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PROC cDNA ORF clone, Homo sapiens (human)

Gene Symbol PROC
Entrez Gene ID 5624
Full Name protein C (inactivator of coagulation factors Va and VIIIa)
Synonyms APC, PC, PROC1, THPH3, THPH4
General protein information
Preferred Names
vitamin K-dependent protein C
Names
vitamin K-dependent protein C
autoprothrombin IIA
anticoagulant protein C
blood coagulation factor XIV
NP_000303.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q13-q14

Summary This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]. lac of sum
Disorder MIM:

612283

Disorder Html: Thrombophilia due to protein C deficiency, autosomal dominant,





The following PROC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PROC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu36435 XM_005263715 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $439.00
OHu36436 XM_005263716 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $439.00
OHu36437 XM_005263717 PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319.00
OHu20007 NM_000312 Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu36435
Accession Version XM_005263715.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1569bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804595. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTCTTC CGCCCTGACG 
GCCAGCACAC AGGGACAGCC CTTTCATTCC GCTTCCACCT GGGGGTGCAG GCAGAGCAGC
AGCGGGGGTA GGCACTGCCC GGAGCTCAGA AGTCCTCCTC AGACAGGTGC CAGTGCCTCC
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_005263772.1
CDS15..1583
Misc Feature(1)267..458(+)
Misc Feature(2)498..593(+)
Misc Feature(3)615..722(+)
Misc Feature(4)828..1532(+)
Misc Feature(5)834..1541(+)
Misc Feature(6)954..1403(+)
Misc Feature(7)1383..1466(+)
Translation
Position Chain Variation Link
19 19 c, t dbSNP:779957591
20 20 a, g dbSNP:765866655
28 28 a, g dbSNP:2069936
30 30 c, t dbSNP:148484185
31 31 a, g dbSNP:536613560
32 32 a, t dbSNP:1799810
43 43 c, t dbSNP:755811200
49 49 c, t dbSNP:116169054
55 55 a, c, g dbSNP:542542577
56 56 a, c dbSNP:751804431
62 62 g, t dbSNP:575504175
64 64 c, t dbSNP:543936433
65 65 c, t dbSNP:377257834
66 66 a, g dbSNP:772722834
73 73 c, t dbSNP:148979279
90 90 c, t dbSNP:542626506
103 103 c, t dbSNP:61731661
104 104 c, t dbSNP:528817178
105 105 a, g dbSNP:539608065
118 118 a, g dbSNP:753795993
137 137 c, t dbSNP:545289367
138 138 a, g dbSNP:565186805
140 140 a, g dbSNP:371995306
141 141 g, t dbSNP:748876327
149 149 -, c dbSNP:767560354
149 149 c, t dbSNP:369425880
154 154 c, t dbSNP:368232906
155 155 a, g dbSNP:759002262
157 157 a, t dbSNP:202233007
166 166 a, g dbSNP:775227102
167 167 c, t dbSNP:760735091
168 168 c, g dbSNP:763786052
171 171 c, t dbSNP:753718204
172 172 c, t dbSNP:41269833
178 178 c, g dbSNP:752890313
209 209 c, t dbSNP:750696079
211 211 c, g dbSNP:759805372
216 216 c, t dbSNP:758494619
224 224 a, g dbSNP:780186160
227 227 c, t dbSNP:148490199
228 228 a, g dbSNP:368493458
234 234 a, c dbSNP:781386476
236 236 c, t dbSNP:748548752
238 238 a, g dbSNP:758576042
248 248 c, t dbSNP:770171684
249 249 a, g, t dbSNP:146793243
261 261 c, g dbSNP:771569764
262 262 c, t dbSNP:775126434
263 263 c, t dbSNP:144300387
269 269 c, t dbSNP:764423112
273 273 a, g dbSNP:754243426
287 287 a, c, t dbSNP:552714462
288 288 a, g dbSNP:779710709
292 292 c, g dbSNP:746654539
302 302 c, g dbSNP:754445822
306 306 c, g dbSNP:780914969
307 307 c, t dbSNP:748083494
309 309 c, t dbSNP:769900251
310 310 a, g dbSNP:773107370
315 315 c, t dbSNP:199514227
316 316 a, g dbSNP:770650361
321 321 c, t dbSNP:774572099
322 322 a, g dbSNP:369504169
324 324 a, g dbSNP:767626189
329 329 c, t dbSNP:775598456
335 335 c, g dbSNP:141040323
348 348 c, t dbSNP:764546127
357 357 a, t dbSNP:376049280
366 366 c, t dbSNP:757583846
367 367 a, g dbSNP:574949343
376 376 c, t dbSNP:751218842
382 382 a, c dbSNP:121918148
395 395 c, g, t dbSNP:201463891
401 401 a, g dbSNP:752294542
405 405 a, g dbSNP:199469481
406 406 a, g, t dbSNP:568473236
423 423 a, g dbSNP:121918149
429 429 a, g dbSNP:749192814
445 445 a, g dbSNP:747236088
451 451 a, g dbSNP:768719609
456 456 a, g dbSNP:145854591
476 476 a, g dbSNP:771415643
483 483 c, t dbSNP:774908523
485 485 c, t dbSNP:760374869
494 494 c, t dbSNP:763618496
497 497 a, g dbSNP:776372871
499 499 a, g dbSNP:761171704
500 500 a, c dbSNP:764808999
501 501 a, g dbSNP:750358099
513 513 g, t dbSNP:199469479
519 519 a, c dbSNP:200234655
526 526 a, c, g dbSNP:370147557
527 527 a, g dbSNP:754797791
537 537 c, g dbSNP:374476971
540 540 a, g dbSNP:201563330
541 541 a, c, t dbSNP:748411379
544 544 a, g dbSNP:777973120
546 546 -, agct dbSNP:199469477
558 558 a, g dbSNP:749796486
576 576 c, g dbSNP:771609822
582 582 c, g dbSNP:775031376
583 583 a, g dbSNP:746190838
596 596 c, t dbSNP:200045749
599 599 a, g dbSNP:746382956
610 610 c, t dbSNP:772320207
612 612 a, g dbSNP:780527584
616 616 g, t dbSNP:747735192
617 617 a, c dbSNP:769525590
619 619 a, c dbSNP:772880922
620 620 g, t dbSNP:5936
630 630 a, g dbSNP:370813536
634 634 c, g dbSNP:774204335
636 636 a, t dbSNP:759581480
641 641 -, c dbSNP:772629538
643 643 a, c dbSNP:121918159
648 648 c, t dbSNP:767201513
651 651 c, t dbSNP:570143499
659 659 a, g dbSNP:201952795
665 665 c, g dbSNP:201105510
686 686 a, g dbSNP:764364831
696 696 a, g dbSNP:754130317
721 721 a, g dbSNP:199469474
728 728 c, t dbSNP:757343064
731 731 a, g dbSNP:368367611
735 735 a, c dbSNP:370212196
738 738 g, t dbSNP:199469470
744 744 c, t dbSNP:748920874
760 760 a, g dbSNP:568988569
762 762 c, t dbSNP:146922325
768 768 c, g dbSNP:777364878
769 769 -, aga dbSNP:569796900
771 771 -, aag dbSNP:199469469
774 774 a, c dbSNP:771498658
777 777 c, t dbSNP:371071104
778 778 a, g dbSNP:746989553
785 785 c, t dbSNP:768559685
786 786 c, t dbSNP:776617400
787 787 c, t dbSNP:762098236
789 789 a, c dbSNP:765517843
793 793 a, g dbSNP:773327173
799 799 -, agaagacca dbSNP:776940957
804 804 a, g dbSNP:567588026
820 820 c, t dbSNP:772789753
825 825 -, c dbSNP:761891208
826 826 c, t dbSNP:121918145
827 827 a, g dbSNP:2069927
828 828 a, c, t dbSNP:121918143
829 829 a, g dbSNP:199469476
835 835 c, t dbSNP:753097748
839 839 c, t dbSNP:762556160
855 855 c, t dbSNP:121918152
856 856 a, g, t dbSNP:121918153
863 863 c, g dbSNP:771116175
866 866 a, c dbSNP:199469483
872 872 c, g dbSNP:757925208
875 875 c, g dbSNP:121918155
894 894 a, g dbSNP:779585762
900 900 a, c dbSNP:370086431
901 901 a, t dbSNP:754559546
904 904 c, t dbSNP:781215905
910 910 c, g dbSNP:748099849
911 911 c, t dbSNP:141249033
912 912 a, g dbSNP:777486993
913 913 -, g dbSNP:199469475
913 913 a, g dbSNP:749500010
915 915 -, g dbSNP:200187516
920 920 g, t dbSNP:771095734
925 925 c, t dbSNP:774584131
927 927 c, t dbSNP:759557871
929 929 c, t dbSNP:772146306
932 932 c, g dbSNP:775976369
943 943 c, t dbSNP:375156587
949 949 c, t dbSNP:568121876
950 950 a, g dbSNP:764497897
962 962 a, g dbSNP:754195274
965 965 c, t dbSNP:5937
990 990 c, t dbSNP:121918156
992 992 c, t dbSNP:765900344
1004 1004 c, t dbSNP:765637777
1007 1007 a, c, g dbSNP:371007615
1008 1008 c, t dbSNP:767112991
1009 1009 g, t dbSNP:752290840
1011 1011 c, t dbSNP:121918154
1017 1017 g, t dbSNP:563901001
1022 1022 a, g dbSNP:753825629
1029 1029 c, g dbSNP:757001092
1031 1031 a, g dbSNP:146289521
1034 1034 c, t dbSNP:778740796
1039 1039 a, t dbSNP:375179157
1045 1045 -, agg dbSNP:752654447
1046 1046 g, t dbSNP:758660570
1049 1049 a, g dbSNP:780286813
1056 1056 a, g dbSNP:764737827
1061 1061 c, t dbSNP:768796120
1063 1063 c, t dbSNP:121918151
1072 1072 a, g dbSNP:202150408
1075 1075 a, g dbSNP:144233408
1078 1078 a, g dbSNP:200721675
1081 1081 c, t dbSNP:773761677
1085 1085 c, t dbSNP:759229398
1086 1086 a, c, g dbSNP:199469471
1088 1088 c, t dbSNP:5935
1097 1097 c, t dbSNP:112356403
1099 1099 c, t dbSNP:121918144
1100 1100 a, c dbSNP:753709157
1107 1107 c, t dbSNP:757272256
1111 1111 -, t dbSNP:34222720
1121 1121 c, t dbSNP:13388546
1122 1122 a, g dbSNP:121918146
1124 1124 c, t dbSNP:200731614
1132 1132 c, t dbSNP:121918160
1133 1133 a, g dbSNP:199679356
1139 1139 c, g dbSNP:755005848
1143 1143 a, g dbSNP:762519738
1148 1148 a, c dbSNP:781389633
1160 1160 a, c, g dbSNP:748577703
1163 1163 c, t dbSNP:778455687
1166 1166 a, c, t dbSNP:568793026
1167 1167 a, g dbSNP:571278160
1177 1177 a, t dbSNP:199469480
1179 1179 c, t dbSNP:201907715
1181 1181 c, t dbSNP:760435505
1182 1182 a, g dbSNP:757023301
1189 1189 a, g dbSNP:776245026
1191 1191 c, g dbSNP:761348643
1196 1196 c, t dbSNP:765115028
1197 1197 a, g dbSNP:121918150
1207 1207 c, t dbSNP:369881972
1211 1211 c, t dbSNP:762672544
1212 1212 a, g dbSNP:121918158
1216 1216 c, t dbSNP:766261022
1217 1217 a, g dbSNP:751714439
1220 1220 c, t dbSNP:373299422
1223 1223 c, g dbSNP:781097228
1224 1224 a, g dbSNP:121918147
1227 1227 a, t dbSNP:752782202
1239 1239 c, t dbSNP:121918141
1240 1240 a, g dbSNP:201827066
1244 1244 c, g dbSNP:749815057
1247 1247 a, g dbSNP:771411580
1255 1255 a, g dbSNP:779384632
1258 1258 a, g dbSNP:746611530
1262 1262 c, t dbSNP:548020208
1263 1263 c, t dbSNP:776173921
1264 1264 a, g, t dbSNP:763603757
1271 1271 c, t dbSNP:769300513
1272 1272 a, g, t dbSNP:375912553
1274 1274 c, g dbSNP:766061833
1295 1295 c, t dbSNP:751406743
1296 1296 a, g dbSNP:140582220
1297 1297 c, t dbSNP:767730328
1299 1299 a, g dbSNP:752981292
1304 1304 a, g dbSNP:61731660
1307 1307 a, c dbSNP:778063605
1308 1308 a, g dbSNP:145800354
1312 1312 a, g dbSNP:555974192
1317 1317 a, t dbSNP:757880924
1318 1318 a, g dbSNP:779319957
1319 1319 c, t dbSNP:187228759
1320 1320 a, g dbSNP:368901479
1328 1328 a, g dbSNP:780833999
1358 1358 c, t dbSNP:148855579
1360 1360 c, g dbSNP:769277939
1361 1361 a, g dbSNP:373028935
1371 1371 a, c, g dbSNP:756467027
1376 1376 c, t dbSNP:148035465
1377 1377 c, t dbSNP:759316085
1378 1378 a, g dbSNP:767219916
1381 1381 a, g dbSNP:775849125
1391 1391 c, t dbSNP:146028808
1392 1392 a, g dbSNP:764239787
1393 1393 a, c dbSNP:201399407
1397 1397 c, t dbSNP:780422419
1398 1398 a, g dbSNP:142742242
1409 1409 a, g dbSNP:370637632
1414 1414 a, t dbSNP:758788677
1415 1415 a, g dbSNP:780456728
1418 1418 c, t dbSNP:747775229
1419 1419 a, g dbSNP:374259918
1430 1430 c, t dbSNP:777430545
1431 1431 a, g dbSNP:139741458
1434 1434 a, g dbSNP:572021052
1438 1438 c, g dbSNP:768759265
1440 1440 c, t dbSNP:745857900
1446 1446 c, g dbSNP:144760718
1451 1451 c, t dbSNP:775467256
1455 1455 g, t dbSNP:199469472
1456 1456 a, t dbSNP:760579201
1458 1458 a, g dbSNP:764364405
1469 1469 a, g dbSNP:770534863
1485 1485 c, t dbSNP:761888935
1493 1493 c, t dbSNP:765303744
1495 1495 a, g dbSNP:750931702
1496 1496 c, t dbSNP:151319700
1497 1497 a, g dbSNP:766695272
1499 1499 c, t dbSNP:377613736
1502 1502 c, t dbSNP:755354438
1516 1516 a, g dbSNP:777348309
1518 1518 c, t dbSNP:753436021
1523 1523 c, g, t dbSNP:748650244
1529 1529 c, g dbSNP:121918142
1530 1530 a, c dbSNP:200012319
1532 1532 c, g dbSNP:121918157
1539 1539 c, t dbSNP:368520760
1541 1541 c, t dbSNP:367727016
1542 1542 a, g dbSNP:772096495
1551 1551 a, g dbSNP:780162904
1553 1553 a, g dbSNP:371265125
1556 1556 a, g dbSNP:374484815
1571 1571 c, g dbSNP:776993248
1576 1576 a, c dbSNP:367745240
1579 1579 c, t dbSNP:769898505
1581 1581 c, t dbSNP:370298954
1584 1584 c, t dbSNP:199900627
1588 1588 c, t dbSNP:766818039
1603 1603 a, g dbSNP:752071296
1615 1615 a, g dbSNP:759828747
1626 1626 a, g dbSNP:577754626
1643 1643 -, g dbSNP:369564006
1655 1655 c, t dbSNP:546314105
1656 1656 c, t dbSNP:199469473
1700 1700 c, g dbSNP:1042759
1729 1729 c, t dbSNP:140461934
1737 1737 a, t dbSNP:76963348
1753 1753 g, t dbSNP:563767423
1759 1759 c, t dbSNP:150393087
1791 1791 a, g dbSNP:547719046
1810 1810 a, g dbSNP:542260333
1829 1829 g, t dbSNP:769502673
1850 1850 a, g dbSNP:775089029
1851 1851 a, c, t dbSNP:562021279
1873 1873 c, t dbSNP:527994566
1876 1876 c, t dbSNP:548104755

