAACA CTGTCTCCAA ATTTGACAAC AATGGCAACA GAGACCGGAT GAAACTGACC
GATTTTAACT TCCTAATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA
CGAAAAGGCA CAGATGAGCT CTATGCTGTG AAGATCCTGA AGAAGGACGT TGTGATCCAA
GATGATGACG TGGAGTGCAC TATGGTGGAG AAGCGGGTGT TGGCCCTGCC TGGGAAGCCG
CCCTTCCTGA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTTGTGATG
GAGTACGTGA ATGGGGGCGA CCTCATGTAT CACATCCAGC AAGTCGGCCG GTTCAAGGAG
CCCCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TGTTCTTCTT ACAGAGTAAG
GGCATCATTT ACCGTGACCT AAAACTTGAC AACGTGATGC TCGATTCTGA GGGACACATC
AAGATTGCCG ATTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACCAAGACA
TTCTGTGGCA CTCCAGACTA CATCGCCCCC GAGATAATTG CTTATCAGCC CTATGGGAAG
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG GCAGGCACCC
TTTGAAGGGG AGGATGAAGA TGAACTCTTC CAATCCATCA TGGAACACAA CGTAGCCTAT
CCCAAGTCTA TGTCCAAGGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAACACCCA
GGCAAACGTC TGGGTTGTGG ACCTGAAGGC GAACGTGATA TCAAAGAGCA TGCATTTTTC
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATCC AGCCCCCTTA TAAGCCAAAA
GCTAGAGACA AGAGAGACAC CTCCAACTTC GACAAAGAGT TCACCAGACA GCCTGTGGAA
CTGACCCCCA CTGATAAACT CTTCATCATG AACTTGGACC AAAATGAATT TGCTGGCTTC
TCTTATACTA ACCCAGAGTT TGTCATTAAT GTGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_997700.1
CDS198..2213
Misc Feature(1)30..32(+)
Misc Feature(2)201..203(+)
Misc Feature(3)243..245(+)
Misc Feature(4)246..248(+)
Misc Feature(5)306..455(+)
Misc Feature(6)306..455(+)
Misc Feature(7)327..386(+)
Misc Feature(8)336..344(+)
Misc Feature(9)501..650(+)
Misc Feature(10)501..650(+)
Misc Feature(11)522..581(+)
Misc Feature(12)531..539(+)
Misc Feature(13)672..1064(+)
Misc Feature(14)756..959(+)
Misc Feature(15)1218..2189(+)
Misc Feature(16)1221..1997(+)
Misc Feature(17)1239..1823(+)
Misc Feature(18)1239..1649(+)
Misc Feature(19)1251..1823(+)
Misc Feature(20)1644..1715(+)
Misc Feature(21)1695..1697(+)
Misc Feature(22)1707..1709(+)
Misc Feature(23)2100..2102(+)
Misc Feature(24)2100..2102(+)
Misc Feature(25)2121..2123(+)
Misc Feature(26)2121..2123(+)
Misc Feature(27)2121..2123(+)
Misc Feature(28)2166..2183(+)
Misc Feature(29)2178..2180(+)
Misc Feature(30)2178..2180(+)
Exon (1)1..370
Gene:PRKCB
Gene Synonym:
Exon (2)371..402
Gene:PRKCB
Gene Synonym:
Exon (3)403..485
Gene:PRKCB
Gene Synonym:
Exon (4)486..597
Gene:PRKCB
Gene Synonym:
Exon (5)598..726
Gene:PRKCB
Gene Synonym:
Exon (6)727..883
Gene:PRKCB
Gene Synonym:
Exon (7)884..1018
Gene:PRKCB
Gene Synonym:
Exon (8)1019..1115
Gene:PRKCB
Gene Synonym:
Exon (9)1116..1262
Gene:PRKCB
Gene Synonym:
Exon (10)1263..1436
Gene:PRKCB
Gene Synonym:
Exon (11)1437..1528
Gene:PRKCB
Gene Synonym:
Exon (12)1529..1591
Gene:PRKCB
Gene Synonym:
Exon (13)1592..1730
Gene:PRKCB
Gene Synonym:
Exon (14)1731..1811
Gene:PRKCB
Gene Synonym:
Exon (15)1812..1919
Gene:PRKCB
Gene Synonym:
Exon (16)1920..2060
Gene:PRKCB
Gene Synonym:
Exon (17)2061..2711
