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PROC cDNA ORF clone, Homo sapiens (human)

Gene Symbol PROC
Entrez Gene ID 5624
Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Synonyms APC, PC, PROC1, THPH3, THPH4
General protein information
Preferred Names
vitamin K-dependent protein C
Names
vitamin K-dependent protein C
autoprothrombin IIA
anticoagulant protein C
blood coagulation factor XIV
NP_000303.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q13-q14

Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]. lac of sum
Disorder MIM:

612283

Disorder Html: Thrombophilia due to protein C deficiency, autosomal dominant,

mRNA and Protein(s)

mRNA Protein Name
XM_005263715 XP_005263772 vitamin K-dependent protein C isoform X1
XM_005263716 XP_005263773 vitamin K-dependent protein C isoform X2
XM_005263717 XP_005263774 vitamin K-dependent protein C isoform X3
NM_000312 NP_000303 vitamin K-dependent protein C preproprotein



Homo sapiens (human) PROC NP_000303.1
Pan troglodytes (chimpanzee) PROC XP_515775.3
Macaca mulatta (Rhesus monkey) PROC XP_001087196.2
Canis lupus familiaris (dog) LOC476104 NP_001013871.1
Bos taurus (cattle) PROC NP_001159984.1
Mus musculus (house mouse) Proc NP_032960.3
Rattus norvegicus (Norway rat) Proc NP_036935.1
Gallus gallus (chicken) PROC NP_989772.1
Danio rerio (zebrafish) proca NP_956650.1
Xenopus (Silurana) tropicalis (western clawed frog) proc NP_001015759.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PROC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu36435 XM_005263715 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu36436 XM_005263716 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00
OHu36437 XM_005263717 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu20007
NM_000312 Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu36435
Clone ID Related Accession (Same CDS sequence) XM_005263715
Accession Version XM_005263715.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1569bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804595. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTCTTC CGCCCTGACG 
GCCAGCACAC AGGGACAGCC CTTTCATTCC GCTTCCACCT GGGGGTGCAG GCAGAGCAGC
AGCGGGGGTA GGCACTGCCC GGAGCTCAGA AGTCCTCCTC AGACAGGTGC CAGTGCCTCC
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005263772.1
CDS15..1583
Misc Feature(1)267..458(+)
Misc Feature(2)498..593(+)
Misc Feature(3)615..722(+)
Misc Feature(4)828..1532(+)
Misc Feature(5)834..1541(+)
Misc Feature(6)954..1403(+)
Misc Feature(7)1383..1466(+)
Translation

Target ORF information:

RefSeq Version XM_005263715
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263715

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTCTTC CGCCCTGACG 
GCCAGCACAC AGGGACAGCC CTTTCATTCC GCTTCCACCT GGGGGTGCAG GCAGAGCAGC
AGCGGGGGTA GGCACTGCCC GGAGCTCAGA AGTCCTCCTC AGACAGGTGC CAGTGCCTCC
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36436
Clone ID Related Accession (Same CDS sequence) XM_005263716
Accession Version XM_005263716.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1551bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804596. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGGTGAGGG GGAGAGGTGG
ATGCTGGCGG GCGGCGGGGC GGGGCTGGGG CCGGGTTGGG GGCGCGGCAC CAGCACCAGC
TGCCCGCGCC CTCCCCTGCC CGCAGAGGTG AGCTTCCTCA ATTGCTCGCT GGACAACGGC
GGCTGCACGC ATTACTGCCT AGAGGAGGTG GGCTGGCGGC GCTGTAGCTG TGCGCCTGGC
TACAAGCTGG GGGACGACCT CCTGCAGTGT CACCCCGCAG TGAAGTTCCC TTGTGGGAGG
CCCTGGAAGC GGATGGAGAA GAAGCGCAGT CACCTGAAAC GAGACACAGA AGACCAAGAA
GACCAAGTAG ATCCGCGGCT CATTGATGGG AAGATGACCA GGCGGGGAGA CAGCCCCTGG
CAGGTGGTCC TGCTGGACTC AAAGAAGAAG CTGGCCTGCG GGGCAGTGCT CATCCACCCC
TCCTGGGTGC TGACAGCGGC CCACTGCATG GATGAGTCCA AGAAGCTCCT TGTCAGGCTT
GGAGAGTATG ACCTGCGGCG CTGGGAGAAG TGGGAGCTGG ACCTGGACAT CAAGGAGGTC
TTCGTCCACC CCAACTACAG CAAGAGCACC ACCGACAATG ACATCGCACT GCTGCACCTG
GCCCAGCCCG CCACCCTCTC GCAGACCATA GTGCCCATCT GCCTCCCGGA CAGCGGCCTT
GCAGAGCGCG AGCTCAATCA GGCCGGCCAG GAGACCCTCG TGACGGGCTG GGGCTACCAC
AGCAGCCGAG AGAAGGAGGC CAAGAGAAAC CGCACCTTCG TCCTCAACTT CATCAAGATT
CCCGTGGTCC CGCACAATGA GTGCAGCGAG GTCATGAGCA ACATGGTGTC TGAGAACATG
CTGTGTGCGG GCATCCTCGG GGACCGGCAG GATGCCTGCG AGGGCGACAG TGGGGGGCCC
ATGGTCGCCT CCTTCCACGG CACCTGGTTC CTGGTGGGCC TGGTGAGCTG GGGTGAGGGC
TGTGGGCTCC TTCACAACTA CGGCGTTTAC ACCAAAGTCA GCCGCTACCT CGACTGGATC
CATGGGCACA TCAGAGACAA GGAAGCCCCC CAGAAGAGCT GGGCACCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005263773.1
CDS43..1593
Misc Feature(1)175..366(+)
Misc Feature(2)406..501(+)
Misc Feature(3)625..732(+)
Misc Feature(4)838..1542(+)
Misc Feature(5)844..1551(+)
Misc Feature(6)964..1413(+)
Misc Feature(7)1393..1476(+)
Translation