Target ORF information:

RefSeq Version XM_005263715
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263715

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTCTTC CGCCCTGACG 
GCCAGCACAC AGGGACAGCC CTTTCATTCC GCTTCCACCT GGGGGTGCAG GCAGAGCAGC
AGCGGGGGTA GGCACTGCCC GGAGCTCAGA AGTCCTCCTC AGACAGGTGC CAGTGCCTCC
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36436
Accession Version XM_005263716.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1551bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804596. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGGTGAGGG GGAGAGGTGG
ATGCTGGCGG GCGGCGGGGC GGGGCTGGGG CCGGGTTGGG GGCGCGGCAC CAGCACCAGC
TGCCCGCGCC CTCCCCTGCC CGCAGAGGTG AGCTTCCTCA ATTGCTCGCT GGACAACGGC
GGCTGCACGC ATTACTGCCT AGAGGAGGTG GGCTGGCGGC GCTGTAGCTG TGCGCCTGGC
TACAAGCTGG GGGACGACCT CCTGCAGTGT CACCCCGCAG TGAAGTTCCC TTGTGGGAGG
CCCTGGAAGC GGATGGAGAA GAAGCGCAGT CACCTGAAAC GAGACACAGA AGACCAAGAA
GACCAAGTAG ATCCGCGGCT CATTGATGGG AAGATGACCA GGCGGGGAGA CAGCCCCTGG
CAGGTGGTCC TGCTGGACTC AAAGAAGAAG CTGGCCTGCG GGGCAGTGCT CATCCACCCC
TCCTGGGTGC TGACAGCGGC CCACTGCATG GATGAGTCCA AGAAGCTCCT TGTCAGGCTT
GGAGAGTATG ACCTGCGGCG CTGGGAGAAG TGGGAGCTGG ACCTGGACAT CAAGGAGGTC
TTCGTCCACC CCAACTACAG CAAGAGCACC ACCGACAATG ACATCGCACT GCTGCACCTG
GCCCAGCCCG CCACCCTCTC GCAGACCATA GTGCCCATCT GCCTCCCGGA CAGCGGCCTT
GCAGAGCGCG AGCTCAATCA GGCCGGCCAG GAGACCCTCG TGACGGGCTG GGGCTACCAC
AGCAGCCGAG AGAAGGAGGC CAAGAGAAAC CGCACCTTCG TCCTCAACTT CATCAAGATT
CCCGTGGTCC CGCACAATGA GTGCAGCGAG GTCATGAGCA ACATGGTGTC TGAGAACATG
CTGTGTGCGG GCATCCTCGG GGACCGGCAG GATGCCTGCG AGGGCGACAG TGGGGGGCCC
ATGGTCGCCT CCTTCCACGG CACCTGGTTC CTGGTGGGCC TGGTGAGCTG GGGTGAGGGC
TGTGGGCTCC TTCACAACTA CGGCGTTTAC ACCAAAGTCA GCCGCTACCT CGACTGGATC
CATGGGCACA TCAGAGACAA GGAAGCCCCC CAGAAGAGCT GGGCACCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_005263773.1
CDS43..1593
Misc Feature(1)175..366(+)
Misc Feature(2)406..501(+)
Misc Feature(3)625..732(+)
Misc Feature(4)838..1542(+)
Misc Feature(5)844..1551(+)
Misc Feature(6)964..1413(+)
Misc Feature(7)1393..1476(+)
Translation
Position Chain Variation Link
18 18 a, g dbSNP:539731824
28 28 a, g dbSNP:534761987
47 47 c, t dbSNP:779957591
48 48 a, g dbSNP:765866655
56 56 a, g dbSNP:2069936
58 58 c, t dbSNP:148484185
59 59 a, g dbSNP:536613560
60 60 a, t dbSNP:1799810
71 71 c, t dbSNP:755811200
77 77 c, t dbSNP:116169054
83 83 a, c, g dbSNP:542542577
84 84 a, c dbSNP:751804431
117 117 c, t dbSNP:750696079
119 119 c, g dbSNP:759805372
124 124 c, t dbSNP:758494619
132 132 a, g dbSNP:780186160
135 135 c, t dbSNP:148490199
136 136 a, g dbSNP:368493458
142 142 a, c dbSNP:781386476
144 144 c, t dbSNP:748548752
146 146 a, g dbSNP:758576042
156 156 c, t dbSNP:770171684
157 157 a, g, t dbSNP:146793243
169 169 c, g dbSNP:771569764
170 170 c, t dbSNP:775126434
171 171 c, t dbSNP:144300387
177 177 c, t dbSNP:764423112
181 181 a, g dbSNP:754243426
195 195 a, c, t dbSNP:552714462
196 196 a, g dbSNP:779710709
200 200 c, g dbSNP:746654539
210 210 c, g dbSNP:754445822
214 214 c, g dbSNP:780914969
215 215 c, t dbSNP:748083494
217 217 c, t dbSNP:769900251
218 218 a, g dbSNP:773107370
223 223 c, t dbSNP:199514227
224 224 a, g dbSNP:770650361
229 229 c, t dbSNP:774572099
230 230 a, g dbSNP:369504169
232 232 a, g dbSNP:767626189
237 237 c, t dbSNP:775598456
243 243 c, g dbSNP:141040323
256 256 c, t dbSNP:764546127
265 265 a, t dbSNP:376049280
274 274 c, t dbSNP:757583846
275 275 a, g dbSNP:574949343
284 284 c, t dbSNP:751218842
290 290 a, c dbSNP:121918148
303 303 c, g, t dbSNP:201463891
309 309 a, g dbSNP:752294542
313 313 a, g dbSNP:199469481
314 314 a, g, t dbSNP:568473236
331 331 a, g dbSNP:121918149
337 337 a, g dbSNP:749192814
353 353 a, g dbSNP:747236088
359 359 a, g dbSNP:768719609
364 364 a, g dbSNP:145854591
384 384 a, g dbSNP:771415643
391 391 c, t dbSNP:774908523
393 393 c, t dbSNP:760374869
402 402 c, t dbSNP:763618496
405 405 a, g dbSNP:776372871
407 407 a, g dbSNP:761171704
408 408 a, c dbSNP:764808999
409 409 a, g dbSNP:750358099
421 421 g, t dbSNP:199469479
427 427 a, c dbSNP:200234655
434 434 a, c, g dbSNP:370147557
435 435 a, g dbSNP:754797791
445 445 c, g dbSNP:374476971
448 448 a, g dbSNP:201563330
449 449 a, c, t dbSNP:748411379
452 452 a, g dbSNP:777973120
454 454 -, agct dbSNP:199469477
466 466 a, g dbSNP:749796486
484 484 c, g dbSNP:771609822
490 490 c, g dbSNP:775031376
491 491 a, g dbSNP:746190838
504 504 c, t dbSNP:200045749
509 509 -, g dbSNP:746387774
510 510 a, c, g dbSNP:199469478
511 511 g, t dbSNP:527647588
516 516 a, g dbSNP:764641626
518 518 a, g dbSNP:116738363
524 524 g, t dbSNP:571133684
530 530 c, t dbSNP:766261628
537 537 c, t dbSNP:751520400
538 538 a, g dbSNP:759194129
540 540 a, g dbSNP:767344439
571 571 a, g dbSNP:752855475
573 573 c, t dbSNP:756414294
578 578 c, t dbSNP:777687270
580 580 a, g dbSNP:540118149
587 587 c, t dbSNP:757439108
599 599 c, t dbSNP:779507789
609 609 a, g dbSNP:746382956
620 620 c, t dbSNP:772320207
622 622 a, g dbSNP:780527584
626 626 g, t dbSNP:747735192
627 627 a, c dbSNP:769525590
629 629 a, c dbSNP:772880922
630 630 g, t dbSNP:5936
640 640 a, g dbSNP:370813536
644 644 c, g dbSNP:774204335
646 646 a, t dbSNP:759581480
651 651 -, c dbSNP:772629538
653 653 a, c dbSNP:121918159
658 658 c, t dbSNP:767201513
661 661 c, t dbSNP:570143499
669 669 a, g dbSNP:201952795
675 675 c, g dbSNP:201105510
696 696 a, g dbSNP:764364831
706 706 a, g dbSNP:754130317
731 731 a, g dbSNP:199469474
738 738 c, t dbSNP:757343064
741 741 a, g dbSNP:368367611
745 745 a, c dbSNP:370212196
748 748 g, t dbSNP:199469470
754 754 c, t dbSNP:748920874
770 770 a, g dbSNP:568988569
772 772 c, t dbSNP:146922325
778 778 c, g dbSNP:777364878
779 779 -, aga dbSNP:569796900
781 781 -, aag dbSNP:199469469
784 784 a, c dbSNP:771498658
787 787 c, t dbSNP:371071104
788 788 a, g dbSNP:746989553
795 795 c, t dbSNP:768559685
796 796 c, t dbSNP:776617400
797 797 c, t dbSNP:762098236
799 799 a, c dbSNP:765517843
803 803 a, g dbSNP:773327173