Gene:PRKCB
Gene Synonym:
Translation
Position Chain Variation Link
28 28 a, g dbSNP:371723231
164 164 c, g dbSNP:763455165
165 165 a, g dbSNP:766094053
166 166 c, t dbSNP:751296237
173 173 c, t dbSNP:188342168
174 174 c, g dbSNP:767070226
178 178 a, t dbSNP:535808203
185 185 c, t dbSNP:756077698
188 188 c, g dbSNP:777496943
189 189 a, g dbSNP:374642745
208 208 c, g dbSNP:757085223
211 211 a, c, t dbSNP:201366670
215 215 a, g dbSNP:768549392
220 220 a, c dbSNP:781362818
222 222 c, t dbSNP:575795787
223 223 a, c dbSNP:368093414
232 232 a, t dbSNP:370984906
235 235 a, g dbSNP:749669754
237 237 a, g dbSNP:771388864
247 247 c, t dbSNP:773819749
253 253 a, g dbSNP:759234204
255 255 c, t dbSNP:766899029
262 262 a, g dbSNP:200442462
263 263 c, t dbSNP:775089575
267 267 c, g dbSNP:760228327
269 269 c, t dbSNP:763989321
275 275 c, g dbSNP:753829465
276 276 a, c dbSNP:75964872
284 284 a, g dbSNP:146177740
296 296 a, g dbSNP:751689932
311 311 a, g dbSNP:755247718
326 326 c, t dbSNP:781315165
359 359 c, g, t dbSNP:115667450
383 383 a, g dbSNP:769737298
406 406 g, t dbSNP:370311602
416 416 a, g dbSNP:759454355
428 428 a, g dbSNP:764380918
452 452 a, c dbSNP:754076764
461 461 c, t dbSNP:115750906
462 462 a, g dbSNP:371650623
466 466 a, t dbSNP:750901145
476 476 a, t dbSNP:758927501
482 482 c, g, t dbSNP:371087215
483 483 a, g dbSNP:751886977
484 484 a, g dbSNP:755399339
487 487 a, g dbSNP:777534524
493 493 a, g dbSNP:748776658
496 496 g, t dbSNP:3729895
500 500 a, g dbSNP:756894368
520 520 c, t dbSNP:778983154
521 521 a, g dbSNP:116749372
524 524 c, t dbSNP:771951442
536 536 a, g dbSNP:377143661
554 554 a, g dbSNP:564776408
565 565 a, g dbSNP:769874764
582 582 g, t dbSNP:773546270
603 603 a, g dbSNP:759666193
610 610 a, c dbSNP:772430325
622 622 a, g dbSNP:550043137
626 626 c, t dbSNP:760934314
627 627 a, g dbSNP:764534677
638 638 a, t dbSNP:753475682
647 647 a, g dbSNP:761578978
655 655 c, t dbSNP:765028943
656 656 c, g dbSNP:372836893
665 665 a, g dbSNP:757992423
669 669 c, t dbSNP:779838345
670 670 a, g dbSNP:751524971
672 672 c, t dbSNP:754659392
674 674 c, t dbSNP:573327064
683 683 c, t dbSNP:749465077
690 690 c, g dbSNP:199648786
692 692 a, g dbSNP:556028547
695 695 c, t dbSNP:576008026
710 710 c, t dbSNP:115645964
711 711 a, g dbSNP:200811816
717 717 a, g dbSNP:775803818
719 719 c, t dbSNP:116345778
725 725 c, t dbSNP:540341676
732 732 g, t dbSNP:779094238
746 746 c, t dbSNP:746115990
747 747 c, g dbSNP:573366163
768 768 c, t dbSNP:758345369
782 782 c, t dbSNP:543897172
783 783 a, g dbSNP:747105951
785 785 a, g dbSNP:769253047
791 791 a, g dbSNP:777343122
798 798 a, t dbSNP:748510627
799 799 c, t dbSNP:770291872
803 803 c, t dbSNP:3729896
833 833 a, c, t dbSNP:762695587
837 837 a, g dbSNP:773891890
885 885 c, g dbSNP:200005518
898 898 c, t dbSNP:770589472
899 899 a, c, g dbSNP:114093019
902 902 c, t dbSNP:771584055