Target ORF information:

RefSeq Version XM_005263716
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263716

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGGTGAGGG GGAGAGGTGG
ATGCTGGCGG GCGGCGGGGC GGGGCTGGGG CCGGGTTGGG GGCGCGGCAC CAGCACCAGC
TGCCCGCGCC CTCCCCTGCC CGCAGAGGTG AGCTTCCTCA ATTGCTCGCT GGACAACGGC
GGCTGCACGC ATTACTGCCT AGAGGAGGTG GGCTGGCGGC GCTGTAGCTG TGCGCCTGGC
TACAAGCTGG GGGACGACCT CCTGCAGTGT CACCCCGCAG TGAAGTTCCC TTGTGGGAGG
CCCTGGAAGC GGATGGAGAA GAAGCGCAGT CACCTGAAAC GAGACACAGA AGACCAAGAA
GACCAAGTAG ATCCGCGGCT CATTGATGGG AAGATGACCA GGCGGGGAGA CAGCCCCTGG
CAGGTGGTCC TGCTGGACTC AAAGAAGAAG CTGGCCTGCG GGGCAGTGCT CATCCACCCC
TCCTGGGTGC TGACAGCGGC CCACTGCATG GATGAGTCCA AGAAGCTCCT TGTCAGGCTT
GGAGAGTATG ACCTGCGGCG CTGGGAGAAG TGGGAGCTGG ACCTGGACAT CAAGGAGGTC
TTCGTCCACC CCAACTACAG CAAGAGCACC ACCGACAATG ACATCGCACT GCTGCACCTG
GCCCAGCCCG CCACCCTCTC GCAGACCATA GTGCCCATCT GCCTCCCGGA CAGCGGCCTT
GCAGAGCGCG AGCTCAATCA GGCCGGCCAG GAGACCCTCG TGACGGGCTG GGGCTACCAC
AGCAGCCGAG AGAAGGAGGC CAAGAGAAAC CGCACCTTCG TCCTCAACTT CATCAAGATT
CCCGTGGTCC CGCACAATGA GTGCAGCGAG GTCATGAGCA ACATGGTGTC TGAGAACATG
CTGTGTGCGG GCATCCTCGG GGACCGGCAG GATGCCTGCG AGGGCGACAG TGGGGGGCCC
ATGGTCGCCT CCTTCCACGG CACCTGGTTC CTGGTGGGCC TGGTGAGCTG GGGTGAGGGC
TGTGGGCTCC TTCACAACTA CGGCGTTTAC ACCAAAGTCA GCCGCTACCT CGACTGGATC
CATGGGCACA TCAGAGACAA GGAAGCCCCC CAGAAGAGCT GGGCACCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36437
Clone ID Related Accession (Same CDS sequence) XM_005263717
Accession Version XM_005263717.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1449bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804597. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005263774.1
CDS28..1476
Misc Feature(1)160..351(+)
Misc Feature(2)391..486(+)
Misc Feature(3)508..615(+)
Misc Feature(4)721..1425(+)
Misc Feature(5)727..1434(+)
Misc Feature(6)847..1296(+)
Misc Feature(7)1276..1359(+)
Translation