809 809 -, agaagacca dbSNP:776940957
814 814 a, g dbSNP:567588026
830 830 c, t dbSNP:772789753
835 835 -, c dbSNP:761891208
836 836 c, t dbSNP:121918145
837 837 a, g dbSNP:2069927
838 838 a, c, t dbSNP:121918143
839 839 a, g dbSNP:199469476
845 845 c, t dbSNP:753097748
849 849 c, t dbSNP:762556160
865 865 c, t dbSNP:121918152
866 866 a, g, t dbSNP:121918153
873 873 c, g dbSNP:771116175
876 876 a, c dbSNP:199469483
882 882 c, g dbSNP:757925208
885 885 c, g dbSNP:121918155
904 904 a, g dbSNP:779585762
910 910 a, c dbSNP:370086431
911 911 a, t dbSNP:754559546
914 914 c, t dbSNP:781215905
920 920 c, g dbSNP:748099849
921 921 c, t dbSNP:141249033
922 922 a, g dbSNP:777486993
923 923 -, g dbSNP:199469475
923 923 a, g dbSNP:749500010
925 925 -, g dbSNP:200187516
930 930 g, t dbSNP:771095734
935 935 c, t dbSNP:774584131
937 937 c, t dbSNP:759557871
939 939 c, t dbSNP:772146306
942 942 c, g dbSNP:775976369
953 953 c, t dbSNP:375156587
959 959 c, t dbSNP:568121876
960 960 a, g dbSNP:764497897
972 972 a, g dbSNP:754195274
975 975 c, t dbSNP:5937
1000 1000 c, t dbSNP:121918156
1002 1002 c, t dbSNP:765900344
1014 1014 c, t dbSNP:765637777
1017 1017 a, c, g dbSNP:371007615
1018 1018 c, t dbSNP:767112991
1019 1019 g, t dbSNP:752290840
1021 1021 c, t dbSNP:121918154
1027 1027 g, t dbSNP:563901001
1032 1032 a, g dbSNP:753825629
1039 1039 c, g dbSNP:757001092
1041 1041 a, g dbSNP:146289521
1044 1044 c, t dbSNP:778740796
1049 1049 a, t dbSNP:375179157
1055 1055 -, agg dbSNP:752654447
1056 1056 g, t dbSNP:758660570
1059 1059 a, g dbSNP:780286813
1066 1066 a, g dbSNP:764737827
1071 1071 c, t dbSNP:768796120
1073 1073 c, t dbSNP:121918151
1082 1082 a, g dbSNP:202150408
1085 1085 a, g dbSNP:144233408
1088 1088 a, g dbSNP:200721675
1091 1091 c, t dbSNP:773761677
1095 1095 c, t dbSNP:759229398
1096 1096 a, c, g dbSNP:199469471
1098 1098 c, t dbSNP:5935
1107 1107 c, t dbSNP:112356403
1109 1109 c, t dbSNP:121918144
1110 1110 a, c dbSNP:753709157
1117 1117 c, t dbSNP:757272256
1121 1121 -, t dbSNP:34222720
1131 1131 c, t dbSNP:13388546
1132 1132 a, g dbSNP:121918146
1134 1134 c, t dbSNP:200731614
1142 1142 c, t dbSNP:121918160
1143 1143 a, g dbSNP:199679356
1149 1149 c, g dbSNP:755005848
1153 1153 a, g dbSNP:762519738
1158 1158 a, c dbSNP:781389633
1170 1170 a, c, g dbSNP:748577703
1173 1173 c, t dbSNP:778455687
1176 1176 a, c, t dbSNP:568793026
1177 1177 a, g dbSNP:571278160
1187 1187 a, t dbSNP:199469480
1189 1189 c, t dbSNP:201907715
1191 1191 c, t dbSNP:760435505
1192 1192 a, g dbSNP:757023301
1199 1199 a, g dbSNP:776245026
1201 1201 c, g dbSNP:761348643
1206 1206 c, t dbSNP:765115028
1207 1207 a, g dbSNP:121918150
1217 1217 c, t dbSNP:369881972
1221 1221 c, t dbSNP:762672544
1222 1222 a, g dbSNP:121918158
1226 1226 c, t dbSNP:766261022
1227 1227 a, g dbSNP:751714439
1230 1230 c, t dbSNP:373299422
1233 1233 c, g dbSNP:781097228
1234 1234 a, g dbSNP:121918147
1237 1237 a, t dbSNP:752782202
1249 1249 c, t dbSNP:121918141
1250 1250 a, g dbSNP:201827066
1254 1254 c, g dbSNP:749815057
1257 1257 a, g dbSNP:771411580
1265 1265 a, g dbSNP:779384632
1268 1268 a, g dbSNP:746611530
1272 1272 c, t dbSNP:548020208
1273 1273 c, t dbSNP:776173921
1274 1274 a, g, t dbSNP:763603757
1281 1281 c, t dbSNP:769300513
1282 1282 a, g, t dbSNP:375912553
1284 1284 c, g dbSNP:766061833
1305 1305 c, t dbSNP:751406743
1306 1306 a, g dbSNP:140582220
1307 1307 c, t dbSNP:767730328
1309 1309 a, g dbSNP:752981292
1314 1314 a, g dbSNP:61731660
1317 1317 a, c dbSNP:778063605
1318 1318 a, g dbSNP:145800354
1322 1322 a, g dbSNP:555974192
1327 1327 a, t dbSNP:757880924
1328 1328 a, g dbSNP:779319957
1329 1329 c, t dbSNP:187228759
1330 1330 a, g dbSNP:368901479
1338 1338 a, g dbSNP:780833999
1368 1368 c, t dbSNP:148855579
1370 1370 c, g dbSNP:769277939
1371 1371 a, g dbSNP:373028935
1381 1381 a, c, g dbSNP:756467027
1386 1386 c, t dbSNP:148035465
1387 1387 c, t dbSNP:759316085
1388 1388 a, g dbSNP:767219916
1391 1391 a, g dbSNP:775849125
1401 1401 c, t dbSNP:146028808
1402 1402 a, g dbSNP:764239787
1403 1403 a, c dbSNP:201399407
1407 1407 c, t dbSNP:780422419
1408 1408 a, g dbSNP:142742242
1419 1419 a, g dbSNP:370637632
1424 1424 a, t dbSNP:758788677
1425 1425 a, g dbSNP:780456728
1428 1428 c, t dbSNP:747775229
1429 1429 a, g dbSNP:374259918
1440 1440 c, t dbSNP:777430545
1441 1441 a, g dbSNP:139741458
1444 1444 a, g dbSNP:572021052
1448 1448 c, g dbSNP:768759265
1450 1450 c, t dbSNP:745857900
1456 1456 c, g dbSNP:144760718
1461 1461 c, t dbSNP:775467256
1465 1465 g, t dbSNP:199469472
1466 1466 a, t dbSNP:760579201
1468 1468 a, g dbSNP:764364405
1479 1479 a, g dbSNP:770534863
1495 1495 c, t dbSNP:761888935
1503 1503 c, t dbSNP:765303744
1505 1505 a, g dbSNP:750931702
1506 1506 c, t dbSNP:151319700
1507 1507 a, g dbSNP:766695272
1509 1509 c, t dbSNP:377613736
1512 1512 c, t dbSNP:755354438
1526 1526 a, g dbSNP:777348309
1528 1528 c, t dbSNP:753436021
1533 1533 c, g, t dbSNP:748650244
1539 1539 c, g dbSNP:121918142
1540 1540 a, c dbSNP:200012319
1542 1542 c, g dbSNP:121918157
1549 1549 c, t dbSNP:368520760
1551 1551 c, t dbSNP:367727016
1552 1552 a, g dbSNP:772096495
1561 1561 a, g dbSNP:780162904
1563 1563 a, g dbSNP:371265125
1566 1566 a, g dbSNP:374484815
1581 1581 c, g dbSNP:776993248
1586 1586 a, c dbSNP:367745240
1589 1589 c, t dbSNP:769898505
1591 1591 c, t dbSNP:370298954
1594 1594 c, t dbSNP:199900627
1598 1598 c, t dbSNP:766818039
1613 1613 a, g dbSNP:752071296
1625 1625 a, g dbSNP:759828747
1636 1636 a, g dbSNP:577754626
1653 1653 -, g dbSNP:369564006
1665 1665 c, t dbSNP:546314105
1666 1666 c, t dbSNP:199469473
1710 1710 c, g dbSNP:1042759
1739 1739 c, t dbSNP:140461934
1747 1747 a, t dbSNP:76963348
1763 1763 g, t dbSNP:563767423
1769 1769 c, t dbSNP:150393087
1801 1801 a, g dbSNP:547719046
1820 1820 a, g dbSNP:542260333
1839 1839 g, t dbSNP:769502673
1860 1860 a, g dbSNP:775089029
1861 1861 a, c, t dbSNP:562021279
1883 1883 c, t dbSNP:527994566
1886 1886 c, t dbSNP:548104755