911 911 a, g dbSNP:17847891
935 935 c, t dbSNP:760639179
947 947 c, t dbSNP:763829980
953 953 a, g dbSNP:753635581
993 993 c, g dbSNP:777404333
995 995 c, t dbSNP:766610202
1002 1002 a, g dbSNP:756684442
1009 1009 c, t dbSNP:751743022
1013 1013 c, t dbSNP:755036948
1016 1016 a, c dbSNP:781448514
1024 1024 a, g dbSNP:745475837
1046 1046 c, t dbSNP:17847884
1061 1061 c, g dbSNP:779746680
1067 1067 a, g dbSNP:746506850
1070 1070 a, g dbSNP:568306326
1078 1078 a, g dbSNP:199901715
1085 1085 a, g dbSNP:748062707
1090 1090 a, g dbSNP:147975795
1101 1101 a, c dbSNP:536939564
1102 1102 a, g dbSNP:762879227
1103 1103 a, g dbSNP:115598469
1117 1117 c, g dbSNP:141851225
1120 1120 a, c dbSNP:760838283
1125 1125 a, g dbSNP:764189258
1127 1127 c, t dbSNP:201781724
1142 1142 a, g dbSNP:146104501
1143 1143 a, g dbSNP:749777388
1147 1147 c, t dbSNP:202044032
1148 1148 a, g dbSNP:750938251
1159 1159 c, t dbSNP:139055681
1160 1160 a, g dbSNP:766756709
1161 1161 a, g dbSNP:751175487
1162 1162 c, t dbSNP:754563290
1169 1169 c, t dbSNP:780936454
1172 1172 c, g dbSNP:374744056
1174 1174 c, t dbSNP:755710261
1175 1175 c, t dbSNP:777796805
1177 1177 a, g dbSNP:749243156
1178 1178 a, g dbSNP:114856527
1187 1187 c, g dbSNP:778877195
1192 1192 c, g dbSNP:149128755
1203 1203 c, t dbSNP:768732945
1205 1205 a, g dbSNP:539838175
1215 1215 a, c dbSNP:776981512
1217 1217 c, t dbSNP:116346810
1226 1226 c, t dbSNP:56041613
1233 1233 a, g dbSNP:773665394
1235 1235 a, g dbSNP:763468825
1236 1236 g, t dbSNP:766920124
1259 1259 a, c, g dbSNP:556610239
1278 1278 a, c dbSNP:750377270
1282 1282 a, g dbSNP:758085883
1286 1286 a, c dbSNP:779917484
1288 1288 c, g dbSNP:148312044
1295 1295 a, g dbSNP:756297068
1301 1301 c, t dbSNP:202161442
1302 1302 a, g dbSNP:141758720
1325 1325 c, t dbSNP:749354695
1346 1346 c, t dbSNP:543064850
1347 1347 a, g dbSNP:200238437
1352 1352 a, g dbSNP:774656581
1359 1359 a, c dbSNP:746420133
1365 1365 a, g dbSNP:267604474
1369 1369 a, g dbSNP:772277246
1372 1372 a, g dbSNP:775901586
1374 1374 g, t dbSNP:761166216
1380 1380 a, g dbSNP:763837460
1382 1382 a, c dbSNP:776487939
1388 1388 c, t dbSNP:432998
1396 1396 c, t dbSNP:764831474
1397 1397 a, g, t dbSNP:141827066
1418 1418 a, c dbSNP:766266252
1434 1434 a, t dbSNP:369508594
1435 1435 g, t dbSNP:201855972
1460 1460 c, g dbSNP:754699676
1463 1463 c, t dbSNP:55942437
1470 1470 -, g dbSNP:767358252
1472 1472 g, t dbSNP:754012268
1493 1493 c, t dbSNP:536103282
1502 1502 c, t dbSNP:369762663
1507 1507 a, g dbSNP:750515509
1521 1521 c, t dbSNP:758468877
1523 1523 c, t dbSNP:780652979
1529 1529 a, t dbSNP:751735254
1535 1535 c, t dbSNP:755505988
1536 1536 a, g dbSNP:781780434
1545 1545 a, g dbSNP:748531840
1550 1550 c, t dbSNP:770067840
1553 1553 c, t dbSNP:777415569
1554 1554 a, g dbSNP:748923188
1556 1556 c, t dbSNP:770380229
1568 1568 a, g dbSNP:376961976
1579 1579 a, g dbSNP:370646498