Target ORF information:

RefSeq Version XM_005263717
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263717

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20007
Clone ID Related Accession (Same CDS sequence) NM_000312
Accession Version NM_000312.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1386bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA642156.1, BC034377.1 and BM975043.1. This sequence is a reference standard in the RefSeqGene project. On Dec 10, 2009 this sequence version replaced gi:109389366. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02750.1, BC034377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGCAGC TCACAAGCCT CCTGCTGTTC GTGGCCACCT GGGGAATTTC CGGCACACCA 
GCTCCTCTTG ACTCAGTGTT CTCCAGCAGC GAGCGTGCCC ACCAGGTGCT GCGGATCCGC
AAACGTGCCA ACTCCTTCCT GGAGGAGCTC CGTCACAGCA GCCTGGAGCG GGAGTGCATA
GAGGAGATCT GTGACTTCGA GGAGGCCAAG GAAATTTTCC AAAATGTGGA TGACACACTG
GCCTTCTGGT CCAAGCACGT CGACGGTGAC CAGTGCTTGG TCTTGCCCTT GGAGCACCCG
TGCGCCAGCC TGTGCTGCGG GCACGGCACG TGCATCGACG GCATCGGCAG CTTCAGCTGC
GACTGCCGCA GCGGCTGGGA GGGCCGCTTC TGCCAGCGCG AGGTGAGCTT CCTCAATTGC
TCGCTGGACA ACGGCGGCTG CACGCATTAC TGCCTAGAGG AGGTGGGCTG GCGGCGCTGT
AGCTGTGCGC CTGGCTACAA GCTGGGGGAC GACCTCCTGC AGTGTCACCC CGCAGTGAAG
TTCCCTTGTG GGAGGCCCTG GAAGCGGATG GAGAAGAAGC GCAGTCACCT GAAACGAGAC
ACAGAAGACC AAGAAGACCA AGTAGATCCG CGGCTCATTG ATGGGAAGAT GACCAGGCGG
GGAGACAGCC CCTGGCAGGT GGTCCTGCTG GACTCAAAGA AGAAGCTGGC CTGCGGGGCA
GTGCTCATCC ACCCCTCCTG GGTGCTGACA GCGGCCCACT GCATGGATGA GTCCAAGAAG
CTCCTTGTCA GGCTTGGAGA GTATGACCTG CGGCGCTGGG AGAAGTGGGA GCTGGACCTG
GACATCAAGG AGGTCTTCGT CCACCCCAAC TACAGCAAGA GCACCACCGA CAATGACATC
GCACTGCTGC ACCTGGCCCA GCCCGCCACC CTCTCGCAGA CCATAGTGCC CATCTGCCTC
CCGGACAGCG GCCTTGCAGA GCGCGAGCTC AATCAGGCCG GCCAGGAGAC CCTCGTGACG
GGCTGGGGCT ACCACAGCAG CCGAGAGAAG GAGGCCAAGA GAAACCGCAC CTTCGTCCTC
AACTTCATCA AGATTCCCGT GGTCCCGCAC AATGAGTGCA GCGAGGTCAT GAGCAACATG
GTGTCTGAGA ACATGCTGTG TGCGGGCATC CTCGGGGACC GGCAGGATGC CTGCGAGGGC
GACAGTGGGG GGCCCATGGT CGCCTCCTTC CACGGCACCT GGTTCCTGGT GGGCCTGGTG
AGCTGGGGTG AGGGCTGTGG GCTCCTTCAC AACTACGGCG TTTACACCAA AGTCAGCCGC
TACCTCGACT GGATCCATGG GCACATCAGA GACAAGGAAG CCCCCCAGAA GAGCTGGGCA
CCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000303.1
CDS95..1480
Misc Feature(1)164..355(+)
Misc Feature(2)218..220(+)
Misc Feature(3)236..238(+)
Misc Feature(4)236..238(+)
Misc Feature(5)239..241(+)
Misc Feature(6)239..241(+)
Misc Feature(7)260..262(+)
Misc Feature(8)260..262(+)
Misc Feature(9)266..268(+)
Misc Feature(10)266..268(+)
Misc Feature(11)275..277(+)
Misc Feature(12)275..277(+)
Misc Feature(13)278..280(+)
Misc Feature(14)278..280(+)
Misc Feature(15)293..295(+)
Misc Feature(16)293..295(+)
Misc Feature(17)296..298(+)
Misc Feature(18)296..298(+)
Misc Feature(19)305..307(+)
Misc Feature(20)305..307(+)
Misc Feature(21)395..490(+)
Misc Feature(22)431..433(+)
Misc Feature(23)431..433(+)
Misc Feature(24)509..511(+)
Misc Feature(25)512..619(+)
Misc Feature(26)683..685(+)
Misc Feature(27)689..691(+)
Misc Feature(28)725..1429(+)
Misc Feature(29)725..730(+)
Misc Feature(30)731..1438(+)
Misc Feature(31)851..1300(+)
Misc Feature(32)962..964(+)
Misc Feature(33)1157..1159(+)
Misc Feature(34)1205..1207(+)
Misc Feature(35)1280..1363(+)
Exon (1)1..73
Gene:PROC
Gene Synonym:
Exon (2)74..164
Gene:PROC
Gene Synonym:
Exon (3)165..331
Gene:PROC
Gene Synonym:
Exon (4)332..356
Gene:PROC
Gene Synonym:
Exon (5)357..494
Gene:PROC
Gene Synonym:
Exon (6)495..629
Gene:PROC
Gene Synonym:
Exon (7)630..772
Gene:PROC
Gene Synonym:
Exon (8)773..890
Gene:PROC
Gene Synonym:
Exon (9)891..1780
Gene:PROC
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000312
Organism Homo sapiens (human)
Definition Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000312