Target ORF information:

RefSeq Version XM_005263716
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263716

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGGTGAGGG GGAGAGGTGG
ATGCTGGCGG GCGGCGGGGC GGGGCTGGGG CCGGGTTGGG GGCGCGGCAC CAGCACCAGC
TGCCCGCGCC CTCCCCTGCC CGCAGAGGTG AGCTTCCTCA ATTGCTCGCT GGACAACGGC
GGCTGCACGC ATTACTGCCT AGAGGAGGTG GGCTGGCGGC GCTGTAGCTG TGCGCCTGGC
TACAAGCTGG GGGACGACCT CCTGCAGTGT CACCCCGCAG TGAAGTTCCC TTGTGGGAGG
CCCTGGAAGC GGATGGAGAA GAAGCGCAGT CACCTGAAAC GAGACACAGA AGACCAAGAA
GACCAAGTAG ATCCGCGGCT CATTGATGGG AAGATGACCA GGCGGGGAGA CAGCCCCTGG
CAGGTGGTCC TGCTGGACTC AAAGAAGAAG CTGGCCTGCG GGGCAGTGCT CATCCACCCC
TCCTGGGTGC TGACAGCGGC CCACTGCATG GATGAGTCCA AGAAGCTCCT TGTCAGGCTT
GGAGAGTATG ACCTGCGGCG CTGGGAGAAG TGGGAGCTGG ACCTGGACAT CAAGGAGGTC
TTCGTCCACC CCAACTACAG CAAGAGCACC ACCGACAATG ACATCGCACT GCTGCACCTG
GCCCAGCCCG CCACCCTCTC GCAGACCATA GTGCCCATCT GCCTCCCGGA CAGCGGCCTT
GCAGAGCGCG AGCTCAATCA GGCCGGCCAG GAGACCCTCG TGACGGGCTG GGGCTACCAC
AGCAGCCGAG AGAAGGAGGC CAAGAGAAAC CGCACCTTCG TCCTCAACTT CATCAAGATT
CCCGTGGTCC CGCACAATGA GTGCAGCGAG GTCATGAGCA ACATGGTGTC TGAGAACATG
CTGTGTGCGG GCATCCTCGG GGACCGGCAG GATGCCTGCG AGGGCGACAG TGGGGGGCCC
ATGGTCGCCT CCTTCCACGG CACCTGGTTC CTGGTGGGCC TGGTGAGCTG GGGTGAGGGC
TGTGGGCTCC TTCACAACTA CGGCGTTTAC ACCAAAGTCA GCCGCTACCT CGACTGGATC
CATGGGCACA TCAGAGACAA GGAAGCCCCC CAGAAGAGCT GGGCACCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu36437
Accession Version XM_005263717.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1449bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_005403.18) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578804597. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_005263774.1
CDS28..1476
Misc Feature(1)160..351(+)
Misc Feature(2)391..486(+)
Misc Feature(3)508..615(+)
Misc Feature(4)721..1425(+)
Misc Feature(5)727..1434(+)
Misc Feature(6)847..1296(+)
Misc Feature(7)1276..1359(+)
Translation
Position Chain Variation Link
3 3 a, g dbSNP:539731824
13 13 a, g dbSNP:534761987
32 32 c, t dbSNP:779957591
33 33 a, g dbSNP:765866655
41 41 a, g dbSNP:2069936
43 43 c, t dbSNP:148484185
44 44 a, g dbSNP:536613560
45 45 a, t dbSNP:1799810
56 56 c, t dbSNP:755811200
62 62 c, t dbSNP:116169054
68 68 a, c, g dbSNP:542542577
69 69 a, c dbSNP:751804431
102 102 c, t dbSNP:750696079
104 104 c, g dbSNP:759805372
109 109 c, t dbSNP:758494619
117 117 a, g dbSNP:780186160
120 120 c, t dbSNP:148490199
121 121 a, g dbSNP:368493458
127 127 a, c dbSNP:781386476
129 129 c, t dbSNP:748548752
131 131 a, g dbSNP:758576042
141 141 c, t dbSNP:770171684
142 142 a, g, t dbSNP:146793243
154 154 c, g dbSNP:771569764
155 155 c, t dbSNP:775126434
156 156 c, t dbSNP:144300387
162 162 c, t dbSNP:764423112
166 166 a, g dbSNP:754243426
180 180 a, c, t dbSNP:552714462
181 181 a, g dbSNP:779710709
185 185 c, g dbSNP:746654539
195 195 c, g dbSNP:754445822
199 199 c, g dbSNP:780914969
200 200 c, t dbSNP:748083494
202 202 c, t dbSNP:769900251
203 203 a, g dbSNP:773107370
208 208 c, t dbSNP:199514227
209 209 a, g dbSNP:770650361
214 214 c, t dbSNP:774572099
215 215 a, g dbSNP:369504169
217 217 a, g dbSNP:767626189
222 222 c, t dbSNP:775598456
228 228 c, g dbSNP:141040323
241 241 c, t dbSNP:764546127
250 250 a, t dbSNP:376049280
259 259 c, t dbSNP:757583846
260 260 a, g dbSNP:574949343
269 269 c, t dbSNP:751218842
275 275 a, c dbSNP:121918148
288 288 c, g, t dbSNP:201463891
294 294 a, g dbSNP:752294542
298 298 a, g dbSNP:199469481
299 299 a, g, t dbSNP:568473236
316 316 a, g dbSNP:121918149
322 322 a, g dbSNP:749192814
338 338 a, g dbSNP:747236088
344 344 a, g dbSNP:768719609
349 349 a, g dbSNP:145854591
369 369 a, g dbSNP:771415643
376 376 c, t dbSNP:774908523
378 378 c, t dbSNP:760374869
387 387 c, t dbSNP:763618496
390 390 a, g dbSNP:776372871
392 392 a, g dbSNP:761171704
393 393 a, c dbSNP:764808999
394 394 a, g dbSNP:750358099
406 406 g, t dbSNP:199469479
412 412 a, c dbSNP:200234655
419 419 a, c, g dbSNP:370147557
420 420 a, g dbSNP:754797791
430 430 c, g dbSNP:374476971
433 433 a, g dbSNP:201563330
434 434 a, c, t dbSNP:748411379
437 437 a, g dbSNP:777973120
439 439 -, agct dbSNP:199469477
451 451 a, g dbSNP:749796486
469 469 c, g dbSNP:771609822
475 475 c, g dbSNP:775031376
476 476 a, g dbSNP:746190838
489 489 c, t dbSNP:200045749
492 492 a, g dbSNP:746382956
503 503 c, t dbSNP:772320207
505 505 a, g dbSNP:780527584
509 509 g, t dbSNP:747735192
510 510 a, c dbSNP:769525590
512 512 a, c dbSNP:772880922
513 513 g, t dbSNP:5936
523 523 a, g dbSNP:370813536
527 527 c, g dbSNP:774204335
529 529 a, t dbSNP:759581480
534 534 -, c dbSNP:772629538
536 536 a, c dbSNP:121918159
541 541 c, t dbSNP:767201513
544 544 c, t dbSNP:570143499
552 552 a, g dbSNP:201952795
558 558 c, g dbSNP:201105510
579 579 a, g dbSNP:764364831
589 589 a, g dbSNP:754130317
614 614 a, g dbSNP:199469474
621 621 c, t dbSNP:757343064
624 624 a, g dbSNP:368367611
628 628 a, c dbSNP:370212196
631 631 g, t dbSNP:199469470
637 637 c, t dbSNP:748920874
653 653 a, g dbSNP:568988569
655 655 c, t dbSNP:146922325
661 661 c, g dbSNP:777364878
662 662 -, aga dbSNP:569796900
664 664 -, aag dbSNP:199469469
667 667 a, c dbSNP:771498658
670 670 c, t dbSNP:371071104
671 671 a, g dbSNP:746989553
678 678 c, t dbSNP:768559685
679 679 c, t dbSNP:776617400
680 680 c, t dbSNP:762098236
682 682 a, c dbSNP:765517843
686 686 a, g dbSNP:773327173
692 692 -, agaagacca dbSNP:776940957
697 697 a, g dbSNP:567588026
713 713 c, t dbSNP:772789753
718 718 -, c dbSNP:761891208
719 719 c, t dbSNP:121918145
720 720 a, g dbSNP:2069927
721 721 a, c, t dbSNP:121918143
722 722 a, g dbSNP:199469476
728 728 c, t dbSNP:753097748