1589 1589 c, t dbSNP:200457901
1610 1610 c, t dbSNP:745373140
1619 1619 c, t dbSNP:771588066
1628 1628 c, g dbSNP:775433458
1646 1646 c, t dbSNP:746954626
1660 1660 g, t dbSNP:768685403
1667 1667 a, g dbSNP:776256139
1670 1670 c, t dbSNP:752583432
1681 1681 c, g dbSNP:761763038
1696 1696 a, c dbSNP:111341519
1704 1704 a, g dbSNP:766692518
1712 1712 a, c dbSNP:774726787
1721 1721 c, t dbSNP:17847876
1727 1727 c, t dbSNP:367690547
1738 1738 c, t dbSNP:751018138
1745 1745 a, g dbSNP:376039132
1781 1781 a, g dbSNP:780923538
1784 1784 c, t dbSNP:748126363
1807 1807 g, t dbSNP:769663948
1832 1832 c, t dbSNP:777925353
1854 1854 a, g dbSNP:749084012
1856 1856 c, t dbSNP:770775429
1862 1862 a, g dbSNP:571472508
1867 1867 a, c dbSNP:780076694
1868 1868 c, t dbSNP:747289504
1869 1869 a, g dbSNP:368238909
1884 1884 c, t dbSNP:17847879
1899 1899 a, g dbSNP:761943712
1902 1902 a, g dbSNP:770267855
1907 1907 c, t dbSNP:773720305
1919 1919 c, g dbSNP:763157141
1920 1920 a, c dbSNP:201555288
1933 1933 a, t dbSNP:769865916
1945 1945 a, g dbSNP:773667135
1960 1960 a, c, g dbSNP:35631544
1967 1967 c, t dbSNP:3729904
1968 1968 a, g dbSNP:774746011
1971 1971 c, t dbSNP:767640161
1972 1972 a, g dbSNP:767265943
1975 1975 a, g dbSNP:775297421
1976 1976 c, t dbSNP:574612696
1989 1989 a, g dbSNP:114846751
1998 1998 c, t dbSNP:753672328
1999 1999 a, g dbSNP:757200847
2006 2006 c, t dbSNP:765130298
2009 2009 c, t dbSNP:750215960
2019 2019 a, c dbSNP:758199138
2025 2025 c, t dbSNP:781322629
2026 2026 a, g dbSNP:563116744
2036 2036 c, t dbSNP:756137300
2047 2047 a, t dbSNP:371799088
2058 2058 a, g dbSNP:777885939
2082 2082 a, c dbSNP:773514796
2083 2083 a, g dbSNP:763241619
2084 2084 c, t dbSNP:771315885
2087 2087 c, t dbSNP:778710250
2103 2103 a, g dbSNP:759718537
2117 2117 a, g dbSNP:767852403
2123 2123 c, t dbSNP:148637931
2125 2125 a, c dbSNP:760907855
2133 2133 a, c dbSNP:764466114
2136 2136 c, t dbSNP:554313951
2144 2144 c, g dbSNP:756874692
2150 2150 c, t dbSNP:778605803
2159 2159 a, c, g dbSNP:749890233
2184 2184 a, g dbSNP:779793250
2190 2190 c, g dbSNP:747003127
2191 2191 c, t dbSNP:142427207
2202 2202 a, g dbSNP:781115157
2215 2215 c, t dbSNP:748016236
2227 2227 c, g dbSNP:771275086
2228 2228 c, t dbSNP:424741
2229 2229 a, g dbSNP:367894275
2231 2231 c, g, t dbSNP:140062455
2232 2232 a, g dbSNP:374831115
2233 2233 c, t dbSNP:530749955
2237 2237 a, c, g dbSNP:764633636
2259 2259 c, g dbSNP:543785816
2264 2264 c, t dbSNP:764726776
2265 2265 a, g dbSNP:777590273
2304 2304 a, g dbSNP:187700395
2327 2327 a, g dbSNP:113336763
2331 2331 c, t dbSNP:563551037
2348 2348 c, t dbSNP:532856714
2366 2366 c, t dbSNP:192474372
2397 2397 c, g dbSNP:185685652
2409 2409 c, t dbSNP:368074978
2410 2410 a, g dbSNP:190510502
2414 2414 c, t dbSNP:530936284
2415 2415 a, g dbSNP:746616204
2428 2428 c, g dbSNP:569510913
2486 2486 c, t dbSNP:181492069