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGCAGC TCACAAGCCT CCTGCTGTTC GTGGCCACCT GGGGAATTTC CGGCACACCA 
GCTCCTCTTG ACTCAGTGTT CTCCAGCAGC GAGCGTGCCC ACCAGGTGCT GCGGATCCGC
AAACGTGCCA ACTCCTTCCT GGAGGAGCTC CGTCACAGCA GCCTGGAGCG GGAGTGCATA
GAGGAGATCT GTGACTTCGA GGAGGCCAAG GAAATTTTCC AAAATGTGGA TGACACACTG
GCCTTCTGGT CCAAGCACGT CGACGGTGAC CAGTGCTTGG TCTTGCCCTT GGAGCACCCG
TGCGCCAGCC TGTGCTGCGG GCACGGCACG TGCATCGACG GCATCGGCAG CTTCAGCTGC
GACTGCCGCA GCGGCTGGGA GGGCCGCTTC TGCCAGCGCG AGGTGAGCTT CCTCAATTGC
TCGCTGGACA ACGGCGGCTG CACGCATTAC TGCCTAGAGG AGGTGGGCTG GCGGCGCTGT
AGCTGTGCGC CTGGCTACAA GCTGGGGGAC GACCTCCTGC AGTGTCACCC CGCAGTGAAG
TTCCCTTGTG GGAGGCCCTG GAAGCGGATG GAGAAGAAGC GCAGTCACCT GAAACGAGAC
ACAGAAGACC AAGAAGACCA AGTAGATCCG CGGCTCATTG ATGGGAAGAT GACCAGGCGG
GGAGACAGCC CCTGGCAGGT GGTCCTGCTG GACTCAAAGA AGAAGCTGGC CTGCGGGGCA
GTGCTCATCC ACCCCTCCTG GGTGCTGACA GCGGCCCACT GCATGGATGA GTCCAAGAAG
CTCCTTGTCA GGCTTGGAGA GTATGACCTG CGGCGCTGGG AGAAGTGGGA GCTGGACCTG
GACATCAAGG AGGTCTTCGT CCACCCCAAC TACAGCAAGA GCACCACCGA CAATGACATC
GCACTGCTGC ACCTGGCCCA GCCCGCCACC CTCTCGCAGA CCATAGTGCC CATCTGCCTC
CCGGACAGCG GCCTTGCAGA GCGCGAGCTC AATCAGGCCG GCCAGGAGAC CCTCGTGACG
GGCTGGGGCT ACCACAGCAG CCGAGAGAAG GAGGCCAAGA GAAACCGCAC CTTCGTCCTC
AACTTCATCA AGATTCCCGT GGTCCCGCAC AATGAGTGCA GCGAGGTCAT GAGCAACATG
GTGTCTGAGA ACATGCTGTG TGCGGGCATC CTCGGGGACC GGCAGGATGC CTGCGAGGGC
GACAGTGGGG GGCCCATGGT CGCCTCCTTC CACGGCACCT GGTTCCTGGT GGGCCTGGTG
AGCTGGGGTG AGGGCTGTGG GCTCCTTCAC AACTACGGCG TTTACACCAA AGTCAGCCGC
TACCTCGACT GGATCCATGG GCACATCAGA GACAAGGAAG CCCCCCAGAA GAGCTGGGCA
CCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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