732 732 c, t dbSNP:762556160
748 748 c, t dbSNP:121918152
749 749 a, g, t dbSNP:121918153
756 756 c, g dbSNP:771116175
759 759 a, c dbSNP:199469483
765 765 c, g dbSNP:757925208
768 768 c, g dbSNP:121918155
787 787 a, g dbSNP:779585762
793 793 a, c dbSNP:370086431
794 794 a, t dbSNP:754559546
797 797 c, t dbSNP:781215905
803 803 c, g dbSNP:748099849
804 804 c, t dbSNP:141249033
805 805 a, g dbSNP:777486993
806 806 -, g dbSNP:199469475
806 806 a, g dbSNP:749500010
808 808 -, g dbSNP:200187516
813 813 g, t dbSNP:771095734
818 818 c, t dbSNP:774584131
820 820 c, t dbSNP:759557871
822 822 c, t dbSNP:772146306
825 825 c, g dbSNP:775976369
836 836 c, t dbSNP:375156587
842 842 c, t dbSNP:568121876
843 843 a, g dbSNP:764497897
855 855 a, g dbSNP:754195274
858 858 c, t dbSNP:5937
883 883 c, t dbSNP:121918156
885 885 c, t dbSNP:765900344
897 897 c, t dbSNP:765637777
900 900 a, c, g dbSNP:371007615
901 901 c, t dbSNP:767112991
902 902 g, t dbSNP:752290840
904 904 c, t dbSNP:121918154
910 910 g, t dbSNP:563901001
915 915 a, g dbSNP:753825629
922 922 c, g dbSNP:757001092
924 924 a, g dbSNP:146289521
927 927 c, t dbSNP:778740796
932 932 a, t dbSNP:375179157
938 938 -, agg dbSNP:752654447
939 939 g, t dbSNP:758660570
942 942 a, g dbSNP:780286813
949 949 a, g dbSNP:764737827
954 954 c, t dbSNP:768796120
956 956 c, t dbSNP:121918151
965 965 a, g dbSNP:202150408
968 968 a, g dbSNP:144233408
971 971 a, g dbSNP:200721675
974 974 c, t dbSNP:773761677
978 978 c, t dbSNP:759229398
979 979 a, c, g dbSNP:199469471
981 981 c, t dbSNP:5935
990 990 c, t dbSNP:112356403
992 992 c, t dbSNP:121918144
993 993 a, c dbSNP:753709157
1000 1000 c, t dbSNP:757272256
1004 1004 -, t dbSNP:34222720
1014 1014 c, t dbSNP:13388546
1015 1015 a, g dbSNP:121918146
1017 1017 c, t dbSNP:200731614
1025 1025 c, t dbSNP:121918160
1026 1026 a, g dbSNP:199679356
1032 1032 c, g dbSNP:755005848
1036 1036 a, g dbSNP:762519738
1041 1041 a, c dbSNP:781389633
1053 1053 a, c, g dbSNP:748577703
1056 1056 c, t dbSNP:778455687
1059 1059 a, c, t dbSNP:568793026
1060 1060 a, g dbSNP:571278160
1070 1070 a, t dbSNP:199469480
1072 1072 c, t dbSNP:201907715
1074 1074 c, t dbSNP:760435505
1075 1075 a, g dbSNP:757023301
1082 1082 a, g dbSNP:776245026
1084 1084 c, g dbSNP:761348643
1089 1089 c, t dbSNP:765115028
1090 1090 a, g dbSNP:121918150
1100 1100 c, t dbSNP:369881972
1104 1104 c, t dbSNP:762672544
1105 1105 a, g dbSNP:121918158
1109 1109 c, t dbSNP:766261022
1110 1110 a, g dbSNP:751714439
1113 1113 c, t dbSNP:373299422
1116 1116 c, g dbSNP:781097228
1117 1117 a, g dbSNP:121918147
1120 1120 a, t dbSNP:752782202
1132 1132 c, t dbSNP:121918141
1133 1133 a, g dbSNP:201827066
1137 1137 c, g dbSNP:749815057
1140 1140 a, g dbSNP:771411580
1148 1148 a, g dbSNP:779384632
1151 1151 a, g dbSNP:746611530
1155 1155 c, t dbSNP:548020208
1156 1156 c, t dbSNP:776173921
1157 1157 a, g, t dbSNP:763603757
1164 1164 c, t dbSNP:769300513
1165 1165 a, g, t dbSNP:375912553
1167 1167 c, g dbSNP:766061833
1188 1188 c, t dbSNP:751406743
1189 1189 a, g dbSNP:140582220
1190 1190 c, t dbSNP:767730328
1192 1192 a, g dbSNP:752981292
1197 1197 a, g dbSNP:61731660
1200 1200 a, c dbSNP:778063605
1201 1201 a, g dbSNP:145800354
1205 1205 a, g dbSNP:555974192
1210 1210 a, t dbSNP:757880924
1211 1211 a, g dbSNP:779319957
1212 1212 c, t dbSNP:187228759
1213 1213 a, g dbSNP:368901479
1221 1221 a, g dbSNP:780833999
1251 1251 c, t dbSNP:148855579
1253 1253 c, g dbSNP:769277939
1254 1254 a, g dbSNP:373028935
1264 1264 a, c, g dbSNP:756467027
1269 1269 c, t dbSNP:148035465
1270 1270 c, t dbSNP:759316085
1271 1271 a, g dbSNP:767219916
1274 1274 a, g dbSNP:775849125
1284 1284 c, t dbSNP:146028808
1285 1285 a, g dbSNP:764239787
1286 1286 a, c dbSNP:201399407
1290 1290 c, t dbSNP:780422419
1291 1291 a, g dbSNP:142742242
1302 1302 a, g dbSNP:370637632
1307 1307 a, t dbSNP:758788677
1308 1308 a, g dbSNP:780456728
1311 1311 c, t dbSNP:747775229
1312 1312 a, g dbSNP:374259918
1323 1323 c, t dbSNP:777430545
1324 1324 a, g dbSNP:139741458
1327 1327 a, g dbSNP:572021052
1331 1331 c, g dbSNP:768759265
1333 1333 c, t dbSNP:745857900
1339 1339 c, g dbSNP:144760718
1344 1344 c, t dbSNP:775467256
1348 1348 g, t dbSNP:199469472
1349 1349 a, t dbSNP:760579201
1351 1351 a, g dbSNP:764364405
1362 1362 a, g dbSNP:770534863
1378 1378 c, t dbSNP:761888935
1386 1386 c, t dbSNP:765303744
1388 1388 a, g dbSNP:750931702
1389 1389 c, t dbSNP:151319700
1390 1390 a, g dbSNP:766695272
1392 1392 c, t dbSNP:377613736
1395 1395 c, t dbSNP:755354438
1409 1409 a, g dbSNP:777348309
1411 1411 c, t dbSNP:753436021
1416 1416 c, g, t dbSNP:748650244
1422 1422 c, g dbSNP:121918142
1423 1423 a, c dbSNP:200012319
1425 1425 c, g dbSNP:121918157
1432 1432 c, t dbSNP:368520760
1434 1434 c, t dbSNP:367727016
1435 1435 a, g dbSNP:772096495
1444 1444 a, g dbSNP:780162904
1446 1446 a, g dbSNP:371265125
1449 1449 a, g dbSNP:374484815
1464 1464 c, g dbSNP:776993248
1469 1469 a, c dbSNP:367745240
1472 1472 c, t dbSNP:769898505
1474 1474 c, t dbSNP:370298954
1477 1477 c, t dbSNP:199900627
1481 1481 c, t dbSNP:766818039
1496 1496 a, g dbSNP:752071296
1508 1508 a, g dbSNP:759828747
1519 1519 a, g dbSNP:577754626
1536 1536 -, g dbSNP:369564006
1548 1548 c, t dbSNP:546314105
1549 1549 c, t dbSNP:199469473
1593 1593 c, g dbSNP:1042759
1622 1622 c, t dbSNP:140461934
1630 1630 a, t dbSNP:76963348
1646 1646 g, t dbSNP:563767423
1652 1652 c, t dbSNP:150393087
1684 1684 a, g dbSNP:547719046
1703 1703 a, g dbSNP:542260333
1722 1722 g, t dbSNP:769502673
1743 1743 a, g dbSNP:775089029
1744 1744 a, c, t dbSNP:562021279
1766 1766 c, t dbSNP:527994566
1769 1769 c, t dbSNP:548104755