2515 2515 c, t dbSNP:563616555
2516 2516 g, t dbSNP:558172407
2548 2548 a, g dbSNP:770455975
2600 2600 a, g dbSNP:552569497
2601 2601 c, t dbSNP:144042856
2618 2618 g, t dbSNP:564592733
2630 2630 -, t dbSNP:34526646
2639 2639 c, t dbSNP:1063471
2652 2652 c, t dbSNP:146441057
2683 2683 a, t dbSNP:775921208
2685 2685 a, g dbSNP:574068314

Target ORF information:

RefSeq Version NM_212535
Organism Homo sapiens (human)
Definition Homo sapiens protein kinase C, beta (PRKCB), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_212535

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 
GCCCGCAAAG GCGCCCTCCG GCAGAAGAAC GTGCATGAGG TCAAGAACCA CAAATTCACC
GCCCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC
GGGAAGCAGG GATTCCAGTG CCAAGTTTGC TGCTTTGTGG TGCACAAGCG GTGCCATGAA
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGTCCAG CCTCCGATGA CCCCCGCAGC
AAACACAAGT TTAAGATCCA CACGTACTCC AGCCCCACGT TTTGTGACCA CTGTGGGTCA
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAATGTGCAC
AAGCGCTGCG TGATGAATGT TCCCAGCCTG TGTGGCACGG ACCACACGGA GCGCCGCGGC
CGCATCTACA TCCAGGCCCA CATCGACAGG GACGTCCTCA TTGTCCTCGT AAGAGATGCT
AAAAACCTTG TACCTATGGA CCCCAATGGC CTGTCAGATC CCTACGTAAA ACTGAAACTG
ATTCCCGATC CCAAAAGTGA GAGCAAACAG AAGACCAAAA CCATCAAATG CTCCCTCAAC
CCTGAGTGGA ATGAGACATT TAGATTTCAG CTGAAAGAAT CGGACAAAGA CAGAAGACTG
TCAGTAGAGA TTTGGGATTG GGATTTGACC AGCAGGAATG ACTTCATGGG ATCTTTGTCC
TTTGGGATTT CTGAACTTCA GAAAGCCAGT GTTGATGGCT GGTTTAAGTT ACTGAGCCAG
GAGGAAGGCG AGTACTTCAA TGTGCCTGTG CCACCAGAAG GAAGTGAGGC CAATGAAGAA
CTGCGGCAGA AATTTGAGAG GGCCAAGATC AGTCAGGGAA CCAAGGTCCC GGAAGAAAAG
ACGACCAACA CTGTCTCCAA ATTTGACAAC AATGGCAACA GAGACCGGAT GAAACTGACC
GATTTTAACT TCCTAATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA
CGAAAAGGCA CAGATGAGCT CTATGCTGTG AAGATCCTGA AGAAGGACGT TGTGATCCAA
GATGATGACG TGGAGTGCAC TATGGTGGAG AAGCGGGTGT TGGCCCTGCC TGGGAAGCCG
CCCTTCCTGA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTTGTGATG
GAGTACGTGA ATGGGGGCGA CCTCATGTAT CACATCCAGC AAGTCGGCCG GTTCAAGGAG
CCCCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TGTTCTTCTT ACAGAGTAAG
GGCATCATTT ACCGTGACCT AAAACTTGAC AACGTGATGC TCGATTCTGA GGGACACATC
AAGATTGCCG ATTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACCAAGACA
TTCTGTGGCA CTCCAGACTA CATCGCCCCC GAGATAATTG CTTATCAGCC CTATGGGAAG
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG GCAGGCACCC
TTTGAAGGGG AGGATGAAGA TGAACTCTTC CAATCCATCA TGGAACACAA CGTAGCCTAT
CCCAAGTCTA TGTCCAAGGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAACACCCA
GGCAAACGTC TGGGTTGTGG ACCTGAAGGC GAACGTGATA TCAAAGAGCA TGCATTTTTC
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATCC AGCCCCCTTA TAAGCCAAAA
GCTAGAGACA AGAGAGACAC CTCCAACTTC GACAAAGAGT TCACCAGACA GCCTGTGGAA
CTGACCCCCA CTGATAAACT CTTCATCATG AACTTGGACC AAAATGAATT TGCTGGCTTC
TCTTATACTA ACCCAGAGTT TGTCATTAAT GTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.