Target ORF information:

RefSeq Version XM_005263717
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263717

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
ATGGCGGCAG GACGGCGAAC TTGCAGTATC TCCACGACCC GCCCCTGTGC CAGTGCCTCC 
AGAATGTGGC AGCTCACAAG CCTCCTGCTG TTCGTGGCCA CCTGGGGAAT TTCCGGCACA
CCAGCTCCTC TTGACTCAGT GTTCTCCAGC AGCGAGCGTG CCCACCAGGT GCTGCGGATC
CGCAAACGTG CCAACTCCTT CCTGGAGGAG CTCCGTCACA GCAGCCTGGA GCGGGAGTGC
ATAGAGGAGA TCTGTGACTT CGAGGAGGCC AAGGAAATTT TCCAAAATGT GGATGACACA
CTGGCCTTCT GGTCCAAGCA CGTCGACGGT GACCAGTGCT TGGTCTTGCC CTTGGAGCAC
CCGTGCGCCA GCCTGTGCTG CGGGCACGGC ACGTGCATCG ACGGCATCGG CAGCTTCAGC
TGCGACTGCC GCAGCGGCTG GGAGGGCCGC TTCTGCCAGC GCGAGGTGAG CTTCCTCAAT
TGCTCGCTGG ACAACGGCGG CTGCACGCAT TACTGCCTAG AGGAGGTGGG CTGGCGGCGC
TGTAGCTGTG CGCCTGGCTA CAAGCTGGGG GACGACCTCC TGCAGTGTCA CCCCGCAGTG
AAGTTCCCTT GTGGGAGGCC CTGGAAGCGG ATGGAGAAGA AGCGCAGTCA CCTGAAACGA
GACACAGAAG ACCAAGAAGA CCAAGTAGAT CCGCGGCTCA TTGATGGGAA GATGACCAGG
CGGGGAGACA GCCCCTGGCA GGTGGTCCTG CTGGACTCAA AGAAGAAGCT GGCCTGCGGG
GCAGTGCTCA TCCACCCCTC CTGGGTGCTG ACAGCGGCCC ACTGCATGGA TGAGTCCAAG
AAGCTCCTTG TCAGGCTTGG AGAGTATGAC CTGCGGCGCT GGGAGAAGTG GGAGCTGGAC
CTGGACATCA AGGAGGTCTT CGTCCACCCC AACTACAGCA AGAGCACCAC CGACAATGAC
ATCGCACTGC TGCACCTGGC CCAGCCCGCC ACCCTCTCGC AGACCATAGT GCCCATCTGC
CTCCCGGACA GCGGCCTTGC AGAGCGCGAG CTCAATCAGG CCGGCCAGGA GACCCTCGTG
ACGGGCTGGG GCTACCACAG CAGCCGAGAG AAGGAGGCCA AGAGAAACCG CACCTTCGTC
CTCAACTTCA TCAAGATTCC CGTGGTCCCG CACAATGAGT GCAGCGAGGT CATGAGCAAC
ATGGTGTCTG AGAACATGCT GTGTGCGGGC ATCCTCGGGG ACCGGCAGGA TGCCTGCGAG
GGCGACAGTG GGGGGCCCAT GGTCGCCTCC TTCCACGGCA CCTGGTTCCT GGTGGGCCTG
GTGAGCTGGG GTGAGGGCTG TGGGCTCCTT CACAACTACG GCGTTTACAC CAAAGTCAGC
CGCTACCTCG ACTGGATCCA TGGGCACATC AGAGACAAGG AAGCCCCCCA GAAGAGCTGG
GCACCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20007
Accession Version NM_000312.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1386bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product vitamin K-dependent protein C preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA642156.1, BC034377.1 and BM975043.1. This sequence is a reference standard in the RefSeqGene project. On Dec 10, 2009 this sequence version replaced gi:109389366. Summary: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X02750.1, BC034377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2145122 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGCAGC TCACAAGCCT CCTGCTGTTC GTGGCCACCT GGGGAATTTC CGGCACACCA 
GCTCCTCTTG ACTCAGTGTT CTCCAGCAGC GAGCGTGCCC ACCAGGTGCT GCGGATCCGC
AAACGTGCCA ACTCCTTCCT GGAGGAGCTC CGTCACAGCA GCCTGGAGCG GGAGTGCATA
GAGGAGATCT GTGACTTCGA GGAGGCCAAG GAAATTTTCC AAAATGTGGA TGACACACTG
GCCTTCTGGT CCAAGCACGT CGACGGTGAC CAGTGCTTGG TCTTGCCCTT GGAGCACCCG
TGCGCCAGCC TGTGCTGCGG GCACGGCACG TGCATCGACG GCATCGGCAG CTTCAGCTGC
GACTGCCGCA GCGGCTGGGA GGGCCGCTTC TGCCAGCGCG AGGTGAGCTT CCTCAATTGC
TCGCTGGACA ACGGCGGCTG CACGCATTAC TGCCTAGAGG AGGTGGGCTG GCGGCGCTGT
AGCTGTGCGC CTGGCTACAA GCTGGGGGAC GACCTCCTGC AGTGTCACCC CGCAGTGAAG
TTCCCTTGTG GGAGGCCCTG GAAGCGGATG GAGAAGAAGC GCAGTCACCT GAAACGAGAC
ACAGAAGACC AAGAAGACCA AGTAGATCCG CGGCTCATTG ATGGGAAGAT GACCAGGCGG
GGAGACAGCC CCTGGCAGGT GGTCCTGCTG GACTCAAAGA AGAAGCTGGC CTGCGGGGCA
GTGCTCATCC ACCCCTCCTG GGTGCTGACA GCGGCCCACT GCATGGATGA GTCCAAGAAG
CTCCTTGTCA GGCTTGGAGA GTATGACCTG CGGCGCTGGG AGAAGTGGGA GCTGGACCTG
GACATCAAGG AGGTCTTCGT CCACCCCAAC TACAGCAAGA GCACCACCGA CAATGACATC
GCACTGCTGC ACCTGGCCCA GCCCGCCACC CTCTCGCAGA CCATAGTGCC CATCTGCCTC
CCGGACAGCG GCCTTGCAGA GCGCGAGCTC AATCAGGCCG GCCAGGAGAC CCTCGTGACG
GGCTGGGGCT ACCACAGCAG CCGAGAGAAG GAGGCCAAGA GAAACCGCAC CTTCGTCCTC
AACTTCATCA AGATTCCCGT GGTCCCGCAC AATGAGTGCA GCGAGGTCAT GAGCAACATG
GTGTCTGAGA ACATGCTGTG TGCGGGCATC CTCGGGGACC GGCAGGATGC CTGCGAGGGC
GACAGTGGGG GGCCCATGGT CGCCTCCTTC CACGGCACCT GGTTCCTGGT GGGCCTGGTG
AGCTGGGGTG AGGGCTGTGG GCTCCTTCAC AACTACGGCG TTTACACCAA AGTCAGCCGC
TACCTCGACT GGATCCATGG GCACATCAGA GACAAGGAAG CCCCCCAGAA GAGCTGGGCA
CCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000303.1
CDS95..1480
Misc Feature(1)164..355(+)
Misc Feature(2)218..220(+)
Misc Feature(3)236..238(+)
Misc Feature(4)236..238(+)
Misc Feature(5)239..241(+)
Misc Feature(6)239..241(+)
Misc Feature(7)260..262(+)
Misc Feature(8)260..262(+)
Misc Feature(9)266..268(+)
Misc Feature(10)266..268(+)
Misc Feature(11)275..277(+)
Misc Feature(12)275..277(+)
Misc Feature(13)278..280(+)
Misc Feature(14)278..280(+)
Misc Feature(15)293..295(+)
Misc Feature(16)293..295(+)
Misc Feature(17)296..298(+)
Misc Feature(18)296..298(+)
Misc Feature(19)305..307(+)
Misc Feature(20)305..307(+)
Misc Feature(21)395..490(+)
Misc Feature(22)431..433(+)
Misc Feature(23)431..433(+)
Misc Feature(24)509..511(+)
Misc Feature(25)512..619(+)
Misc Feature(26)683..685(+)
Misc Feature(27)689..691(+)
Misc Feature(28)725..1429(+)
Misc Feature(29)725..730(+)
Misc Feature(30)731..1438(+)
Misc Feature(31)851..1300(+)
Misc Feature(32)962..964(+)
Misc Feature(33)1157..1159(+)
Misc Feature(34)1205..1207(+)
Misc Feature(35)1280..1363(+)
Exon (1)1..73
Gene:PROC
Gene Synonym:
Exon (2)74..164
Gene:PROC
Gene Synonym:
Exon (3)165..331
Gene:PROC
Gene Synonym:
Exon (4)332..356
Gene:PROC
Gene Synonym:
Exon (5)357..494
Gene:PROC
Gene Synonym:
Exon (6)495..629
Gene:PROC
Gene Synonym:
Exon (7)630..772
Gene:PROC
Gene Synonym:
Exon (8)773..890
Gene:PROC
Gene Synonym:
Exon (9)891..1780
Gene:PROC
Gene Synonym:
Translation
Position Chain Variation Link
3 3 a, g dbSNP:539731824
13 13 a, g dbSNP:534761987
32 32 c, t dbSNP:779957591
33 33 a, g dbSNP:765866655
41 41 a, g dbSNP:2069936
43 43 c, t dbSNP:148484185
44 44 a, g dbSNP:536613560
45 45 a, t dbSNP:1799810
56 56 c, t dbSNP:755811200
62 62 c, t dbSNP:116169054
68 68 a, c, g dbSNP:542542577
69 69 a, c dbSNP:751804431
75 75 c, g dbSNP:752890313
106 106 c, t dbSNP:750696079
108 108 c, g dbSNP:759805372
113 113 c, t dbSNP:758494619
121 121 a, g dbSNP:780186160
124 124 c, t dbSNP:148490199
125 125 a, g dbSNP:368493458
131 131 a, c dbSNP:781386476
133 133 c, t dbSNP:748548752
135 135 a, g dbSNP:758576042
145 145 c, t dbSNP:770171684
146 146 a, g, t dbSNP:146793243
158 158 c, g dbSNP:771569764
159 159 c, t dbSNP:775126434
160 160 c, t dbSNP:144300387
166 166 c, t dbSNP:764423112
170 170 a, g dbSNP:754243426
184 184 a, c, t dbSNP:552714462
185 185 a, g dbSNP:779710709
189 189 c, g dbSNP:746654539
199 199 c, g dbSNP:754445822
203 203 c, g dbSNP:780914969
204 204 c, t dbSNP:748083494
206 206 c, t dbSNP:769900251
207 207 a, g dbSNP:773107370
212 212 c, t dbSNP:199514227
213 213 a, g dbSNP:770650361
218 218 c, t dbSNP:774572099
219 219 a, g dbSNP:369504169
221 221 a, g dbSNP:767626189
226 226 c, t dbSNP:775598456
232 232 c, g dbSNP:141040323
245 245 c, t dbSNP:764546127
254 254 a, t dbSNP:376049280
263 263 c, t dbSNP:757583846
264 264 a, g dbSNP:574949343
273 273 c, t dbSNP:751218842
279 279 a, c dbSNP:121918148
292 292 c, g, t dbSNP:201463891
298 298 a, g dbSNP:752294542
302 302 a, g dbSNP:199469481
303 303 a, g, t dbSNP:568473236
320 320 a, g dbSNP:121918149
326 326 a, g dbSNP:749192814
342 342 a, g dbSNP:747236088
348 348 a, g dbSNP:768719609
353 353 a, g dbSNP:145854591
373 373 a, g dbSNP:771415643
380 380 c, t dbSNP:774908523
382 382 c, t dbSNP:760374869
391 391 c, t dbSNP:763618496
394 394 a, g dbSNP:776372871
396 396 a, g dbSNP:761171704
397 397 a, c dbSNP:764808999
398 398 a, g dbSNP:750358099
410 410 g, t dbSNP:199469479
416 416 a, c dbSNP:200234655
423 423 a, c, g dbSNP:370147557
424 424 a, g dbSNP:754797791
434 434 c, g dbSNP:374476971
437 437 a, g dbSNP:201563330
438 438 a, c, t dbSNP:748411379
441 441 a, g dbSNP:777973120
443 443 -, agct dbSNP:199469477
455 455 a, g dbSNP:749796486
473 473 c, g dbSNP:771609822
479 479 c, g dbSNP:775031376
480 480 a, g dbSNP:746190838
493 493 c, t dbSNP:200045749
496 496 a, g dbSNP:746382956
507 507 c, t dbSNP:772320207
509 509 a, g dbSNP:780527584
513 513 g, t dbSNP:747735192
514 514 a, c dbSNP:769525590
516 516 a, c dbSNP:772880922
517 517 g, t dbSNP:5936
527 527 a, g dbSNP:370813536
531 531 c, g dbSNP:774204335
533 533 a, t dbSNP:759581480
538 538 -, c dbSNP:772629538
540 540 a, c dbSNP:121918159
545 545 c, t dbSNP:767201513
548 548 c, t dbSNP:570143499
556 556 a, g dbSNP:201952795
562 562 c, g dbSNP:201105510
583 583 a, g dbSNP:764364831
593 593 a, g dbSNP:754130317
618 618 a, g dbSNP:199469474
625 625 c, t dbSNP:757343064
628 628 a, g dbSNP:368367611
632 632 a, c dbSNP:370212196
635 635 g, t dbSNP:199469470
641 641 c, t dbSNP:748920874
657 657 a, g dbSNP:568988569
659 659 c, t dbSNP:146922325
665 665 c, g dbSNP:777364878
666 666 -, aga dbSNP:569796900
668 668 -, aag dbSNP:199469469
671 671 a, c dbSNP:771498658
674 674 c, t dbSNP:371071104
675 675 a, g dbSNP:746989553
682 682 c, t dbSNP:768559685
683 683 c, t dbSNP:776617400
684 684 c, t dbSNP:762098236
686 686 a, c dbSNP:765517843
690 690 a, g dbSNP:773327173
696 696 -, agaagacca dbSNP:776940957
701 701 a, g dbSNP:567588026
717 717 c, t dbSNP:772789753
722 722 -, c dbSNP:761891208
723 723 c, t dbSNP:121918145
724 724 a, g dbSNP:2069927
725 725 a, c, t dbSNP:121918143
726 726 a, g dbSNP:199469476
732 732 c, t dbSNP:753097748
736 736 c, t dbSNP:762556160
752 752 c, t dbSNP:121918152
753 753 a, g, t dbSNP:121918153
760 760 c, g dbSNP:771116175
763 763 a, c dbSNP:199469483
769 769 c, g dbSNP:757925208
772 772 c, g dbSNP:121918155
791 791 a, g dbSNP:779585762
797 797 a, c dbSNP:370086431
798 798 a, t dbSNP:754559546
801 801 c, t dbSNP:781215905
807 807 c, g dbSNP:748099849
808 808 c, t dbSNP:141249033
809 809 a, g dbSNP:777486993
810 810 -, g dbSNP:199469475
810 810 a, g dbSNP:749500010
812 812 -, g dbSNP:200187516
817 817 g, t dbSNP:771095734
822 822 c, t dbSNP:774584131
824 824 c, t dbSNP:759557871
826 826 c, t dbSNP:772146306
829 829 c, g dbSNP:775976369
840 840 c, t dbSNP:375156587
846 846 c, t dbSNP:568121876
847 847 a, g dbSNP:764497897
859 859 a, g dbSNP:754195274
862 862 c, t dbSNP:5937
887 887 c, t dbSNP:121918156
889 889 c, t dbSNP:765900344
901 901 c, t dbSNP:765637777
904 904 a, c, g dbSNP:371007615
905 905 c, t dbSNP:767112991
906 906 g, t dbSNP:752290840
908 908 c, t dbSNP:121918154
914 914 g, t dbSNP:563901001
919 919 a, g dbSNP:753825629
926 926 c, g dbSNP:757001092
928 928 a, g dbSNP:146289521
931 931 c, t dbSNP:778740796
936 936 a, t dbSNP:375179157
942 942 -, agg dbSNP:752654447
943 943 g, t dbSNP:758660570
946 946 a, g dbSNP:780286813
953 953 a, g dbSNP:764737827
958 958 c, t dbSNP:768796120
960 960 c, t dbSNP:121918151
969 969 a, g dbSNP:202150408
972 972 a, g dbSNP:144233408
975 975 a, g dbSNP:200721675
978 978 c, t dbSNP:773761677
982 982 c, t dbSNP:759229398
983 983 a, c, g dbSNP:199469471
985 985 c, t dbSNP:5935
994 994 c, t dbSNP:112356403
996 996 c, t dbSNP:121918144
997 997 a, c dbSNP:753709157
1004 1004 c, t dbSNP:757272256
1008 1008 -, t dbSNP:34222720
1018 1018 c, t dbSNP:13388546
1019 1019 a, g dbSNP:121918146
1021 1021 c, t dbSNP:200731614
1029 1029 c, t dbSNP:121918160
1030 1030 a, g dbSNP:199679356
1036 1036 c, g dbSNP:755005848
1040 1040 a, g dbSNP:762519738
1045 1045 a, c dbSNP:781389633
1057 1057 a, c, g dbSNP:748577703
1060 1060 c, t dbSNP:778455687
1063 1063 a, c, t dbSNP:568793026
1064 1064 a, g dbSNP:571278160
1074 1074 a, t dbSNP:199469480
1076 1076 c, t dbSNP:201907715
1078 1078 c, t dbSNP:760435505
1079 1079 a, g dbSNP:757023301
1086 1086 a, g dbSNP:776245026
1088 1088 c, g dbSNP:761348643
1093 1093 c, t dbSNP:765115028
1094 1094 a, g dbSNP:121918150
1104 1104 c, t dbSNP:369881972
1108 1108 c, t dbSNP:762672544
1109 1109 a, g dbSNP:121918158
1113 1113 c, t dbSNP:766261022
1114 1114 a, g dbSNP:751714439
1117 1117 c, t dbSNP:373299422
1120 1120 c, g dbSNP:781097228
1121 1121 a, g dbSNP:121918147
1124 1124 a, t dbSNP:752782202
1136 1136 c, t dbSNP:121918141
1137 1137 a, g dbSNP:201827066
1141 1141 c, g dbSNP:749815057
1144 1144 a, g dbSNP:771411580
1152 1152 a, g dbSNP:779384632
1155 1155 a, g dbSNP:746611530
1159 1159 c, t dbSNP:548020208
1160 1160 c, t dbSNP:776173921
1161 1161 a, g, t dbSNP:763603757
1168 1168 c, t dbSNP:769300513
1169 1169 a, g, t dbSNP:375912553
1171 1171 c, g dbSNP:766061833
1192 1192 c, t dbSNP:751406743
1193 1193 a, g dbSNP:140582220
1194 1194 c, t dbSNP:767730328
1196 1196 a, g dbSNP:752981292
1201 1201 a, g dbSNP:61731660
1204 1204 a, c dbSNP:778063605
1205 1205 a, g dbSNP:145800354
1209 1209 a, g dbSNP:555974192
1214 1214 a, t dbSNP:757880924
1215 1215 a, g dbSNP:779319957
1216 1216 c, t dbSNP:187228759
1217 1217 a, g dbSNP:368901479
1225 1225 a, g dbSNP:780833999
1255 1255 c, t dbSNP:148855579
1257 1257 c, g dbSNP:769277939
1258 1258 a, g dbSNP:373028935
1268 1268 a, c, g dbSNP:756467027
1273 1273 c, t dbSNP:148035465
1274 1274 c, t dbSNP:759316085
1275 1275 a, g dbSNP:767219916
1278 1278 a, g dbSNP:775849125
1288 1288 c, t dbSNP:146028808
1289 1289 a, g dbSNP:764239787
1290 1290 a, c dbSNP:201399407
1294 1294 c, t dbSNP:780422419
1295 1295 a, g dbSNP:142742242
1306 1306 a, g dbSNP:370637632
1311 1311 a, t dbSNP:758788677
1312 1312 a, g dbSNP:780456728
1315 1315 c, t dbSNP:747775229
1316 1316 a, g dbSNP:374259918
1327 1327 c, t dbSNP:777430545
1328 1328 a, g dbSNP:139741458
1331 1331 a, g dbSNP:572021052
1335 1335 c, g dbSNP:768759265
1337 1337 c, t dbSNP:745857900
1343 1343 c, g dbSNP:144760718
1348 1348 c, t dbSNP:775467256
1352 1352 g, t dbSNP:199469472
1353 1353 a, t dbSNP:760579201
1355 1355 a, g dbSNP:764364405
1366 1366 a, g dbSNP:770534863
1382 1382 c, t dbSNP:761888935
1390 1390 c, t dbSNP:765303744
1392 1392 a, g dbSNP:750931702
1393 1393 c, t dbSNP:151319700
1394 1394 a, g dbSNP:766695272
1396 1396 c, t dbSNP:377613736
1399 1399 c, t dbSNP:755354438
1413 1413 a, g dbSNP:777348309
1415 1415 c, t dbSNP:753436021
1420 1420 c, g, t dbSNP:748650244
1426 1426 c, g dbSNP:121918142
1427 1427 a, c dbSNP:200012319
1429 1429 c, g dbSNP:121918157
1436 1436 c, t dbSNP:368520760
1438 1438 c, t dbSNP:367727016
1439 1439 a, g dbSNP:772096495
1448 1448 a, g dbSNP:780162904
1450 1450 a, g dbSNP:371265125
1453 1453 a, g dbSNP:374484815
1468 1468 c, g dbSNP:776993248
1473 1473 a, c dbSNP:367745240
1476 1476 c, t dbSNP:769898505
1478 1478 c, t dbSNP:370298954
1481 1481 c, t dbSNP:199900627
1485 1485 c, t dbSNP:766818039
1500 1500 a, g dbSNP:752071296
1512 1512 a, g dbSNP:759828747
1523 1523 a, g dbSNP:577754626
1540 1540 -, g dbSNP:369564006
1552 1552 c, t dbSNP:546314105
1553 1553 c, t dbSNP:199469473
1597 1597 c, g dbSNP:1042759
1626 1626 c, t dbSNP:140461934
1634 1634 a, t dbSNP:76963348
1650 1650 g, t dbSNP:563767423
1656 1656 c, t dbSNP:150393087
1688 1688 a, g dbSNP:547719046
1707 1707 a, g dbSNP:542260333
1726 1726 g, t dbSNP:769502673
1747 1747 a, g dbSNP:775089029
1748 1748 a, c, t dbSNP:562021279
1770 1770 c, t dbSNP:527994566
1773 1773 c, t dbSNP:548104755

Target ORF information:

RefSeq Version NM_000312
Organism Homo sapiens (human)
Definition Homo sapiens protein C (inactivator of coagulation factors Va and VIIIa) (PROC), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000312

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTGGCAGC TCACAAGCCT CCTGCTGTTC GTGGCCACCT GGGGAATTTC CGGCACACCA 
GCTCCTCTTG ACTCAGTGTT CTCCAGCAGC GAGCGTGCCC ACCAGGTGCT GCGGATCCGC
AAACGTGCCA ACTCCTTCCT GGAGGAGCTC CGTCACAGCA GCCTGGAGCG GGAGTGCATA
GAGGAGATCT GTGACTTCGA GGAGGCCAAG GAAATTTTCC AAAATGTGGA TGACACACTG
GCCTTCTGGT CCAAGCACGT CGACGGTGAC CAGTGCTTGG TCTTGCCCTT GGAGCACCCG
TGCGCCAGCC TGTGCTGCGG GCACGGCACG TGCATCGACG GCATCGGCAG CTTCAGCTGC
GACTGCCGCA GCGGCTGGGA GGGCCGCTTC TGCCAGCGCG AGGTGAGCTT CCTCAATTGC
TCGCTGGACA ACGGCGGCTG CACGCATTAC TGCCTAGAGG AGGTGGGCTG GCGGCGCTGT
AGCTGTGCGC CTGGCTACAA GCTGGGGGAC GACCTCCTGC AGTGTCACCC CGCAGTGAAG
TTCCCTTGTG GGAGGCCCTG GAAGCGGATG GAGAAGAAGC GCAGTCACCT GAAACGAGAC
ACAGAAGACC AAGAAGACCA AGTAGATCCG CGGCTCATTG ATGGGAAGAT GACCAGGCGG
GGAGACAGCC CCTGGCAGGT GGTCCTGCTG GACTCAAAGA AGAAGCTGGC CTGCGGGGCA
GTGCTCATCC ACCCCTCCTG GGTGCTGACA GCGGCCCACT GCATGGATGA GTCCAAGAAG
CTCCTTGTCA GGCTTGGAGA GTATGACCTG CGGCGCTGGG AGAAGTGGGA GCTGGACCTG
GACATCAAGG AGGTCTTCGT CCACCCCAAC TACAGCAAGA GCACCACCGA CAATGACATC
GCACTGCTGC ACCTGGCCCA GCCCGCCACC CTCTCGCAGA CCATAGTGCC CATCTGCCTC
CCGGACAGCG GCCTTGCAGA GCGCGAGCTC AATCAGGCCG GCCAGGAGAC CCTCGTGACG
GGCTGGGGCT ACCACAGCAG CCGAGAGAAG GAGGCCAAGA GAAACCGCAC CTTCGTCCTC
AACTTCATCA AGATTCCCGT GGTCCCGCAC AATGAGTGCA GCGAGGTCAT GAGCAACATG
GTGTCTGAGA ACATGCTGTG TGCGGGCATC CTCGGGGACC GGCAGGATGC CTGCGAGGGC
GACAGTGGGG GGCCCATGGT CGCCTCCTTC CACGGCACCT GGTTCCTGGT GGGCCTGGTG
AGCTGGGGTG AGGGCTGTGG GCTCCTTCAC AACTACGGCG TTTACACCAA AGTCAGCCGC
TACCTCGACT GGATCCATGG GCACATCAGA GACAAGGAAG CCCCCCAGAA GAGCTGGGCA
CCTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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